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Article ; Online: El «signo de la comba» como causa de insuficiencia mitral reversible durante la TAVI transapical

Uxía Taboada Rodríguez / Víctor X. Mosquera / Alberto Bouzas-Mosquera / José Joaquín Cuenca-Castillo

Cirugía Cardiovascular, Vol 30, Iss 6, Pp 348-

2023 Volume 350

Abstract: Resumen: La insuficiencia mitral (IM) es una complicación que puede ocurrir durante el implante valvular aórtico transcatéter (TAVI) y puede requerir un tratamiento diferente dependiendo de su mecanismo. En este artículo, se describe el «signo de la ... ...

Abstract	Resumen: La insuficiencia mitral (IM) es una complicación que puede ocurrir durante el implante valvular aórtico transcatéter (TAVI) y puede requerir un tratamiento diferente dependiendo de su mecanismo. En este artículo, se describe el «signo de la comba» como causa de insuficiencia mitral severa debido al atrapamiento de la guía de alto soporte (Amplatz) en las cuerdas tendinosas del velo anterior mitral (VAM), causando el tethering del mismo contra la pared ventricular durante la realización de una TAVI transapical. Abstract: Mitral regurgitation is a complication that may occur during transcatheter aortic valve implantation (TAVI) and may require different treatments depending on the mechanism. In this report we describe for a «skipping rope sign» in transapical TAVI as a cause of severe mitral regurgitation due to extreme tethering of the anterior mitral leaflet caused by an extra-stiff guidewire entangled in its chordae tendineae during a transapical TAVI.
Keywords	Transapical TAVI ; Complications ; Mitral regurgitation ; Medicine ; R ; Surgery ; RD1-811
Language	Spanish
Publishing date	2023-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical and structural outcomes of neocommissural alignment in transaxillary and transcarotid transcatheter aortic valve implantation with a self-expandable transcatheter heart valve.

Mosquera, Victor X / Muinelo-Paul, Adrian / Pato-López, Oscar / Bouzas-Mosquera, Alberto / Cuenca-Castillo, José J

JTCVS techniques

2023 Volume 22, Page(s) 150–158

Abstract: Objectives: This study analyzes neocommissural alignment and the clinical and hemodynamic outcomes after transaxillary and transcarotid implantation of the Acurate neo2 transcatheter heart valve.: Methods: We performed a retrospective, single-center ... ...

Abstract	Objectives: This study analyzes neocommissural alignment and the clinical and hemodynamic outcomes after transaxillary and transcarotid implantation of the Acurate neo2 transcatheter heart valve. Methods: We performed a retrospective, single-center analysis of early outcomes after transaxillary and transcarotid implantation of the Acurate neo2 transcatheter heart valve. Primary outcomes were neocommisural alignment, in-hospital mortality, and valve hemodynamic performance. Commissural alignment between native and transcatheter heart valves was assessed by transesophageal echocardiogram before and after the procedure. Results: Between October 2021 and November 2022, 40 consecutive patients were treated with the Acurate neo2 through a transaxillary or transcarotid approach. Access was achieved via the left subclavian artery in 30 cases and the left common carotid artery in 10 cases, with a mean vessel diameter of 6.7 mm. Implants most commonly used were size M (37.5%), L (35%), and S (27.5%). On the basis of transesophageal echocardiogram analysis, there was no significant difference in mean commissural orientation between native (mean, 65.1°; SD, 41.3°) and neocommissures (mean, 64°; SD, 44.1°) ( Conclusions: This patient-specific technique for transaxillary and transcarotid insertion of the Acurate neo2 delivery system prevents implantations with more than mild commissural misalignment and with a high device success rate.
Language	English
Publishing date	2023-07-21
Publishing country	United States
Document type	Journal Article
ISSN	2666-2507
ISSN (online)	2666-2507
DOI	10.1016/j.xjtc.2023.06.017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The key for successfully managing aortobronchial and aortoesophageal fistulae may lay in their etiology.

Mosquera, Victor X

The Journal of thoracic and cardiovascular surgery

2014 Volume 148, Issue 6, Page(s) 3257–3258

MeSH term(s)	Aortic Diseases/therapy ; Bronchial Fistula/therapy ; Endovascular Procedures ; Esophageal Fistula/therapy ; Female ; Humans ; Male ; Vascular Fistula/therapy ; Vascular Surgical Procedures
Language	English
Publishing date	2014-12
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2014.09.068
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Article ; Online: Giant ascending aortic aneurysm with impending rupture as presentation of cutis laxa 1B: a case report.

Used-Gavín, Alejandro / Larrañaga-Moreira, José María / Lago-Cascudo, Rafael / Mosquera-Rodríguez, Víctor X / Barriales-Villa, Roberto

European heart journal. Case reports

2023 Volume 7, Issue 11, Page(s) ytad530

Abstract: Background: Thoracic aortic aneurysms are rarely symptomatic but can result in acute aortic syndromes, associated with a high mortality rate. While most cases may be acquired, a genetic basis is evident in approximately 20-25% of the cases, especially ... ...

Abstract	Background: Thoracic aortic aneurysms are rarely symptomatic but can result in acute aortic syndromes, associated with a high mortality rate. While most cases may be acquired, a genetic basis is evident in approximately 20-25% of the cases, especially among patients under 50 years of age, and those exhibiting syndromic features or family history. Although autosomal dominant inheritance is predominant in familial aortopathies, exceptions exist, such as cutis laxa 1B (CL1B)-related aortic disease, caused by variants in Case summary: We present the case of a 26-year-old male with a giant ascending aorta aneurysm and massive pericardial effusion, which was ultimately diagnosed of CL1B due to the p.Ser137Cys variant in the Discussion: This case underscores the importance of genetic testing in young patients presenting with aortopathies, syndromic features, or atypical presentations, irrespective of family history.
Language	English
Publishing date	2023-11-20
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytad530
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Article: Combined Therapeutics for Atherosclerosis Treatment Using Polymeric Nanovectors.

Leal, Baltazar Hiram / Velasco, Brenda / Cambón, Adriana / Pardo, Alberto / Fernandez-Vega, Javier / Arellano, Lilia / Al-Modlej, Abeer / Mosquera, Víctor X / Bouzas, Alberto / Prieto, Gerardo / Barbosa, Silvia / Taboada, Pablo

Pharmaceutics

2022 Volume 14, Issue 2

Abstract: Atherosclerosis is an underlying risk factor in cardiovascular diseases (CVDs). The combination of drugs with microRNAs (miRNA) inside a single nanocarrier has emerged as a promising anti-atherosclerosis strategy to achieve the exploitation of their ... ...

Abstract	Atherosclerosis is an underlying risk factor in cardiovascular diseases (CVDs). The combination of drugs with microRNAs (miRNA) inside a single nanocarrier has emerged as a promising anti-atherosclerosis strategy to achieve the exploitation of their complementary mechanisms of action to achieve synergistic therapeutic effects while avoiding some of the drawbacks associated with current systemic statin therapies. We report the development of nanometer-sized polymeric PLGA nanoparticles (NPs) capable of simultaneously encapsulating and delivering miRNA-124a and the statin atorvastatin (ATOR). The polymeric NPs were functionalized with an antibody able to bind to the vascular adhesion molecule-1 (VCAM1) overexpressed in the inflamed arterial endothelium. The dual-loaded NPs were non-toxic to cells in a large range of concentrations, successfully attached overexpressed VCAM receptors and released the cargoes in a sustainable manner inside cells. The combination of both ATOR and miRNA drastically reduced the levels of proinflammatory cytokines such as IL-6 and TNF-α and of reactive oxygen species (ROS) in LPS-activated macrophages and vessel endothelial cells. In addition, dual-loaded NPs precluded the accumulation of low-density lipoproteins (LdL) inside macrophages as well as morphology changes to a greater extent than in single-loaded NPs. The reported findings validate the present NPs as suitable delivery vectors capable of simultaneously targeting inflamed cells in atherosclerosis and providing an efficient approach to combination nanomedicines.
Language	English
Publishing date	2022-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics14020258
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Article ; Online: Non-contrast transoesophageal echo-guided transapical transcatheter aortic valve replacement: 10-year experience of a renoprotective strategy.

Mosquera, Victor X / Bouzas-Mosquera, Alberto / Vilela-González, Yago / Oujo-González, Bárbara / Velasco-García, Carlos / Cuenca-Castillo, José J / Herrera-Noreña, José M

Interactive cardiovascular and thoracic surgery

2021 Volume 33, Issue 2, Page(s) 195–202

Abstract: Objectives: This study aims to evaluate the efficacy, safety and long-term outcomes of a renoprotective non-contrast, transoesophageal echocardiography-guided transapical (TA) transcatheter aortic valve replacement (TAVR) strategy with a balloon- ... ...

Abstract	Objectives: This study aims to evaluate the efficacy, safety and long-term outcomes of a renoprotective non-contrast, transoesophageal echocardiography-guided transapical (TA) transcatheter aortic valve replacement (TAVR) strategy with a balloon-expandable prosthesis, as well as to determine its impact on renal function. Methods: Between 2009 and 2019, 200 consecutive patients underwent a non-contrast, transoesophageal echocardiography-guided TA TAVR with a balloon-expandable prosthesis. Results: The device success rate was 95.5%. Transoesophageal echocardiography-guided deployment demonstrated a low rate of procedure-related complications: 9.5% of acute kidney injury, 8% postoperative bleeding, 6% low-cardiac output, 4.5% postprocedural aortic regurgitation ≥+2, 4% implantation of permanent pacemaker and 2% stroke. There were no significant differences between preoperative and on discharge estimated glomerular filtration rate (53.9 ± 22.2 vs 54.3 ± 22.9 ml/min/1.73 m2, P = 0.60). Logistic regression analysis confirmed postoperative bleeding as an independent predictor for acute kidney injury (odds ratio (OR) 11.148, 95% confidence interval 3.537-35.140, P < 0.001). In-hospital mortality was 7.5%. The mean follow-up was 48.5 ± 39.9 months. Renal function and patient's chronic kidney disease stage did not significantly vary during follow-up. Long-term cumulative survival at 1, 5 and 10 years was 84.2 ± 0.027%, 42.9 ± 0.038% and 32.5 ± 0.044%, respectively. Renal function affected on neither in-hospital mortality nor long-term survival. Conclusions: Non-contrast, transoesophageal echocardiography-guided TA TAVR is a safe and reproducible technique with a low incidence of periprocedural complications that avoids the use of contrast and mitigates the incidence of acute kidney injury.
MeSH term(s)	Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Cardiac Catheterization ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Risk Factors ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	English
Publishing date	2021-04-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivab080
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Article: Gold Nanorod-Based Nanohybrids for Combinatorial Therapeutics.

Villar-Alvarez, Eva / Cambón, Adriana / Pardo, Alberto / Mosquera, Víctor X / Bouzas-Mosquera, Alberto / Topete, Antonio / Barbosa, Silvia / Taboada, Pablo / Mosquera, Víctor

ACS omega

2018 Volume 3, Issue 10, Page(s) 12633–12647

Abstract: In this work, multifunctional nanocarriers consisting of poly(sodium-4-styrenesulfonate) (PSS)/doxorubicin (DOXO)/poly-l-lysine hydrobromide (PLL)/hyaluronic acid (HA)-coated and (PSS/DOXO/PLL) ...

Abstract	In this work, multifunctional nanocarriers consisting of poly(sodium-4-styrenesulfonate) (PSS)/doxorubicin (DOXO)/poly-l-lysine hydrobromide (PLL)/hyaluronic acid (HA)-coated and (PSS/DOXO/PLL)
Language	English
Publishing date	2018-10-04
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN	2470-1343
DOI	10.1021/acsomega.8b01591
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Article ; Online: El impacto de determinadas disfunciones orgánicas preoperatorias en pacientes sometidos a sustitución valvular aórtica

Victor X. Mosquera Rodríguez

Cirugía Cardiovascular, Vol 20, Iss 4, Pp 214-

2013 Volume 215

Keywords	Medicine ; R ; Surgery ; RD1-811
Language	Spanish
Publishing date	2013-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Balloon-expanding transcatheter aortic valve implantation for degenerated Mitroflow bioprostheses: clinical and echocardiographic long-term outcomes.

Mosquera, Victor X / Bouzas-Mosquera, Alberto / Vilela-González, Yago / Velasco, Carlos / Salgado-Fernández, Jorge / Calviño-Santos, Ramón / Vázquez-González, Nicolás / Vázquez-Rodríguez, José M / Herrera-Noreña, José M

Interactive cardiovascular and thoracic surgery

2021 Volume 33, Issue 2, Page(s) 173–180

Abstract: Objectives: This study aims to analyse the risks associated with valve-in-valve procedures for treating structural valve deterioration in Mitroflow bioprostheses, as well as to determine the impact of the original Mitroflow size on the patients' long- ... ...

Abstract	Objectives: This study aims to analyse the risks associated with valve-in-valve procedures for treating structural valve deterioration in Mitroflow bioprostheses, as well as to determine the impact of the original Mitroflow size on the patients' long-term outcomes. Methods: Between January 2012 and September 2019, 21 patients (61.9% males; mean age 82.4 ± 5.4 years) were treated for Mitroflow deterioration with valve-in-valve procedures (12 transapical and 9 transfemoral). Results: Mean EuroSCORE I and EuroSCORE II were 28.2% ± 13.6% and 10.5% ± 6.1%, respectively. Six patients presented an indexed aortic root diameter <14 mm/m2 and 7 patients a diameter of sinus of Valsalva <30 mm. Implanted transcatheter valve sizes were 20 mm in 6 cases, 23 mm in 14 cases and 26 mm in 1 patient. A Valve Academic Research Consortium-2 complication occurred in 23.8% of cases, including 3 coronary occlusions. In-hospital mortality was 9.5%. The 20 mm transcatheter valves presented significantly higher postoperative peak and mean aortic gradients than other sizes (54.1 ± 11.3 mmHg vs 29.9 ± 9.6 mmHg, P = 0.003; and 29.3 ± 7.7 mmHg vs 17.4 ± 5.9 mmHg, P = 0.015, respectively). There were 12 cases of patient-prosthesis mismatch (57.1%) and 3 cases (14.3%) of severe patient-prosthesis mismatch. Cumulative survival was 85.7% ± 7.6% at 1 year, 74.3% ± 10% at 2 years and 37.1% ± 14.1% at 5 years. Conclusions: Valve-in-valve procedures with balloon-expandable transcatheter valves associate a high risk of coronary occlusion in patients with indexed aortic root diameter <14 mm/m2 and low coronary ostia <12 mm. Valve-in valve procedures with 20 mm balloon-expandable transcatheter valves in ≤21 mm Mitroflow bioprosthesis leave significant residual transvalvular gradients that might obscure patients' long-term outcomes.
MeSH term(s)	Aged ; Aged, 80 and over ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Bioprosthesis ; Echocardiography ; Female ; Fluoroscopy ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Male ; Prosthesis Design ; Prosthesis Failure ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	English
Publishing date	2021-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivab065
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Article ; Online: Treatment solution by Rivas-Oural et al.

Rivas-Oural, Alba / Mosquera, Victor X / Fraga-Manteiga, Daniel / Cuenca, Jose J

Interactive cardiovascular and thoracic surgery

2017 Volume 24, Issue 3, Page(s) 472–473

Language	English
Publishing date	2017-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2095298-3
ISSN	1569-9285 ; 1569-9293
ISSN (online)	1569-9285
ISSN	1569-9293
DOI	10.1093/icvts/ivw335
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