LIVIVO - Search results -

Search results

Result 1 - 10 of total 36260

Search options

Article ; Online: Noel Warner Ph.D.

Preffer, Frederic / Dunne, Jack / Recktenwald, Diether / Blidy, Andrew / Lanier, Lewis / Trotter, Joe / Daley, Michael J

Cytometry. Part B, Clinical cytometry

2023 Volume 104, Issue 1, Page(s) 7–9

MeSH term(s)	Humans ; Flow Cytometry
Language	English
Publishing date	2023-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2099657-3
ISSN	1552-4957 ; 1552-4949 ; 0196-4763
ISSN (online)	1552-4957
ISSN	1552-4949 ; 0196-4763
DOI	10.1002/cyto.b.22112
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1688: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Dopamine D

Lewis, Mechelle M / Van Scoy, Lauren J / De Jesus, Sol / Hakun, Jonathan G / Eslinger, Paul J / Fernandez-Mendoza, Julio / Kong, Lan / Yang, Yang / Snyder, Bethany L / Loktionova, Natalia / Duvvuri, Sridhar / Gray, David L / Huang, Xuemei / Mailman, Richard B

Biomolecules

2023 Volume 13, Issue 5

Abstract: ... metrics inadequately gauge efficacy in LsPD patients. We explored if a D ...

Abstract	Current pharmacotherapy has limited efficacy and/or intolerable side effects in late-stage Parkinson's disease (LsPD) patients whose daily life depends primarily on caregivers and palliative care. Clinical metrics inadequately gauge efficacy in LsPD patients. We explored if a D
MeSH term(s)	Humans ; Parkinson Disease/drug therapy ; Levodopa/therapeutic use ; Levodopa/adverse effects ; Dopamine Agonists/therapeutic use ; Antiparkinson Agents/therapeutic use ; Dopamine
Chemical Substances	Levodopa (46627O600J) ; Dopamine Agonists ; Antiparkinson Agents ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2023-05-12
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13050829
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Precise Measurement of the D_{s}^{+} Lifetime at Belle II.

Adachi, I / Aggarwal, L / Aihara, H / Akopov, N / Aloisio, A / Anh Ky, N / Asner, D M / Atmacan, H / Aushev, T / Aushev, V / Aversano, M / Babu, V / Bae, H / Bahinipati, S / Bambade, P / Banerjee, Sw / Barrett, M / Baudot, J / Bauer, M /

Baur, A / Beaubien, A / Becker, J / Behera, P K / Bennett, J V / Bernlochner, F U / Bertacchi, V / Bertemes, M / Bertholet, E / Bessner, M / Bettarini, S / Bhuyan, B / Bianchi, F / Bilka, T / Biswas, D / Bodrov, D / Bondar, A / Bozek, A / Bračko, M / Branchini, P / Briere, R A / Browder, T E / Budano, A / Bussino, S / Campajola, M / Cao, L / Casarosa, G / Cecchi, C / Cerasoli, J / Chang, M-C / Chang, P / Cheema, P / Chekelian, V / Cheon, B G / Chilikin, K / Chirapatpimol, K / Cho, H-E / Cho, K / Choi, S-K / Choudhury, S / Cochran, J / Corona, L / Das, S / Dattola, F / De La Motte, S A / de Marino, G / De Nardo, G / De Nuccio, M / De Pietro, G / de Sangro, R / Destefanis, M / Dey, S / Dhamija, R / Di Canto, A / Di Capua, F / Dingfelder, J / Doležal, Z / Domínguez Jiménez, I / Dong, T V / Dorigo, M / Dort, K / Dreyer, S / Dubey, S / Dujany, G / Ecker, P / Epifanov, D / Feichtinger, P / Ferlewicz, D / Finck, C / Finocchiaro, G / Fodor, A / Forti, F / Frey, A / Fulsom, B G / Gabrielli, A / Ganiev, E / Garcia-Hernandez, M / Garmash, A / Gaudino, G / Gaur, V / Gaz, A / Gellrich, A / Ghevondyan, G / Ghosh, D / Ghumaryan, H / Giakoustidis, G / Giordano, R / Giri, A / Glazov, A / Gobbo, B / Godang, R / Gogota, O / Goldenzweig, P / Gradl, W / Graziani, E / Greenwald, D / Gruberová, Z / Gu, T / Guan, Y / Gudkova, K / Han, Y / Hayasaka, K / Hayashii, H / Hazra, S / Hearty, C / Heredia de la Cruz, I / Hershenhorn, A / Higuchi, T / Hill, E C / Hoek, M / Hohmann, M / Hsu, C-L / Humair, T / Iijima, T / Inami, K / Ipsita, N / Ishikawa, A / Ito, S / Itoh, R / Iwasaki, M / Jackson, P / Jacobs, W W / Jaffe, D E / Jang, E-J / Ji, Q P / Jia, S / Jin, Y / Junkerkalefeld, H / Kaliyar, A B / Kandra, J / Karyan, G / Kawasaki, T / Keil, F / Ketter, C / Kiesling, C / Kim, C-H / Kim, D Y / Kim, K-H / Kim, Y-K / Kindo, H / Kinoshita, K / Kodyš, P / Koga, T / Kohani, S / Kojima, K / Korobov, A / Korpar, S / Kowalewski, R / Kraetzschmar, T M G / Križan, P / Krokovny, P / Kuhr, T / Kumar, J / Kumar, M / Kumar, R / Kumara, K / Kuzmin, A / Kwon, Y-J / Lacaprara, S / Lai, Y-T / Lam, T / Lange, J S / Laurenza, M / Leboucher, R / Le Diberder, F R / Leitl, P / Levit, D / Lewis, P M / Li, L K / Libby, J / Liu, Q Y / Liu, Z Q / Liventsev, D / Longo, S / Lueck, T / Lyu, C / Ma, Y / Maggiora, M / Maharana, S P / Maiti, R / Maity, S / Manfredi, R / Manoni, E / Mantovano, M / Marcantonio, D / Marcello, S / Marinas, C / Martellini, C / Martini, A / Martinov, T / Massaccesi, L / Masuda, M / Matsuda, T / Matsuoka, K / Matvienko, D / Maurya, S K / McKenna, J A / Mehta, R / Meier, F / Merola, M / Metzner, F / Milesi, M / Miller, C / Mirra, M / Miyabayashi, K / Mohanty, G B / Molina-Gonzalez, N / Mondal, S / Moneta, S / Moser, H-G / Mrvar, M / Mussa, R / Nakamura, I / Nakazawa, Y / Narimani Charan, A / Naruki, M / Natkaniec, Z / Natochii, A / Nayak, L / Nazaryan, G / Nisar, N K / Nishida, S / Ono, H / Otani, F / Oxford, E R / Pakhlov, P / Pakhlova, G / Paladino, A / Panta, A / Paoloni, E / Pardi, S / Passeri, A / Patra, S / Paul, S / Pedlar, T K / Peruzzi, I / Peschke, R / Pestotnik, R / Pham, F / Piccolo, M / Piilonen, L E / Podobnik, T / Pokharel, S / Praz, C / Prell, S / Prencipe, E / Prim, M T / Purwar, H / Rados, P / Raeuber, G / Raiz, S / Reif, M / Reiter, S / Remnev, M / Ripp-Baudot, I / Rizzo, G / Roney, J M / Rostomyan, A / Rout, N / Russo, G / Sandilya, S / Sangal, A / Santelj, L / Sato, Y / Savinov, V / Scavino, B / Schmitt, C / Schwanda, C / Schwartz, A J / Seino, Y / Selce, A / Senyo, K / Serrano, J / Sevior, M E / Sfienti, C / Shan, W / Shi, X D / Shillington, T / Shiu, J-G / Shtol, D / Sibidanov, A / Simon, F / Sobie, R J / Sobotzik, M / Soffer, A / Sokolov, A / Solovieva, E / Spataro, S / Spruck, B / Starič, M / Stavroulakis, P / Stottler, Z S / Stroili, R / Sumihama, M / Svidras, H / Takahashi, M / Takizawa, M / Tamponi, U / Tanida, K / Tenchini, F / Tittel, O / Tonelli, D / Torassa, E / Trabelsi, K / Tsaklidis, I / Unger, K / Unno, Y / Uno, K / Uno, S / Urquijo, P / Ushiroda, Y / Vahsen, S E / van Tonder, R / Varvell, K E / Veronesi, M / Vismaya, V S / Vitale, L / Volpe, R / Wach, B / Wallner, S / Wang, E / Wang, M-Z / Wang, X L / Wang, Z / Warburton, A / Watanabe, M / Wessel, C / Won, E / Xu, X P / Yabsley, B D / Yamada, S / Yan, W / Yang, S B / Yoshihara, K / Yuan, C Z / Yusa, Y / Zhang, Y / Zhilich, V / Zhou, J S / Zhou, Q D / Zhukova, V I / Žlebčík, R

Physical review letters

2023 Volume 131, Issue 17, Page(s) 171803

Abstract: We measure the lifetime of the D_{s}^{+} meson using a data sample of 207 fb^{-1} collected ... determined by fitting the decay-time distribution of a sample of 116×10^{3} D_{s}^{+}→ϕπ^{+} decays ... Our result is τ_{D_{s}^{+}}=(499.5±1.7±0.9) fs, where the first uncertainty is statistical and the second is ...

Abstract	We measure the lifetime of the D_{s}^{+} meson using a data sample of 207 fb^{-1} collected by the Belle II experiment running at the SuperKEKB asymmetric-energy e^{+}e^{-} collider. The lifetime is determined by fitting the decay-time distribution of a sample of 116×10^{3} D_{s}^{+}→ϕπ^{+} decays. Our result is τ_{D_{s}^{+}}=(499.5±1.7±0.9) fs, where the first uncertainty is statistical and the second is systematic. This result is significantly more precise than previous measurements.
Language	English
Publishing date	2023-11-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.171803
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 58/153: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A Dopamine D

Yang, Yang / Lewis, Mechelle M / Kong, Lan / Mailman, Richard B

The Journal of pharmacology and experimental therapeutics

2022 Volume 382, Issue 2, Page(s) 88–99

Abstract: ... D ...

Abstract	Methylphenidate is used widely to treat symptoms of attention-deficit/hyperactivity disorder (ADHD), but like other stimulants has significant side effects. This study used a rodent model (spontaneously hypertensive rat) of spatial working memory (sWM) to compare the effects of methylphenidate with the novel dopamine D
MeSH term(s)	Animals ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Central Nervous System Stimulants/pharmacology ; Dopamine ; Dopamine Agonists/pharmacology ; Memory, Short-Term ; Methylphenidate/pharmacology ; Prefrontal Cortex ; Rats ; Receptors, Dopamine D1/physiology ; Retrospective Studies
Chemical Substances	Central Nervous System Stimulants ; Dopamine Agonists ; Receptors, Dopamine D1 ; Methylphenidate (207ZZ9QZ49) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2022-06-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	3106-9
ISSN	1521-0103 ; 0022-3565
ISSN (online)	1521-0103
ISSN	0022-3565
DOI	10.1124/jpet.122.001215
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uf I Zs.40: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Dopamine D

Yang, Yang / Lewis, Mechelle M / Huang, Xuemei / Dokholyan, Nikolay V / Mailman, Richard B

The international journal of biochemistry & cell biology

2022 Volume 148, Page(s) 106235

Abstract: ... ligands for the dopamine D ...

Abstract	The awareness of the potential importance of functional selectivity/biased signaling has led to the discovery of biased compounds as both research tools and novel drugs. A major pan-receptor focus has been to identify GPCR-selective ligands that have bias in G protein-dependent vs. β-arrestin related signaling. Although this field has exploded during the past two decades, it is only recently that highly β-arrestin biased ligands for the dopamine D
MeSH term(s)	Animals ; Arrestins/metabolism ; Biology ; Dopamine/metabolism ; Ligands ; Neurophysiology ; Signal Transduction ; beta-Arrestin 1/metabolism ; beta-Arrestins/metabolism
Chemical Substances	Arrestins ; Ligands ; beta-Arrestin 1 ; beta-Arrestins ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2022-06-07
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1228429-4
ISSN	1878-5875 ; 1357-2725
ISSN (online)	1878-5875
ISSN	1357-2725
DOI	10.1016/j.biocel.2022.106235
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 431: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats.

Bates, James N / Getsy, Paulina M / Coffee, Gregory A / Baby, Santhosh M / MacFarlane, Peter M / Hsieh, Yee-Hsee / Knauss, Zackery T / Bubier, Jason A / Mueller, Devin / Lewis, Stephen J

Frontiers in pharmacology

2024 Volume 14, Page(s) 1336440

Abstract: We examined whether co-injections of the cell-permeant D-cysteine analogues, D-cysteine ethyl ester ... D-CYSee) and D-cysteine ethyl amide (D-CYSea), prevent acquisition of physical dependence induced ... that had received co-injections of D-CYSee (250 μmol/kg, IV) or D-CYSea (100 μmol/kg, IV), but not D ...

Abstract	We examined whether co-injections of the cell-permeant D-cysteine analogues, D-cysteine ethyl ester (D-CYSee) and D-cysteine ethyl amide (D-CYSea), prevent acquisition of physical dependence induced by twice-daily injections of fentanyl, and reverse acquired dependence to these injections in freely-moving male Sprague Dawley rats. Injection of the opioid receptor antagonist, naloxone HCl (NLX, 1.5 mg/kg, IV), elicited a series of withdrawal phenomena that included cardiorespiratory and behavioral responses, and falls in body weight and body temperature, in rats that received 5 or 10 injections of fentanyl (125 μg/kg, IV), and the same number of vehicle co-injections. Regarding the development of physical dependence, the NLX-precipitated withdrawal phenomena were markedly reduced in fentanyl-injected rats that had received co-injections of D-CYSee (250 μmol/kg, IV) or D-CYSea (100 μmol/kg, IV), but not D-cysteine (250 μmol/kg, IV). Regarding reversal of established dependence to fentanyl, the NLX-precipitated withdrawal phenomena in rats that had received 10 injections of fentanyl (125 μg/kg, IV) was markedly reduced in rats that received co-injections of D-CYSee (250 μmol/kg, IV) or D-CYSea (100 μmol/kg, IV), but not D-cysteine (250 μmol/kg, IV), starting with injection 6 of fentanyl. This study provides evidence that co-injections of D-CYSee and D-CYSea prevent the acquisition of physical dependence, and reverse acquired dependence to fentanyl in male rats. The lack of effect of D-cysteine suggests that the enhanced cell-penetrability of D-CYSee and D-CYSea into cells, particularly within the brain, is key to their ability to interact with intracellular signaling events involved in acquisition to physical dependence to fentanyl.
Language	English
Publishing date	2024-04-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1336440
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Reply to A Drewnowski et al, O Devinsky, D A Booth and E L Gibson, and D J Millward.

Ludwig, David S / Aronne, Louis J / Astrup, Arne / de Cabo, Rafael / Cantley, Lewis C / Friedman, Mark I / Heymsfield, Steven B / Johnson, James D / King, Janet C / Krauss, Ronald M / Lieberman, Daniel E / Taubes, Gary / Volek, Jeff S / Westman, Eric C / Willett, Walter C / Yancy, William S / Ebbeling, Cara B

The American journal of clinical nutrition

2022 Volume 115, Issue 2, Page(s) 595–597

Language	English
Publishing date	2022-02-09
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.1093/ajcn/nqab385
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ue I Zs.208: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Arrestin-3 Agonism at Dopamine D

Schamiloglu, Selin / Lewis, Elinor / Keeshen, Caroline M / Hergarden, Anne C / Bender, Kevin J / Whistler, Jennifer L

Biological psychiatry

2023 Volume 94, Issue 7, Page(s) 531–542

Abstract: ... this unpredictability in treatment efficacy remain unclear. All SGAs bind the dopamine D: Methods: Here, we used ...

Abstract	Background: Second-generation antipsychotics (SGAs) are frontline treatments for serious mental illness. Often, individual patients benefit only from some SGAs and not others. The mechanisms underlying this unpredictability in treatment efficacy remain unclear. All SGAs bind the dopamine D Methods: Here, we used a combination of two-photon calcium imaging, in vitro signaling assays, and mouse behavior to assess signaling by SGAs at D3R. Results: We report that some clinically important SGAs function as arrestin-3 agonists at D3R, resulting in modulation of calcium channels localized to the site of action potential initiation in prefrontal cortex pyramidal neurons. We further show that chronic treatment with an arrestin-3 agonist SGA, but not an antagonist SGA, abolishes D3R function through postendocytic receptor degradation by GASP1 (G protein-coupled receptor-associated sorting protein-1). Conclusions: These results implicate D3R-arrestin-3 signaling as a source of SGA variability, highlighting the importance of including arrestin-3 signaling in characterizations of drug action. Furthermore, they suggest that postendocytic receptor trafficking that occurs during chronic SGA treatment may contribute to treatment efficacy.
MeSH term(s)	Mice ; Animals ; Dopamine ; beta-Arrestin 2/metabolism ; Antipsychotic Agents/pharmacology ; Receptors, Dopamine D3/metabolism ; Dopamine Agonists/pharmacology ; Drug Tolerance ; Receptors, Dopamine D1/metabolism
Chemical Substances	Dopamine (VTD58H1Z2X) ; beta-Arrestin 2 ; Antipsychotic Agents ; Receptors, Dopamine D3 ; Dopamine Agonists ; Receptors, Dopamine D1
Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	209434-4
ISSN	1873-2402 ; 0006-3223
ISSN (online)	1873-2402
ISSN	0006-3223
DOI	10.1016/j.biopsych.2023.03.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 720: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Chromatographic Phospholipid Trapping for Automated H/D Exchange Mass Spectrometry of Membrane Protein-Lipid Assemblies.

Hammerschmid, Dietmar / Calvaresi, Valeria / Bailey, Chloe / Russell Lewis, Benjamin / Politis, Argyris / Morris, Michael / Denbigh, Laetitia / Anderson, Malcolm / Reading, Eamonn

Analytical chemistry

2023 Volume 95, Issue 5, Page(s) 3002–3011

Abstract: ... with the ∼115 kDa transmembrane protein AcrB─proving efficient and automated phospholipid capture with minimal D ...

Abstract	Lipid interactions modulate the function, folding, structure, and organization of membrane proteins. Hydrogen/deuterium exchange mass spectrometry (HDX-MS) has emerged as a useful tool to understand the structural dynamics of these proteins within lipid environments. Lipids, however, have proven problematic for HDX-MS analysis of membrane-embedded proteins due to their presence of impairing proteolytic digestion, causing liquid chromatography column fouling, ion suppression, and/or mass spectral overlap. Herein, we describe the integration of a chromatographic phospholipid trap column into the HDX-MS apparatus to enable online sample delipidation prior to protease digestion of deuterium-labeled protein-lipid assemblies. We demonstrate the utility of this method on membrane scaffold protein-lipid nanodisc─both empty and loaded with the ∼115 kDa transmembrane protein AcrB─proving efficient and automated phospholipid capture with minimal D-to-H back-exchange, peptide carry-over, and protein loss. Our results provide insights into the efficiency of phospholipid capture by ZrO
MeSH term(s)	Phospholipids ; Deuterium ; Membrane Lipids ; Mass Spectrometry/methods ; Deuterium Exchange Measurement/methods ; Membrane Proteins ; Peptide Hydrolases
Chemical Substances	Phospholipids ; Deuterium (AR09D82C7G) ; Membrane Lipids ; Membrane Proteins ; Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.2c04876
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4033: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: FGL1 as a modulator of plasma D-dimer levels: Exome-wide marker analysis of plasma tPA, PAI-1, and D-dimer.

Thibord, Florian / Song, Ci / Pattee, Jack / Rodriguez, Benjamin A T / Chen, Ming-Huei / O'Donnell, Christopher J / Kleber, Marcus E / Delgado, Graciela E / Guo, Xiuqing / Yao, Jie / Taylor, Kent D / Ozel, Ayse Bilge / Brody, Jennifer A / McKnight, Barbara / Gyorgy, Beata / Simonsick, Eleanor / Leonard, Hampton L / Carrasquilla, Germán D / Guindo-Martinez, Marta /

Silveira, Angela / Temprano-Sagrera, Gerard / Yanek, Lisa R / Becker, Diane M / Mathias, Rasika A / Becker, Lewis C / Raffield, Laura M / Kilpeläinen, Tuomas O / Grarup, Niels / Pedersen, Oluf / Hansen, Torben / Linneberg, Allan / Hamsten, Anders / Watkins, Hugh / Sabater-Lleal, Maria / Nalls, Mike A / Trégouët, David-Alexandre / Morange, Pierre-Emmanuel / Psaty, Bruce M / Tracy, Russel P / Smith, Nicholas L / Desch, Karl C / Cushman, Mary / Rotter, Jerome I / de Vries, Paul S / Pankratz, Nathan D / Folsom, Aaron R / Morrison, Alanna C / März, Winfried / Tang, Weihong / Johnson, Andrew D

Journal of thrombosis and haemostasis : JTH

2021 Volume 19, Issue 8, Page(s) 2019–2028

Abstract: ... Plasminogen activator-inhibitor 1 (PAI-1), tissue plasminogen activator (tPA), and the plasma product D-dimer are ... studies of PAI-1, tPA, and D-dimer.: Objectives: We sought to discover new genetic loci contributing ... effects meta-analyses of PAI-1 (n = 15 603), tPA (n = 6876,) and D-dimer (n = 19 306) from 12 cohorts ...

Abstract	Background: Use of targeted exome-arrays with common, rare variants and functionally enriched variation has led to discovery of new genes contributing to population variation in risk factors. Plasminogen activator-inhibitor 1 (PAI-1), tissue plasminogen activator (tPA), and the plasma product D-dimer are important components of the fibrinolytic system. There have been few large-scale genome-wide or exome-wide studies of PAI-1, tPA, and D-dimer. Objectives: We sought to discover new genetic loci contributing to variation in these traits using an exome-array approach. Methods: Cohort-level analyses and fixed effects meta-analyses of PAI-1 (n = 15 603), tPA (n = 6876,) and D-dimer (n = 19 306) from 12 cohorts of European ancestry with diverse study design were conducted, including single-variant analyses and gene-based burden testing. Results: Five variants located in NME7, FGL1, and the fibrinogen locus, all associated with D-dimer levels, achieved genome-wide significance (P < 5 × 10 Conclusion: This work provides new evidence for a role of FGL1 in hemostasis.
MeSH term(s)	Exome ; Fibrin Fibrinogen Degradation Products ; Fibrinogen/genetics ; Fibrinolysis ; Humans ; Plasminogen Activator Inhibitor 1/genetics ; Tissue Plasminogen Activator/genetics
Chemical Substances	FGL1 protein, human ; Fibrin Fibrinogen Degradation Products ; Plasminogen Activator Inhibitor 1 ; fibrin fragment D ; Fibrinogen (9001-32-5) ; Tissue Plasminogen Activator (EC 3.4.21.68)
Language	English
Publishing date	2021-05-30
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1111/jth.15345
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5805: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 295: Show issues

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito