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  1. Article ; Online: Advancing Care in Severe Asthma: The Art of Switching Biologics.

    Dragonieri, Silvano / Portacci, Andrea / Quaranta, Vitaliano Nicola / Carpagnano, Giovanna Elisiana

    Advances in respiratory medicine

    2024  Volume 92, Issue 2, Page(s) 110–122

    Abstract: Biologics targeting IgE, IL-5, IL-4/IL-13, and TSLP are crucial in severe asthma treatment. Research, including randomized controlled trials and real-world studies, has been conducted to assess their efficacy and identify patient characteristics that may ...

    Abstract Biologics targeting IgE, IL-5, IL-4/IL-13, and TSLP are crucial in severe asthma treatment. Research, including randomized controlled trials and real-world studies, has been conducted to assess their efficacy and identify patient characteristics that may predict positive responses. The effectiveness of switching biologics, especially given overlaps in treatment eligibility, and the clinical outcomes post-cessation are critical areas of investigation. This work reviews the effects of switching between these biologics and the indicators of treatment success or failure. Insights are primarily derived from real-world experiences, focusing on patients transitioning from one monoclonal antibody to another. Moreover, this review aims to provide insights into the effectiveness, safety, and broader implications of switching biologics, enhancing understanding for clinicians to optimize severe asthma management. The article underlines the importance of a patient-centered approach, biomarker assessment, and the evolving nature of asthma treatment in making informed decisions about biologic therapy.
    MeSH term(s) Humans ; Biological Products/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Interleukin-13
    Chemical Substances Biological Products ; Antibodies, Monoclonal, Humanized ; Antibodies, Monoclonal ; Interleukin-13
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2893877-X
    ISSN 2543-6031 ; 2451-4934
    ISSN (online) 2543-6031
    ISSN 2451-4934
    DOI 10.3390/arm92020014
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  2. Article: Muscle herniae: Conservative and surgical management. Systematic review.

    Quaranta, Marco / Poeta, Nicola / Oliva, Francesco / Maffulli, Nicola

    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

    2022  Volume 21, Issue 3, Page(s) 181–189

    Abstract: Background: Muscle herniae are often unrecognized. The primary objective of this systematic review is to evaluate the outcomes of conservative and surgical management for muscle herniae. The secondary objective is to define the most appropriate ... ...

    Abstract Background: Muscle herniae are often unrecognized. The primary objective of this systematic review is to evaluate the outcomes of conservative and surgical management for muscle herniae. The secondary objective is to define the most appropriate management for muscle herniae depending on aetiology and size of the fascial defect.
    Methods: The PRISMA guidelines were used to organize this systematic review to assess the different management modalities and identify possible criteria useful to guide the management of muscle herniae. An electronic search of PubMed and Scopus databases was performed.
    Results: A total of 132 patients were identified. Conservative management was carried out in 22 (16.7%) patients, and 110 (83.3%) patients underwent surgical procedures. Pain was reported in 3/22 (13.6%) patients managed conservatively. Post-surgical pain was reported in 0/5 (0%) patients treated with autologous graft repair, 1/15 (6.7%) patient with mesh repair, 2/13 (15.4%) patients with direct repair and 11/77 (14.3%) patients with fasciotomy. Return to normal activity was possible in 16/22 (72.7%) patients treated conservatively, 5/5 (100%) patients undergoing autologous graft repair, 13/15 (86.7%) with mesh repair, 62/77 (80.52%) with fasciotomy and 4/12 (33.3%) with direct repair.
    Conclusion: In congenital muscle herniae, fasciotomy should be considered the surgical choice to prevent complications. In post-traumatic muscle hernia, a small fascial defect can be treated with the direct suture repair, while mesh repair and autologous graft repair should be considered the most appropriate procedures to avoid severe complications such as compartment syndrome.
    MeSH term(s) Humans ; Herniorrhaphy/methods ; Hernia ; Muscles ; Fasciotomy ; Surgical Mesh
    Language English
    Publishing date 2022-03-12
    Publishing country Scotland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2102927-1
    ISSN 1479-666X
    ISSN 1479-666X
    DOI 10.1016/j.surge.2022.02.003
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    Zs.A 5756: Show issues Location:
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  3. Article ; Online: Stem cells and discogenic back pain.

    Miranda, Luca / Quaranta, Marco / Oliva, Francesco / Maffulli, Nicola

    British medical bulletin

    2023  Volume 146, Issue 1, Page(s) 73–87

    Abstract: Background: Chronic low back pain, common from the sixth decade, negatively impacts the quality of life of patients and health care systems. Recently, mesenchymal stem cells (MSCs) have been introduced in the management of degenerative discogenic pain. ... ...

    Abstract Background: Chronic low back pain, common from the sixth decade, negatively impacts the quality of life of patients and health care systems. Recently, mesenchymal stem cells (MSCs) have been introduced in the management of degenerative discogenic pain. The present study summarizes the current knowledge on the effectiveness of MSCs in patients with discogenic back pain.
    Sources of data: We performed a systematic review of the literature following the PRISMA guidelines. We searched PubMed and Google Scholar database, and identified 14 articles about management of chronic low back pain with MSCs injection therapy. We recorded information on type of stem cells employed, culture medium, clinical scores and MRI outcomes.
    Areas of agreement: We identified a total of 303 patients. Ten studies used bone marrow stem cells. In the other four studies, different stem cells were used (of adipose, umbilical, or chondrocytic origin and a pre-packaged product). The most commonly used scores were Visual Analogue Scale and Oswestry Disability Index.
    Areas of controversy: There are few studies with many missing data.
    Growing points: The studies analysed demonstrate that intradiscal injections of MSCs are effective on discogenic low-back pain. This effect may result from inhibition of nociceptors, reduction of catabolism and repair of injured or degenerated tissues.
    Areas timely for developing research: Further research should define the most effective procedure, trying to standardize a single method.
    MeSH term(s) Humans ; Low Back Pain/therapy ; Low Back Pain/drug therapy ; Quality of Life ; Treatment Outcome ; Mesenchymal Stem Cells ; Magnetic Resonance Imaging
    Language English
    Publishing date 2023-04-29
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 213294-1
    ISSN 1471-8391 ; 0007-1420
    ISSN (online) 1471-8391
    ISSN 0007-1420
    DOI 10.1093/bmb/ldad008
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  4. Article ; Online: Intralabyrinthine schwannomas: a two-case series and literature review with a focus on hearing rehabilitation.

    Curatoli, Luigi / Pontillo, Vito / Quaranta, Nicola

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2023  Volume 280, Issue 5, Page(s) 2073–2079

    Abstract: Purpose: Intralabyrinthine schwannomas (ILSs) are an uncommon finding. Diagnosis is challenging and no gold standard treatment exists yet. In this article, we present a two-cases series and review the latest available literature to assess the best ... ...

    Abstract Purpose: Intralabyrinthine schwannomas (ILSs) are an uncommon finding. Diagnosis is challenging and no gold standard treatment exists yet. In this article, we present a two-cases series and review the latest available literature to assess the best diagnostic and therapeutic scheme.
    Methods: We reviewed the latest available literature assessing most frequent and relevant sets of symptoms, clinical features of the disease, diagnostic tests and imaging, possible treatments and after-surgery hearing rehabilitation techniques. We then compared literature data to our own series ones.
    Results: ILSs clinical presentation and development may overlap with other, more common otological conditions. Full audiometric battery test, electrophysiological study of VEMPS and MRI with contrast enhancement all appear to be critical to correctly diagnose these tumors. Several treatments exist: radiological follow-up, radiation therapy, full or partial surgical excision. Hearing rehabilitation is mostly accomplished through simultaneous cochlear implantation.
    Conclusions: Our case-series data matches the available literature. ILSs are a rare type of vestibular schwannomas. Diagnosis in challenging and delayed in time as all the diagnostic tests, yet sensitive, are not specific for ILSs. The most suitable treatment seems to be surgical excision of these tumors followed by simultaneous cochlear implantation to restore hearing.
    MeSH term(s) Humans ; Neurilemmoma/diagnosis ; Neurilemmoma/surgery ; Neurilemmoma/pathology ; Neuroma, Acoustic/complications ; Neuroma, Acoustic/diagnosis ; Neuroma, Acoustic/surgery ; Hearing ; Hearing Tests ; Hearing Loss, Sensorineural/diagnosis
    Language English
    Publishing date 2023-01-17
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-07823-2
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  5. Article ; Online: Quality of life after revision mastoidectomy with mastoid obliteration.

    Pontillo, Vito / Ciprelli, Sabino / Grillo, Rossella / Quaranta, Nicola

    Acta otorrinolaringologica espanola

    2023  Volume 74, Issue 6, Page(s) 352–358

    Abstract: Aims: To evaluate the postoperative quality of life (QoL) after revision canal wall down mastoidectomy with mastoid obliteration (rCWD).: Material and methods: A retrospective analysis was conducted on patients treated by rCWD for cholesteatoma ... ...

    Abstract Aims: To evaluate the postoperative quality of life (QoL) after revision canal wall down mastoidectomy with mastoid obliteration (rCWD).
    Material and methods: A retrospective analysis was conducted on patients treated by rCWD for cholesteatoma between 2016 and 2019. A control group including all patients treated by primary canal wall down with mastoid obliteration (pCWD) for cholesteatoma between 2009 and 2014 was used for the comparison of the postoperative QoL, assessed by the COMQ-12.
    Results: The rCWD and pCWD groups respectively counted 38 and 78 patients with an average follow-up of 30 and 62 months respectively. No significant difference was found in terms of QoL between the two groups. An intra-group analysis among rCWD patients, showed that patients treated by canal wall down (CWD) at the primary surgery had a significantly worse post-revision QoL compared to those initially treated by canal wall up (CWU), specifically in the hearing and balance domains of the questionnaire.
    Conclusions: Revision mastoid obliteration leads to similar QoL results to those obtained after primary CWD with obliteration. Patients who had undergone a CWD as primary surgery complain worse hearing and balance problems compared to those primarily submitted to CWU, even after revision surgery.
    MeSH term(s) Humans ; Mastoidectomy/adverse effects ; Quality of Life ; Mastoid/surgery ; Retrospective Studies ; Cholesteatoma, Middle Ear/surgery
    Language English
    Publishing date 2023-06-17
    Publishing country Spain
    Document type Journal Article
    ISSN 2173-5735
    ISSN (online) 2173-5735
    DOI 10.1016/j.otoeng.2023.06.004
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  6. Article: Single-Sided Deafness and Hearing Rehabilitation Modalities: Contralateral Routing of Signal Devices, Bone Conduction Devices, and Cochlear Implants.

    Pantaleo, Alessandra / Murri, Alessandra / Cavallaro, Giada / Pontillo, Vito / Auricchio, Debora / Quaranta, Nicola

    Brain sciences

    2024  Volume 14, Issue 1

    Abstract: Single sided deafness (SSD) is characterized by significant sensorineural hearing loss, severe or profound, in only one ear. SSD adversely affects various aspects of auditory perception, including causing impairment in sound localization, difficulties ... ...

    Abstract Single sided deafness (SSD) is characterized by significant sensorineural hearing loss, severe or profound, in only one ear. SSD adversely affects various aspects of auditory perception, including causing impairment in sound localization, difficulties with speech comprehension in noisy environments, and decreased spatial awareness, resulting in a significant decline in overall quality of life (QoL). Several treatment options are available for SSD, including cochlear implants (CI), contralateral routing of signal (CROS), and bone conduction devices (BCD). The lack of consensus on outcome domains and measurement tools complicates treatment comparisons and decision-making. This narrative overview aims to summarize the treatment options available for SSD in adult and pediatric populations, discussing their respective advantages and disadvantages. Rerouting devices (CROS and BCD) attenuate the effects of head shadow and improve sound awareness and signal-to-noise ratio in the affected ear; however, they cannot restore binaural hearing. CROS devices, being non-implantable, are the least invasive option. Cochlear implantation is the only strategy that can restore binaural hearing, delivering significant improvements in speech perception, spatial localization, tinnitus control, and overall QoL. Comprehensive preoperative counseling, including a discussion of alternative technologies, implications of no treatment, expectations, and auditory training, is critical to optimizing therapeutic outcomes.
    Language English
    Publishing date 2024-01-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci14010099
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  7. Article ; Online: Dupilumab's impact on nasal citology: Real life experience after 1 year of treatment.

    Gelardi, Matteo / Giancaspro, Rossana / Quaranta, Vitaliano Nicola / La Gatta, Emanuel / Ruzza, Annamaria / Cassano, Michele

    American journal of otolaryngology

    2024  Volume 45, Issue 4, Page(s) 104275

    Abstract: Background: Biologic agents are considered a new revolutionized therapy for severe and recurrent forms of CRSwNP which disease burden is not sufficiently controlled by conservative and/or surgical treatments. Recent Research has focused on evaluating ... ...

    Abstract Background: Biologic agents are considered a new revolutionized therapy for severe and recurrent forms of CRSwNP which disease burden is not sufficiently controlled by conservative and/or surgical treatments. Recent Research has focused on evaluating their real-life efficacy in CRSwNP, as only limited reports on real-life data are available. However, in most studies, the response to treatment is evaluated in terms of improvement in Nasal Polyp Score (NPS) or in Sino-Nasal Outcome test (SNOT-22) scores. However, both criteria do not consider nasal immunophlogosis, which can be easily assessed by nasal cytology. The aim of our study was to evaluate changings in the nasal inflammatory infiltrate of CRSwNP patients treated with Dupilumab for 12 months.
    Methods: 27 patients suffering from severe CRSwNP treated with Dupilumab were recruited. Nasal cytology findings, NPS, SNOT-22, ACT scores and blood eosinophil count at T0 (before treatment) and at T1 (after 1 year of treatment) were compared.
    Results: After 1 year of biological therapy with Dupilumab, NPS, SNOT-22 and, among the 17 asthmatic patients, ACT scores improved significantly. At T1, a statistically significant percentage of patients showed negative citology. Moreover, a significant reduction in the mast cell-eosinophilic pattern and an increase of neutrophils and bacteria was reported.
    Conclusions: The response to treatment can be considered both in the case of negative nasal cytology and in the case of the appearance of neutrophils and bacteria. In this context, eosinophils, the specific target of biological therapies, play a crucial role in regulating tissue homeostasis and, consequently, the nasal immunophlogosis.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2024.104275
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    Zs.A 1637: Show issues Location:
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  8. Article ; Online: Osteoarthritis of the Knee in Middle-age Athletes: Many Measures are Practiced, but Lack Sound Scientific Evidence.

    Quaranta, Marco / Riccio, Ivano / Oliva, Francesco / Maffulli, Nicola

    Sports medicine and arthroscopy review

    2022  Volume 30, Issue 2, Page(s) 102–110

    Abstract: Osteoarthritis of the knee generally affects individuals from the fifth decade, the typical age of middle-age athletes. In the early stages, management is conservative and multidisciplinary. It is advisable to avoid sports with high risk of trauma, but ... ...

    Abstract Osteoarthritis of the knee generally affects individuals from the fifth decade, the typical age of middle-age athletes. In the early stages, management is conservative and multidisciplinary. It is advisable to avoid sports with high risk of trauma, but it is important that patients continue to be physically active. Conservative management offers several options; however, it is unclear which ones are really useful. This narrative review briefly reports the conservative options for which there is no evidence of effectiveness, or there is only evidence of short-term effectiveness.
    MeSH term(s) Athletes ; Humans ; Knee ; Knee Joint ; Middle Aged ; Osteoarthritis, Knee/therapy ; Sports
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1174179-x
    ISSN 1538-1951 ; 1062-8592
    ISSN (online) 1538-1951
    ISSN 1062-8592
    DOI 10.1097/JSA.0000000000000341
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    Zs.A 3879: Show issues Location:
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  9. Article ; Online: Can single-inhaler Beclometasone Dipropionate/Formoterol Fumarate/Glycopyrronium therapy postpone or save biologics for severe asthma?

    Dragonieri, Silvano / Quaranta, Vitaliano Nicola / Portacci, Andrea / Carpagnano, Giovanna Elisiana

    Pulmonary pharmacology & therapeutics

    2023  Volume 83, Page(s) 102270

    Abstract: Inhaled corticosteroids, along with beta2-agonists and anti-muscarinics, represent the cornerstone of asthma treatment. Although the advent of monoclonal antibodies has dramatically changed severe asthma management, there are still patients ineligible or ...

    Abstract Inhaled corticosteroids, along with beta2-agonists and anti-muscarinics, represent the cornerstone of asthma treatment. Although the advent of monoclonal antibodies has dramatically changed severe asthma management, there are still patients ineligible or with poor response to biologics. Moreover, high costs associated with monoclonal antibodies prescription are still an open issue, leading clinicians to carefully assess cost-benefit ratio before their administration. From this perspective, the use of single-inhaler Beclometasone Dipropionate/Formoterol Fumarate/Glycopyrronium in patients with severe asthma could not only improve their clinical and functional performance, but also postpone biologic prescription, with positive repercussions on healthcare costs.
    MeSH term(s) Humans ; Formoterol Fumarate/therapeutic use ; Beclomethasone/therapeutic use ; Glycopyrrolate/therapeutic use ; Anti-Asthmatic Agents/therapeutic use ; Administration, Inhalation ; Drug Combinations ; Asthma/drug therapy ; Nebulizers and Vaporizers ; Antibodies, Monoclonal/therapeutic use ; Biological Products/therapeutic use ; Bronchodilator Agents/therapeutic use
    Chemical Substances Formoterol Fumarate (W34SHF8J2K) ; Beclomethasone (KGZ1SLC28Z) ; Glycopyrrolate (V92SO9WP2I) ; Anti-Asthmatic Agents ; Drug Combinations ; Antibodies, Monoclonal ; Biological Products ; Bronchodilator Agents
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Letter
    ZDB-ID 1399707-5
    ISSN 1522-9629 ; 1094-5539
    ISSN (online) 1522-9629
    ISSN 1094-5539
    DOI 10.1016/j.pupt.2023.102270
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    Zs.A 2389: Show issues Location:
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  10. Article ; Online: Voice Differences When Wearing and Not Wearing a Surgical Mask.

    Fiorella, Maria Luisa / Cavallaro, Giada / Di Nicola, Vincenzo / Quaranta, Nicola

    Journal of voice : official journal of the Voice Foundation

    2021  Volume 37, Issue 3, Page(s) 467.e1–467.e7

    Abstract: Objective: The purpose of our study was to investigate the impact of surgical mask on some vocal parameters such as F0, vocal intensity, jitter, shimmer and harmonics-to-noise ratio in order to understand how surgical mask can affect voice and verbal ... ...

    Abstract Objective: The purpose of our study was to investigate the impact of surgical mask on some vocal parameters such as F0, vocal intensity, jitter, shimmer and harmonics-to-noise ratio in order to understand how surgical mask can affect voice and verbal communication in adults.
    Methods: The study was carried out on a selected group of 60 healthy subjects. All subjects were trained to voice a vocal sample of a sustained /a/, at a conversational voice intensity for the Maximum Phonation Time (MPT), wearing the surgical mask and then without wearing the surgical mask. Voice samples were recorded directly in Praat.
    Results: There were no statistically significant differences in any acoustic parameter between the masked and unmasked condition. There was a non-significant decrease in vocal intensity in 65% of the subjects while wearing a surgical mask.
    Conclusions: The statistical comparison carried out between all the acoustic voice parameters observed, extracted wearing and not wearing a surgical mask did not reveal any significant statistical difference. Most of the subjects, after wearing the surgical mask, presented a decrease in vocal intensity measured. Our conclusion was that wearing a mask is likely to induce the unconscious need to increase the vocal effort, resulting over time in a greater risk of developing functional dysphonia. The reduction of intensity can affect also social interaction and speech audibility, especially for individuals with hearing loss.
    MeSH term(s) Adult ; Humans ; Voice Quality ; Dysphonia/diagnosis ; Dysphonia/etiology ; Acoustics ; Voice ; Speech Acoustics ; Phonation
    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 17459-2
    ISSN 1873-4588 ; 1557-8658 ; 0892-1997
    ISSN (online) 1873-4588 ; 1557-8658
    ISSN 0892-1997
    DOI 10.1016/j.jvoice.2021.01.026
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