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Article ; Online: A Comprehensive Review of the Effect of Honey on Human Health.

Palma-Morales, Marta / Huertas, Jesús R / Rodríguez-Pérez, Celia

2023 Volume 15, Issue 13

Abstract: Honey is a nutritious, healthy, and natural food, to which antioxidant, anti-inflammatory, and antimicrobial properties have been attributed, mainly due to its content of phenolic compounds. The aim of this review is to analyze the available evidence of ... ...

Abstract	Honey is a nutritious, healthy, and natural food, to which antioxidant, anti-inflammatory, and antimicrobial properties have been attributed, mainly due to its content of phenolic compounds. The aim of this review is to analyze the available evidence of the effect of honey on humans. Forty-eight clinical trials published between 1985 and 2022 were analyzed, with a total of 3655 subjects. More beneficial effects of honey intake than no or negative effects on different cardiovascular and metabolic risk factors, glucose tolerance, mucositis caused by chemo-radiotherapy, cough in children and wound healing, among others have been observed. Although the number of studies conducted to date is limited and the different investigations are not standardized, beneficial effects of honey intake have been observed, especially when its intake replaces the intake of other sweeteners. In addition, honey could be a safe adjuvant to be administered alongside drugs used for certain diseases.
MeSH term(s)	Child ; Humans ; Honey ; Anti-Infective Agents/pharmacology ; Antioxidants/pharmacology ; Cardiovascular System
Chemical Substances	Anti-Infective Agents ; Antioxidants
Language	English
Publishing date	2023-07-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15133056
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Occurrence of nano/microplastics from wild and farmed edible species. Potential effects of exposure on human health.

Rodríguez-Pérez, Celia / Sáenz de Rodrigáñez, Miguel / Pula, Héctor J

Advances in food and nutrition research

2022 Volume 103, Page(s) 273–311

Abstract: The occurrence of nano/microplastics (N/MPs) has become a global concern due to their risk on the aquatic environment, food webs and ecosystems, thus, potentially affecting human health. This chapter focuses on the most recent evidence about the ... ...

Abstract	The occurrence of nano/microplastics (N/MPs) has become a global concern due to their risk on the aquatic environment, food webs and ecosystems, thus, potentially affecting human health. This chapter focuses on the most recent evidence about the occurrence of N/MPs in the most consumed wild and farmed edible species, the occurrence of N/MPs in humans, the potential impact of N/MPs on human health as well as future research recommendations for assessing N/MPs in wild and farmed edible species. Additionally, the N/MP particles in human biological samples, which include the standardization of methods for collection, characterization, and analysis of N/MPs that might allow evaluating the potential risk of the intake of N/MPs in human health, are discussed. Thus, the chapter consequently includes relevant information about the content of N/MPs of more than 60 edible species such as algae, sea cucumber, mussels, squids, crayfish, crabs, clams, and fishes.
MeSH term(s)	Humans ; Microplastics ; Plastics ; Ecosystem ; Farms ; Food Chain
Chemical Substances	Microplastics ; Plastics
Language	English
Publishing date	2022-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1011108-6
ISSN	1043-4526
ISSN	1043-4526
DOI	10.1016/bs.afnr.2022.08.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: How Healthy Is It to Fortify Cocoa-Based Products with Cocoa Flavanols? A Comprehensive Review.

Palma-Morales, Marta / Melgar-Locatelli, Sonia / Castilla-Ortega, Estela / Rodríguez-Pérez, Celia

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 7

Abstract: 1) Background: Cocoa's healthy benefits may be attributed to the potent antioxidant activity of cocoa polyphenols, mainly flavanols, which have been characterised as existing in a high concentration in cocoa. However, the phenolic composition of cocoa ... ...

Abstract	(1) Background: Cocoa's healthy benefits may be attributed to the potent antioxidant activity of cocoa polyphenols, mainly flavanols, which have been characterised as existing in a high concentration in cocoa. However, the phenolic composition of cocoa and cocoa-derived products is highly variable, and manufacturing processes might significantly reduce their phenolic content. For that reason, the full characterisation of cocoa and cocoa-derived products before evaluating their bioactivity is crucial. The aim of this review is to analyse the available evidence on the effect of flavanol-fortified cocoa-derived products on human health. (2) Methods: Forty-eight clinical trials focused on the health effect of consuming flavanol-fortified drinks, bars and chocolate have been reviewed, with a total of 1523 subjects. (3) Results: Although studies differ widely in methodology, dosage, duration, and target population, beneficial effects of flavanol-rich cocoa consumption have been observed at doses ranging from 45.3 mg/d to 1078 mg/d, especially on cardiovascular health and cognitive function. (4) Conclusions: Considering the high consumption and acceptability of cocoa and cocoa-derived products, the fortification of cocoa products as well as other highly consumed foods with cocoa flavanols could be an effective strategy for health promotion.
Language	English
Publishing date	2023-07-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12071376
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comprehensive Characterization and Quantification of Antioxidant Compounds in Finger Lime ( Citrus australasica L.) by HPLC-QTof-MS and UPLC-MS/MS

Ramón Aznar / Celia Rodríguez-Pérez / Dilip K. Rai

Applied Sciences, Vol 12, Iss 1712, p

2022 Volume 1712

Abstract: Australian finger limes ( Citrus australasica L.), an unusual citrus due to its unique pulp with a caviar-like appearance, has reached the global market as a promising source of bioactive compounds that promote health. This research was, therefore, ... ...

Abstract	Australian finger limes ( Citrus australasica L.), an unusual citrus due to its unique pulp with a caviar-like appearance, has reached the global market as a promising source of bioactive compounds that promote health. This research was, therefore, performed to shed light on the bioactivity and composition of different parts of Citrus australasica L. (peel and pulp). Initial ultrasound-assisted extraction using MeOH:H 2 O (80:20, v / v ) was carried out. After that, four fractions (hexane, ethyl acetate, butanol and water) were generated through liquid–liquid partitioning, and the total phenolic content (TPC) and antioxidant activity were evaluated using the Folin–Ciocalteu and the ferric reducing antioxidant power (FRAP) assays, respectively. The ethyl acetate fraction in the peel, which presented the highest values of TPC and antioxidant activity, was characterized using high-performance liquid chromatography coupled to quadrupole time-of-flight (HPLC-QTof) mass spectrometry. Fifteen compounds were identified, of which seven were characterized for the first time in this matrix. Moreover, ten phenolic compounds were quantified using ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS). The major compounds in the sample were citric acid, pyrogallol, caffeic acid, coumarin, rutin, naringin, 2-coumaric acid, didymin, naringenin and isorhamnetin, which were found in a range from 2.7 to 8106.7 µg/g sample dry weight. Finally, the results presented in this novel work confirmed that the peel by-product of C. australasica L. is a potential source of bioactive compounds and could result in a positive outcome for the food, cosmetics and pharmaceutical industries.
Keywords	Australian finger limes ; phenolic compounds ; flavonoids ; limonoids ; antioxidant activity ; HPLC ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Reported Changes in Dietary Habits During the COVID-19 Lockdown in the Danish Population: The Danish COVIDiet Study.

Giacalone, Davide / Frøst, Michael Bom / Rodríguez-Pérez, Celia

Frontiers in nutrition

2020 Volume 7, Page(s) 592112

Abstract: This paper focuses on the effect of the COVID-19 lockdown on the dietary habits of adult Danes. Two aspects were specifically considered: 1) reported changes in intake of specific food categories and 2) effect on healthy eating, operationalized as ... ...

Abstract	This paper focuses on the effect of the COVID-19 lockdown on the dietary habits of adult Danes. Two aspects were specifically considered: 1) reported changes in intake of specific food categories and 2) effect on healthy eating, operationalized as adherence to the Mediterranean diet (MEDAS score). Respondents (
Language	English
Publishing date	2020-12-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2020.592112
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Exploring the Nutritional Composition and Bioactive Compounds in Different Cocoa Powders.

Razola-Díaz, María Del Carmen / Aznar-Ramos, María José / Verardo, Vito / Melgar-Locatelli, Sonia / Castilla-Ortega, Estela / Rodríguez-Pérez, Celia

Antioxidants (Basel, Switzerland)

2023 Volume 12, Issue 3

Abstract: Cocoa, the main derivative of the seeds ... ...

Abstract	Cocoa, the main derivative of the seeds of
Language	English
Publishing date	2023-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12030716
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Relationship in dietary habits variations during COVID-19 lockdown in Kosovo: The COVIDiet study.

Sulejmani, Erhan / Hyseni, Arjeta / Xhabiri, Gafur / Rodríguez-Pérez, Celia

Appetite

2021 Volume 164, Page(s) 105244

Abstract: Changes in dietary habits and association with lifestyle during the coronavirus disease 2019 (COVID-19) lockdown in the Kosovo population have not been studied yet. Therefore, the intent of the present study was to determine whether if COVID-19 lockdown ... ...

Abstract	Changes in dietary habits and association with lifestyle during the coronavirus disease 2019 (COVID-19) lockdown in the Kosovo population have not been studied yet. Therefore, the intent of the present study was to determine whether if COVID-19 lockdown had any impact in lifestyle, including dietary habits and physical activity (PA) patterns of people from different areas of Kosovo. Dietary habits, PA, body weight and sociodemographic variables were measured through validated online survey started one week after lockdown decision and lasted for next two month (May and June 2020). Six hundred eighty-nine participants (women 79% and men 21%) aged between 20 and 65 years from the Kosovo territory participated in the research. Multivariate models showed that participants in family home residence, participants from Gjilan, participants female and participants with professional educations reported a higher likelihood of turning into a higher adherence to the Mediterranean diet (MedDiet) (OR: 6.09, 5.25, 5.17, 4.19, respectively). The weight gained during the lockdown was positively associated with a higher cooking frequency (OR; 2.90, p < 0.01), lower meat and fish consumption (OR; 1.15, p = 0.02; OR; 1.04, p = 0.04, respectively), higher fast-food consumption (OR; 0.49, p = 0.02) and no physical activity performance (OR; 0.43, p = 0.02) during the COVID-19 lockdown. The dietary habits during COVID-19 lockdown could be related to the improvements in adherence to the MedDiet and physical activities that may minimize related health complications.
MeSH term(s)	Adult ; Aged ; COVID-19 ; Communicable Disease Control ; Feeding Behavior ; Female ; Humans ; Kosovo ; Male ; Middle Aged ; SARS-CoV-2 ; Young Adult
Language	English
Publishing date	2021-04-10
Publishing country	England
Document type	Journal Article
ZDB-ID	1461347-5
ISSN	1095-8304 ; 0195-6663
ISSN (online)	1095-8304
ISSN	0195-6663
DOI	10.1016/j.appet.2021.105244
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sex-specific variations in spatial reference memory acquisition: Insights from a comprehensive behavioral test battery in C57BL/6JRj mice.

Melgar-Locatelli, Sonia / Mañas-Padilla, M Carmen / Gavito, Ana L / Rivera, Patricia / Rodríguez-Pérez, Celia / Castilla-Ortega, Estela / Castro-Zavala, Adriana

Behavioural brain research

2023 Volume 459, Page(s) 114806

Abstract: Sex differences in declarative memory are described in humans, revealing a female or a male advantage depending on the task. Specifically, spatial memory (i.e., spatial navigation) is typically most efficient in men. This sexual dimorphism has been ... ...

Abstract	Sex differences in declarative memory are described in humans, revealing a female or a male advantage depending on the task. Specifically, spatial memory (i.e., spatial navigation) is typically most efficient in men. This sexual dimorphism has been replicated in male rats but not clearly in mice. In this study, sex differences in spatial memory were assessed in thirty-six C57BL/6 J mice (Janvier Labs; i.e., C57BL/6JRj mice), a widely used mouse substrain. Both male and female mice (12 weeks-old) were subjected to standard behavioral paradigms: the elevated plus maze, the open field test, the novel object and place tests, the forced swimming test, and the water maze test for spatial navigation. Across assessment, no sex differences were found in measures of locomotor activity, emotional and behavioral responses, and object and place recognition memories. In the water maze, male mice were faster in learning the platform location in the reference memory training and used more spatial strategies during the first training days. However, both sexes reached a similar asymptotic performance and performed similarly in the probe trial for long-term memory consolidation. No sex differences were found in the cued training, platform inversion sessions, or spatial working memory sessions. Hippocampal expression of the brain-derived neurotrophic factor was similar in both sexes, either in basal conditions or after performing the behavioral training battery. Importantly, female mice were not more variable than males in any measure analyzed. This outcome encourages the investigation of sex differences in animal models and the usefulness of including female mice in behavioral research.
MeSH term(s)	Humans ; Rats ; Mice ; Female ; Male ; Animals ; Spatial Memory ; Mice, Inbred C57BL ; Behavior Rating Scale ; Maze Learning/physiology ; Swimming
Language	English
Publishing date	2023-12-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	449927-x
ISSN	1872-7549 ; 0166-4328
ISSN (online)	1872-7549
ISSN	0166-4328
DOI	10.1016/j.bbr.2023.114806
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Changes in dietary habits during Covid-19 lockdown in Egypt: the Egyptian COVIDiet study.

Abdelkawy, Khaled / Elbarbry, Fawzy / El-Masry, Soha M / Zakaria, Amr Y / Rodríguez-Pérez, Celia / El-Khodary, Noha M

BMC public health

2023 Volume 23, Issue 1, Page(s) 956

Abstract: Purpose: COVID-19 lockdown changed social habits and lifestyle, including dietary habits, of people worldwide. However, limited information is available about these changes in Egypt. This cross-sectional study investigates the effects of COVID-19 ... ...

Abstract	Purpose: COVID-19 lockdown changed social habits and lifestyle, including dietary habits, of people worldwide. However, limited information is available about these changes in Egypt. This cross-sectional study investigates the effects of COVID-19 lockdown on dietary habits among the Egyptian populations. Methods: An online questionnaire, based on sociodemographic data and dietary adherence in accordance with the validated PREDIMED MedDiet Adherence Screener (MEDAS), was used all over the Egyptian governorates. The dietary changes were statistically evaluated for significance in relation to age, gender, body mass index (BMI), education level and governorates. Results: A total of 1010 participants (76% aged below 36 years, 77% female, 22% obese, and 62% university-level education) answered the questionnaire. Respondents ≤ 20 years had a significant increase in weight and consumption of carbonated beverages, commercial pastries, fried and fast food. Egyptians > 50 years old had a significant decrease in physical activity. Underweight people (less than 3% of participants) increased their fast food intake with a prominent rise in weight. However, obese people increased cooking frequency and increased eating times with a decrease in physical activity. Male participants reported increased intake of carbonated beverages and fast food, while female participants increased the intake of homemade pastries with a significant decrease in physical activity. Approximately 50% of participants with postgraduate education reported decreased intake of fast food and carbonated beverages as well as decreased body weight. Residents of Cairo showed a significant increase in vegetable intake, and fried food intake with a decrease in seafood consumption. Participants from the Delta region had a significant increase in pastries intake. Conclusion: The findings of this study explored the need for increasing awareness about healthy lifestyle in future lockdown periods.
MeSH term(s)	Humans ; Male ; Female ; Aged ; Middle Aged ; COVID-19/epidemiology ; COVID-19/prevention & control ; Egypt/epidemiology ; Cross-Sectional Studies ; Communicable Disease Control ; Feeding Behavior ; Obesity/epidemiology ; Fast Foods
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-15777-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: How Healthy Is It to Fortify Cocoa-Based Products with Cocoa Flavanols? A Comprehensive Review

Palma-Morales, Marta / Melgar-Locatelli, Sonia / Castilla-Ortega, Estela / Rodríguez-Pérez, Celia

Antioxidants. 2023 July 03, v. 12, no. 7

2023

Abstract: 1) Background: Cocoa’s healthy benefits may be attributed to the potent antioxidant activity of cocoa polyphenols, mainly flavanols, which have been characterised as existing in a high concentration in cocoa. However, the phenolic composition of cocoa ... ...

Abstract	(1) Background: Cocoa’s healthy benefits may be attributed to the potent antioxidant activity of cocoa polyphenols, mainly flavanols, which have been characterised as existing in a high concentration in cocoa. However, the phenolic composition of cocoa and cocoa-derived products is highly variable, and manufacturing processes might significantly reduce their phenolic content. For that reason, the full characterisation of cocoa and cocoa-derived products before evaluating their bioactivity is crucial. The aim of this review is to analyse the available evidence on the effect of flavanol-fortified cocoa-derived products on human health. (2) Methods: Forty-eight clinical trials focused on the health effect of consuming flavanol-fortified drinks, bars and chocolate have been reviewed, with a total of 1523 subjects. (3) Results: Although studies differ widely in methodology, dosage, duration, and target population, beneficial effects of flavanol-rich cocoa consumption have been observed at doses ranging from 45.3 mg/d to 1078 mg/d, especially on cardiovascular health and cognitive function. (4) Conclusions: Considering the high consumption and acceptability of cocoa and cocoa-derived products, the fortification of cocoa products as well as other highly consumed foods with cocoa flavanols could be an effective strategy for health promotion.
Keywords	antioxidant activity ; chocolate ; cognition ; flavanols ; health promotion ; human health ; polyphenols
Language	English
Dates of publication	2023-0703
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox12071376
Database	NAL-Catalogue (AGRICOLA)

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