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  1. Article ; Online: Associations Between Internalizing and Externalizing Symptoms on Subsequent Tobacco Product Initiation and Sustained Use as a Function of Sex Among Adolescents Ages 12-17.

    Kittaneh, Ahmad A / Lechner, William V

    Journal of studies on alcohol and drugs

    2022  Volume 83, Issue 6, Page(s) 812–819

    Abstract: Objective: Previous studies have found positive associations between internalizing and externalizing symptoms and the initiation of tobacco use among adolescents. However, few studies have examined the relationship between these symptoms and sustained ... ...

    Abstract Objective: Previous studies have found positive associations between internalizing and externalizing symptoms and the initiation of tobacco use among adolescents. However, few studies have examined the relationship between these symptoms and sustained tobacco use patterns or how they may vary as a function of sex. The current study examined whether these symptoms predict initiation and sustained use of multiple tobacco products within a longitudinal cohort design.
    Method: Waves 1-3 of the Population Assessment of Tobacco and Health Study (2013-2016) were used to assess relationships between internalizing and externalizing symptoms, sex, and tobacco use categories (cigarettes, e-cigarettes, poly-tobacco use, other tobacco use) in 6,170 adolescents (
    Results: Internalizing and externalizing symptoms predicted initiation of several tobacco categories at the 2-year follow-up. Examining sustained use patterns revealed a more consistent relationship with externalizing symptoms across tobacco categories, whereas associations with internalizing symptoms were limited. Sex moderated the relationship between elevated internalizing symptoms and increased odds of subsequent e-cigarette and poly-tobacco initiation, with stronger relationships observed among females. In addition, the relationship between elevated externalizing symptoms and sustained other tobacco use was stronger in females as compared with males.
    Conclusions: Although both internalizing and externalizing symptoms predict tobacco initiation across several product categories, externalizing symptoms may reflect a more reliable signal of sustained tobacco use in adolescents. Mental health symptoms and subsequent tobacco use differed by sex, with females demonstrating stronger relationships for several products.
    MeSH term(s) Adolescent ; Male ; Female ; Humans ; Child ; Electronic Nicotine Delivery Systems ; Nicotiana ; Longitudinal Studies ; Tobacco Products ; Tobacco Use/epidemiology ; Tobacco Use/psychology
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2266450-6
    ISSN 1938-4114 ; 1934-2683 ; 1937-1888 ; 0096-882X
    ISSN (online) 1938-4114 ; 1934-2683
    ISSN 1937-1888 ; 0096-882X
    DOI 10.15288/jsad.21-00334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cigarette and e-cigarette use as a function of psychological distress following COVID-19 related university campus closures.

    Bista, Saroj / Lechner, William V / Anderson, Megan / Kenne, Kaylie N / Kenne, Deric R

    The American journal of drug and alcohol abuse

    2023  Volume 49, Issue 2, Page(s) 239–248

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Young Adult ; Humans ; Female ; Male ; COVID-19/epidemiology ; Electronic Nicotine Delivery Systems ; Vaping/epidemiology ; Nicotine ; Universities ; Pandemics ; Cross-Sectional Studies ; Tobacco Products ; Psychological Distress
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 193086-2
    ISSN 1097-9891 ; 0095-2990
    ISSN (online) 1097-9891
    ISSN 0095-2990
    DOI 10.1080/00952990.2023.2171300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Assessment of psychological distress as a function of positive psychological variables during the COVID-19 pandemic: A university longitudinal study.

    Laurene, Kimberly R / Kodukula, Geethika / Lechner, William V / Grega, Chelsea / Lumpkin, Evelyn / Kenne, Deric R

    Journal of American college health : J of ACH

    2022  Volume 72, Issue 1, Page(s) 229–235

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Female ; Male ; Humans ; COVID-19/epidemiology ; Longitudinal Studies ; Pandemics ; Students ; Universities ; Psychological Distress
    Language English
    Publishing date 2022-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604907-2
    ISSN 1940-3208 ; 0744-8481
    ISSN (online) 1940-3208
    ISSN 0744-8481
    DOI 10.1080/07448481.2022.2032086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of Electronic Cigarette Use on Cardiovascular-Disease-Related Inflammatory Biomarkers in Smokers with HIV in a Switching Study in the United States

    Patricia A. Cioe / William V. Lechner / Jennifer W. Tidey / Christopher W. Kahler

    Pharmacoepidemiology, Vol 2, Iss 10, Pp 106-

    2023  Volume 113

    Abstract: People with HIV (PWH) experience higher rates of cardiovascular events (CVEs) compared with the general population. A substantial body of evidence supports that select biomarkers of inflammation (soluble CD14 [sCD14], soluble CD163 [sCD163], highly ... ...

    Abstract People with HIV (PWH) experience higher rates of cardiovascular events (CVEs) compared with the general population. A substantial body of evidence supports that select biomarkers of inflammation (soluble CD14 [sCD14], soluble CD163 [sCD163], highly sensitive C-reactive protein [hs-CRP], interleukin-6 [IL-6]) and coagulation (D-dimer) are elevated in PWH and related to increased rates of CVEs. Our previous work showed that smoking compared with nonsmoking was associated with significantly elevated sCD14, a biomarker of monocyte activation. We aimed to explore the effect of electronic cigarette (EC) provision on inflammatory biomarkers in PWH who smoked daily and then switched to an EC. Nineteen PWH were enrolled in a pilot study in which an EC and e-liquid were provided weekly for 8 weeks. Blood specimens for inflammatory biomarker analysis were obtained at baseline (BL) and at week 8. Biomarker levels were high at BL and did not differ significantly at week 8. There were small nonsignificant reductions in sCD163 and CRP levels. Non-significant increases in IL-6, D-dimer, and sCD14 levels were also noted. Use of ECs for 8 weeks does not appear to significantly increase or decrease inflammatory biomarker levels in SWH. Further research with larger samples and a control group is needed.
    Keywords HIV ; tobacco ; electronic cigarettes ; inflammation ; biomarkers ; Therapeutics. Pharmacology ; RM1-950 ; Other systems of medicine ; RZ201-999 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Effects of Negative Emotion on Abstinence Induced Change in Urge to Vape and Measures of Vaping Dependence.

    Kittaneh, Ahmad A / Sidhu, Natasha K / Tackett, Alayna P / Lechner, William V

    Substance use & misuse

    2021  Volume 56, Issue 6, Page(s) 768–776

    Abstract: Introduction: Negative emotion and craving to smoke are established factors driving the maintenance of combustible cigarette use and dependence. The current study aimed to examine whether these findings extend to e-cigarette use. Toward that aim, change ...

    Abstract Introduction: Negative emotion and craving to smoke are established factors driving the maintenance of combustible cigarette use and dependence. The current study aimed to examine whether these findings extend to e-cigarette use. Toward that aim, change in vaping urge following abstinence was examined as a function of negative emotion. Additionally, a mediation model which previously demonstrated relationships between negative emotion, craving, and
    Method: Daily e-cigarette users (
    Results: Multivariate regression and two mediation models were utilized to examine factors associated with vaping dependence. The results of these models indicated that negative affect predicted vaping urge following observed abstinence. The relationship between negative affect and measures of vaping dependence and habit, respectively, were significantly mediated by changes in urge during the abstinence period.
    Conclusions: These preliminary results indicate that psychological constructs underlying vaping dependence are similar to those previously found to be associated with combustible cigarette dependence. Further research examining whether these constructs, namely negative affect and change in urge following abstinence, will be important variables to target for vaping cessation treatments is needed.
    MeSH term(s) Adult ; Child ; Electronic Nicotine Delivery Systems ; Emotions ; Humans ; Smokers ; Smoking Cessation ; Vaping ; Young Adult
    Language English
    Publishing date 2021-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1310358-1
    ISSN 1532-2491 ; 1082-6084
    ISSN (online) 1532-2491
    ISSN 1082-6084
    DOI 10.1080/10826084.2021.1892143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Combined Working Memory Training and Transcranial Magnetic Stimulation Demonstrates Low Feasibility and Potentially Worse Outcomes on Delay to Smoking and Cognitive Tasks: A Randomized 2 × 2 Factorial Design Pilot and Feasibility Study.

    Lechner, William V / Philip, Noah S / Kahler, Christopher W / Houben, Katrijn / Tirrell, Eric / Carpenter, Linda L

    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

    2022  Volume 24, Issue 12, Page(s) 1871–1880

    Abstract: Introduction: Repetitive Transcranial Magnetic Stimulation (rTMS) has shown promising results in treating several Substance Use Disorders including Tobacco Use Disorder. However, questions remain regarding how to optimize treatment outcomes. Enhancement ...

    Abstract Introduction: Repetitive Transcranial Magnetic Stimulation (rTMS) has shown promising results in treating several Substance Use Disorders including Tobacco Use Disorder. However, questions remain regarding how to optimize treatment outcomes. Enhancement of working memory by rTMS is a potential therapeutic mechanism. The current pilot study examined whether rTMS plus a cognitive training program could enhance the effects of rTMS on smoking behaviors using a controlled, factorial design.
    Aims and methods: We hypothesized that cognitive training plus stimulation would improve control over smoking behaviors, resulting in enhanced cognitive performance and increased latency to smoke on a delay to smoking analog task. Using a 2 × 2 factorial design, nicotine dependent smokers (n = 43) were randomized to receive 10 sessions of active (10 Hz) or sham rTMS delivered to the left dorsolateral prefrontal cortex, plus active or sham working memory training (WMT) prior to and following stimulation.
    Results: Contrary to hypotheses, we observed a significant interaction effect, indicating that combining the two active interventions (rTMS+WMT) resulted in worse performance on the smoking analog task (B = -33.0, 95% CI = -64.39, -1.61, p < .05), compared to delivering either intervention alone. Additionally, although active rTMS (compared to sham rTMS) improved letter-sequencing performance (B = 1.23, 95% CI = 0.08-2.38, p < .05), and active WMT (compared to sham WMT) improved back-digit task performance (B = 1.53, 95% CI = 0.02-3.05, p < .05), combining interventions worsened the effect of each on a back-digit task (B = -3.01, 95% CI = -5.96, -0.052, p < .05).
    Conclusions: These preliminary findings indicate potential iatrogenic effects of combining rTMS and this working memory training intervention and underscore the need for rigorous evaluation of substance specific conceptual frameworks when selecting future combination interventions.
    Implications: Counter to hypothesis, this study found no additional benefit of adding a working memory training program to a rTMS protocol in a sample of daily smokers. The combination condition (active rTMS + active training) resulted in worse performance on a delay to smoking analog task and a measure of working memory performance compared to delivering either intervention alone. These preliminary findings inform strategies for optimizing rTMS in smokers and highlight the need for future studies to consider several key components of candidate combination interventions, including effects on regulation of substance use.
    Clinical trial registration (if any): The trial was registered at ClinicalTrials.gov (NCT03337113).
    MeSH term(s) Humans ; Cognition ; Feasibility Studies ; Memory, Short-Term ; Pilot Projects ; Prefrontal Cortex/physiology ; Smoking ; Transcranial Magnetic Stimulation/methods ; Treatment Outcome
    Language English
    Publishing date 2022-07-30
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1452315-2
    ISSN 1469-994X ; 1462-2203
    ISSN (online) 1469-994X
    ISSN 1462-2203
    DOI 10.1093/ntr/ntac183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Tobacco Use Status as a Function of Transgender Identity: The Mediating Role of Psychological Distress.

    Kittaneh, Ahmad A / Patel, Sweta / Sidhu, Natasha K / Lechner, William V / Kenne, Deric R

    Tobacco use insights

    2021  Volume 14, Page(s) 1179173X211004267

    Abstract: Aim: The current study examined differences between individuals identifying as transgender and people identifying as cisgender in terms of (1) psychological distress (eg, anxiety, depression, and suicidal ideation), (2) rates of combustible and e- ... ...

    Abstract Aim: The current study examined differences between individuals identifying as transgender and people identifying as cisgender in terms of (1) psychological distress (eg, anxiety, depression, and suicidal ideation), (2) rates of combustible and e-cigarette use, and (3) the potential for elevated psychological distress stemming from transgender identification to be associated with increased rates of smoking and vaping.
    Method: This was a secondary analysis of data from a study examining behavioral health, perceptions and behaviors associated with alcohol and other drug use, and mental health status at a large mid-western university. Differences in current use of cigarette and e-cigarette products were examined between self-identified transgender (n = 253) and cisgender (n = 18 371) respondents.
    Results: Overall, 17.2% (n = 2727) of the sample endorsed past 30-day use of cigarettes or e-cigarettes. Results demonstrated a significant effect of gender identity, with individuals identifying as transgender reporting higher odds of using cigarettes or e-cigarettes (AOR = 2.82, 95% CI 1.26-6.31). Regression analyses revealed significant effects of transgender identity on symptoms of anxiety (
    Discussion: This is the first study of our knowledge to examine the association between psychological symptoms and smoking and vaping products with transgender identity. The results of this study support previous findings that transgender individuals are at risk for elevated substance use and extend the literature by demonstrating this this risk is associated with elevated psychological distress.
    Language English
    Publishing date 2021-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2532401-9
    ISSN 1179-173X
    ISSN 1179-173X
    DOI 10.1177/1179173X211004267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Interventions with potential to target executive function deficits in addiction: current state of the literature.

    Lechner, William V / Sidhu, Natasha K / Kittaneh, Ahmad A / Anand, Amit

    Current opinion in psychology

    2019  Volume 30, Page(s) 24–28

    Abstract: The inability to stop or reduce substance use despite motivation to do so is thought to result, in part, from self-control failure and can be understood within the framework of dual process models of addiction. These models view addictive behavior as the ...

    Abstract The inability to stop or reduce substance use despite motivation to do so is thought to result, in part, from self-control failure and can be understood within the framework of dual process models of addiction. These models view addictive behavior as the relative balance between automatic impulses and executive decision processes. This review focuses on treatments that aim to improve executive decision processes which often become dysregulated and ineffective in individuals with substance use disorders. It is posited that improving these executive function deficits should restore control over automatic impulses and drug seeking behavior.
    MeSH term(s) Behavior, Addictive ; Drug Therapy ; Executive Function/physiology ; Humans ; Mindfulness ; Motivation ; Substance-Related Disorders/therapy
    Language English
    Publishing date 2019-02-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2831565-0
    ISSN 2352-2518 ; 2352-250X ; 2352-250X
    ISSN (online) 2352-2518 ; 2352-250X
    ISSN 2352-250X
    DOI 10.1016/j.copsyc.2019.01.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Coping via substance use, internal attribution bias, and their depressive interplay: Findings from a three-week daily diary study using a clinical sample.

    Heggeness, Luke F / Lechner, William V / Ciesla, Jeffrey A

    Addictive behaviors

    2018  Volume 89, Page(s) 70–77

    Abstract: Background: The relationship between depression and coping-oriented substance use is extensively documented; however, the cognitive processes moderating this bidirectional relationship are not well-understood. The present study investigated whether ... ...

    Abstract Background: The relationship between depression and coping-oriented substance use is extensively documented; however, the cognitive processes moderating this bidirectional relationship are not well-understood. The present study investigated whether internal attribution bias coupled with a tendency to use drugs and/or alcohol to cope predicts increases in depression and daily-levels of general negative affectivity, sadness, and hostility.
    Method: Sixty-seven adults diagnosed with depression were recruited from out-patient treatment settings (66% female, 81% White, M
    Results: Substance use to cope predicted increases in depression among individuals with high-level internal attribution bias. Further, coping via substance use moderated the relationship between internal attribution bias and daily-level sadness, such that sadness was highest among individuals with a high internal attribution bias coupled with greater levels of coping via substance use. A modest, yet, non-significant upward trend in daily-level hostility was also observed.
    Conclusions: Results suggested that depressed individuals who habitually perceive themselves as being responsible or blameworthy for negative life events are at an increased risk of worsening depressive symptoms and experiencing greater daily levels of sadness over a relatively brief period of time, particularly, when tending to engage in substance use as a mechanism to cope. This interaction effect can elicit greater daily-level sadness as well. Findings may aid in the identification and treatment of individuals at risk of maintaining or worsening their depressive symptoms.
    MeSH term(s) Adaptation, Psychological/drug effects ; Adult ; Affect/drug effects ; Alcohol Drinking/psychology ; Depressive Disorder/psychology ; Female ; Humans ; Male ; Prospective Studies ; Self Report ; Substance-Related Disorders/psychology
    Language English
    Publishing date 2018-09-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 197618-7
    ISSN 1873-6327 ; 0306-4603
    ISSN (online) 1873-6327
    ISSN 0306-4603
    DOI 10.1016/j.addbeh.2018.09.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Tobacco Use Status as a Function of Transgender Identity

    Ahmad A Kittaneh / Sweta Patel / Natasha K Sidhu / William V Lechner / Deric R Kenne

    Tobacco Use Insights, Vol

    The Mediating Role of Psychological Distress

    2021  Volume 14

    Abstract: Aim: The current study examined differences between individuals identifying as transgender and people identifying as cisgender in terms of (1) psychological distress (eg, anxiety, depression, and suicidal ideation), (2) rates of combustible and e- ... ...

    Abstract Aim: The current study examined differences between individuals identifying as transgender and people identifying as cisgender in terms of (1) psychological distress (eg, anxiety, depression, and suicidal ideation), (2) rates of combustible and e-cigarette use, and (3) the potential for elevated psychological distress stemming from transgender identification to be associated with increased rates of smoking and vaping. Method: This was a secondary analysis of data from a study examining behavioral health, perceptions and behaviors associated with alcohol and other drug use, and mental health status at a large mid-western university. Differences in current use of cigarette and e-cigarette products were examined between self-identified transgender (n = 253) and cisgender (n = 18 371) respondents. Results: Overall, 17.2% (n = 2727) of the sample endorsed past 30-day use of cigarettes or e-cigarettes. Results demonstrated a significant effect of gender identity, with individuals identifying as transgender reporting higher odds of using cigarettes or e-cigarettes (AOR = 2.82, 95% CI 1.26-6.31). Regression analyses revealed significant effects of transgender identity on symptoms of anxiety ( b = 3.45, 95% CI = 1.64, 5.25, P < .001.); depression, ( b = 4.14, 95% CI = 2.21, 6.07, P < .001); and suicidal ideation, ( b = 2.51, 95% CI = 1.48, 3.55, P < .001.), respectively. Finally, we observed significant indirect effects of transgender identity on cigarette and e-cigarette product use via increased symptoms of depression (indirect effect = 0.13, 95% CI [0.07, 0.19], P < .05), and suicidal ideation (indirect effect = 0.22, 95% CI [0.15, 0.28], P < .05), but not symptoms of anxiety. Discussion: This is the first study of our knowledge to examine the association between psychological symptoms and smoking and vaping products with transgender identity. The results of this study support previous findings that transgender individuals are at risk for elevated substance use and extend the literature by demonstrating ...
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 150
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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