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  1. Article: Endometrial Cancer and BRCA Mutations: A Systematic Review.

    Gasparri, Maria Luisa / Bellaminutti, Serena / Farooqi, Ammad Ahmad / Cuccu, Ilaria / Di Donato, Violante / Papadia, Andrea

    Journal of clinical medicine

    2022  Volume 11, Issue 11

    Abstract: This systematic review identifies, evaluates, and summarises the findings of all relevant individual studies on the prevalence of BRCA mutation (BRCAm) in endometrial cancer patients and the incidence of endometrial cancer in BRCAm women patients. ... ...

    Abstract This systematic review identifies, evaluates, and summarises the findings of all relevant individual studies on the prevalence of BRCA mutation (BRCAm) in endometrial cancer patients and the incidence of endometrial cancer in BRCAm women patients. Consequently, the benefits and limits of a prophylactic hysterectomy at the time of the risk-reducing salpingo-oophorectomy are analysed and discussed. A systematic literature search was performed in the databases of PubMed, Cochrane, and Web of Science until May 2022; 13 studies met the eligibility criteria. Overall, 1613 endometrial cancer patients from 11 cohorts were tested for BRCA1/2 mutation. BRCA1/2m were identified in 4.3% of women with endometrial cancer (70/1613). BRCA1m was the most represented (71.4%) pathogenic variant. Alongside, a total of 209 BRCAm carriers from 14 studies were diagnosed with endometrial cancer. Only 5 out of 14 studies found a correlation between BRCAm and an increased risk of endometrial cancer. Nevertheless, two studies found a statistical difference only for BRCA1m women. The present systematic review does not provide strong evidence in favour of performing routine hysterectomy at the time of risk-reducing salpingo-oophorectomy; however, it provides epidemiological data that can be useful for counselling patients in order to offer a tailored approach.
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11113114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assessment of sentinel Lymph node mapping with different volumes of Indocyanine green in early-stage ENdometrial cancer: the ALIEN study.

    Mauro, Jessica / Raimondo, Diego / Di Martino, Giampaolo / Gasparri, Maria Luisa / Restaino, Stefano / Neola, Daniele / Clivio, Luca / Calidona, Carmelo / Fruscio, Robert / Vizzielli, Giuseppe / Uccella, Stefano / Papadia, Andrea / Seracchioli, Renato / Buda, Alessandro

    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

    2024  

    Abstract: Objective: To evaluate the impact of different volumes of indocyanine green (ICG) on the detection rate and bilateral mapping of sentinel lymph nodes in patients with apparent uterine-confined endometrial cancer.: Methods: All patients who underwent ... ...

    Abstract Objective: To evaluate the impact of different volumes of indocyanine green (ICG) on the detection rate and bilateral mapping of sentinel lymph nodes in patients with apparent uterine-confined endometrial cancer.
    Methods: All patients who underwent surgical staging with sentinel node mapping in six reference centers were included. Two different protocols of ICG intracervical injection were used: (1) 2 mL group: total volume of 2 mL injected superficially; (2) 4 mL group: total volume of 4 mL, 2 mL deeply and 2 mL superficially. Logistic regression was used to analyze factors that could influence dye migration and detection rates. A sensitivity analysis was carried out to determine how independent variables could affect the sentinel node detection rate.
    Results: Of 442 eligible patients, 352 were analyzed (172 in the 2 mL group and 180 in the 4 mL group). The bilateral detection rates of the 2 mL and 4 mL groups were 84.9% and 86.1%, respectively (p=0.76). The overall detection rate was higher with a volume of 4 mL than with 2 mL (97.8% vs 92.4%, respectively; p=0.024). In the univariate analysis the rate of bilateral mapping fell from 87.5% to 73.5% when the International Federation of Gynecology and Obstetrics (FIGO) 2009 tumor stage was >IB (p=0.018). In the multivariate analysis, for both overall and bilateral detection rates a statistically significant difference emerged for the volume of ICG injected and FIGO 2009 stage >IB. Increasing body mass index was associated with worse overall detection rates on univariate analysis (p=0.0006), and significantly decreased from 97% to 91% when the body mass index exceeded 30 kg/m
    Conclusions: In patients with early-stage endometrial cancer, a volume of 2 mL ICG does not seem to compromise the bilateral detection of sentinel lymph nodes. In women with obesity and FIGO 2009 stage >IB, a 4 mL injection should be preferred.
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1070385-8
    ISSN 1525-1438 ; 1048-891X
    ISSN (online) 1525-1438
    ISSN 1048-891X
    DOI 10.1136/ijgc-2023-005100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Instead of feeling blue, go green!

    Gasparri, Maria Luisa / Mueller, Michael D / Papadia, Andrea

    The Lancet. Oncology

    2018  Volume 19, Issue 10, Page(s) 1273–1274

    MeSH term(s) Female ; Fluorescence ; Humans ; Sentinel Lymph Node ; Uterine Neoplasms
    Language English
    Publishing date 2018-08-22
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(18)30514-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  4. Article: A Machine-Learning Approach to Target Clinical and Biological Features Associated with Sarcopenia: Findings from Northern and Southern Italian Aging Populations.

    Zupo, Roberta / Moroni, Alessia / Castellana, Fabio / Gasparri, Clara / Catino, Feliciana / Lampignano, Luisa / Perna, Simone / Clodoveo, Maria Lisa / Sardone, Rodolfo / Rondanelli, Mariangela

    Metabolites

    2023  Volume 13, Issue 4

    Abstract: Epidemiological and public health resonance of sarcopenia in late life requires further research to identify better clinical markers useful for seeking proper care strategies in preventive medicine settings. Using a machine-learning approach, a search ... ...

    Abstract Epidemiological and public health resonance of sarcopenia in late life requires further research to identify better clinical markers useful for seeking proper care strategies in preventive medicine settings. Using a machine-learning approach, a search for clinical and fluid markers most associated with sarcopenia was carried out across older populations from northern and southern Italy. A dataset of adults >65 years of age (
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13040565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Validation of the Persian version of the Satisfaction With Life Scale (SWLS) in Iranian women with breast cancer

    Nooripour, Roghieh / Hosseinian, Simin / Ghanbari, Nikzad / Haghighat, Shahpar / Matacotta, Joshua J. / Gasparri, Maria Luisa

    Current Psychology

    2023  Volume 42, Issue 4, Page(s) 2993–3000

    Abstract: Breast cancer is a major public health issue capable of harming personal satisfaction. The Satisfaction with Life Scale (SWLS) is one of the most commonly employed tools with which life satisfaction could be measured. The present study aims to assess the ...

    Title translation Validierung der persischen Version der Satisfaction With Life Scale (SWLS) bei iranischen Frauen mit Brustkrebs
    Abstract Breast cancer is a major public health issue capable of harming personal satisfaction. The Satisfaction with Life Scale (SWLS) is one of the most commonly employed tools with which life satisfaction could be measured. The present study aims to assess the Persian version of the Satisfaction with Life Scale (SWLS) among Iranian women with breast cancer. In this descriptive cross-sectional study, a total of 115 women coping with breast cancer in Iran were selected through a convenience sampling method. The participants completed a demographic questionnaire, the Persian version of the SWLS, and the DASS-21. The psychometric properties of the SWLS were examined as construct validity based on the confirmatory factor analysis (CFA), reliability using Cronbach's alpha, and divergent validity by examining the relationship with the DASS-21. Results of the CFA indicated that a single-factor model provides a good fit to the data: (sbX2 = 4.40 (p = 0.36); SRMR = 0.019; CFI = 0.99; NFI = .99; IFI = 1.0; RFI = .97; AGFI = 0.94; GFI = 0.99; RMSEA = .029). Cronbach's alpha coefficient for the SWLS was 0.84. Significant negative correlations were found between SWLS and DASS-21 scores for anxiety (r = -0.58), depression (r = -0.61), and stress (r = -0.59) that demonstrated an acceptable divergent validity. As findings, this scale can be used to respect Iranian women with breast cancer as a reliable measurement tool for satisfaction with life. It could thus be recommended more extensively as an indicator of satisfaction with life in other oncological patients. (c) The Author(s), under exclusive licence to Springer Science+Business Media
    Keywords Breast Neoplasms ; Brustkrebs ; Cross Cultural Validity ; Factor Structure ; Faktorenstruktur ; Foreign Language Translation ; Frauen ; Fremdsprachenübersetzung ; Human Females ; Kulturübergreifende Validität ; Lebenszufriedenheit ; Life Satisfaction ; Personality Measures ; Persönlichkeitstests ; Test Validity ; Testvalidität
    Language English
    Document type Article
    ZDB-ID 2021598-8
    ISSN 1936-4733 ; 1046-1310
    ISSN (online) 1936-4733
    ISSN 1046-1310
    DOI 10.1007/s12144-021-01662-2
    Database PSYNDEX

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  6. Article: Body composition as a predictor of chemotherapy-related toxicity in ovarian cancer patients: A systematic review.

    Rizzo, Stefania / Raia, Giorgio / Del Grande, Maria / Gasparri, Maria Luisa / Colombo, Ilaria / Manganaro, Lucia / Papadia, Andrea / Del Grande, Filippo

    Frontiers in oncology

    2022  Volume 12, Page(s) 1057631

    Abstract: Objectives: The main objective of this systematic review was to examine the literature evaluating association of image-based body composition with chemotherapy-related toxicity in ovarian cancer patients. A secondary objective was to evaluate the ... ...

    Abstract Objectives: The main objective of this systematic review was to examine the literature evaluating association of image-based body composition with chemotherapy-related toxicity in ovarian cancer patients. A secondary objective was to evaluate the different definitions of sarcopenia across studies.
    Methods: This systematic review was conducted according to the PRISMA-DTA statement and the protocol was registered on Prospero. A comprehensive literature search of 3 electronic databases was performed by two authors. For each eligible article, information was collected concerning the clinical setting; basic study data; population characteristics; technical aspects; body composition features; chemotherapy drugs administered; association of body composition values and toxicities. The overall quality of the included studies was critically evaluated.
    Results: After the initial retrieval of 812 articles, the systematic review included 6 articles (5/6 studies were retrospective; one was prospective). The number of patients ranged between 69 and 239; mean/median age ranged between 55 and 65 years; the percentage of sarcopenic patients ranged between 25% and 54%. The cut-off values to define sarcopenia and the vertebral levels for evaluation of body composition were different. Five studies included chemotherapy based on carboplatin and paclitaxel, 1 included chemotherapy based on pegylated liposomal doxorubicin. Among the studies including carboplatin and paclitaxel, 3/5 demonstrated an association with toxicity, whereas 2/5 did not. Altogether, 4/6 papers demonstrated an association between the body composition values and the development of chemotherapy-related toxicities.
    Conclusions: There is a wide variability of results about the association of body composition and chemotherapy-related toxicity in ovarian cancer patients. Therefore further studies, possibly including a comprehensive assessment of body compartments and where the definition of body composition cut-offs is constant, are warranted to better understand this association.
    Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022337753, identifier (CRD42022337753).
    Language English
    Publishing date 2022-11-02
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1057631
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Computed Tomography Based Radiomics as a Predictor of Survival in Ovarian Cancer Patients: A Systematic Review.

    Rizzo, Stefania / Manganaro, Lucia / Dolciami, Miriam / Gasparri, Maria Luisa / Papadia, Andrea / Del Grande, Filippo

    Cancers

    2021  Volume 13, Issue 3

    Abstract: The objective of this systematic review was to assess the results of radiomics for prediction of overall survival (OS) and progression free survival (PFS) in ovarian cancer (OC) patients. A secondary objective was to evaluate the findings of papers that ... ...

    Abstract The objective of this systematic review was to assess the results of radiomics for prediction of overall survival (OS) and progression free survival (PFS) in ovarian cancer (OC) patients. A secondary objective was to evaluate the findings of papers that based their analyses on inter-site heterogeneity. This systematic review was conducted according to the PRISMA statement. After the initial retrieval of 145 articles, the final systematic review comprised six articles. Association between radiomic features and OS was evaluated in 3/6 studies (50%); all articles showed a significant association between radiomic features and OS. Association with PFS was evaluated in 5/6 (83%) articles; the period of follow-up ranged between six and 36 months. All the articles showed significant association between radiomic models and PFS. Inter-site textural features were used for analysis in 2/6 (33%) articles. They demonstrated that high levels of inter-site textural heterogeneity were significantly associated with incomplete surgical resection in breast cancer gene-negative patients, and that lower heterogeneity was associated with complete resectability. There were some differences among papers in methodology; for example, only 3/6 (50%) articles included validation cohorts. In conclusion, radiomic models have demonstrated promising results as predictors of survival in OC patients, although larger studies are needed to allow clinical applicability.
    Language English
    Publishing date 2021-02-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13030573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Whole-Body Composition Features by Computed Tomography in Ovarian Cancer: Pilot Data on Survival Correlations.

    Raia, Giorgio / Del Grande, Maria / Colombo, Ilaria / Nerone, Marta / Manganaro, Lucia / Gasparri, Maria Luisa / Papadia, Andrea / Del Grande, Filippo / Rizzo, Stefania

    Cancers

    2023  Volume 15, Issue 9

    Abstract: Background: The primary objective of this study was to assess the associations of computed tomography (CT)-based whole-body composition values with overall survival (OS) and progression-free survival (PFS) in epithelial ovarian cancer (EOC) patients. ... ...

    Abstract Background: The primary objective of this study was to assess the associations of computed tomography (CT)-based whole-body composition values with overall survival (OS) and progression-free survival (PFS) in epithelial ovarian cancer (EOC) patients. The secondary objective was the association of body composition with chemotherapy-related toxicity.
    Methods: Thirty-four patients (median age 64.9 years; interquartile range 55.4-75.4) with EOC and thorax and abdomen CT scans were included. Clinical data recorded: age; weight; height; stage; chemotherapy-related toxicity; and date of last contact, progression and death. Automatic extraction of body composition values was performed by dedicated software. Sarcopenia was defined according to predefined cutoffs. Statistical analysis included univariate tests to investigate associations of sarcopenia and body composition with chemotoxicity. Association of body composition parameters and OS/PFS was evaluated by log-rank test and Cox proportional hazard model. Multivariate models were adjusted for FIGO stage and/or age at diagnosis.
    Results: We found significant associations of skeletal muscle volume with OS (
    Conclusions: In this exploratory study, we found significant associations of whole-body composition parameters with OS and PFS. These results open a window to the possibility to perform body composition profiling without approximate estimations.
    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15092602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Self-responsibility for Our Good Health.

    Gasparri, Maria Luisa / Mueller, Michael D / Papadia, Andrea

    JAMA oncology

    2016  Volume 2, Issue 9, Page(s) 1242

    MeSH term(s) Humans ; Social Responsibility
    Language English
    Publishing date 2016--01
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2016.3079
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  10. Article ; Online: Immunobiology of Solid Cancers: Cellular and Molecular Pathways as Potential Diagnostic and Therapeutic Targets.

    Ruscito, Ilary / Braicu, Elena Ioana / Gasparri, Maria Luisa / Zizzari, Ilaria Grazia

    BioMed research international

    2018  Volume 2018, Page(s) 6532019

    MeSH term(s) Animals ; Humans ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/therapy
    Language English
    Publishing date 2018-03-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2018/6532019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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