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  1. Article ; Online: Male fertility and semen quality are decreasing - Do we have the expertise to deal with this challenge?

    Perheentupa, Antti / Toppari, Jorma

    Acta obstetricia et gynecologica Scandinavica

    2023  Volume 102, Issue 12, Page(s) 1606–1607

    MeSH term(s) Humans ; Male ; Semen Analysis ; Fertility
    Language English
    Publishing date 2023-08-31
    Publishing country United States
    Document type Editorial
    ZDB-ID 80019-3
    ISSN 1600-0412 ; 0001-6349
    ISSN (online) 1600-0412
    ISSN 0001-6349
    DOI 10.1111/aogs.14693
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  2. Article ; Online: Insulin-like Factor 3 Emerges from the Shadow of Testosterone as a Leydig Cell Biomarker.

    Toppari, Jorma

    The Journal of clinical endocrinology and metabolism

    2020  Volume 106, Issue 1, Page(s) e370–e371

    MeSH term(s) Biomarkers ; Humans ; Insulin ; Leydig Cells ; Male ; Testis ; Testosterone
    Chemical Substances Biomarkers ; Insulin ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2020-09-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgaa603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Deteriorating Semen Quality: The Role of the Environment.

    Virtanen, Helena E / Rodprasert, Wiwat / Toppari, Jorma

    Seminars in reproductive medicine

    2024  Volume 41, Issue 6, Page(s) 226–240

    Abstract: Since the end of the last century, several reports have suggested that semen quality is declining, especially in Western countries. Furthermore, cross-sectional studies using similar protocols have suggested regional differences in semen quality of young ...

    Abstract Since the end of the last century, several reports have suggested that semen quality is declining, especially in Western countries. Furthermore, cross-sectional studies using similar protocols have suggested regional differences in semen quality of young and fertile men. Reasons for these regional differences and local adverse trends in semen quality are unknown, but environmental factors are suspected to have a role. Besides adulthood environmental exposures, those occurring during testicular development may also affect semen quality. Longitudinal follow-up studies and mixture risk analyses are needed to study the effect of fetal, childhood, and adult life environment on semen quality.
    MeSH term(s) Male ; Adult ; Humans ; Child ; Semen Analysis ; Sperm Count ; Cross-Sectional Studies ; Fertility ; Environmental Exposure ; Semen
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2042479-6
    ISSN 1526-4564 ; 1526-8004
    ISSN (online) 1526-4564
    ISSN 1526-8004
    DOI 10.1055/s-0044-1782151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Beauty of Age-dependent Standardization in Pediatric Endocrine Research and Practice.

    Koskenniemi, Jaakko J / Toppari, Jorma

    The Journal of clinical endocrinology and metabolism

    2022  Volume 107, Issue 8, Page(s) e3528–e3529

    MeSH term(s) Biomarkers ; Child ; Endocrinology ; Humans ; Reference Standards
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac243
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  5. Article: Cryptorchidism and puberty.

    Rodprasert, Wiwat / Virtanen, Helena E / Toppari, Jorma

    Frontiers in endocrinology

    2024  Volume 15, Page(s) 1347435

    Abstract: Cryptorchidism is the condition in which one or both testes have not descended adequately into the scrotum. The congenital form of cryptorchidism is one of the most prevalent urogenital anomalies in male newborns. In the acquired form of cryptorchidism, ... ...

    Abstract Cryptorchidism is the condition in which one or both testes have not descended adequately into the scrotum. The congenital form of cryptorchidism is one of the most prevalent urogenital anomalies in male newborns. In the acquired form of cryptorchidism, the testis that was previously descended normally is no longer located in the scrotum. Cryptorchidism is associated with an increased risk of infertility and testicular germ cell tumors. However, data on pubertal progression are less well-established because of the limited number of studies. Here, we aim to review the currently available data on pubertal development in boys with a history of non-syndromic cryptorchidism-both congenital and acquired cryptorchidism. The review is focused on the timing of puberty, physical changes, testicular growth, and endocrine development during puberty. The available evidence demonstrated that the timing of the onset of puberty in boys with a history of congenital cryptorchidism does not differ from that of non-cryptorchid boys. Hypothalamic-pituitary-gonadal hormone measurements showed an impaired function or fewer Sertoli cells and/or germ cells among boys with a history of cryptorchidism, particularly with a history of bilateral cryptorchidism treated with orchiopexy. Leydig cell function is generally not affected in boys with a history of cryptorchidism. Data on pubertal development among boys with acquired cryptorchidism are lacking; therefore, more research is needed to investigate pubertal progression among such boys.
    MeSH term(s) Infant, Newborn ; Humans ; Male ; Cryptorchidism/pathology ; Testicular Neoplasms/pathology ; Leydig Cells/pathology ; Puberty/physiology
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2024.1347435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Retinoblastoma-E2F Transcription Factor Interplay Is Essential for Testicular Development and Male Fertility.

    Mäkelä, Juho-Antti / Toppari, Jorma

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 903684

    Abstract: The retinoblastoma (RB) protein family members (pRB, p107 and p130) are key regulators of cell cycle progression, but also play crucial roles in apoptosis, and stem cell self-renewal and differentiation. RB proteins exert their effects through binding to ...

    Abstract The retinoblastoma (RB) protein family members (pRB, p107 and p130) are key regulators of cell cycle progression, but also play crucial roles in apoptosis, and stem cell self-renewal and differentiation. RB proteins exert their effects through binding to E2F transcription factors, which are essential developmental and physiological regulators of tissue and organ homeostasis. According to the canonical view, phosphorylation of RB results in release of E2Fs and induction of genes needed for progress of the cell cycle. However, there are eight members in the E2F transcription factor family with both activator (E2F1-3a) and repressor (E2F3b-E2F8) roles, highlighting the functional diversity of RB-E2F pathway. In this review article we summarize the data showing that RB-E2F interaction is a key cell-autonomous mechanism responsible for establishment and maintenance of lifelong male fertility. We also review the expression pattern of RB proteins and E2F transcription factors in the testis and male germ cells. The available evidence supports that RB and E2F family members are widely and dynamically expressed in the testis, and they are known to have versatile roles during spermatogenesis. Knowledge of the function and significance of RB-E2F interplay for testicular development and spermatogenesis comes primarily from gene knock-out (KO) studies. Several studies conducted in Sertoli cell-specific
    MeSH term(s) Animals ; E2F3 Transcription Factor/genetics ; E2F3 Transcription Factor/metabolism ; Fertility ; Male ; Mice ; Retinal Neoplasms ; Retinoblastoma/genetics ; Retinoblastoma Protein/genetics ; Retinoblastoma Protein/metabolism
    Chemical Substances E2F3 Transcription Factor ; Retinoblastoma Protein
    Language English
    Publishing date 2022-05-19
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.903684
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  7. Article: CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity.

    Nygård, Lucas / Valta, Milla / Laine, Antti-Pekka / Toppari, Jorma / Knip, Mikael / Veijola, Riitta / Hyöty, Heikki / Ilonen, Jorma / Lempainen, Johanna

    Frontiers in genetics

    2023  Volume 14, Page(s) 1248701

    Abstract: Enteroviral infections have been linked to the development of islet autoimmunity (IA) and type 1 diabetes (T1D), and the coxsackie and adenovirus receptor (CXADR) is one of the ligands used by adenoviruses and enteroviruses for cell internalization. ... ...

    Abstract Enteroviral infections have been linked to the development of islet autoimmunity (IA) and type 1 diabetes (T1D), and the coxsackie and adenovirus receptor (CXADR) is one of the ligands used by adenoviruses and enteroviruses for cell internalization. Two
    Language English
    Publishing date 2023-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.1248701
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  8. Article ; Online: Pubertal testicular volume references for ruler, orchidometer, and ultrasonography measurements based on a longitudinal follow-up.

    Koskela, Mikael / Virtanen, Helena E / Rodprasert, Wiwat / Jahnukainen, Kirsi / Toppari, Jorma / Koskenniemi, Jaakko J

    Andrology

    2024  

    Abstract: Background: Testicular volume is a marker of male pubertal development. Various clinical conditions and their treatments may influence testicular growth.: Objectives: To create ruler-based age-dependent pubertal testicular volume references that ... ...

    Abstract Background: Testicular volume is a marker of male pubertal development. Various clinical conditions and their treatments may influence testicular growth.
    Objectives: To create ruler-based age-dependent pubertal testicular volume references that enable calculation of standard deviation (SD) scores.
    Materials and methods: Study cohort comprised 65 boys who attended clinical examination twice a year from the age of 8.5 years until the attainment of final testicular size. Forty-nine (75.4%) boys completed the follow-up and 16 (24.6%) boys dropped out before the attainment of final post-pubertal testicular size. At each follow-up visit testicular size was measured with a ruler, orchidometer, and ultrasonography. LMS or LMSP method served as the technique for creating reference growth curves for testicular volumes. Using the novel references for ruler measurements, development of SD scores was assessed in a cohort of boys with unilateral cryptorchidism.
    Results: Reference growth curves were constructed separately for ruler, orchidometer, and ultrasonography measurements. Median orchidometer volume of 4 mL, marker of male pubertal onset, occurred at the age of 11.7 years, whereas +2SD curve surpassed 4 mL at 10.2 years and -2SD curve at 13.7 years. Modeled ages at the attainment of 4 mL testicular volume based on ruler measurements were 9.7 years for +2SD curve, 11.5 years for median curve, and 13.6 years for -2SD curve. Ultrasonography-based volume of 1.3 mL corresponded with the median modeled orchidometer-based volume of 4 mL. In boys with unilateral cryptorchidism, ruler-based SD scores decreased during puberty in undescended testes, but not in descended testes.
    Discussion and conclusion: The present study provides reference values for pubertal testicular volume measured with a ruler enabling an age-dependent assessment of testicular size. Comparison with measurements by an orchidometer and ultrasonography is also presented.
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.13629
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  9. Article ; Online: History of the European Academy of Andrology.

    Nieschlag, Eberhard / Forti, Gianni / Wu, Frederick / Toppari, Jorma / Krausz, Csilla

    Andrology

    2022  Volume 10 Suppl 2, Page(s) 4–9

    MeSH term(s) Academies and Institutes ; Andrology
    Language English
    Publishing date 2022-10-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.13244
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  10. Book: Male reproductive health and environmental chemicals with estrogenic effects

    Toppari, Jorma

    (Miljøprojekt ; 290)

    1995  

    Institution Dänemark / Miljøstyrelsen
    Author's details [authors: Jorma Toppari ...]. Danish Environmental Protection Agency
    Series title Miljøprojekt ; 290
    Collection
    Keywords Estrogens, Non-Steroidal / adverse effects ; Environmental Exposure / adverse effects ; Reproduction / drug effects ; Sperm Count / drug effects ; Semen / metabolism ; Hypospadias / epidemiology ; Cryptorchism / epidemiology ; Testicular neoplasms / epidemiology
    Language English
    Size 166 S. : graph. Darst.
    Publishing place København
    Publishing country Denmark
    Document type Book
    HBZ-ID HT006792880
    ISBN 87-7810-345-2 ; 978-87-7810-345-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1996 A 3929 order for loan Magazin

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