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Article ; Online: Manganese losses induced by severe soil acidification in the extensive Lei bamboo (Phyllostachys violascens) plantation stands in Eastern China.

Zong, Yutong / Li, Zichuan / Gui, Renyi / Chen, De / Yuan, Mengting / Chai, Yanjun / Shan, Shengdao / Wong, Ming Hung

2023 Volume 339, Page(s) 139669

Abstract: ... managed Lei bamboo (Phyllostachys violascens) stands are usually subjected to severe soil acidification ... in a chronosequence of Lei bamboo stands (0, 2, 6, 11, and 16 years of stand age). The results showed that the Mn ...

Abstract	Manganese (Mn) is a critical element in soils, essential to plant growth. Long-term and intensively managed Lei bamboo (Phyllostachys violascens) stands are usually subjected to severe soil acidification and Mn activation. However, Mn migration from topsoil to deep soil induced by severe soil acidification was poorly recognized and studied. The distribution and changes of the total and the operationally defined Mn forms in soil profiles and its potential stress and environmental effect were investigated in a chronosequence of Lei bamboo stands (0, 2, 6, 11, and 16 years of stand age). The results showed that the Mn amount was significantly decreased in topsoil and accumulated in subsoil with the long-term and intensive fertilizer application. Soil exchangeable Mn and superphosphate extractable Mn demonstrated large different variation to total Mn, whereas their sum was largely higher than and highly correlated with 8-hydroxyquinoline (HQN) extractable Mn. Soil organic carbon, pH value, exchangeable bases, and soil redox simultaneously controlled soil Mn depletion. In conclusion, long-term and intensive fertilizer application leads to soil acidification and accelerated soil Mn depletion in bamboo stand soil, promoting Mn accumulation in bamboo shoots.
MeSH term(s)	Soil ; Carbon/analysis ; Manganese ; Fertilizers ; Poaceae ; China ; Hydrogen-Ion Concentration
Chemical Substances	Soil ; Carbon (7440-44-0) ; Manganese (42Z2K6ZL8P) ; Fertilizers
Language	English
Publishing date	2023-07-30
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.139669
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Article ; Online: Manganese losses induced by severe soil acidification in the extensive Lei bamboo (Phyllostachys violascens) plantation stands in Eastern China

Zong, Yutong / Li, Zichuan / Gui, Renyi / Chen, De / Yuan, Mengting / Chai, Yanjun / Shan, Shengdao / Wong, Ming Hung

Chemosphere. 2023 Oct., v. 339 p.139669-

2023

Abstract	Manganese (Mn) is a critical element in soils, essential to plant growth. Long-term and intensively managed Lei bamboo (Phyllostachys violascens) stands are usually subjected to severe soil acidification and Mn activation. However, Mn migration from topsoil to deep soil induced by severe soil acidification was poorly recognized and studied. The distribution and changes of the total and the operationally defined Mn forms in soil profiles and its potential stress and environmental effect were investigated in a chronosequence of Lei bamboo stands (0, 2, 6, 11, and 16 years of stand age). The results showed that the Mn amount was significantly decreased in topsoil and accumulated in subsoil with the long-term and intensive fertilizer application. Soil exchangeable Mn and superphosphate extractable Mn demonstrated large different variation to total Mn, whereas their sum was largely higher than and highly correlated with 8-hydroxyquinoline (HQN) extractable Mn. Soil organic carbon, pH value, exchangeable bases, and soil redox simultaneously controlled soil Mn depletion. In conclusion, long-term and intensive fertilizer application leads to soil acidification and accelerated soil Mn depletion in bamboo stand soil, promoting Mn accumulation in bamboo shoots.
Keywords	8-hydroxyquinoline ; Phyllostachys violascens ; bamboos ; chronosequences ; environmental impact ; fertilizer application ; manganese ; pH ; plant growth ; soil acidification ; soil organic carbon ; stand age ; subsoil ; superphosphate ; topsoil ; China ; Bamboo stand ; Intensive fertilizer application ; Acidification ; Mn losses ; Extractable mn
Language	English
Dates of publication	2023-10
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.139669
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparative studies on the chemical composition and pharmacological effects of vinegar-processed antler glue modified from Lei Gong Pao Zhi Lun and traditional water-processed antler glue.

Shi, Mengqi / Li, Tianshi / Zhao, Yan / He, Zhongmei / Zong, Ying / Chen, Weijia / Du, Rui

Journal of ethnopharmacology

2023 Volume 321, Page(s) 117508

Abstract: ... of preparing antler glue by boiling antlers in vinegar and then concentrating them is recorded in Lei Gong Pao ... method of antler glue is water extraction and concentration. But Lei Gong Pao Zhi Lun differs in Chinese ... Zhi Lun (Master Lei's Discourse on Medicinal Processing). In modern times, the typical processing ...

Abstract	Ethnopharmacological relevance: Antler glue is a classic medicinal to enhance sexual function in traditional Chinese medicine (TCM), which was first recorded in Shen Nong Ben Cao Jing (Shennong's Classic of the Materia Medica). Vinegar-processing is a classic method of processing traditional Chinese medicine. The method of preparing antler glue by boiling antlers in vinegar and then concentrating them is recorded in Lei Gong Pao Zhi Lun (Master Lei's Discourse on Medicinal Processing). In modern times, the typical processing method of antler glue is water extraction and concentration. However, it is not clear whether there is a difference in the effect of these two processing methods on the chemical composition and pharmacological activity of antler glue. Aim of the study: The Chinese Pharmacopoeia (2020) records that the processing method of antler glue is water extraction and concentration. But Lei Gong Pao Zhi Lun differs in Chinese Pharmacopoeia (2020), which records the processing method of vinegar extraction and concentration. The effect of the two processing methods on antler glue's chemical composition and pharmacological activity is unknown. So this study aimed to elucidate the difference between different processing methods on the chemical composition and the treatment effect on oligoasthenospermia of antler glue. Materials and methods: So the automatic amino acid analyzer is used to determine the amino acid content of two different processing methods of antler glue. Proteomics was performed to detect the protein components of two different processing methods of antler glue and analyze them. Cyclophosphamide-induced mice models of oligoasthenospermia were used to study the different pharmacological effects of antler glue in two different processing methods. An automatic sperm analyzer observed the quantity and quality of sperm in mice epididymis. Serum sex hormone testosterone (T), luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in mice were tested using the enzyme-linked immunosorbent assay (ELISA) kits. Hematoxylin-eosin (H&E) staining was used to analyze pathological alterations in mouse testicular tissue. The transcriptome has been used to reveal the potential mechanism of antler glue in treating oligoasthenospermia. Mitochondrial complex activity assay kits were used to assay the activity of mitochondrial respiratory chain complex I-V in mouse testicular tissue. Western blot was used to determine the expression of related proteins in mouse testicular tissue. Results: Vinegar-processing can increase the alanine, proline, and glycine content in antler glue, reduce the length of protein peptides in antler glue, and produce a variety of unique proteins. Vinegar-processed antler glue (VAG) increased sperm density, sperm survival, sperm viability, and serum sex hormone levels in oligozoospermic mice. It reversed testicular damage caused by cyclophosphamide, and the effects were differently superior to those of water-processed antler glue (WAG). In addition, transcriptomics and related experiments have shown that VAG can increase the expression of Ndufa2, Uqcr11, Cox6b1, and Atp5i genes and proteins in mouse testis, thus promoting adenosine diphosphate (ATP) synthesis by increasing the activity of mitochondrial respiratory chain complexes I, III, IV and V. By promoting the oxidative phosphorylation process to produce more ATP, VAG can achieve the therapeutic effect of oligoasthenospermia. Conclusion: Vinegar-processing method can increase the content of active ingredients in antler glue. VAG increases ATP levels in the testes by promoting the process of oxidative phosphorylation to treat oligozoospermia.
MeSH term(s)	Humans ; Mice ; Male ; Animals ; Antlers/chemistry ; Acetic Acid ; Semen/chemistry ; Proteins ; Gonadal Steroid Hormones ; Oligospermia ; Amino Acids ; Cyclophosphamide ; Adenosine Triphosphate
Chemical Substances	Acetic Acid (Q40Q9N063P) ; Proteins ; Gonadal Steroid Hormones ; Amino Acids ; Cyclophosphamide (8N3DW7272P) ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2023-12-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117508
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Article ; Online: Two-End-Member Mixing in the Fluids Emitted From Mud Volcano Lei-Gong-Huo, Eastern Taiwan

Hung-Chun Chao / Chen-Feng You / In-Tian Lin / Hou-Chun Liu / Ling-Ho Chung / Chun-Chang Huang / Chuan-Hsiung Chung

Frontiers in Earth Science, Vol

Evidence From Sr Isotopes

2022 Volume 9

Abstract: ... at depth. Mud volcano Lei-Gong-Huo (MV LGH) is a unique mud volcano, which is located on the mélange ...

Abstract	Mud volcano is one of the most important conduits for deep seated materials to migrate upward in sedimentary basins, convergent margins, and subduction zones. Understanding their temporal and spatial characteristics and variations provides us the important information on fluid sources and chemical compositions at depth. Mud volcano Lei-Gong-Huo (MV LGH) is a unique mud volcano, which is located on the mélange formation lying on the andesitic volcanic arc. Fluids emitted from 46 mud pools in MV LGH in eastern Taiwan were sampled and their major trace constitutes as well as H, O, and Sr isotopes (87Sr/86Sr and δ88Sr) were measured. Major constitutes of the fluids are Cl−, Na, and Ca. Compared with seawater, LGH fluids have lower Cl−, δD, δ18O, Na/Cl, K/Cl, and Mg/Cl but higher Ca/Cl ratios, indicating water–rock interaction of igneous rock and the ancient seawater at the source region. This interpretation is further supported by Sr isotopes, which show low value of 87Sr/86Sr ratio down to 0.70708. The result of spatial distribution showing strong negative correlation between Na and Ca concentration as well as Ca and 87Sr/86Sr ratios indicates that two end-member mixing is the major chemical characteristic. The fluids interacting with igneous rock carry high Ca, high δ88Sr, low Na, and low 87Sr/86Sr ratio, while those interacting with sedimentary rock carry low Ca, low δ88Sr, high Na, and high 87Sr/86Sr ratio. The source from the igneous region dominates the eastern and southeastern parts of the mud pools while sedimentary source dominates the western and northwestern parts. Most mud pools show mixing behavior between the two sources. Some of the sedimentary-dominated mud pools reveal existence of residual ancient water as indicated by 87Sr/86Sr. The major factor to fractionate the stable Sr isotopes in LGH waters is the source lithology. In summary, fluids emitted by mud pools in LGH originate from two sources, which are water–rock interactions of igneous rock with the ancient seawater from the east and sedimentary rock from the west at depth, resulting from the complex geologic background of mélange formation.
Keywords	mud volcano ; radiogenic Sr isotopes ; stable Sr isotopes ; sediment-hosted geothermal systems ; water–rock interaction ; Science ; Q
Subject code	550
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model.

Li, Qiaofeng / Lan, Taijin / He, Songhua / Chen, Weiwei / Li, Xiaolan / Zhang, Weiquan / Liu, Ying / Zhang, Qiuping / Chen, Xin / Han, Yaoyao / Su, Zhiheng / Zhu, Dan / Guo, Hongwei

Chinese medicine

2021 Volume 16, Issue 1, Page(s) 99

Abstract: Background: Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang ...

Abstract	Background: Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China. It consists of three herbs, namely Eclipta prostrata (L.) L., Smilax glabra Roxb, and Centella asiatica (L.) Urb. It has been widely used as health protection tea for hundreds of years to prevent hypertension in Guangxi Zhuang Autonomous Region. The purpose of this study is to validate the antihypertensive effect of LFG on the spontaneously hypertensive rat (SHR) model, and to further identify the effective components and anti-hypertension mechanism of LFG. Methods: The effects of LFG on blood pressure, body weight, and heart rate were investigated in vivo using the SHR model. The levels of NO, ANG II, and ET-1 in the serum were measured, and pathological changes in the heart were examined by H&E staining. The main active components of LFG, their corresponding targets, and hypertension associated pathways were discerned through network pharmacology analysis based on the Traditional Chinese Medicine Systems Pharmacology (TCMSP), Traditional Chinese Medicine Integrated Database (TCMID), and the Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM). Then the predicted results were further verified by molecular biology experiments such as RT-qPCR and western blot. Additionally, the potential active compounds were predicted by molecular docking technology, and the chemical constituents of LFG were analyzed and identified by UPLC-QTOF/MS technology. Finally, an in vitro assay was performed to investigate the protective effects of potential active compounds against hydrogen peroxide (H Results: LFG could effectively reduce blood pressure and increase serum NO content in SHR model. Histological results showed that LFG could ameliorate pathological changes such as cardiac hypertrophy and interstitial inflammation. From network pharmacology analysis, 53 candidate active compounds of LFG were collected, which linked to 765 potential targets, and 828 hypertension associated targets were retrieved, from which 12 overlapped targets both related to candidate active compounds from LFG and hypertension were screened and used as the potential targets of LFG on antihypertensive effect. The molecular biology experiments of the 12 overlapped targets showed that LFG could upregulate the mRNA and protein expressions of NOS3 and proto-oncogene tyrosine-protein kinase SRC (SRC) in the thoracic aorta. Pathway enrichment analysis showed that the PI3K-AKT signaling pathway was closely related to the expression of NOS3 and SRC. Moreover, western blot results showed that LFG significantly increased the protein expression levels of PI3K and phosphorylated AKT in SHR model, suggesting that LFG may active the PI3K-AKT signaling pathway to decrease hypertension. Molecular docking study further supported that p-hydroxybenzoic acid, cedar acid, shikimic acid, salicylic acid, nicotinic acid, linalool, and histidine can be well binding with NOS3, SRC, PI3K, and AKT. UPLC-QTOF/MS analysis confirmed that p-hydroxybenzoic acid, shikimic acid, salicylic acid, and nicotinic acid existed in LFG. Pre-treatment of HUVEC with nicotinic acid could alleviate the effect on cell viability induced by H Conclusions: LFG can reduce the blood pressure in SHR model, which might be attributed to increasing the NO level in serum for promoting vasodilation via upregulating SRC expression level and activating the PI3K-AKT-NOS3 signaling pathway. Nicotinic acid might be the potential compound for LFG antihypertensive effect.
Language	English
Publishing date	2021-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-021-00507-1
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Article ; Online: Short-Term Effects of Bamboo Biochar and Oyster Shell Powder on Soil Organic Carbon Fraction, Microbial Respiration, and Enzymatic Stoichiometry in a Lei Bamboo Plantation

Ji, Haonan / Yuan, Gensheng / Liu, Yang / Yu, Jinzhu / Li, Songhao / Wu, Qifeng / Qin, Hua / Chen, Junhui

Forests. 2023 Apr. 21, v. 14, no. 4

2023

Abstract: Both biochar and oyster shell powder have been known as promising amendments to ameliorate soil acidity and enhance soil fertility. However, it is still unclear how their application alone and in combination affect the soil organic carbon (C) fraction ... ...

Abstract	Both biochar and oyster shell powder have been known as promising amendments to ameliorate soil acidity and enhance soil fertility. However, it is still unclear how their application alone and in combination affect the soil organic carbon (C) fraction and microbial activity in subtropical bamboo plantations. Therefore, to investigate the effects of biochar and oyster shell powder on soil microbial respiration, organic C fractions, microbial biomass, and enzyme activities related to C, N and P cycling, topsoil samples were collected from plots in a bamboo (Phyllostachys praecox) plantation that has been amended with oyster shell powder at 4 t ha⁻¹ (T), bamboo biochar at 10 t ha⁻¹ (B), and their combination (TB, with 4 t ha⁻¹ T and 10 t ha⁻¹ B) for 8 months. Our results showed that T alone significantly increased soil microbial respiration by 21.5%, whereas B alone and TB significantly decreased soil microbial respiration and metabolic quotient compared with T. T alone also increased soil pH, the size of labile C pool and the activities of β−glucosidase and cellobiosidase, whereas TB rather than B increased soil pH, the recalcitrant C pool size and declined these enzyme activities relative to T. T alone significantly enhanced microbial C limitation by 28.6% and decreased P limitation by 13.0%, while TB decreased microbial C limitation and increased microbial C use efficiency (CUE). Structural equation modeling indicated that T enhanced soil microbial respiration through increasing soil pH and enzyme activity, while biochar co-addition weakened the stimulation of T on microbial respiration by increasing soil recalcitrant C pool size and microbial metabolic quotient. Our study suggests that adding bamboo biochar together with oyster shell powder could be a better strategy to decrease soil C loss and ameliorate soil acidity in bamboo plantations compared with the application of oyster shell powder alone.
Keywords	Phyllostachys violascens ; bamboos ; biochar ; carbon sinks ; enzyme activity ; enzymes ; equations ; microbial activity ; microbial biomass ; oyster shells ; soil fertility ; soil organic carbon ; soil pH ; stoichiometry ; topsoil
Language	English
Dates of publication	2023-0421
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f14040853
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Response of carbon uptake to abiotic and biotic drivers in an intensively managed Lei bamboo forest.

Liu, Yuli / Zhou, Guomo / Du, Huaqiang / Berninger, Frank / Mao, Fangjie / Li, Xuejian / Chen, Liang / Cui, Lu / Li, Yangguang / Zhu, Di'en / Xu, Lin

Journal of environmental management

2018 Volume 223, Page(s) 713–722

Abstract: Lei bamboo (Phyllostachys praecox) is widely distributed in southeastern China. We used eddy ... covariance to analyze carbon sequestration capacity of a Lei bamboo forest (2011-2013) and to identify ...

Abstract	Lei bamboo (Phyllostachys praecox) is widely distributed in southeastern China. We used eddy covariance to analyze carbon sequestration capacity of a Lei bamboo forest (2011-2013) and to identify the seasonal biotic and abiotic determinants of carbon fluxes. A machine learning algorithm called random forest (RF) was used to identify factors that affected carbon fluxes. The RF model predicted well the gross ecosystem productivity (GEP), ecosystem respiration (RE) and net ecosystem exchange (NEE), and displayed variations in the drivers between different seasons. Mean annual NEE, RE, and GEP were -105.2 ± 23.1, 1264.5 ± 45.2, and 1369.6 ± 52.5 g C m
MeSH term(s)	Carbon ; Carbon Cycle ; Carbon Dioxide ; Carbon Sequestration ; China ; Ecosystem ; Models, Theoretical
Chemical Substances	Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0)
Language	English
Publishing date	2018-07-03
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2018.06.046
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Article: The impact of intensive management on net ecosystem productivity and net primary productivity of a Lei bamboo forest

Zhang, Minxia / Chen, Shulin / Jiang, Hong / Peng, Changhui / Zhang, Jinmeng / Zhou, Guomo

Elsevier B.V. Ecological modelling. 2020 Nov. 01, v. 435

2020

Abstract: ... temporal scales. In this study, we used a representative Lei bamboo (Phyllostachys praecox C.D. Chu & C.S ... NPP) of the Lei bamboo forest under IM and nonintensive management (NIM) in 2011–2013 and 2015 ... showed that the Triplex-Flux model was suitable for studying the carbon cycle in the Lei bamboo forest ...

Abstract	The study of carbon sequestration capacity under intensive management (IM)¹1IM, intensive management; NIM, non-intensive management; NEP, net ecosystem production; NPP, net primary productivity; GPP, gross primary productivity; EC, eddy covariance; A, the net CO₂ assimilation rate for leaf; Vc, Rubisco-limited gross photosynthetic rate; Vⱼ, light-limited gross photosynthesis rate; gₛ, stomatal conductance; Rd, leaf dark respiration; Acₐₙₒₚy, net CO₂ assimilation rates in the canopy; LAI, leaf area index; Rd, leaf dark respiration; Rₑ, ecosystem respiration; Rₐ, autotrophic respiration; Rₘ, maintain respiration; Rₕ, heterotrophic respiration Ta_7m, air temperature at 7 m above the ground; Ts_5cm, soil temperature at 5 cm below the ground; rₕ, relative humidity; vpd, vapor pressure deficit; PPFD, photosynthetic photon flux density measures (such as cutting, thinning, plowing, and fertilization) has become a major issue of carbon budgets in the context of global climate change. Bamboo forest, also known as “the second largest forest in the world,” plays an important role in the carbon cycle. Due to its high economic value, IM practices have been widely used to manage bamboo forests, which in turn may affect the global carbon cycle and carbon budget balance of the ecosystem. However, due to a lack of long-term field experiments and suitable representative models for carbon cycle research in bamboo forests, there is little understanding of the effects of IM measures on carbon sources/sinks in bamboo forest ecosystems at large temporal scales. In this study, we used a representative Lei bamboo (Phyllostachys praecox C.D. Chu & C.S. Chao) forest occurring in Taihuyuan town, Zhejiang Province, China as the study object and a new generation Triplex-Flux model to simulate the net ecosystem productivity (NEP) and net primary productivity (NPP) of the Lei bamboo forest under IM and nonintensive management (NIM) in 2011–2013 and 2015. The aim was to reveal the impact of IM on the carbon cycle of a bamboo forest ecosystem. The results showed that the Triplex-Flux model was suitable for studying the carbon cycle in the Lei bamboo forest. On a 30 min time scale, R² values ranged between 0.78–0.91 (p<0.01) and the RMSE varied between 0.04–0.09 gC m⁻¹. On a daily scale, the model was also able to simulate the NEP of the Lei bamboo forest (R²>0.42, p<0.001). However, the Triplex-Flux model failed to reveal the NEP patterns, as there were certain deviations between some of the simulated NEP peak and valley values, which were underestimated at noon and overestimated at night. IM played a key role in controlling carbon budget of the Lei bamboo forest. On a seasonal scale, the effect of IM measures was the most significant in spring; harvesting old bamboo wood and removing new shoots caused a 27.71% and 58.52% decrease in NEP and NPP, respectively. Hooking tips and trimming diseased branches had little impact on NEP and NPP (0.02% and 7.27%, respectively) in autumn. On an annual scale, IM measures resulted in average annual decrease in NEP and NPP by 27.20% and 13.72%, respectively. Our findings can provide a reference base that may be applicable to studying the carbon cycle in bamboo forests across the country and even at larger scales.
Keywords	Phyllostachys violascens ; air temperature ; autumn ; bamboos ; branches ; canopy ; carbon ; carbon dioxide ; carbon sequestration ; climate change ; cutting ; economic valuation ; ecosystem respiration ; eddy covariance ; fertilizer application ; field experimentation ; forest ecosystems ; forests ; global carbon budget ; gross primary productivity ; harvesting ; leaf area index ; leaves ; light intensity ; net ecosystem production ; net primary productivity ; photosynthesis ; plowing ; relative humidity ; shoots ; simulation models ; soil temperature ; spring ; stomatal conductance ; vapor pressure deficit ; wood ; China
Language	English
Dates of publication	2020-1101
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	191971-4
ISSN	0304-3800
ISSN	0304-3800
DOI	10.1016/j.ecolmodel.2020.109248
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model

Qiaofeng Li / Taijin Lan / Songhua He / Weiwei Chen / Xiaolan Li / Weiquan Zhang / Ying Liu / Qiuping Zhang / Xin Chen / Yaoyao Han / Zhiheng Su / Dan Zhu / Hongwei Guo

Chinese Medicine, Vol 16, Iss 1, Pp 1-

2021 Volume 21

Abstract: Abstract Background Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang ...

Abstract	Abstract Background Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China. It consists of three herbs, namely Eclipta prostrata (L.) L., Smilax glabra Roxb, and Centella asiatica (L.) Urb. It has been widely used as health protection tea for hundreds of years to prevent hypertension in Guangxi Zhuang Autonomous Region. The purpose of this study is to validate the antihypertensive effect of LFG on the spontaneously hypertensive rat (SHR) model, and to further identify the effective components and anti-hypertension mechanism of LFG. Methods The effects of LFG on blood pressure, body weight, and heart rate were investigated in vivo using the SHR model. The levels of NO, ANG II, and ET-1 in the serum were measured, and pathological changes in the heart were examined by H&E staining. The main active components of LFG, their corresponding targets, and hypertension associated pathways were discerned through network pharmacology analysis based on the Traditional Chinese Medicine Systems Pharmacology (TCMSP), Traditional Chinese Medicine Integrated Database (TCMID), and the Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM). Then the predicted results were further verified by molecular biology experiments such as RT-qPCR and western blot. Additionally, the potential active compounds were predicted by molecular docking technology, and the chemical constituents of LFG were analyzed and identified by UPLC-QTOF/MS technology. Finally, an in vitro assay was performed to investigate the protective effects of potential active compounds against hydrogen peroxide (H2O2) induced oxidative damage in human umbilical vein endothelial cells (HUVEC). Results LFG could effectively reduce blood pressure and increase serum NO content in SHR model. Histological results showed that LFG could ameliorate pathological changes such as cardiac hypertrophy and interstitial inflammation. From network ...
Keywords	Centella asiatica (L.) Urb ; Eclipta prostrata (L.) L ; Smilax glabra Roxb ; Hypertension ; Network pharmacology ; Other systems of medicine ; RZ201-999
Subject code	500
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Sui lei fu cai

Chen, Lüsheng

"Mei shu bao" 'Chen Lüsheng guan dian' zhuan lan wen ji 2006 nian, 2007 nian

2008

Author's details	Chen Lüsheng
Keywords	Art criticism ; Art, Chinese ; Painting, Chinese
Language	Chinese
Size	470 p, Ill
Edition	Di 1 ban
Publisher	Guangxi mei shu chu ban she
Publishing place	Nanning
Document type	Book
ISBN	9787807461777 ; 7807461772
Database	Former special subject collection: coastal and deep sea fishing

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In stock of ZB MED Bonn / Germany

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Inter-library loan at ZB MED