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Article ; Online: The Outcome of Sutureless in Partial Nephrectomy: A Systematic Review and Meta-Analysis.

Liu, Peng / Li, Yan / Shi, Benkang / Zhang, Qiujie / Guo, Hu

2022 Volume 2022, Page(s) 5260131

Abstract: Purpose: To compare the effect of sutureless versus standard suture (double-layer suture) during renorrhaphy in laparoscopic or robotic-assisted partial nephrectomy on perioperative and renal function outcomes.: Methods: PubMed, Embase, and other ... ...

Abstract	Purpose: To compare the effect of sutureless versus standard suture (double-layer suture) during renorrhaphy in laparoscopic or robotic-assisted partial nephrectomy on perioperative and renal function outcomes. Methods: PubMed, Embase, and other sources were searched for randomized controlled trials or retrospective studies comparing sutureless partial nephrectomy versus standard suture partial nephrectomy. A systematic review and meta-analysis were performed by two reviewers independently. Results: Five retrospective studies were included with a total of 634 patients. The results showed that there was a significant difference in the decline of estimated glomerular filtration rate ( Conclusion: Sutureless during renorrhaphy is feasible and safe compared with standard suture. Sutureless can shorten the operating time and warm ischemia time without increasing postoperative complications, and thus, it protects renal function.
MeSH term(s)	Humans ; Kidney Neoplasms/surgery ; Laparoscopy/adverse effects ; Nephrectomy/methods ; Postoperative Complications/etiology ; Retrospective Studies ; Robotic Surgical Procedures/methods ; Treatment Outcome
Language	English
Publishing date	2022-09-22
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2022/5260131
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Article ; Online: Based on ARASENS trial: efficacy and safety of darolutamide as an emerging option of endocrinotherapy for metastatic hormone-sensitive prostate cancer-an updated systematic review and network meta-analysis.

Dou, Maoyang / Liang, Hao / Liu, Yang / Zhang, Qiujie / Li, Ruowen / Chen, Shouzhen / Shi, Benkang

Journal of cancer research and clinical oncology

2023 Volume 149, Issue 10, Page(s) 7017–7027

Abstract: Purpose: The newly published ARASENS trial has demonstrated the clinical efficacy of darolutamide for metastatic hormone-sensitive prostate cancer (mHSPC). However, the use of darolutamide as the latest first-line androgen receptor pathway inhibitor for ...

Abstract	Purpose: The newly published ARASENS trial has demonstrated the clinical efficacy of darolutamide for metastatic hormone-sensitive prostate cancer (mHSPC). However, the use of darolutamide as the latest first-line androgen receptor pathway inhibitor for mHSPC has not been compared with other androgen receptor targeted agents (ARTAs). Given the lack of head-to-head randomized trials, we performed this updated meta-analysis to conduct indirect comparison for the efficacy and safety of darolutamide with other new-generation ARTAs. Methods: By searching the databases of PubMed, Scopus, Cochrane Library, and Embase, 9 large randomized controlled trials evaluating ARTAs for mHSPC patients were eventually screened according to PRISMA. We extracted data from overall survival, castration-resistant progression, and adverse events for network meta-analysis using the Bayesian and standard frequentist models. Results: Darolutamide combination emerged with superiority (HR = 0.68, 95%CrI = 0.57-0.81) among four androgen receptor inhibitors for patients with high Gleason score (HR = 0.71, 95%CrI = 0.59-0.86). Darolutamide was best tolerated in several androgen suppression-related adverse events (AEs). Conclusion: Darolutamide appears to be an optional androgen receptor inhibitor for mHSPC patients, especially for patients with Gleason score ≥ 8. Its well-tolerated characteristic may provide a preferred drug option for patients with poor cardiovascular function and bone health.
MeSH term(s)	Male ; Humans ; Receptors, Androgen/metabolism ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/pathology ; Network Meta-Analysis ; Bayes Theorem ; Androgen Receptor Antagonists/adverse effects ; Hormones ; Androgen Antagonists/therapeutic use ; Randomized Controlled Trials as Topic
Chemical Substances	Receptors, Androgen ; darolutamide ; Androgen Receptor Antagonists ; Hormones ; Androgen Antagonists
Language	English
Publishing date	2023-03-01
Publishing country	Germany
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-023-04658-6
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Article ; Online: Nomograms for predicting survival in patients with micropapillary bladder cancer: a real-world analysis based on the surveillance, epidemiology, and end results database and external validation in a tertiary center.

Liu, Peng / Xu, Lei / Chen, Guanghao / Shi, Benkang / Zhang, Qiujie / Chen, Shouzhen

BMC urology

2023 Volume 23, Issue 1, Page(s) 16

Abstract: Background: The present study aimed to construct and validate nomograms that can be used to predict cancer-specific survival (CSS) and overall survival (OS) in patients with micropapillary bladder cancer.: Methods: The data of 627 patients diagnosed ... ...

Abstract	Background: The present study aimed to construct and validate nomograms that can be used to predict cancer-specific survival (CSS) and overall survival (OS) in patients with micropapillary bladder cancer. Methods: The data of 627 patients diagnosed with micropapillary bladder cancer between 2000 and 2018 were obtained from the surveillance, epidemiology, and end results database. Patients were randomly divided into the training and internal validation sets (7:3). The Cox proportional hazards regression model was applied to evaluate the association between variables and survival and then nomograms were constructed to predict the survival of an individual patient. The performance of nomograms was validated by using calibration curves, concordance index, receiver operating characteristic curves with the calculated area under the curve and decision curve analysis in the training and internal validation set. Data from 41 micropapillary bladder cancer patients at Qilu Hospital of Shandong University from 2000 to 2022 were collected for external validation. Results: Several independent risk factors were taken into the two nomograms (CSS and OS), including age, marital status, AJCC TMN stage, surgical approach, lymph node ratio, and tumor size while the OS nomogram additionally contained race. The concordance index of the training set, internal validation set, and external verification set were all over 0.7. The calibration curve indicated good consistence between the nomogram prediction and actual survival. Area under the curve and decision curve analysis results indicated great clinical usefulness of nomograms. Conclusions: The nomograms predicting the survival outcome of patients with micropapillary bladder cancer would provide a valuable tool to help clinicians to evaluate the risk of patients and make individual treatment strategies.
MeSH term(s)	Humans ; Nomograms ; Prognosis ; Neoplasm Staging ; SEER Program ; Urinary Bladder Neoplasms/epidemiology ; Urinary Bladder Neoplasms/pathology
Language	English
Publishing date	2023-02-13
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-023-01183-z
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Article: Comparison of different types of therapy for overactive bladder: A systematic review and network meta-analysis.

Liu, Peng / Li, Yan / Shi, Benkang / Zhang, Qiujie / Guo, Hu

Frontiers in medicine

2022 Volume 9, Page(s) 1014291

Abstract: To compare the efficacy and safety of different interventions [including antimuscarinics, mirabegron, OnabotulinumtoxinA, sacral neuromodulation (SNM) and peripheral tibial nerve stimulation (PTNS)] for treating idiopathic overactive bladder (OAB). ... ...

Abstract	To compare the efficacy and safety of different interventions [including antimuscarinics, mirabegron, OnabotulinumtoxinA, sacral neuromodulation (SNM) and peripheral tibial nerve stimulation (PTNS)] for treating idiopathic overactive bladder (OAB). PubMed, Embase, Cochrane Library, and other sources were searched for randomized controlled trials (RCTs) comparing interventions for overactive bladder from 1 January 2000 to 19 April 2021. A systematic review and network meta-analysis were performed by two authors independently. Fifty-five RCTs involving 32,507 patients were included in this analysis. Overall, antimuscarinics, mirabegron, OnabotulinumtoxinA, sacral neuromodulation, and peripheral tibial nerve stimulation were more efficacious than placebo, and sacral neuromodulation showed the best effect for reducing micturition frequency, urgency episodes and urgency urinary incontinence episodes. OnabotulinumtoxinA was the best intervention for achieving reductions of 100 and ≥50% in the number of urinary incontinence episodes/day, and peripheral tibial nerve stimulation was the best intervention for reducing urinary incontinence episodes. Antimuscarinics, mirabegron and peripheral tibial nerve stimulation had a similar efficacy for reducing micturition frequency, urinary incontinence episodes and urgency urinary incontinence episodes. The results revealed that all interventions examined herein were efficacious for managing adult overactive bladder syndrome compared with placebo. Furthermore, sacral neuromodulation and OnabotulinumtoxinA were the most efficient treatments for overactive bladder. Systematic review registration: [https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=251966], identifier [CRD42021251966].
Language	English
Publishing date	2022-10-20
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.1014291
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Article: Growing socio-spatial inequality in neo-liberal times? Comparing Beijing and London

Shi, Qiujie / Dorling, Danny

Applied geography. 2020 Feb., v. 115

2020

Abstract: Growing socio-spatial inequality has become one of the topics that most excites social, economic and urban geographers most recently. Contrary to the general expectation, this paper finds a failure of this growth in inequality to be more applicable ... ...

Abstract	Growing socio-spatial inequality has become one of the topics that most excites social, economic and urban geographers most recently. Contrary to the general expectation, this paper finds a failure of this growth in inequality to be more applicable globally. Although escalated in London, socio-spatial inequality became less acute in Beijing over the same 2000–2010 period. This failure of replicability challenges our traditional understanding of the causes of the problem, as the two commonly accused shifts, one towards service economy and the other towards neoliberalism, are both evident in both cities. What makes the two cities different is the recent speed of change. The fast-developing Beijing has compressed de-agriculturalisation, de-industrialisation and tertiarisation into a just few decades, which were changes seen within London successively over many more decades. Beijing's current explosive urban expansion was seen by London around a century ago. Hence the link between growing socio-spatial inequality and the shifts towards service economy and neoliberalism is not universal but depends on a fully-industrialised, slow-changing urban condition. This is a condition that is not ubiquitous but is largely restricted to now economically slowing down Western societies. These results highlight not only how important is the speed of change in theorising socio-spatial inequality, but also how great is the potential of a wider set of urban comparisons in advancing a more global research agenda.
Keywords	cities ; economic policy ; urbanization ; China
Language	English
Dates of publication	2020-02
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0143-6228
DOI	10.1016/j.apgeog.2019.102139
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Changes in population movement make COVID-19 spread differently from SARS.

Shi, Qiujie / Dorling, Danny / Cao, Guangzhong / Liu, Tao

Social science & medicine (1982)

2020 Volume 255, Page(s) 113036

Abstract: This comment discusses the contribution of population movement to the spread of COVID-19, with a reference to the spread of SARS 17 years ago. We argue that the changing geography of migration, the diversification of jobs taken by migrants, the rapid ... ...

Abstract	This comment discusses the contribution of population movement to the spread of COVID-19, with a reference to the spread of SARS 17 years ago. We argue that the changing geography of migration, the diversification of jobs taken by migrants, the rapid growth of tourism and business trips, and the longer distance taken by people for family reunion are what make the spread of COVID-19 so differently from that of SARS. These changes in population movement are expected to continue. Hence, new strategies in disease prevention and control should be taken accordingly, which are also proposed in the comment.
MeSH term(s)	COVID-19 ; China/epidemiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Human Migration/statistics & numerical data ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Severe Acute Respiratory Syndrome/epidemiology ; Severe Acute Respiratory Syndrome/transmission
Keywords	covid19
Language	English
Publishing date	2020-05-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2020.113036
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Article ; Online: Metagenomics combined with metabolomics reveals the effect of Enterobacter sp. inoculation on the rhizosphere microenvironment of Bidens pilosa L. in heavy metal contaminated soil.

Li, Yi / Shi, Xinwei / Tan, Weilan / Ling, Qiujie / Pei, Fengmei / Luo, Shiyu / Qin, Peiqing / Yuan, Huijian / Huang, Liuan / Yu, Fangming

Journal of hazardous materials

2023 Volume 458, Page(s) 132033

Abstract: Metagenomics analysis was performed to determine the effects of Enterobacter sp. FM-1 (FM-1) on key genera as well as functional genes in the rhizosphere of Bidens pilosa L. (B. pilosa L.). Moreover, metabolomics was used to reveal the differences among ... ...

Abstract	Metagenomics analysis was performed to determine the effects of Enterobacter sp. FM-1 (FM-1) on key genera as well as functional genes in the rhizosphere of Bidens pilosa L. (B. pilosa L.). Moreover, metabolomics was used to reveal the differences among rhizosphere metabolites after FM-1 inoculation. FM-1 inoculation significantly increased the activity of enzymes associated with the carbon cycle in soil; among them, invertase activity increased by 5.52 units compared to a control. Specifically, the relative abundance of beneficial genera increased significantly, such as Lysobacter (0.45-2.58 unit increase) in low-contamination soils (LC) and Pseudomonas (31.17-45.99 unit increase) in high-contamination soils (HC). Comparison of different transformation processes of the C cycle revealed that inoculation of FM-1 increased the abundance of functional genes related to the carbon cycle in LC soil. In contrast, the nitrogen cycling pathway was significantly elevated in both the LC and HC soils. FM-1 inoculation reduced HM resistance gene abundance in the rhizosphere soil of B. pilosa L. in the LC soil. Moreover, FM-1 and B. pilosa L. interactions promoted the secretion of rhizosphere metabolites, in which lipids and amino acids played important roles in the phytoremediation process. Overall, we explored the rhizosphere effects induced by plantmicrobe interactions, providing new insights into the functional microbes and rhizosphere metabolites involved in phytoremediation.
MeSH term(s)	Bidens ; Rhizosphere ; Soil/chemistry ; Enterobacter/metabolism ; Metagenomics ; Soil Pollutants/metabolism ; Metals, Heavy/metabolism ; Biodegradation, Environmental ; Metabolomics ; Soil Microbiology ; Cadmium/analysis
Chemical Substances	Soil ; Soil Pollutants ; Metals, Heavy ; Cadmium (00BH33GNGH)
Language	English
Publishing date	2023-07-11
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.132033
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Article: Targeting M2 Macrophages Alleviates Airway Inflammation and Remodeling in Asthmatic Mice

Wang, Qiujie / Hong, Luna / Chen, Ming / Shi, Jiangting / Lin, Xiaoling / Huang, Linjie / Tang, Tiantian / Guo, Yimin / Yuan, Xiaoqing / Jiang, Shanping

Frontiers in molecular biosciences

2021 Volume 8, Page(s) 717969

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-09-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2021.717969
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Article ; Online: Metagenomics reveals taxon-specific responses of soil nitrogen cycling under different fertilization regimes in heavy metal contaminated soil.

Shi, Xinwei / Tan, Weilan / Tang, Shuting / Ling, Qiujie / Tang, Chijian / Qin, Peiqing / Luo, Shiyu / Zhao, Yinjun / Yu, Fangming / Li, Yi

Journal of environmental management

2023 Volume 345, Page(s) 118766

Abstract: Soil deficiency, cyclic erosion, and heavy metal pollution have led to fertility loss and ecological function decline in mining areas. Fertilization is an important way to rapidly replenish soil nutrients, which have a major influence on the soil ... ...

Abstract	Soil deficiency, cyclic erosion, and heavy metal pollution have led to fertility loss and ecological function decline in mining areas. Fertilization is an important way to rapidly replenish soil nutrients, which have a major influence on the soil nitrogen cycling process, but different fertilization regimes have different impacts on soil properties and microbial functional potentials. Here, metagenomic sequencing was used to investigate the different responses of key functional genes of microbial nitrogen cycling to fertilization regimes and explore the potential effects of soil physicochemical properties on the key functional genes. The results indicated that AC-HH (ammonium chloride-high frequency and concentration) treatment significantly increased the gene abundance of norC (13.40-fold), nirK (5.46-fold), and napA (5.37-fold). U-HH (urea-high frequency and concentration) treatment significantly increased the gene abundance of hao (6.24-fold), pmoA-amoA (4.32-fold) norC (7.00-fold), nosZ (3.69-fold), and nirK (6.88-fold). Functional genes were distributed differently among the 10 dominant phyla. The nifH and nifK genes were distributed only in Proteobacteria. The hao gene was distributed in Gemmatimonadetes, Nitrospirae and Proteobacteria. Fertilization regimes caused changes in functional redundancy in soil, and nirK and nirB, which are involved in denitrification, were present in different genera. Fertilization regimes with high frequency and high concentration were more likely to increase the gene abundance at the genus level. In summary, this study provides insights into the taxon-specific response of soil nitrogen cycling under different fertilization regimes, where changes in fertilization regimes affect microbial nitrogen cycling by altering soil physicochemical properties in a complex dynamic environment.
MeSH term(s)	Soil/chemistry ; Metagenomics ; Soil Microbiology ; Bacteria/genetics ; Fertilization ; Nitrogen
Chemical Substances	Soil ; Nitrogen (N762921K75)
Language	English
Publishing date	2023-08-14
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.118766
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Article ; Online: TREM2 Insufficiency Protects against Pulmonary Fibrosis by Inhibiting M2 Macrophage Polarization.

Luo, Qiujie / Deng, Dawei / Li, Yang / Shi, Hongjie / Zhao, Jinping / Qian, Qiaofeng / Wang, Wei / Cai, Jie / Yu, Wenjun / Liu, Jinping

International immunopharmacology

2023 Volume 118, Page(s) 110070

Abstract: Rationale Idiopathic pulmonary fibrosis (IPF) is a lung disease with high mortality, limited treatment options and an unknown aetiology. M2 macrophages play a critical role in the pathological process of IPF. Triggering receptor expressed on myeloid ... ...

Abstract	Rationale Idiopathic pulmonary fibrosis (IPF) is a lung disease with high mortality, limited treatment options and an unknown aetiology. M2 macrophages play a critical role in the pathological process of IPF. Triggering receptor expressed on myeloid cells-2 (TREM2) participates in the regulation of macrophages, although its role in IPF remains elusive. Methods: This study examined the role of TREM2 in macrophage regulation using a well-established bleomycin (BLM)-induced pulmonary fibrosis (PF) mouse model. TREM2 insufficiency was induced by intratracheal treatment with TREM2-specific siRNA. The effects of TREM2 on IPF were evaluated using histological staining and molecular biological methods. Results: TREM2 expression levels were significantly elevated in the lungs of IPF patients and mice with BLM-induced pulmonary fibrosis mice. Bioinformatics analysis revealed that IPF patients with higher TREM2 expression had a shorter survival time, and that TREM2 expression was closely associated with fibroblasts and M2 macrophages. Gene Ontology (GO) enrichment analysis showed that found TREM2-related differentially expressed genes (DEGs) were associated with inflammatory responses, extracellular matrix (ECM) and collagen formation. Single-cell RNA sequencing analysis revealed that TREM2 was predominantly expressed in macrophages. TREM2 insufficiency inhibited BLM-induced pulmonary fibrosis and M2 macrophage polarization. Mechanistic studies showed that TREM2 insufficiency suppressed the activation of STAT6 and the expression of fibrotic factors such as Fibronectin (Fib), Collagen I (Col I) and α- smooth muscle actin (α-SMA). Conclusion: Our study showed that TREM2 insufficiency might alleviate pulmonary fibrosis possibly through macrophage polarization regulation via STAT6 activation, providing a promising macrophage-related approach for the clinical therapy of pulmonary fibrosis.
MeSH term(s)	Mice ; Animals ; Lung/pathology ; Idiopathic Pulmonary Fibrosis/genetics ; Bleomycin/metabolism ; Macrophages/metabolism ; Collagen Type I/metabolism ; Mice, Inbred C57BL ; Membrane Glycoproteins/genetics ; Membrane Glycoproteins/metabolism ; Receptors, Immunologic/genetics ; Receptors, Immunologic/metabolism
Chemical Substances	Bleomycin (11056-06-7) ; Collagen Type I ; Trem2 protein, mouse ; Membrane Glycoproteins ; Receptors, Immunologic
Language	English
Publishing date	2023-03-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.110070
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