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  1. Article ; Online: Recent advances in understanding the human host immune response in tuberculous meningitis.

    Barnacle, James R / Davis, Angharad G / Wilkinson, Robert J

    Frontiers in immunology

    2024  Volume 14, Page(s) 1326651

    Abstract: Tuberculous meningitis (TBM), the most severe form of tuberculosis, causes death in approximately 25% cases despite antibiotic therapy, and half of survivors are left with neurological disability. Mortality and morbidity are contributed to by a ... ...

    Abstract Tuberculous meningitis (TBM), the most severe form of tuberculosis, causes death in approximately 25% cases despite antibiotic therapy, and half of survivors are left with neurological disability. Mortality and morbidity are contributed to by a dysregulated immune response, and adjunctive host-directed therapies are required to modulate this response and improve outcomes. Developing such therapies relies on improved understanding of the host immune response to TBM. The historical challenges in TBM research of limited
    MeSH term(s) Adult ; Child ; Humans ; Tuberculosis, Meningeal ; MicroRNAs ; Central Nervous System ; Mycobacterium tuberculosis ; B-Lymphocytes
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1326651
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  2. Article: Needle in a haystack: a case report of splenic foreign body-associated sepsis.

    Turner, Benedict R H / Barnacle, James / Sheth, Hemant

    Journal of surgical case reports

    2021  Volume 2021, Issue 11, Page(s) rjab525

    Abstract: Instances of foreign bodies impacted in solid organs are rare, and rarer still are reports of objects in the spleen. A 42-year-old presented septic with abdominal pain, high inflammatory markers and haemodynamic instability. She was found to have a ... ...

    Abstract Instances of foreign bodies impacted in solid organs are rare, and rarer still are reports of objects in the spleen. A 42-year-old presented septic with abdominal pain, high inflammatory markers and haemodynamic instability. She was found to have a splenic haematoma and a 4-cm hyperdense foreign body within the spleen. Ultrasound-guided drainage of the haematoma isolated
    Language English
    Publishing date 2021-11-29
    Publishing country England
    Document type Journal Article
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjab525
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  3. Article ; Online: Investigating competencies needed by European-trained doctors in rural South African hospitals.

    Barnacle, James R / Johnson, Oliver / Couper, Ian

    African journal of primary health care & family medicine

    2020  Volume 12, Issue 1, Page(s) e1–e7

    Abstract: Background: Many European-trained doctors (ETDs) recruited to work in rural district hospitals in South Africa have insufficient generalist competencies for the range of practice required. Africa Health Placements recruits ETDs to work in rural ... ...

    Abstract Background: Many European-trained doctors (ETDs) recruited to work in rural district hospitals in South Africa have insufficient generalist competencies for the range of practice required. Africa Health Placements recruits ETDs to work in rural hospitals in Africa. Many of these doctors feel inadequately prepared. The Stellenbosch University Ukwanda Centre for Rural Health is launching a Postgraduate Diploma in Rural Medicine to help prepare doctors for such work.
    Aim: To determine the competencies gap for ETDs working in rural district hospitals in South Africa to inform the curriculum of the PG Dip (Rural Medicine).
    Setting: Rural district hospitals in South Africa.
    Methods: Nine hospitals in the Eastern Cape, KwaZulu-Natal and Mpumalanga were purposefully selected by Africa Health Placements as receiving ETDs. An online survey was developed asking about the most important competencies and weaknesses for ETDs when working rurally. The clinical manager and any ETDs currently working in each hospital were invited to complete the survey.
    Results: Surveys were completed by 19 ETDs and five clinical managers. The top clinical competencies in relation to 10 specific domains were identified. The results also indicate broader competencies required, specific skills gaps, the strengths that ETDs bring to South Africa and how ETDs prepare themselves for working in this context.
    Conclusion: This study identifies the important competency gaps among ETDs and provides useful direction for the diploma and other future training initiatives. The diploma faculty must reflect on these findings and ensure the curriculum is aligned with these gaps.
    MeSH term(s) Adult ; Clinical Competence ; Curriculum ; Europe/ethnology ; Female ; Foreign Medical Graduates/psychology ; Hospitals, District ; Hospitals, Rural ; Humans ; Male ; South Africa ; Surveys and Questionnaires
    Language English
    Publishing date 2020-08-25
    Publishing country South Africa
    Document type Journal Article
    ZDB-ID 2526836-3
    ISSN 2071-2936 ; 2071-2928
    ISSN (online) 2071-2936
    ISSN 2071-2928
    DOI 10.4102/phcfm.v12i1.2322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Investigating competencies needed by European-trained doctors in rural South African hospitals

    James R. Barnacle / Oliver Johnson / Ian Couper

    African Journal of Primary Health Care & Family Medicine, Vol 12, Iss 1, Pp e1-e

    2020  Volume 7

    Abstract: Background: Many European-trained doctors (ETDs) recruited to work in rural district hospitals in South Africa have insufficient generalist competencies for the range of practice required. Africa Health Placements recruits ETDs to work in rural hospitals ...

    Abstract Background: Many European-trained doctors (ETDs) recruited to work in rural district hospitals in South Africa have insufficient generalist competencies for the range of practice required. Africa Health Placements recruits ETDs to work in rural hospitals in Africa. Many of these doctors feel inadequately prepared. The Stellenbosch University Ukwanda Centre for Rural Health is launching a Postgraduate Diploma in Rural Medicine to help prepare doctors for such work. Aim: To determine the competencies gap for ETDs working in rural district hospitals in South Africa to inform the curriculum of the PG Dip (Rural Medicine). Setting: Rural district hospitals in South Africa. Methods: Nine hospitals in the Eastern Cape, KwaZulu-Natal and Mpumalanga were purposefully selected by Africa Health Placements as receiving ETDs. An online survey was developed asking about the most important competencies and weaknesses for ETDs when working rurally. The clinical manager and any ETDs currently working in each hospital were invited to complete the survey. Results: Surveys were completed by 19 ETDs and five clinical managers. The top clinical competencies in relation to 10 specific domains were identified. The results also indicate broader competencies required, specific skills gaps, the strengths that ETDs bring to South Africa and how ETDs prepare themselves for working in this context. Conclusion: This study identifies the important competency gaps among ETDs and provides useful direction for the diploma and other future training initiatives. The diploma faculty must reflect on these findings and ensure the curriculum is aligned with these gaps.
    Keywords medical education ; rural medicine ; foreign-qualified doctors ; clinical skills ; competencies ; european-trained doctors ; Medicine ; R ; Public aspects of medicine ; RA1-1270
    Subject code 027 ; 910
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher AOSIS
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: The first three reported cases of

    Barnacle, James R / Chow, Yimmy J / Borman, Andrew M / Wyllie, Steven / Dominguez, Valentin / Russell, Katherine / Roberts, Helen / Armstrong-James, Darius / Whittington, Ashley M

    Medical mycology case reports

    2022  Volume 39, Page(s) 14–17

    Abstract: An epidemic of cat-transmitted sporotrichosis caused ... ...

    Abstract An epidemic of cat-transmitted sporotrichosis caused by
    Language English
    Publishing date 2022-12-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2670415-8
    ISSN 2211-7539
    ISSN 2211-7539
    DOI 10.1016/j.mmcr.2022.12.004
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  6. Article ; Online: Changes in the hospital admission profile of COVID-19 positive patients at a central London trust.

    Barnacle, James R / Cairney, Gary / Rainsley, James / Mercuri, Luca / Gibani, Malick M / Cooke, Graham S / Brett, Stephen J

    The Journal of infection

    2020  Volume 82, Issue 1, Page(s) 159–198

    MeSH term(s) COVID-19 ; Hospitalization ; Hospitals ; Humans ; London/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.07.022
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1501: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article: Cytomegalovirus Retinitis Screening and Treatment in Human Immunodeficiency Virus Patients in Malawi: A Feasibility Study.

    Ocieczek, Paulina / Barnacle, James R / Gumulira, Joe / Phiri, Sam / Heller, Tom / Grabska-Liberek, Iwona

    Open forum infectious diseases

    2019  Volume 6, Issue 11, Page(s) ofz439

    Abstract: Background: Cytomegalovirus retinitis is a treatable cause of blindness in people with human immunodeficiency virus (HIV) typically with CD4 counts <50 cells/mm: Methods: Patients with CD4 counts <200 cells/mm: Results: Five of the 102 people with ...

    Abstract Background: Cytomegalovirus retinitis is a treatable cause of blindness in people with human immunodeficiency virus (HIV) typically with CD4 counts <50 cells/mm
    Methods: Patients with CD4 counts <200 cells/mm
    Results: Five of the 102 people with HIV screened had cytomegalovirus retinitis (4.9%). All affected patients had CD4 counts <50 cells/mm
    Conclusions: Cytomegalovirus retinitis screening based on CD4 count is essential to early recognition because visual acuity and symptoms are unreliable. Cytomegalovirus retinitis is a significant yet neglected public health issue in Malawi. Oral valganciclovir is essential to reduce blindness and mortality in those diagnosed but is not yet available. Further screening and advocacy are needed.
    Language English
    Publishing date 2019-11-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofz439
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  8. Article: Changes in the hospital admission profile of COVID-19 positive patients at a central London trust

    Barnacle, James R / Cairney, Gary / Rainsley, James / Mercuri, Luca / Gibani, Malick M / Cooke, Graham S / Brett, Stephen J

    J. infect

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #662832
    Database COVID19

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  9. Article ; Online: Changes in the hospital admission profile of COVID-19 positive patients at a central London trust

    Barnacle, James R / Cairney, Gary / Rainsley, James / Mercuri, Luca / Gibani, Malick M / Cooke, Graham S / Brett, Stephen J

    Journal of Infection ; ISSN 0163-4453

    2020  

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.jinf.2020.07.022
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The clinical presentation of monkeypox: a retrospective case-control study of patients with possible or probable monkeypox in a West London cohort.

    Rimmer, Stephanie / Barnacle, James / Gibani, Malick M / Wu, Meng-San / Dissanayake, Oshani / Mehta, Ravi / Herdman, Trent / Gilchrist, Mark / Muir, David / Ebrahimsa, Umar / Mora-Peris, Borja / Dosekun, Olamide / Garvey, Lucy / Peters, Joanna / Davies, Frances / Cooke, Graham / Abbara, Aula

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2022  Volume 126, Page(s) 48–53

    Abstract: Objectives: Since May 2022, cases of human monkeypox virus (hMPXV) with human-to-human cross-transmission have significantly increased in nonendemic countries. Our aim was to characterize diagnostic features of patients with confirmed and possible ... ...

    Abstract Objectives: Since May 2022, cases of human monkeypox virus (hMPXV) with human-to-human cross-transmission have significantly increased in nonendemic countries. Our aim was to characterize diagnostic features of patients with confirmed and possible monkeypox to guide future risk stratification and to describe a virtual care model.
    Methods: We performed a retrospective case-control study of 140 patients assessed and screened for suspected monkeypox; on hMPXV polymerase chain reaction testing, 70 were confirmed positive, and 70 were negative. Data were compared to generate odds ratios of demographic and clinical features.
    Results: Patients who tested positive were predominantly cis-male (99%) and self-identified as gay, bisexual, and other men who have sex with men (94%). Lymphadenopathy at presentation was associated with a higher likelihood of a positive result (odds ratio [OR] 7.69 [95% confidence interval (CI) 3.58, 16.51]). Patients who tested positive were more likely to have a rash affecting the genital (OR 5.38 [95% CI 2.57, 11.23]) or buttocks/perianal region (OR 3.79 [1.70, 8.45]) than negative controls. A total of 79% of patients were engaged with a virtual ward follow-up.
    Conclusion: These data can inform a risk-based approach to the management of suspected monkeypox in gay, bisexual, and other men who have sex with men populations. Lymphadenopathy at presentation and the location of the rash were more associated with a positive hMPXV result. Health authorities can consider a virtual ward approach in the hMPHXV outbreak.
    MeSH term(s) Humans ; Male ; Case-Control Studies ; Retrospective Studies ; Mpox (monkeypox)/diagnosis ; Mpox (monkeypox)/epidemiology ; Homosexuality, Male ; London ; Sexual and Gender Minorities ; Exanthema ; Lymphadenopathy
    Language English
    Publishing date 2022-11-19
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2022.11.020
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    Zs.A 4516: Show issues Location:
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