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Article: PAI-1 as a critical factor in the resolution of sepsis and acute kidney injury in old age.

Bruno, Maria E C / Mukherjee, Sujata / Sturgill, Jamie L / Cornea, Virgilius / Yeh, Peng / Hawk, Gregory S / Saito, Hiroshi / Starr, Marlene E

Frontiers in cell and developmental biology

2024 Volume 11, Page(s) 1330433

Abstract: Elevated plasma levels of plasminogen activator inhibitor type 1 (PAI-1) are documented in patients ... that PAI-1 in plasma is positively associated with acute kidney injury (AKI) in septic patients and mice ... The objective of this study was to determine if PAI-1 is causally related to AKI and worse sepsis outcomes using ...

Abstract	Elevated plasma levels of plasminogen activator inhibitor type 1 (PAI-1) are documented in patients with sepsis and levels positively correlate with disease severity and mortality. Our prior work demonstrated that PAI-1 in plasma is positively associated with acute kidney injury (AKI) in septic patients and mice. The objective of this study was to determine if PAI-1 is causally related to AKI and worse sepsis outcomes using a clinically-relevant and age-appropriate murine model of sepsis. Sepsis was induced by cecal slurry (CS)-injection to wild-type (WT, C57BL/6) and PAI-1 knockout (KO) mice at young (5-9 months) and old (18-22 months) age. Survival was monitored for at least 10 days or mice were euthanized for tissue collection at 24 or 48 h post-insult. Contrary to our expectation, PAI-1 KO mice at old age were significantly more sensitive to CS-induced sepsis compared to WT mice (24% vs. 65% survival,
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1330433
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Article ; Online: PAI-1 as a critical factor in the resolution of sepsis and acute kidney injury in old age

Maria E. C. Bruno / Sujata Mukherjee / Jamie L. Sturgill / Virgilius Cornea / Peng Yeh / Gregory S. Hawk / Hiroshi Saito / Marlene E. Starr

Frontiers in Cell and Developmental Biology, Vol

2024 Volume 11

Abstract	Elevated plasma levels of plasminogen activator inhibitor type 1 (PAI-1) are documented in patients with sepsis and levels positively correlate with disease severity and mortality. Our prior work demonstrated that PAI-1 in plasma is positively associated with acute kidney injury (AKI) in septic patients and mice. The objective of this study was to determine if PAI-1 is causally related to AKI and worse sepsis outcomes using a clinically-relevant and age-appropriate murine model of sepsis. Sepsis was induced by cecal slurry (CS)-injection to wild-type (WT, C57BL/6) and PAI-1 knockout (KO) mice at young (5–9 months) and old (18–22 months) age. Survival was monitored for at least 10 days or mice were euthanized for tissue collection at 24 or 48 h post-insult. Contrary to our expectation, PAI-1 KO mice at old age were significantly more sensitive to CS-induced sepsis compared to WT mice (24% vs. 65% survival, p = 0.0037). In comparison, loss of PAI-1 at young age had negligible effects on sepsis survival (86% vs. 88% survival, p = 0.8106) highlighting the importance of age as a biological variable. Injury to the kidney was the most apparent pathological consequence and occurred earlier in aged PAI-1 KO mice. Coagulation markers were unaffected by loss of PAI-1, suggesting thrombosis-independent mechanisms for PAI-1-mediated protection. In summary, although high PAI-1 levels are clinically associated with worse sepsis outcomes, loss of PAI-1 rendered mice more susceptible to kidney injury and death in a CS-induced model of sepsis using aged mice. These results implicate PAI-1 as a critical factor in the resolution of sepsis in old age.
Keywords	aging ; biological variables ; cecal slurry ; kidney injury ; PAI-1 ; sepsis ; Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Coculture of cancer cells with platelets increases their survival and metastasis by activating the TGFβ/Smad/PAI-1 and PI3K/AKT pathways.

Tong, Haibo / Li, Koukou / Zhou, Muya / Wu, Renfei / Yang, Hongmei / Peng, Zheng / Zhao, Qi / Luo, Kathy Qian

International journal of biological sciences

2023 Volume 19, Issue 13, Page(s) 4259–4277

Abstract: When cancer cells enter the bloodstream, they can interact with platelets to acquire stronger survival and metastatic abilities. To elucidate the underlying mechanisms, we cocultured metastatic melanoma and triple-negative breast cancer cells with ... ...

Abstract	When cancer cells enter the bloodstream, they can interact with platelets to acquire stronger survival and metastatic abilities. To elucidate the underlying mechanisms, we cocultured metastatic melanoma and triple-negative breast cancer cells with species-homologous platelets. We found that cocultured cancer cells displayed higher viabilities in circulation, stronger capacities for cell migration, invasion, and colony formation
MeSH term(s)	Animals ; Mice ; Humans ; Blood Platelets ; Plasminogen Activator Inhibitor 1/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Proto-Oncogene Proteins c-akt ; Coculture Techniques ; Triple Negative Breast Neoplasms/genetics ; Melanoma
Chemical Substances	Plasminogen Activator Inhibitor 1 ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2023-08-15
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.85986
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Article ; Online: PAI-1 Polymorphisms Have Significant Associations With Cancer Risk, Especially Feminine Cancer.

Wang, Jiaxi / Peng, Yuanyuan / Guo, Hejia / Li, Cuiping

Technology in cancer research & treatment

2021 Volume 20, Page(s) 15330338211037813

Abstract: Background: The plasminogen activator inhibitor-1 (PAI-1) was found in many types of tumor cells ... which involved in tumorigenesis. Some studies investigated the associations between PAI-1 polymorphisms and ... the strength of relationship between PAI-1 and cancer.: Methods: Articles that meet the requirements were ...

Abstract	Background: The plasminogen activator inhibitor-1 (PAI-1) was found in many types of tumor cells, which involved in tumorigenesis. Some studies investigated the associations between PAI-1 polymorphisms and various cancers, but the results were inconsistent. So this study did a meta-analysis to assess the strength of relationship between PAI-1 and cancer. Methods: Articles that meet the requirements were searched from PubMed, EMBASE, MEDLINE, Scopus, CNKI, Wanfang and SinoMed electronic databases before June 17th 2021. Stata version 11.2 was performed to merge the odds ratios (ORs) values and calculate 95% confidence intervals (CIs). Stratified analyses were assessed on the basis of types of cancer, ethnicity and source of the control group. Heterogeneity and sensitivity analysis were tested, and publication bias was also estimated. A meta-regression analysis was applied to explore sources of heterogeneity. The false-positive report probabilities (FPRP) and the Bayesian False Discovery Probability (BFDP) test were used to assess the credibility of statistically significant associations. Results: Ultimately, in this study, 33 eligible reports were included with 9550 cases and 10431 controls for the rs1799889 polymorphism, 5 reports with 2705 cases and 3168 controls for the rs2227631 polymorphism, and 4 reports with 2799 cases and 4011 controls for the rs2227667 polymorphism. The ORs and 95% CIs showed a statistically significant relationship between rs1799889 4G>5G polymorphism and cancer risk, especially in feminine cancer. The term refers to cancers that occur in the female reproductive system, such as ovarian, breast, endometrial and cervical cancer. Moreover, there was no association observed for the PAI-1 promoter A>G polymorphism (rs2227631 and rs2227667). In further subgroup analyses of 4G>5G polymorphism (rs1799889), an increased susceptibility to cancer was observed in Caucasians group and some types of cancer groups. Conclusions: This article comes to a conclusion that the rs1799889 polymorphism might help to increase the risk of cancer; moreover, the susceptibility to feminine cancer is more evident.
MeSH term(s)	Alleles ; Bayes Theorem ; Biomarkers, Tumor ; Female ; Genetic Association Studies ; Genetic Heterogeneity ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Neoplasms/diagnosis ; Neoplasms/etiology ; Odds Ratio ; Plasminogen Activator Inhibitor 1/genetics ; Polymorphism, Single Nucleotide ; Risk Assessment ; Risk Factors ; Sex Factors
Chemical Substances	Biomarkers, Tumor ; Plasminogen Activator Inhibitor 1 ; SERPINE1 protein, human
Language	English
Publishing date	2021-09-14
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	2146365-7
ISSN	1533-0338 ; 1533-0346
ISSN (online)	1533-0338
ISSN	1533-0346
DOI	10.1177/15330338211037813
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Zs.A 5871: Show issues

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Article ; Online: Use of Diterpene Ginkgolides Meglumine Injection to Regulate Plasma Levels of PAI-1 and t-PA in Patients With Acute Atherosclerotic Cerebral Infarction.

Chen, Rui / Yan, Luxia / Xie, Peng / Tian, Jisha / Zhao, Ying / Liu, Yue / Xu, Jie / Wang, Yuqian / Zhao, Liandong

The neurologist

2022 Volume 27, Issue 6, Page(s) 299–303

Abstract: ... of plasma plasminogen activator inhibitor (PAI)-1 and tissue plasminogen activator (t-PA).: Methods ... thromboelastography undertaken, and plasma levels of PAI-1 and t-PA measured.: Results: The National Institutes ... Compared with the control group, the plasma PAI-1 level of patients in the DGMI group was lower ...

Abstract	Background: To: (i) explore the effect of diterpene ginkgolides meglumine injection (DGMI) on neurological deficit symptoms in acute atherosclerotic cerebral infarction (AACI) patients; (ii) measure the level of plasma plasminogen activator inhibitor (PAI)-1 and tissue plasminogen activator (t-PA). Methods: Eighty AACI patients were divided equally and randomly into the DGMI group and control group. In addition to basic treatment, the DGMI group was treated with DGMI (25 mg/d) for 14 days. The control group had basic treatment without DGMI. Before and after treatment, the degree of neurological deficit was assessed, thromboelastography undertaken, and plasma levels of PAI-1 and t-PA measured. Results: The National Institutes of Health Stroke Scale score of patients in the DGMI group after treatment was lower than that in the control group, and the Barthel Index was higher than that in the control group ( P <0.05). Thromboelastography revealed that, in the DGMI group, the R value and K value after treatment were higher than before treatment, the angle and maximum amplitude value were lower than before treatment, and both were significant ( P <0.05). Compared with the control group, the plasma PAI-1 level of patients in the DGMI group was lower than that in the control group, and the t-PA level was higher than that in the control group ( P <0.05) after 14 days of treatment. Conclusions: DGMI may affect the activity of the blood coagulation and fibrinolysis system by regulating the plasma level of PAI-1 and t-PA, and improving neurological deficit symptoms. DGMI is important for improving the prognosis of patients with AACI.
MeSH term(s)	Humans ; Tissue Plasminogen Activator/therapeutic use ; Tissue Plasminogen Activator/pharmacology ; Plasminogen Activator Inhibitor 1/pharmacology ; Ginkgolides/pharmacology ; Ginkgolides/therapeutic use ; Fibrinolysis ; Meglumine/pharmacology ; Stroke ; Brain Ischemia ; Acute Disease ; Cerebral Infarction/drug therapy
Chemical Substances	Tissue Plasminogen Activator (EC 3.4.21.68) ; Plasminogen Activator Inhibitor 1 ; Ginkgolides ; Meglumine (6HG8UB2MUY)
Language	English
Publishing date	2022-11-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1361380-7
ISSN	2331-2637 ; 1074-7931
ISSN (online)	2331-2637
ISSN	1074-7931
DOI	10.1097/NRL.0000000000000399
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Zs.A 4641: Show issues

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Article ; Online: Plasminogen activator inhibitor-1 (PAI-1) expression in endometriosis.

Alotaibi, Fahad T / Peng, Bo / Klausen, Christian / Lee, Anna F / Abdelkareem, Amr O / Orr, Natasha L / Noga, Heather / Bedaiwy, Mohamed A / Yong, Paul J

PloS one

2019 Volume 14, Issue 7, Page(s) e0219064

Abstract: ... Our objective is to investigate whether plasminogen activator inhibitor-1 expression (PAI-1) in endometriotic ... and Histoscore were used to examine the expression of PAI-1 in glandular epithelium (GECs) and stroma ... dyspareunia score.: Results: PAI-1 expression in GECs and SCs of the DIE group was significantly higher ...

Abstract	Purpose: Deep infiltrating endometriosis (DIE) is defined as an endometriotic lesion penetrating to a depth of >5 mm and is associated with pelvic pain, but the underlying mechanisms are unclear. Our objective is to investigate whether plasminogen activator inhibitor-1 expression (PAI-1) in endometriotic tissues is increased in women with DIE. Methods: In this blinded in vitro study, immunohistochemistry and Histoscore were used to examine the expression of PAI-1 in glandular epithelium (GECs) and stroma (SCs) in a total of 62 women: deep infiltrating uterosacral/rectovaginal endometriosis (DIE; n = 13), ovarian endometrioma (OMA; n = 14), superficial peritoneal uterosacral/cul-de-sac endometriosis (SUP; n = 23), uterine (eutopic) endometrium from women with endometriosis (UE; n = 6), and non-endometriosis eutopic endometrium (UC; n = 6). The following patient characteristics were also collected: age, American Fertility Society stage, hormonal suppression, phase of menstrual cycle, dysmenorrhea score and deep dyspareunia score. Results: PAI-1 expression in GECs and SCs of the DIE group was significantly higher than that of SUP group (p = 0.01, p = 0.01, respectively) and UE group (p = 0.03, p = 0.04, respectively). Interestingly, increased PAI-1 expression in GECs and SCs was also significantly correlated with increased dysmenorrhea (r = 0.38, p = 0.01; r = 0.34, p = 0.02, respectively). Conclusions: We found higher expression of PAI-1 in DIE, and an association between PAI-1 and worse dysmenorrhea.
MeSH term(s)	Adult ; Dysmenorrhea/metabolism ; Dysmenorrhea/pathology ; Endometriosis/metabolism ; Endometriosis/pathology ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Female ; Humans ; Immunohistochemistry ; Middle Aged ; Peritoneal Diseases/metabolism ; Peritoneal Diseases/pathology ; Plasminogen Activator Inhibitor 1/metabolism ; Rectal Diseases/metabolism ; Rectal Diseases/pathology ; Stromal Cells/metabolism ; Stromal Cells/pathology ; Uterine Diseases/metabolism ; Uterine Diseases/pathology ; Vaginal Diseases/metabolism ; Vaginal Diseases/pathology ; Young Adult
Chemical Substances	Plasminogen Activator Inhibitor 1 ; SERPINE1 protein, human
Language	English
Publishing date	2019-07-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0219064
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Article ; Online: Cytokine Storm in Acute Viral Respiratory Injury: Role of Qing-Fei-Pai-Du Decoction in Inhibiting the Infiltration of Neutrophils and Macrophages through TAK1/IKK/NF-[Formula: see text]B Pathway.

The American journal of Chinese medicine

2023 Volume 51, Issue 5, Page(s) 1153–1188

Abstract: ... Fei-Pai-Du decoction (QFPDD), a Chinese herbal formula, is widely used in China to treat COVID-19 ...

Abstract	COVID-19 has posed unprecedented challenges to global public health since its outbreak. The Qing-Fei-Pai-Du decoction (QFPDD), a Chinese herbal formula, is widely used in China to treat COVID-19. It exerts an impressive therapeutic effect by inhibiting the progression from mild to critical disease in the clinic. However, the underlying mechanisms remain obscure. Both SARS-CoV-2 and influenza viruses elicit similar pathological processes. Their severe manifestations, such as acute respiratory distress syndrome (ARDS), multiple organ failure (MOF), and viral sepsis, are correlated with the cytokine storm. During flu infection, QFPDD reduced the lung indexes and downregulated the expressions of MCP-1, TNF-[Formula: see text], IL-6, and IL-1[Formula: see text] in broncho-alveolar lavage fluid (BALF), lungs, or serum samples. The infiltration of neutrophils and inflammatory monocytes in lungs was decreased dramatically, and lung injury was ameliorated in QFPDD-treated flu mice. In addition, QFPDD also inhibited the polarization of M1 macrophages and downregulated the expressions of IL-6, TNF-[Formula: see text], MIP-2, MCP-1, and IP-10, while also upregulating the IL-10 expression. The phosphorylated TAK1, IKK[Formula: see text]/[Formula: see text], and I[Formula: see text]B[Formula: see text] and the subsequent translocation of phosphorylated p65 into the nuclei were decreased by QFPDD. These findings indicated that QFPDD reduces the intensity of the cytokine storm by inhibiting the NF-[Formula: see text]B signaling pathway during severe viral infections, thereby providing theoretical and experimental support for its clinical application in respiratory viral infections.
MeSH term(s)	Animals ; Mice ; Interleukin-6/metabolism ; COVID-19/metabolism ; SARS-CoV-2 ; Neutrophils/metabolism ; Cytokine Release Syndrome ; Macrophages/metabolism ; NF-kappa B/metabolism
Chemical Substances	Interleukin-6 ; NF-kappa B
Language	English
Publishing date	2023-07-05
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X23500532
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Zs.A 1110: Show issues

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Article ; Online: ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk promoting pancreatic cancer progression.

Rossi Sebastiano, Matteo / Pozzato, Chiara / Saliakoura, Maria / Yang, Zhang / Peng, Ren-Wang / Galiè, Mirco / Oberson, Kevin / Simon, Hans-Uwe / Karamitopoulou, Evanthia / Konstantinidou, Georgia

Science advances

2020 Volume 6, Issue 44

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked fibrosis and low immunogenicity, features that are linked to treatment resistance and poor clinical outcomes. Therefore, understanding how PDAC regulates the desmoplastic and immune ... ...

Abstract	Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked fibrosis and low immunogenicity, features that are linked to treatment resistance and poor clinical outcomes. Therefore, understanding how PDAC regulates the desmoplastic and immune stromal components is of great clinical importance. We found that acyl-CoA synthetase long-chain 3 (ACSL3) is up-regulated in PDAC and correlates with increased fibrosis. Our in vivo results show that
MeSH term(s)	Animals ; Carcinoma, Pancreatic Ductal/metabolism ; Cell Line, Tumor ; Coenzyme A Ligases/genetics ; Fibrosis ; Mice ; Pancreatic Neoplasms/pathology ; Plasminogen Activator Inhibitor 1/genetics ; Serpin E2
Chemical Substances	Plasminogen Activator Inhibitor 1 ; Serpin E2 ; Serpine2 protein, mouse ; Acsl3 protein, mouse (EC 6.1.2.3) ; Coenzyme A Ligases (EC 6.2.1.-)
Language	English
Publishing date	2020-10-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abb9200
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Article ; Online: A long-acting PAI-1 inhibitor reduces thrombus formation.

Peng, Shuangzhou / Xue, Guangpu / Gong, Lihu / Fang, Chao / Chen, Jingfei / Yuan, Cai / Chen, Zhuo / Yao, Lishan / Furie, Bruce / Huang, Mingdong

Thrombosis and haemostasis

2017 Volume 117, Issue 7, Page(s) 1338–1347

Abstract: Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type and ... urokinase-type plasminogen activators (t/uPA) and plays an important role in fibrinolysis. Inhibition of PAI-1 activity prevents ... thrombosis and accelerates fibrinolysis, indicating that PAI-1 inhibitors may be used as effective ...

Abstract	Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type and urokinase-type plasminogen activators (t/uPA) and plays an important role in fibrinolysis. Inhibition of PAI-1 activity prevents thrombosis and accelerates fibrinolysis, indicating that PAI-1 inhibitors may be used as effective antithrombotic agents. We previously designed a PAI-1 inhibitor (PAItrap) which is a variant of inactivated urokinase protease domain. In the present study, we fused PAItrap with human serum albumin (HSA) to develop a long-acting PAI-1 inhibitor. Unfortunately, the fusion protein PAItrap-HSA lost some potency compared to PAItrap (33 nM vs 10 nM). Guided by computational method, we carried out further optimisation to enhance inhibitory potency for PAI-1. The new PAItrap, denominated PAItrap(H37R)-HSA, which was the H37R variant of PAItrap fused to HSA, gave a six-fold improvement of IC
MeSH term(s)	Animals ; Bleeding Time ; Disease Models, Animal ; Drug Design ; Fibrinolysis/drug effects ; Fibrinolytic Agents/blood ; Fibrinolytic Agents/chemistry ; Fibrinolytic Agents/pharmacology ; Half-Life ; Humans ; In Vitro Techniques ; Mice ; Mice, Inbred C57BL ; Models, Molecular ; Mutagenesis, Site-Directed ; Peptide Fragments/pharmacology ; Plasminogen Activator Inhibitor 1/blood ; Plasminogen Activator Inhibitor 1/chemistry ; Plasminogen Activator Inhibitor 1/pharmacology ; Protein Engineering ; Recombinant Fusion Proteins/blood ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/pharmacology ; Serine Proteinase Inhibitors/blood ; Serine Proteinase Inhibitors/chemistry ; Serine Proteinase Inhibitors/pharmacology ; Serpin E2/antagonists & inhibitors ; Thrombosis/prevention & control ; Urokinase-Type Plasminogen Activator/pharmacology
Chemical Substances	Fibrinolytic Agents ; PAItrap peptide ; Peptide Fragments ; Plasminogen Activator Inhibitor 1 ; Recombinant Fusion Proteins ; SERPINE1 protein, human ; Serine Proteinase Inhibitors ; Serpin E2 ; Serpine2 protein, mouse ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73)
Language	English
Publishing date	2017--28
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	518294-3
ISSN	2567-689X ; 0340-6245
ISSN (online)	2567-689X
ISSN	0340-6245
DOI	10.1160/TH16-11-0891
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Article: Plasminogen activator inhibitor-1 (PAI-1) 4G/5G promoter polymorphisms and risk of venous thromboembolism - a meta-analysis and systematic review.

Zhang, Qiang / Jin, YunRui / Li, XueMei / Peng, XingQiao / Peng, Na / Song, JiFang / Xu, Mingfang

VASA. Zeitschrift fur Gefasskrankheiten

2020 Volume 49, Issue 2, Page(s) 141–146

MeSH term(s)	Genetic Predisposition to Disease ; Humans ; Plasminogen ; Plasminogen Activator Inhibitor 1/genetics ; Polymorphism, Genetic ; Promoter Regions, Genetic ; Venous Thromboembolism/genetics
Chemical Substances	Plasminogen Activator Inhibitor 1 ; SERPINE1 protein, human ; Plasminogen (9001-91-6)
Language	English
Publishing date	2020-01-10
Publishing country	Switzerland
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	120977-2
ISSN	1664-2872 ; 0301-1526
ISSN (online)	1664-2872
ISSN	0301-1526
DOI	10.1024/0301-1526/a000839
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