LIVIVO - Search results -

Search results

Result 1 - 10 of total 17368

Search options

Article ; Online: Mechanisms of pancreatic tumor suppression mediated by Xiang-lian pill: An integrated in silico exploration and experimental validation.

Jiao, Juying / Cheng, Chien-Shan / Xu, Panling / Yang, Peiwen / Zhang, Ke / Jing, Yanhua / Chen, Zhen

2022 Volume 298, Page(s) 115586

Abstract: Ethnopharmacological relevance: Xiang-lian pill, consisting of Coptis chinensis Franch ... coprocessed with Tetradium ruticarpum (A.Juss.) T.G.Hartley (Yu-huang-lian) and Aucklandia lappa DC. (Mu-xiang ... in Xiang-lian pill has been indicated to have anticancer effects on a variety of cancers, but its effects ...

Abstract	Ethnopharmacological relevance: Xiang-lian pill, consisting of Coptis chinensis Franch. coprocessed with Tetradium ruticarpum (A.Juss.) T.G.Hartley (Yu-huang-lian) and Aucklandia lappa DC. (Mu-xiang), is traditionally used to relieve fever, abdominal pain, and gastrointestinal inflammatory symptoms observed in patients with malignancies of the gastrointestinal tract. Each of the three herbs contained in Xiang-lian pill has been indicated to have anticancer effects on a variety of cancers, but its effects on pancreatic cancer remain unexplored. The main extracts of these herbs have anti-pancreatic cancer effects, but the comprehensive mechanism of this compound prescription of Xiang-lian pill in pancreatic cancer remains to be revealed. Aim of the study: To explore the main active ingredients, potential anti-pancreatic cancer targets, and related mechanisms of the Xiang-lian pill and to determine its therapeutic value in vivo. Materials and methods: Network pharmacology and bioinformatics analysis were applied to screen the potential effective ingredients and key targets. Liquid/gas-mass spectrometry was performed for ingredients validation. Molecular docking and the cellular thermal shift assay were performed to test the binding efficiency between ingredients and targets. A murine pancreatic cancer model was established and administered different doses of the Xiang-lian pill. Hematoxylin-eosin staining was used for histopathological observation. Immunohistochemistry and immunoblotting were conducted for target validation. In vitro studies (cell viability and clonogenicity assays) were conducted to investigate the impact of three main ingredients in Xiang-lian pill on pancreatic cancer cells. PTGS2 overexpression was performed to reversely confirm the antitumor mechanisms of rutaecarpine as a specific PTGS2 inhibitor. Results: Xiang-lian pill suppressed pancreatic cancer growth in the dose range of 0.78-2.34g/kg with no significant toxicity. Sixteen potentially active ingredients and 26 corresponding therapeutic targets for pancreatic cancer were identified. PTGS2, PTGS1, KCNH2, PRSS1, and HSP90AA1 were the top 5 significant genes targeted by the Xiang-lian pill. Evodiamine, rutaecarpine and stigmasterol bound to PTGS2 and PTGS1 with different affinities and inhibited pancreatic cancer cell proliferation. The PTGS2-associated metabolic pathway MEK/ERK was downregulated by rutaecarpine in vitro and the Xiang-lian pill in vivo. Conclusions: Xiang-lian pill mainly regulates inflammation, apoptosis, metastasis, and metabolism to exert an antitumor effect. The main active ingredients in Xiang-lian pill exhibit antitumor roles through directly binding to key targets in pancreatic cancer. PTGS2 mediated MEK/ERK inhibition by rutaecarpine represents a key therapeutic mechanism of Xiang-lian pill.
MeSH term(s)	Animals ; Cyclooxygenase 2 ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Mice ; Mitogen-Activated Protein Kinase Kinases ; Molecular Docking Simulation ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms
Chemical Substances	Drugs, Chinese Herbal ; Cyclooxygenase 2 (EC 1.14.99.1) ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2)
Language	English
Publishing date	2022-08-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115586
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1494: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Carya luana C.‐Y. Deng et X.‐G. Xiang, sp. nov. (Juglandaceae), a new species from Guizhou, China, identified based on whole plastome phylogeny and morphometrics

Xiang, Xiao‐Guo / Deng, Chao‐Yi / Yan, Hua / Liu, Yu‐Juan / Liu, Zeng‐Cai / Cheng, Kun / Ban, Qi‐Ming / Lang, Yuan‐Xing

Nordic Journal of Botany. 2023 May, v. 2023, no. 5 p.e03867-

2023

Abstract: Carya luana sp. nov., a new species of Juglandaceae from Guizhou, China, is described and illustrated. The new species is easily distinguished from other Carya species by having lanceolate leaflets and obovate fruits with a 4–6 mm thick husk, but is ... ...

Abstract	Carya luana sp. nov., a new species of Juglandaceae from Guizhou, China, is described and illustrated. The new species is easily distinguished from other Carya species by having lanceolate leaflets and obovate fruits with a 4–6 mm thick husk, but is otherwise morphologically close to C. tonkinensis and C. kweichowensis. Based on phylogenetic reconstruction of whole plastomes, C. luana is the sister of C. tonkinensis, while formed a clade with C. tonkinensis and C. hunanensis on ITS. A morphometric analysis demonstrate that C. luana, C. tonkinensis and C. kweichowensis are morphologically distinct. The conservation status of C. luana is assessed as Endangered (EN) according to the IUCN Red List Categories and Criteria. A new identification key to all Asian Carya species is provided.
Keywords	Carya ; botany ; conservation status ; hulls ; morphometry ; new species ; phylogeny ; taxonomic keys ; China
Language	English
Dates of publication	2023-05
Publishing place	Blackwell Publishing Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2406507-9
ISSN	1756-1051 ; 0107-055X
ISSN (online)	1756-1051
ISSN	0107-055X
DOI	10.1111/njb.03867
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: A Comprehensive Analysis of the Myocardial Transcriptome in ZBED6-Knockout Bama Xiang Pigs

Wang, Shengnan / Tian, Wenjie / Pan, Dengke / Liu, Ling / Xu, Cheng / Ma, Yuehui / Wang, Dandan / Jiang, Lin

Genes. 2022 Aug. 01, v. 13, no. 8

2022

Abstract: ... of mRNAs and lncRNAs in myocardial tissue obtained from Bama Xiang pigs in the ZBED6 knockout group (ZBED6 ...

Abstract	The ZBED6 gene is a transcription factor that regulates the expression of IGF2 and affects muscle growth and development. However, its effect on the growth and development of the heart is still unknown. Emerging evidence suggests that long noncoding RNAs (lncRNAs) can regulate genes at the epigenetic, transcriptional, and posttranscriptional levels and play an important role in the development of eukaryotes. To investigate the function of ZBED6 in the cardiac development of pigs, we constructed the expression profiles of mRNAs and lncRNAs in myocardial tissue obtained from Bama Xiang pigs in the ZBED6 knockout group (ZBED6-KO) and the wild-type group (ZBED6-WT). A total of 248 differentially expressed genes (DEGs) and 209 differentially expressed lncRNAs (DELs) were detected, and 105 potential cis target genes of DELs were identified. The functional annotation analysis based on the Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) databases revealed two GO items related to muscle development by the cis target genes of DELs. Moreover, IGF2 was the direct target gene of ZBED6 by ChIP-PCR experiment. Our results explored the mechanism and expression profile of mRNAs and lncRNAs of ZBED6 gene knockout on myocardium tissue development, mining the key candidate genes in that process like IGF2.
Keywords	epigenetics ; eukaryotic cells ; gene expression regulation ; gene ontology ; gene targeting ; genes ; growth and development ; muscle development ; muscles ; myocardium ; transcription (genetics) ; transcription factors ; transcriptome
Language	English
Dates of publication	2022-0801
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13081382
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: Mechanisms of pancreatic tumor suppression mediated by Xiang-lian pill: An integrated in silico exploration and experimental validation

Jiao, Juying / Cheng, Chien-shan / Xu, Panling / Yang, Peiwen / Zhang, Ke / Jing, Yanhua / Chen, Zhen

Journal of ethnopharmacology. 2022 Nov. 15, v. 298

2022

Abstract: Xiang-lian pill, consisting of Coptis chinensis Franch. coprocessed with Tetradium ruticarpum ... A.Juss.) T.G.Hartley (Yu-huang-lian) and Aucklandia lappa DC. (Mu-xiang), is traditionally used ... with malignancies of the gastrointestinal tract. Each of the three herbs contained in Xiang-lian pill has been ...

Abstract	Xiang-lian pill, consisting of Coptis chinensis Franch. coprocessed with Tetradium ruticarpum (A.Juss.) T.G.Hartley (Yu-huang-lian) and Aucklandia lappa DC. (Mu-xiang), is traditionally used to relieve fever, abdominal pain, and gastrointestinal inflammatory symptoms observed in patients with malignancies of the gastrointestinal tract. Each of the three herbs contained in Xiang-lian pill has been indicated to have anticancer effects on a variety of cancers, but its effects on pancreatic cancer remain unexplored. The main extracts of these herbs have anti-pancreatic cancer effects, but the comprehensive mechanism of this compound prescription of Xiang-lian pill in pancreatic cancer remains to be revealed. To explore the main active ingredients, potential anti-pancreatic cancer targets, and related mechanisms of the Xiang-lian pill and to determine its therapeutic value in vivo. Network pharmacology and bioinformatics analysis were applied to screen the potential effective ingredients and key targets. Liquid/gas-mass spectrometry was performed for ingredients validation. Molecular docking and the cellular thermal shift assay were performed to test the binding efficiency between ingredients and targets. A murine pancreatic cancer model was established and administered different doses of the Xiang-lian pill. Hematoxylin-eosin staining was used for histopathological observation. Immunohistochemistry and immunoblotting were conducted for target validation. In vitro studies (cell viability and clonogenicity assays) were conducted to investigate the impact of three main ingredients in Xiang-lian pill on pancreatic cancer cells. PTGS2 overexpression was performed to reversely confirm the antitumor mechanisms of rutaecarpine as a specific PTGS2 inhibitor. Xiang-lian pill suppressed pancreatic cancer growth in the dose range of 0.78-2.34g/kg with no significant toxicity. Sixteen potentially active ingredients and 26 corresponding therapeutic targets for pancreatic cancer were identified. PTGS2, PTGS1, KCNH2, PRSS1, and HSP90AA1 were the top 5 significant genes targeted by the Xiang-lian pill. Evodiamine, rutaecarpine and stigmasterol bound to PTGS2 and PTGS1 with different affinities and inhibited pancreatic cancer cell proliferation. The PTGS2-associated metabolic pathway MEK/ERK was downregulated by rutaecarpine in vitro and the Xiang-lian pill in vivo. Xiang-lian pill mainly regulates inflammation, apoptosis, metastasis, and metabolism to exert an antitumor effect. The main active ingredients in Xiang-lian pill exhibit antitumor roles through directly binding to key targets in pancreatic cancer. PTGS2 mediated MEK/ERK inhibition by rutaecarpine represents a key therapeutic mechanism of Xiang-lian pill.
Keywords	Coptis chinensis ; Saussurea ; Tetradium ruticarpum ; antineoplastic activity ; apoptosis ; biochemical pathways ; bioinformatics ; cell proliferation ; cell viability ; computer simulation ; digestive tract ; fever ; gastrointestinal system ; histopathology ; immunoblotting ; immunohistochemistry ; inflammation ; metabolism ; metastasis ; mice ; models ; neoplasm cells ; pain ; pancreatic neoplasms ; spectroscopy ; stigmasterol ; therapeutics ; toxicity ; traditional medicine
Language	English
Dates of publication	2022-1115
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115586
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 90/710: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Neuroprotective effect and mechanism of Mu-Xiang-You-Fang on cerebral ischemia-reperfusion injury in rats.

Zhao, Qipeng / Cheng, Xiuli / Wang, Xiaobo / Wang, Jing / Zhu, Yafei / Ma, Xueqin

Journal of ethnopharmacology

2016 Volume 192, Page(s) 140–147

Abstract: ... of Mu-Xiang-You-Fang (MXYF), a classic Traditional Chinese Medicine used by Chinese minorities to treat ...

Abstract	Ethnopharmacological relevance: The present study is to investigate the neuroprotective effect of Mu-Xiang-You-Fang (MXYF), a classic Traditional Chinese Medicine used by Chinese minorities to treat stroke, on cerebral ischemia-reperfusion (I/R) injury and the related signaling pathways. Materials and methods: Male Sprague-Dawley rats were divided into 6 groups: sham group, I/R group, nimodipine and MXYF (58, 116 and 232mg/kg respectively) groups. Cerebral ischemia model was induced by middle cerebral artery occlusion for 2h followed by reperfusion for 48h. Neurological functional score was evaluated according to the method of Zea longa's score and the infarct area was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining at 48h after reperfusion. The protein expression of cytochrome c (cyt-c), Bcl-2, Bax, caspase-9, caspase-3 and caspase-7 were analyzed by western blot and the mRNA expression of Caspase-9, Caspase-3 and Caspase-7 were determined by the reverse transcription-polymerase chain reaction. Results: Oral administration of MXYF (116 and 232mg/kg) significantly reduced the neurological functional score and attenuated the cerebral infarct area. Western blot analysis showed that the expression of Bcl-2 is enhanced and Bax expression is inhibited after treatment with MXYF (116 and 232mg/kg), leading to significant increase of the ratio between Bcl-2 and Bax. Furthermore, the protein expression of cyt-c, caspase-9, caspase-3 and caspase-7 was significantly inhibited while the mRNA expression of caspase-9, caspase-3 and caspase-7 but not cyt-c was markedly inhibited in the MXYF (116 and 232mg/kg) treatment groups compared with the I/R group. Conclusions: The above data suggested that MXYF has potential neuroprotective activities by the regulation of apoptotic pathway, MXYF is a promising agent in treatment of stroke.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Behavior, Animal/drug effects ; Brain/drug effects ; Brain/metabolism ; Brain/pathology ; Brain/physiopathology ; Cytoprotection ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/pharmacology ; Gas Chromatography-Mass Spectrometry ; Gene Expression Regulation ; Infarction, Middle Cerebral Artery/drug therapy ; Infarction, Middle Cerebral Artery/genetics ; Infarction, Middle Cerebral Artery/metabolism ; Infarction, Middle Cerebral Artery/pathology ; Male ; Neuroprotective Agents/isolation & purification ; Neuroprotective Agents/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Sprague-Dawley ; Reperfusion Injury/genetics ; Reperfusion Injury/metabolism ; Reperfusion Injury/pathology ; Reperfusion Injury/prevention & control ; Signal Transduction/drug effects
Chemical Substances	Apoptosis Regulatory Proteins ; Drugs, Chinese Herbal ; Mu-Xiang-You-Fang ; Neuroprotective Agents ; RNA, Messenger
Language	English
Publishing date	2016-11-04
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2016.07.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1494: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Effectiveness of Xiang-Qi-Tang against Avian Pathogenic Escherichia coli

Chang-Liang He, , , , , , and / Ben-Dong Fu / Peng-Fei Yi / Xu-Bin Wei / Zhong-Qiong Yin / Cheng Lv / Wei Zhang / Xi-Mei Han / Xing-Li Cun

Pakistan Veterinary Journal, Vol 34, Iss 1, Pp 127-

2014 Volume 129

Abstract: Xiang-Qi-Tang (XQT) is a Chinese medicine containing Rhizoma Cyperi (40 g), Andrographis paniculata ...

Abstract	Xiang-Qi-Tang (XQT) is a Chinese medicine containing Rhizoma Cyperi (40 g), Andrographis paniculata (30 g) and Astragalus membranaceus (30 g). The purpose of this study is to investigate the therapeutic effects of XQT on Avian Pathogenic Escherichia coli (APEC)-infected chickens. The chickens were pretreated with XQT 12 h before being inoculated with 108 colony forming unit (CFU) of APEC by subcutaneous injection, and then the mortality and the indexes of health status of chicken in each group were detected. The results showed that high dosage and middle dosage of XQT could significantly decrease the mortality of the chickens challenged with APEC. We further found that XQT improved the infected chickens’ health status through improving the water consumption, feed intake, bodyweight gain, routine blood parameters and decreasing the incidences of pericarditis and perihepatitis. The results of present study suggest that XQT can effectively treat chicken colibacillosis as a potential agent.
Keywords	Chicken colibacillosis ; Escherichia coli ; Herbal medicine ; Animal culture ; SF1-1100 ; Veterinary medicine ; SF600-1100
Subject code	630
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	University of Agriculture, Faisalabad
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Neuroprotective effect and mechanism of Mu-Xiang-You-Fang on cerebral ischemia-reperfusion injury in rats

Zhao, Qipeng / Jing Wang / Xiaobo Wang / Xiuli Cheng / Xueqin Ma / Yafei Zhu

Journal of ethnopharmacology. 2016 Nov. 04, v. 192

2016

Abstract: The present study is to investigate the neuroprotective effect of Mu-Xiang-You-Fang (MXYF ...

Abstract	The present study is to investigate the neuroprotective effect of Mu-Xiang-You-Fang (MXYF), a classic Traditional Chinese Medicine used by Chinese minorities to treat stroke, on cerebral ischemia-reperfusion (I/R) injury and the related signaling pathways.Male Sprague-Dawley rats were divided into 6 groups: sham group, I/R group, nimodipine and MXYF (58, 116 and 232mg/kg respectively) groups. Cerebral ischemia model was induced by middle cerebral artery occlusion for 2h followed by reperfusion for 48h. Neurological functional score was evaluated according to the method of Zea longa’s score and the infarct area was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining at 48h after reperfusion. The protein expression of cytochrome c (cyt-c), Bcl-2, Bax, caspase-9, caspase-3 and caspase-7 were analyzed by western blot and the mRNA expression of Caspase-9, Caspase-3 and Caspase-7 were determined by the reverse transcription-polymerase chain reaction.Oral administration of MXYF (116 and 232mg/kg) significantly reduced the neurological functional score and attenuated the cerebral infarct area. Western blot analysis showed that the expression of Bcl-2 is enhanced and Bax expression is inhibited after treatment with MXYF (116 and 232mg/kg), leading to significant increase of the ratio between Bcl-2 and Bax. Furthermore, the protein expression of cyt-c, caspase-9, caspase-3 and caspase-7 was significantly inhibited while the mRNA expression of caspase-9, caspase-3 and caspase-7 but not cyt-c was markedly inhibited in the MXYF (116 and 232mg/kg) treatment groups compared with the I/R group.The above data suggested that MXYF has potential neuroprotective activities by the regulation of apoptotic pathway, MXYF is a promising agent in treatment of stroke.
Keywords	2,3,5-triphenyltetrazolium chloride ; apoptosis ; caspase-3 ; caspase-7 ; caspase-9 ; cytochrome c ; gene expression ; infarction ; ischemia ; messenger RNA ; models ; neuroprotective effect ; Oriental traditional medicine ; protein synthesis ; rats ; staining ; stroke ; Western blotting
Language	English
Dates of publication	2016-1104
Size	p. 140-147.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2016.07.016
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 90/710: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Book: Lao xiang gang

Cheng, Naishan

dong fang zhi zhu

(Lao cheng shi ; 老城市)

2000

Title variant	Dong fang zhi zhu ; 东方之珠
Institution	Zhong guo di 2 li shi dang an guan 中国第二历史档案馆
Author's details	Cheng nai shan zhu wen; zhong guo di er li shi dang an guan gong gao
Series title	Lao cheng shi 老城市
Keywords	Hong Kong (China)
Language	Chinese
Size	15, 221 p, ill, 21 cm
Edition	Di 1 ban
Publisher	Jiang su mei shu chu ban she
Publishing place	Nan jing
Document type	Book
ISBN	7534411424 ; 7534411432 ; 9787534411427 ; 9787534411434
Database	Former special subject collection: coastal and deep sea fishing

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells.

He, Chang-Liang / Yi, Peng-Fei / Fan, Qiao-Jia / Shen, Hai-Qing / Jiang, Xiao-Lin / Qin, Qian-Qian / Song, Zhou / Zhang, Cui / Wu, Shuai-Cheng / Wei, Xu-Bin / Li, Ying-Lun / Fu, Ben-Dong

Immunopharmacology and immunotoxicology

2013 Volume 35, Issue 2, Page(s) 215–224

Abstract: Xiang-Qi-Tang (XQT) is a Chinese herbal formula containing Cyperus rotundus ...

Abstract	Xiang-Qi-Tang (XQT) is a Chinese herbal formula containing Cyperus rotundus, Astragalus membranaceus and Andrographis paniculata. Alpha-Cyperone (CYP), astragaloside IV (AS-IV) and andrographolide (AND) are the three major active components in this formula. XQT may modulate the inflammatory or coagulant responses. We therefore assessed the effects of XQT on lipopolysaccharide (LPS)-induced inflammatory model of rat cardiac microvascular endothelial cells (RCMECs). XQT, CYP, AS-IV and AND inhibited the production of tumor necrosis factor alpha (TNF-α), intercellular cell adhesion molecule-1 (ICAM-1) and plasminogen activator inhibitor-1 (PAI-1), and up-regulated the mRNA expression of Kruppel-like factor 2 (KLF2). XQT and CYP inhibited the secretion of tissue factor (TF). To further explore the mechanism, we found that XQT, or its active components CYP, AS-IV and AND significantly inhibited extracellular signal-regulated kinase (ERK), c-jun NH2-terminal kinase (JNK) and p38 phosphorylation protein expression as well as decreased the phosphorylation levels of nuclear factor κB (NF-κB) p65 proteins in LPS-stimulated RCMECs. These results suggested that XQT and its active components inhibited the expression of inflammatory and coagulant mediators via mitogen-activated protein kinase (MAPKs) and NF-κB signaling pathways. These findings may contribute to future research on the action mechanisms of this formula, as well as therapy for inflammation- or coagulation-related diseases.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Anticoagulants/pharmacology ; Drugs, Chinese Herbal/pharmacology ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Heart/drug effects ; Inflammation/drug therapy ; Inflammation/metabolism ; Intercellular Adhesion Molecule-1/metabolism ; JNK Mitogen-Activated Protein Kinases/metabolism ; Kruppel-Like Transcription Factors/metabolism ; Lipopolysaccharides/pharmacology ; Microvessels/drug effects ; Microvessels/metabolism ; Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism ; Phosphorylation/drug effects ; Plasminogen Activator Inhibitor 1/metabolism ; Rats ; Rats, Wistar ; Signal Transduction/drug effects ; Thromboplastin/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Anticoagulants ; Drugs, Chinese Herbal ; Kruppel-Like Transcription Factors ; Lipopolysaccharides ; NF-kappa B ; Plasminogen Activator Inhibitor 1 ; Tumor Necrosis Factor-alpha ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Thromboplastin (9035-58-9) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2013-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	807033-7
ISSN	1532-2513 ; 0892-3973
ISSN (online)	1532-2513
ISSN	0892-3973
DOI	10.3109/08923973.2012.744034
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1481: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Xiang-qi-tang increases avian pathogenic Escherichia coli-induced survival rate and regulates serum levels of tumor necrosis factor alpha, interleukin-1 and soluble endothelial protein C receptor in chicken.

He, Chang-Liang / Fu, Ben-Dong / Shen, Hai-Qing / Jiang, Xiao-Lin / Zhang, Chang-Shuai / Wu, Shuai-Cheng / Zhu, Wei / Wei, Xu-Bin

Biological & pharmaceutical bulletin

2011 Volume 34, Issue 3, Page(s) 379–382

Abstract: Xiang-qi-tang (XQT) is a Chinese herbal formula containing rhizoma Cyperi, Andrographis paniculata ...

Abstract	Xiang-qi-tang (XQT) is a Chinese herbal formula containing rhizoma Cyperi, Andrographis paniculata and Astragalus membranaceus. The present study investigated the effects of XQT on the mortality and inflammatory mediators in a chicken model challenged with avian pathogenic Escherichia coli (APEC). To detect the effect of XQT, the chickens were pretreated with the formula 12 h before being challenged with 10(8) colony forming unit (CFU) of APEC. The results showed that 0.6 g/kg XQT significantly elevated the survival rate of infected chickens. To further investigate the mechanism of decreasing mortality of XQT, we examined plasma inflammatory mediator levels. The levels of tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1) and soluble endothelial protein C receptor (sEPCR) were significantly increased in chickens challenged with APEC alone, whereas chickens pretreated with 0.6 g/kg XQT showed marked decrease of these inflammatory mediator levels during the death peak. Taken together, this study demonstrates that XQT has protective effects in APEC-treated chickens. The action mechanisms of XQT involve anti-inflammation and antithrombotic activity. These findings may contribute to future research on the action mechanisms of this formula, as well as prevention of or therapy for avian colibacillosis.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Blood Coagulation Factors ; Chickens ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Escherichia coli Infections/blood ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/mortality ; Escherichia coli Infections/veterinary ; Fibrinolytic Agents/pharmacology ; Fibrinolytic Agents/therapeutic use ; Inflammation Mediators/blood ; Interleukin-1/blood ; Phytotherapy ; Plants, Medicinal ; Poultry Diseases/blood ; Poultry Diseases/drug therapy ; Poultry Diseases/microbiology ; Poultry Diseases/mortality ; Receptors, Cell Surface/blood ; Tumor Necrosis Factor-alpha/blood
Chemical Substances	Anti-Inflammatory Agents ; Blood Coagulation Factors ; Drugs, Chinese Herbal ; Fibrinolytic Agents ; Inflammation Mediators ; Interleukin-1 ; Receptors, Cell Surface ; Tumor Necrosis Factor-alpha ; activated protein C receptor
Language	English
Publishing date	2011-01-07
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.34.379
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1474: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito