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Article ; Online: Dense Persistent Pupillary Membrane in an Adult Patient

Yesim Altay

Journal of Clinical and Analytical Medicine , Vol 5, Iss 144, Pp 397-

2014 Volume 399

Abstract: Persistent pupillary membranes (PPM) are congenital abnormalities which results from an incomplete involution of tunica vasculosa lentis and are rarely seen in adults. A thirty-year old man applied to the hospital with the complaint of uncommon-looking ... ...

Abstract	Persistent pupillary membranes (PPM) are congenital abnormalities which results from an incomplete involution of tunica vasculosa lentis and are rarely seen in adults. A thirty-year old man applied to the hospital with the complaint of uncommon-looking pupils and progressive blurring of vision in the left eye. On examination, uncorrected visual acuity (Snellen ) were 20/100 in the right eye and 20/640 in the left eye with amblyopia. On biomicroscopic examination, there were bilateral dense PPM and cataract in the left eye. Visual field analysis of right and left eyes showed great narrowing of visual fields. We present our case in order to emphasize that analysis of visual field of patients with PPM is as important as central vision when planning its treatment. For planning treatment of patients with PPM, visual impairment, size of pupillary opening, and visual field analysis should be considered.
Keywords	persistent pupillary membrane ; cataract ; amblyopia ; Medicine ; R
Subject code	700
Language	English
Publishing date	2014-06-01T00:00:00Z
Publisher	Derman Medical Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Success Rate of Endocanalicular Laser Dacryocystorhinostomy with Two Different Mitomycin-C Application

Yesim Altay

Journal of Clinical and Analytical Medicine , Vol 6, Iss 97, Pp 25-

2014 Volume 28

Abstract: Aim: To determine the success rate of different application of mitomycin-c (mmc) in endocanalicular multidiode laser dacryocystorhinostomy (ECL-DCR). Material and Method: A prospective comparative study was conducted on 89 patients with primary acquired ... ...

Abstract	Aim: To determine the success rate of different application of mitomycin-c (mmc) in endocanalicular multidiode laser dacryocystorhinostomy (ECL-DCR). Material and Method: A prospective comparative study was conducted on 89 patients with primary acquired nasolacrimal duct obstruction, undergoing ECL-DCR procedures. Group 1 was composed of 44 patients undergoing ECL-DCR with intraoperative 0.4 mg/ml mmc application for 2 minutes and group 2 was composed of 45 patients undergoing ECL-DCR with intraoperative 0.4 mg/ml mmc application for 5 minutes. Patients were followed up for at least 12 months.The main outcome measure for success was resolution or improvement of epiphora and patency of nasolacrimal duct with irrigation. Results: Final success was 26/44(.1) for group 1, and 36/45 () for group 2.The difference was statistically significant (Chi-siquare, p=0.03). Discussion: Diode laser ECL-DCR with 0.4 mg /ml intraoperative mmc application for 5 minutes appears to be an effective treatment modality for primary nasolacrimal duct obstruction.
Keywords	endocanalicular multidiode laser dacryocystorhinostomy ; mitomycin-c ; nasolacrimal duct obstruction ; Medicine ; R
Subject code	610
Language	English
Publishing date	2014-03-01T00:00:00Z
Publisher	Derman Medical Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intraoperative Application of 5-Fluorouracil and Mitomycin C in Primary Pterygium Surgery and its Effect on the Fibroblast Counts of Conjunctival Biopsies

Yesim Altay

Journal of Clinical and Analytical Medicine , Vol 5, Iss 91, Pp 4-

2013 Volume 7

Abstract: Aim: To determine the effectiveness of intraoperative 5-FU and mitomycin C application for prevention of recurrence after primary pterygium excision. Material and Method: We performed a prospective clinical trial of 51 patients with primary pterygia ... ...

Abstract	Aim: To determine the effectiveness of intraoperative 5-FU and mitomycin C application for prevention of recurrence after primary pterygium excision. Material and Method: We performed a prospective clinical trial of 51 patients with primary pterygia randomly assigned to a treatment group in which 15 patients received a single intraoperative application of 25mg/mL 5-FU for 5 minutes, 20 patients received a single intraoperative application of 0.02 % mitomycin C for 5 minutes and 16 patients underwent only surgical excision (control group). Follow-up visits were scheduled for postoperative days 1,3,7,15 and 30 and then every month. Recurrence was defined as 1 mm fibrovascular tissue over the corneascleral limbus onto clear cornea in the area of previous pterygium excision. Conjunctival biopsies were taken peroperatively and at the third month postoperatively, in each group. Results: After mean follow up of 8 months, recurrence rates of surgical excision with 5-FU and mitomycin C and the control group were 20%, 15 %, and 44% of eyes, respectively. The only statistically significant difference was between mitomycin C and control groups (Chi-square; p=0.03). Pathologic examination of conjunctival biopsies did not show any difference in fibroblast counts. No serious complications were seen in 5-FU and mitomycin C groups. Discussion: Application of 0.02% mitomycin C for 5 minutes seems to be more effective than 5-FU for prevention of recurrence. A larger study population is needed to substantiate this result.
Keywords	5-Fluorouracil ; Mitomycin C ; Pterygium ; Medicine ; R
Subject code	610
Language	English
Publishing date	2013-10-01T00:00:00Z
Publisher	Derman Medical Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effects of a Short Video Physical Activity Program on Physical Fitness Among Physical Education Students.

Bulca, Yeşim / Bilgin, Emre / Altay, Figen / Demirhan, Gıyasettin

Perceptual and motor skills

2022 Volume 129, Issue 3, Page(s) 932–945

Abstract: The Brain Break (BB) short video program is designed to improve physical activity (PA), motor skills, and fitness in children. In this study, we examined the effects of an 8-week short video-based Brain Break (HOPSports Company) PA program within ... ...

Abstract	The Brain Break (BB) short video program is designed to improve physical activity (PA), motor skills, and fitness in children. In this study, we examined the effects of an 8-week short video-based Brain Break (HOPSports Company) PA program within physical education (PE) lessons on fitness and fitness knowledge among students. We studied 62 fifth-grade students (experimental group = 28; control group = 34) in the Ankara, Turkey school district. The experimental group received PE lessons once per week for eight weeks with the BB PA program, with extra videos viewed at home three days per week, while the control group received routine PE lessons during this period. We collected student responses to the Fitness Knowledge Test for Children and the Fitnessgram Test Battery before and after the experimental BB program. Results revealed that the experimental group showed increased fitness and fitness knowledge compared to the control group, showing that the BB PA videos can increase fitness and fitness knowledge in students.
MeSH term(s)	Child ; Exercise/physiology ; Humans ; Physical Education and Training ; Physical Fitness/physiology ; Schools ; Students
Language	English
Publishing date	2022-04-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	204507-2
ISSN	1558-688X ; 0031-5125
ISSN (online)	1558-688X
ISSN	0031-5125
DOI	10.1177/00315125221088069
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Digital Droplet PCR Method for the Quantification of AAV Transduction Efficiency in Murine Retina.

Okan, Iskalen Cansu Topcu / Ahmadian, Mehri / Tutuncu, Yesim / Altay, Halit Yusuf / Agca, Cavit

Journal of visualized experiments : JoVE

2021 , Issue 178

Abstract: Many retinal cell biology laboratories now routinely use Adeno-associated viruses (AAVs) for gene editing and regulatory applications. The efficiency of AAV transduction is usually critical, which affects the overall experimental outcomes. One of the ... ...

Abstract	Many retinal cell biology laboratories now routinely use Adeno-associated viruses (AAVs) for gene editing and regulatory applications. The efficiency of AAV transduction is usually critical, which affects the overall experimental outcomes. One of the main determinants for transduction efficiency is the serotype or variant of the AAV vector. Currently, various artificial AAV serotypes and variants are available with different affinities to host cell surface receptors. For retinal gene therapy, this results in varying degrees of transduction efficiencies for different retinal cell types. In addition, the injection route and the quality of AAV production may also affect the retinal AAV transduction efficiencies. Therefore, it is essential to compare the efficiency of different variants, batches, and methodologies. The digital droplet PCR (dd-PCR) method quantifies the nucleic acids with high precision and allows performing absolute quantification of a given target without any standard or a reference. Using dd-PCR, it is also feasible to assess the transduction efficiencies of AAVs by absolute quantification of AAV genome copy numbers within an injected retina. Here, we provide a straightforward method to quantify the transduction rate of AAVs in retinal cells using dd-PCR. With minor modifications, this methodology can also be the basis for the copy number quantification of mitochondrial DNA as well as assessing the efficiency of base editing, critical for several retinal diseases and gene therapy applications.
MeSH term(s)	Animals ; Dependovirus/metabolism ; Genetic Vectors/genetics ; Mice ; Polymerase Chain Reaction ; Retina/metabolism ; Transduction, Genetic
Language	English
Publishing date	2021-12-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/63038
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Intraoperative Application of 5-Fluorouracil and Mitomycin C in Primary Pterygium Surgery and its Effect on the Fibroblast Counts of Conjunctival Biopsies

Yeşim Altay

Journal of Clinical and Analytical Medicine (2014)

2014

Keywords	Medicine ; R
Language	English
Publishing date	2014-01-01T00:00:00Z
Publisher	Derman Medical Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ipsilateral Rotational Autokeratoplasty

Yesim Altay

Journal of Clinical and Analytical Medicine , Vol 7, Iss 5, Pp 753-

2016 Volume 756

Abstract: Corneal opacity is a leading cause of monocular blindness, and corneal transplantation is the most commonly performed solid organ transplantation in the world. Keratoplasty techniques for corneal opacities include lamellar allokeratoplasty and ... ...

Abstract	Corneal opacity is a leading cause of monocular blindness, and corneal transplantation is the most commonly performed solid organ transplantation in the world. Keratoplasty techniques for corneal opacities include lamellar allokeratoplasty and penetrating allokeratoplasty. Ipsilateral rotational autokeratoplasty can be an effective alternative to penetrating allokeratoplasty for some patients with corneal scars. This procedure involves a rotation of the patient%u2019s own cornea to move opacity out of the visual axis. An important consideration when selecting cases for rotational autokeratoplasty is the dimensions of the corneal scar. Although ipsilateral autokeratoplasty may not provide as good a quality of vision as penetrating allokeratoplasty because of higher astigmatism and reduced corneal pupillary clear zone, these disadvantages are often outweighed when the risk of allograft rejection is high, as in pediatric patients and those with vascularised corneas. This technique would at least partially resolve the issue of scarcity of donor corneal tissue in developing countries.
Keywords	cornea ; corneal transplantation ; corneal opacity ; Medicine ; R
Subject code	570
Language	English
Publishing date	2016-09-01T00:00:00Z
Publisher	Derman Medical Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: RETRACTED: Azithromycin 1.5% Ophthalmic Solution for Blepharitis Treatment: Comparison of 14- Versus 30-Day Treatment.

Altay, Yesim / Demirok, Gulizar / Balta, Ozgur / Bolu, Hulya

publication RETRACTED

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

2017

Abstract: ... Treatment: Comparison of 14- Versus 30-Day Treatment," by Altay Yesim, Demirok Gulizar, Balta Ozgur, and ...

Abstract	The online-ahead-of-print published article, "Azithromycin 1.5% Ophthalmic Solution for Blepharitis Treatment: Comparison of 14- Versus 30-Day Treatment," by Altay Yesim, Demirok Gulizar, Balta Ozgur, and Bolu Hulya (DOI: 10.1089/jop.2015.0099) is being officially retracted from Journal of Ocular Pharmacology and Therapeutics (JOPT) due to post-publication authorship disputes and the discovery of simultaneous submission to both JOPT and the International Journal of Ophthalmology, which is a violation of the proper protocols of peer review. Journal of Ocular Pharmacology and Therapeutics and its editorial leadership are committed to maintaining the highest levels of scientific reporting and publishing, and therefore officially retracts the article based on the infringements listed herein.
Language	English
Publishing date	2017-06-05
Publishing country	United States
Document type	Retraction of Publication ; Retracted Publication
ZDB-ID	1237021-6
ISSN	1557-7732 ; 1080-7683
ISSN (online)	1557-7732
ISSN	1080-7683
DOI	10.1089/jop.2015.0099
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Article: Digital droplet pcr method for the quantification of aav transduction efficiency in murine retina

Okan, Iskalen Cansu Topcu / Ahmadian, Mehri / Tutuncu, Yesim / Altay, Halit Yusuf / Agca, Cavit

Journal of visualized experiments. 2021 Dec. 25, , no. 178

2021

Abstract	Many retinal cell biology laboratories now routinely use Adeno-associated viruses (AAVs) for gene editing and regulatory applications. The efficiency of AAV transduction is usually critical, which affects the overall experimental outcomes. One of the main determinants for transduction efficiency is the serotype or variant of the AAV vector. Currently, various artificial AAV serotypes and variants are available with different affinities to host cell surface receptors. For retinal gene therapy, this results in varying degrees of transduction efficiencies for different retinal cell types. In addition, the injection route and the quality of AAV production may also affect the retinal AAV transduction efficiencies. Therefore, it is essential to compare the efficiency of different variants, batches, and methodologies. The digital droplet PCR (dd-PCR) method quantifies the nucleic acids with high precision and allows performing absolute quantification of a given target without any standard or a reference. Using dd-PCR, it is also feasible to assess the transduction efficiencies of AAVs by absolute quantification of AAV genome copy numbers within an injected retina. Here, we provide a straightforward method to quantify the transduction rate of AAVs in retinal cells using dd-PCR. With minor modifications, this methodology can also be the basis for the copy number quantification of mitochondrial DNA as well as assessing the efficiency of base editing, critical for several retinal diseases and gene therapy applications.
Keywords	cell biology ; droplets ; gene therapy ; genes ; mice ; mitochondrial DNA ; retina ; serotypes
Language	English
Dates of publication	2021-1225
Size	p. e63038.
Publishing place	Journal of Visualized Experiments
Document type	Article
ZDB-ID	2259946-0
ISSN	1940-087X
ISSN	1940-087X
DOI	10.3791/63038
Database	NAL-Catalogue (AGRICOLA)

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Article: Intraoperative application of 5-fluorouracil and mitomycin C aschemoadjuvants in primary pterygium surgery.

Altay, Yeşim / Balta, Özgür

Turkish journal of medical sciences

2016 Volume 46, Issue 2, Page(s) 321–327

Abstract: Background/aim: To compare the effectiveness of intraoperative 5 fluorouracil (5-FU) and mitomycin C (MMC) application in preventing recurrence following primary pterygium excision.: Materials and methods: This was a prospective clinical trial that ... ...

Abstract	Background/aim: To compare the effectiveness of intraoperative 5 fluorouracil (5-FU) and mitomycin C (MMC) application in preventing recurrence following primary pterygium excision. Materials and methods: This was a prospective clinical trial that included 93 patients with primary pterygia assigned to three treatment groups in which 29 patients received an intraoperative application of 25 mg/mL 5-FU for 5 min, 32 patients received an intraoperative application of 0.02% MMC for 5 min, and 32 patients underwent only surgical excision (the control group). Follow-up visits were done on postoperative days 1, 3, 7, 15, and 30, and then every month. Results: After a mean follow-up of 14 months, the surgical excision recurrence rates in the 5-FU, MMC, and control groups were 27.6%, 12.5%, and 43.75%, respectively. There was a statistically significant difference in the 5-FU and MMC groups when compared with the control group (chi-square; P = 0.04); however, the difference between the 5-FU and MMC groups was not significant. No serious complications were seen in the 5-FU and MMC groups. Conclusion: Intraoperative application of MMC and 5-FU is effective and safe for the prevention of recurrence. Our findings suggest that MMC is more potent for the prevention of recurrence and it causes less complaints than 5-FU.
MeSH term(s)	Fluorouracil ; Follow-Up Studies ; Humans ; Intraoperative Care ; Mitomycin ; Prospective Studies ; Pterygium ; Treatment Outcome
Chemical Substances	Mitomycin (50SG953SK6) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2016-02-17
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1183461-4
ISSN	1303-6165 ; 1300-0144
ISSN (online)	1303-6165
ISSN	1300-0144
DOI	10.3906/sag-1408-32
Database	MEDical Literature Analysis and Retrieval System OnLINE

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