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  1. Book ; Online: Molecular Basis of Inherited Diseases in Companion Animals

    Bannasch, Danika / Friedenberg, Steven

    2021  

    Keywords Research & information: general ; Biology, life sciences ; Canis familiaris ; dermatology ; immunology ; animal model ; skin ; TLR7 ; toll-like receptor ; syndecan binding protein ; syntenin-1 ; systemic lupus erythematosus ; SLE ; CLE ; whole-genome sequencing ; craniomandibular osteopathy ; calvarial hyperostotic syndrome ; Caffey disease ; infantile cortical hyperostosis ; rare disease ; SLC37A2 ; COL1A1 ; SLC35D1 ; Canis lupus familiaris ; whole-genome sequence ; genodermatosis ; keratinocyte ; SAM syndrome ; precision medicine ; dog ; desmosome ; acantholysis ; calcium ; veterinary medicine ; feline ; Felis catus ; brain malformation ; BMP12 ; neurodevelopment ; genetics ; genomics ; mendelian traits ; genome-wide association study ; whole genome sequencing ; mitochondrion ; phosphoenolpyruvate-carboxykinase ; inborn error of metabolism ; encephalopathy ; SSADHD ; ALDH5A1 ; GABA ; 4-hydroxybutyric acid ; succinic semialdehyde ; GWAS ; inherited ; whole genome sequence ; wgs ; laminin ; Bardet-Biedl syndrome (BBS) ; primary cilia ; ciliopathy ; BBS8 ; progressive retinal atrophy (PRA) ; retinitis pigmentosa ; canine ; dystrophinopathy ; Duchenne ; immunohistochemistry ; neurometabolic disorder ; CHILD syndrome ; ILVEN ; epidermal nevus ; diabetes mellitus ; Burmese cats ; susceptibility ; single-nucleotide polymorphism ; genetic markers ; LIPH ; obesity ; companion animals ; metabolic disease ; comparative genomics ; dogs ; cats ; horses ; contactin ; neurological disorder ; Leonberger ; Saint Bernard ; Labrador retriever ; n/a
    Size 1 electronic resource (232 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044301
    ISBN 9783036504735 ; 3036504737
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Aggression

    Huber, Robert / Brennan, Patricia / Bannasch, Danika

    (Advances in genetics ; 75)

    2011  

    Author's details ed. by Robert Huber ; Danika L. Bannasch ; Patricia Brennan
    Series title Advances in genetics ; 75
    Collection
    Keywords Neurophysiology ; Aggressive behavior in animals
    Subject code 573.8
    Language English
    Size X, 293 S. : Ill., graph. Darst., 23 cm
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT017000253
    ISBN 978-0-12-380858-5 ; 0-12-380858-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 836 -75- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Driving health innovation at the University of California-Davis School of Veterinary Medicine.

    Stetter, Mark / Bannasch, Danika / Hinds, Tom

    American journal of veterinary research

    2023  Volume 84, Issue 5

    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390796-x
    ISSN 1943-5681 ; 0002-9645
    ISSN (online) 1943-5681
    ISSN 0002-9645
    DOI 10.2460/ajvr.23.03.0056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 422: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Special Issue "Molecular Basis of Inherited Diseases in Companion Animals".

    Friedenberg, Steven G / Bannasch, Danika L

    Genes

    2021  Volume 12, Issue 1

    Abstract: The study of inherited diseases in companion animals has exploded over the past 15 years since the publication of the first dog genome in 2005 [ ... ]. ...

    Abstract The study of inherited diseases in companion animals has exploded over the past 15 years since the publication of the first dog genome in 2005 [...].
    MeSH term(s) Animals ; Cat Diseases/diagnosis ; Cat Diseases/genetics ; Cats/genetics ; Disease Models, Animal ; Dog Diseases/diagnosis ; Dog Diseases/genetics ; Dogs/genetics ; Mutation ; Pets/genetics ; Whole Genome Sequencing
    Language English
    Publishing date 2021-01-07
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes12010068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Identification of Genetic Risk Factors for Monogenic and Complex Canine Diseases.

    Leeb, Tosso / Bannasch, Danika / Schoenebeck, Jeffrey J

    Annual review of animal biosciences

    2022  Volume 11, Page(s) 183–205

    Abstract: Advances in DNA sequencing and other technologies have greatly facilitated the identification of genetic risk factors for inherited diseases in dogs. We review recent technological developments based on selected examples from canine disease genetics. The ...

    Abstract Advances in DNA sequencing and other technologies have greatly facilitated the identification of genetic risk factors for inherited diseases in dogs. We review recent technological developments based on selected examples from canine disease genetics. The identification of disease-causing variants in dogs with monogenic diseases may become a widely employed diagnostic approach in clinical veterinary medicine in the not-too-distant future. Diseases with complex modes of inheritance continue to pose challenges to researchers but have also become much more tangible than in the past. In addition to strategies for identifying genetic risk factors, we provide some thoughts on the interpretation of sequence variants that are largely inspired by developments in human clinical genetics.
    MeSH term(s) Animals ; Dogs ; Humans ; Risk Factors ; Dog Diseases/genetics
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2700164-7
    ISSN 2165-8110 ; 2165-8102
    ISSN (online) 2165-8110
    ISSN 2165-8102
    DOI 10.1146/annurev-animal-050622-055534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Current Understanding of the Genetics of Intervertebral Disc Degeneration.

    Dickinson, Peter J / Bannasch, Danika L

    Frontiers in veterinary science

    2020  Volume 7, Page(s) 431

    Abstract: Premature degeneration of the intervertebral disc and its association with specific chondrodystrophic dog breeds has been recognized for over a century. Several lines of evidence including disease breed predisposition, studies suggesting heritability of ... ...

    Abstract Premature degeneration of the intervertebral disc and its association with specific chondrodystrophic dog breeds has been recognized for over a century. Several lines of evidence including disease breed predisposition, studies suggesting heritability of premature intervertebral disc degeneration (IVDD) and association of a dog chromosome 12 (CFA 12) locus with intervertebral disc calcification have strongly supported a genetic component in IVDD in dogs. Recent studies documenting association of IVDD with an overexpressing
    Language English
    Publishing date 2020-07-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2020.00431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Genetic Variants Affecting Skeletal Morphology in Domestic Dogs.

    Bannasch, Danika L / Baes, Christine F / Leeb, Tosso

    Trends in genetics : TIG

    2020  Volume 36, Issue 8, Page(s) 598–609

    Abstract: Purebred dog breeds provide a powerful resource for the discovery of genetic variants affecting skeletal morphology. Domesticated and subsequently purebred dogs have undergone strong artificial selection for a broad range of skeletal variation, which ... ...

    Abstract Purebred dog breeds provide a powerful resource for the discovery of genetic variants affecting skeletal morphology. Domesticated and subsequently purebred dogs have undergone strong artificial selection for a broad range of skeletal variation, which include both the size and shapes of their bones. While the phenotypic variation between breeds is high, within-breed morphological variation is typically low. Approaches for defining genetic variants associated with canine morphology include quantitative within-breed analyses, as well as across-breed analyses, using breed standards as proxies for individual measurements. The ability to identify variants across the genomes of individual dogs can now be paired with precise measures of morphological variation to define the genetic interactions and the phenotypic effect of variants on skeletal morphology.
    MeSH term(s) Animals ; Animals, Domestic/anatomy & histology ; Animals, Domestic/genetics ; Bone and Bones/anatomy & histology ; Bone and Bones/metabolism ; Dogs/anatomy & histology ; Dogs/genetics ; Genetic Variation ; Phenotype
    Language English
    Publishing date 2020-05-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2020.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2272: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Quality of DNA extracted from formalin-fixed, paraffin-embedded canine tissues.

    Dear, Jonathan D / Sykes, Jane E / Bannasch, Danika L

    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

    2020  Volume 32, Issue 4, Page(s) 556–559

    Abstract: Veterinary pathology tissue banks are valuable resources for genetic studies. However, limited data exist as to whether quality DNA can be extracted from these tissues for use in canine genotyping studies. We extracted DNA from 44 formalin-fixed, ... ...

    Abstract Veterinary pathology tissue banks are valuable resources for genetic studies. However, limited data exist as to whether quality DNA can be extracted from these tissues for use in canine genotyping studies. We extracted DNA from 44 formalin-fixed, paraffin-embedded (FFPE) tissue blocks from dogs; 9 of these dogs had DNA available from whole blood samples that had been banked. We genotyped DNA from 30 of 44 tissue blocks and 9 whole blood samples on the Illumina CanineHD BeadChip; DNA quality was insufficient in 14 of 44 samples from tissue blocks. There was significant correlation between the 260/280 ratio and single-nucleotide variation (SNV) call rate (
    MeSH term(s) Animals ; DNA/analysis ; Dogs/genetics ; Formaldehyde/chemistry ; Genotype ; Organ Specificity ; Paraffin Embedding/veterinary
    Chemical Substances Formaldehyde (1HG84L3525) ; DNA (9007-49-2)
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 287603-6
    ISSN 1943-4936 ; 1040-6387
    ISSN (online) 1943-4936
    ISSN 1040-6387
    DOI 10.1177/1040638720929637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3645: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: The Effects of

    Bannasch, Danika / Batcher, Kevin / Leuthard, Fabienne / Bannasch, Michael / Hug, Petra / Marcellin-Little, Denis J / Dickinson, Peter J / Drögemüller, Michaela / Drögemüller, Cord / Leeb, Tosso

    Genes

    2022  Volume 13, Issue 2

    Abstract: ... ...

    Abstract Two
    MeSH term(s) Animals ; Dogs ; Intervertebral Disc Displacement/genetics
    Language English
    Publishing date 2022-02-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes13020325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: An SNN retrocopy insertion upstream of GPR22 is associated with dark red coat color in Poodles.

    Batcher, Kevin / Varney, Scarlett / Affolter, Verena K / Friedenberg, Steven G / Bannasch, Danika

    G3 (Bethesda, Md.)

    2022  Volume 12, Issue 11

    Abstract: Pigment production and distribution is controlled through multiple genes, resulting in a wide range of coat color phenotypes in dogs. Dogs that produce only the pheomelanin pigment vary in intensity from white to deep red. The Poodle breed has a wide ... ...

    Abstract Pigment production and distribution is controlled through multiple genes, resulting in a wide range of coat color phenotypes in dogs. Dogs that produce only the pheomelanin pigment vary in intensity from white to deep red. The Poodle breed has a wide range of officially recognized coat colors, including the pheomelanin-based white, cream, apricot, and red coat colors, which are not fully explained by the previously identified genetic variants involved in pigment intensity. Here, a genome-wide association study for pheomelanin intensity was performed in Poodles which identified an association on canine chromosome 18. Whole-genome sequencing data revealed an SNN retrocopy insertion (SNNL1) in apricot and red Poodles within the associated region on chromosome 18. While equal numbers of melanocytes were observed in all Poodle skin hair bulbs, higher melanin content was observed in the darker Poodles. Several genes involved in melanogenesis were also identified as highly overexpressed in red Poodle skin. The most differentially expressed gene however was GPR22, which was highly expressed in red Poodle skin while unexpressed in white Poodle skin (log2 fold change in expression 6.1, P < 0.001). GPR22 is an orphan G-protein-coupled receptor normally expressed exclusively in the brain and heart. The SNNL1 retrocopy inserted 2.8 kb upstream of GPR22 and is likely disrupting regulation of the gene, resulting in atypical expression in the skin. Thus, we identify the SNNL1 insertion as a candidate variant for the CFA18 pheomelanin intensity locus in red Poodles.
    MeSH term(s) Dogs ; Animals ; Genome-Wide Association Study ; Phenotype ; Pigmentation/genetics ; Whole Genome Sequencing
    Language English
    Publishing date 2022-09-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1093/g3journal/jkac227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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