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  1. Book: Integrative environmental medicine

    Cohen, Aly / Vom Saal, Frederick S.

    (Weil integrative medicine library)

    2017  

    Author's details edited by Aly Cohen, Frederick S. vom Saal
    Series title Weil integrative medicine library
    Keywords Environmental Medicine ; Integrative Medicine
    Language English
    Size xv, 396 Seiten, Illustrationen
    Publisher Oxford University Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT020067992
    ISBN 978-0-19-049091-1 ; 9780190490928 ; 0-19-049091-8 ; 0190490926
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2019 A 700 available for loan (reading room) Lesesaal EG

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  2. Book ; Online ; E-Book: Non-toxic

    Cohen, Aly / Vom Saal, Frederick S.

    guide to living healthy in a chemical world

    2020  

    Abstract: Non-Toxic gives insightful, even-handed, evidence-based discussion about the environment in which we now find ourselves living, the environmental hazards and ways in which we may better protect ourselves and our families from increased risk of illness ... ...

    Author's details Aly Cohen MD, FARC, Frederick vom Saal, Ph.D
    Abstract "Non-Toxic gives insightful, even-handed, evidence-based discussion about the environment in which we now find ourselves living, the environmental hazards and ways in which we may better protect ourselves and our families from increased risk of illness and disease due to harmful chemical and radiation exposure. Espousing the principles developed by famed physician and author, Dr. Andrew Weil, and making them accessible for the general reader, the book takes account of the whole person, including all aspects of lifestyle, in offering guidance to living healthy in a chemical world"--
    Keywords Environmental toxicology
    Subject code 615.902
    Language English
    Size 1 online resource (xii, 399 pages) :, illustrations
    Publisher Oxford University Press
    Publishing place New York, New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-19-008237-2 ; 0-19-008236-4 ; 0-19-008235-6 ; 978-0-19-008237-6 ; 978-0-19-008236-9 ; 978-0-19-008235-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Flaws in design, execution and interpretation limit CLARITY-BPA's value for risk assessments of bisphenol A.

    Vom Saal, Frederick S

    Basic & clinical pharmacology & toxicology

    2019  Volume 125 Suppl 3, Page(s) 32–43

    Abstract: The Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA) involved the Food and Drug Administration, the National Toxicology Program and 14 academic investigators funded by the National Institute of Environmental Health ... ...

    Abstract The Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA) involved the Food and Drug Administration, the National Toxicology Program and 14 academic investigators funded by the National Institute of Environmental Health Sciences. Two key questions to be answered by CLARITY-BPA were as follows: (1) Would the academic investigator studies show effects at low doses of bisphenol A (BPA) while the core guideline study conducted by the FDA only showed toxic effects at high doses? (2) Would the academic investigators be able to replicate their numerous prior studies with animals raised and treated in the FDA's toxicology centre? Several flaws in the design and execution of CLARITY-BPA biased the experiment towards not finding significant results (Type 2 error): (1) use of the oestrogen-insensitive NCTR CD-SD rat, (2) use of a stressful daily gavage BPA administration procedure throughout life, (3) lack of inclusion of non-gavaged negative controls and (4) lack of a comprehensive examination of animals for BPA contamination. In spite of these flaws, in some of the experiments conducted by CLARITY-BPA academic investigators, and also in the FDA's core study, there were significant low-dose effects, but these were ignored by the FDA. Thus, immediately after releasing the results from their core portion of CLARITY-BPA, the FDA issued a statement concluding BPA was "safe," and they ignored non-monotonic dose-response relationships. The FDA should not base its BPA risk assessment only on outdated guideline studies, but instead on the vast (~8000) number of publications documenting the similar health hazards BPA poses to animals and humans.
    MeSH term(s) Animals ; Benzhydryl Compounds/toxicity ; Disease Models, Animal ; Ecotoxicology/methods ; Ecotoxicology/standards ; Endocrine Disruptors/toxicity ; Environmental Exposure/adverse effects ; Environmental Pollutants/toxicity ; Female ; Fetal Development/drug effects ; Guidelines as Topic ; Humans ; National Institute of Environmental Health Sciences (U.S.)/standards ; Phenols/toxicity ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced ; Prenatal Exposure Delayed Effects/prevention & control ; Rats, Sprague-Dawley ; Research Design ; Risk Assessment/methods ; Risk Assessment/standards ; Toxicity Tests/methods ; Toxicity Tests/standards ; United States ; United States Food and Drug Administration/standards
    Chemical Substances Benzhydryl Compounds ; Endocrine Disruptors ; Environmental Pollutants ; Phenols ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2019-02-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2134679-3
    ISSN 1742-7843 ; 1742-7835
    ISSN (online) 1742-7843
    ISSN 1742-7835
    DOI 10.1111/bcpt.13195
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Update on the Health Effects of Bisphenol A: Overwhelming Evidence of Harm.

    Vom Saal, Frederick S / Vandenberg, Laura N

    Endocrinology

    2021  Volume 162, Issue 3

    Abstract: ... of the Endocrine Society that the Food and Drug Administration (FDA)'s assumptions violate basic principles ...

    Abstract In 1997, the first in vivo bisphenol A (BPA) study by endocrinologists reported that feeding BPA to pregnant mice induced adverse reproductive effects in male offspring at the low dose of 2 µg/kg/day. Since then, thousands of studies have reported adverse effects in animals administered low doses of BPA. Despite more than 100 epidemiological studies suggesting associations between BPA and disease/dysfunction also reported in animal studies, regulatory agencies continue to assert that BPA exposures are safe. To address this disagreement, the CLARITY-BPA study was designed to evaluate traditional endpoints of toxicity and modern hypothesis-driven, disease-relevant outcomes in the same set of animals. A wide range of adverse effects was reported in both the toxicity and the mechanistic endpoints at the lowest dose tested (2.5 µg/kg/day), leading independent experts to call for the lowest observed adverse effect level (LOAEL) to be dropped 20 000-fold from the current outdated LOAEL of 50 000 µg/kg/day. Despite criticism by members of the Endocrine Society that the Food and Drug Administration (FDA)'s assumptions violate basic principles of endocrinology, the FDA rejected all low-dose data as not biologically plausible. Their decisions rely on 4 incorrect assumptions: dose responses must be monotonic, there exists a threshold below which there are no effects, both sexes must respond similarly, and only toxicological guideline studies are valid. This review details more than 20 years of BPA studies and addresses the divide that exists between regulatory approaches and endocrine science. Ultimately, CLARITY-BPA has shed light on why traditional methods of evaluating toxicity are insufficient to evaluate endocrine disrupting chemicals.
    MeSH term(s) Animals ; Benzhydryl Compounds/toxicity ; Dose-Response Relationship, Drug ; Endocrine Disruptors/toxicity ; Female ; Humans ; Male ; Mice ; Phenols/toxicity ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced ; Prenatal Exposure Delayed Effects/epidemiology ; Toxicity Tests/methods ; Toxicity Tests/standards ; Toxicity Tests/trends
    Chemical Substances Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2021-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqaa171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: BPA and risk assessment - Authors' reply.

    Hunt, Patricia A / Vom Saal, Frederick S / Stahlhut, Richard / Gerona, Roy

    The lancet. Diabetes & endocrinology

    2020  Volume 8, Issue 4, Page(s) 271–272

    MeSH term(s) Benzhydryl Compounds/toxicity ; Phenols/toxicity ; Risk Assessment
    Chemical Substances Benzhydryl Compounds ; Phenols ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2020-03-17
    Publishing country England
    Document type Letter ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(20)30071-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The Crowded Uterine Horn Mouse Model for Examining Postnatal Metabolic Consequences of Intrauterine Growth Restriction vs. Macrosomia in Siblings.

    Taylor, Julia A / Coe, Benjamin L / Shioda, Toshi / Vom Saal, Frederick S

    Metabolites

    2022  Volume 12, Issue 2

    Abstract: Differential placental blood flow and nutrient transport can lead to both intrauterine growth restriction (IUGR) and macrosomia. Both conditions can lead to adult obesity and other conditions clustered as metabolic syndrome. We previously showed that ... ...

    Abstract Differential placental blood flow and nutrient transport can lead to both intrauterine growth restriction (IUGR) and macrosomia. Both conditions can lead to adult obesity and other conditions clustered as metabolic syndrome. We previously showed that pregnant hemi-ovariectomized mice have a crowded uterine horn, resulting in siblings whose birth weights differ by over 100% due to differential blood flow based on uterine position. We used this crowded uterus model to compare IUGR and macrosomic male mice and also identified IUGR males with rapid (IUGR-R) and low (IUGR-L) postweaning weight gain. At week 12 IUGR-R males were heavier than IUGR-L males and did not differ from macrosomic males. Rapid growth in IUGR-R males led to glucose intolerance compared to IUGR-L males and down-regulation of adipocyte signaling pathways for fat digestion and absorption and type II diabetes. Macrosomia led to increased fat mass and altered adipocyte size distribution compared to IUGR males, and down-regulation of signaling pathways for carbohydrate and fat digestion and absorption relative to IUGR-R. Clustering analysis of gonadal fat transcriptomes indicated more similarities than differences between IUGR-R and macrosomic males compared to IUGR-L males. Our findings suggest two pathways to adult metabolic disease: macrosomia and IUGR with rapid postweaning growth rate.
    Language English
    Publishing date 2022-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo12020102
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  7. Article ; Online: BPA: have flawed analytical techniques compromised risk assessments?

    Gerona, Roy / Vom Saal, Frederick S / Hunt, Patricia A

    The lancet. Diabetes & endocrinology

    2019  Volume 8, Issue 1, Page(s) 11–13

    MeSH term(s) Benzhydryl Compounds/adverse effects ; Benzhydryl Compounds/analysis ; Endocrine Disruptors/adverse effects ; Endocrine Disruptors/analysis ; Environmental Exposure/prevention & control ; Female ; Humans ; Male ; Phenols/adverse effects ; Phenols/analysis ; Risk Assessment
    Chemical Substances Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2019-12-05
    Publishing country England
    Document type Letter ; Research Support, N.I.H., Extramural
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(19)30381-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: European Medicines Agency Conflicts With the European Food Safety Authority (EFSA) on Bisphenol A Regulation.

    Zoeller, R Thomas / Birnbaum, Linda S / Collins, Terrence J / Heindel, Jerrold / Hunt, Patricia A / Iguchi, Taisen / Kortenkamp, Andreas / Myers, John Peterson / Vom Saal, Frederick S / Sonnenschein, Carlos / Soto, Ana M

    Journal of the Endocrine Society

    2023  Volume 7, Issue 9, Page(s) bvad107

    Abstract: The European Food Safety Authority (EFSA) has revised their estimate of the toxicity of bisphenol A (BPA) and, as a result, have recommended reducing the tolerable daily intake (TDI) by 20 000-fold. This would essentially ban the use of BPA in food ... ...

    Abstract The European Food Safety Authority (EFSA) has revised their estimate of the toxicity of bisphenol A (BPA) and, as a result, have recommended reducing the tolerable daily intake (TDI) by 20 000-fold. This would essentially ban the use of BPA in food packaging such as can liners, plastic food containers, and in consumer products. To come to this conclusion, EFSA used a systematic approach according to a pre-established protocol and included all guideline and nonguideline studies in their analysis. They found that Th-17 immune cells increased with very low exposure to BPA and used this endpoint to revise the TDI to be human health protective. A number of regulatory agencies including the European Medicines Agency (EMA) have written formal disagreements with several elements of EFSA's proposal. The European Commission will now decide whether to accept EFSA's recommendation over the objections of EMA. If the Commission accepts EFSA's recommendation, it will be a landmark action using knowledge acquired through independent scientific studies focused on biomarkers of chronic disease to protect human health. The goal of this Perspective is to clearly articulate the monumental nature of this debate and decision and to explain what is at stake. Our perspective is that the weight of evidence clearly supports EFSA's proposal to reduce the TDI by 20 000-fold.
    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/jendso/bvad107
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  9. Article ; Online: Transcriptome analysis of testis reveals the effects of developmental exposure to bisphenol a or 17α-ethinylestradiol in medaka (Oryzias latipes).

    Bhandari, Ramji K / Wang, Xuegeng / Saal, Frederick S Vom / Tillitt, Donald E

    Aquatic toxicology (Amsterdam, Netherlands)

    2020  Volume 225, Page(s) 105553

    Abstract: Endocrine disrupting chemicals (EDCs) can induce abnormalities in organisms via alteration of molecular pathways and subsequent disruption of endocrine functions. Bisphenol A (BPA) and 17α-ethinylestradiol (EE2) are ubiquitous EDCs in the environment. ... ...

    Abstract Endocrine disrupting chemicals (EDCs) can induce abnormalities in organisms via alteration of molecular pathways and subsequent disruption of endocrine functions. Bisphenol A (BPA) and 17α-ethinylestradiol (EE2) are ubiquitous EDCs in the environment. Many aquatic organisms, including fish, are often exposed to varying concentrations of BPA and EE2 throughout their lifespan. Both BPA and EE2 can activate estrogenic signaling pathways and cause adverse effects on reproduction via alteration of pathways associated with steroidogenesis. However, transcriptional pathways that are affected by chronic exposure to these two ubiquitous environmental estrogens during embryonic, larval, and juvenile stages are not clearly understood. In the present study, we examined transcriptional alterations in the testis of medaka fish (Oryzias latipes) chronically exposed to a low concentration of BPA or EE2. Medaka were exposed to BPA (10 μg/L) or EE2 (0.01 μg/L) from 8 h post-fertilization (as embryos) to adulthood 50 days post fertilization (dpf), and transcriptional alterations in the testis were examined by RNA sequencing (RNA-seq). Transcriptomic profiling revealed 651 differentially expressed genes (DEGs) between BPA-exposed and control testes, while 1475 DEGs were found between EE2-exposed and control testes. Gene ontology (GO) analysis showed a significant enrichment of "intracellular receptor signaling pathway", "response to steroid hormone" and "hormone-mediated signaling pathway" in the BPA-induced DEGs, and of "cilium organization", "microtubule-based process" and "organelle assembly" in the EE2-induced DEGs. Pathway analysis showed significant enrichment of "integrin signaling pathway" in both treatment groups, and of "cadherin signaling pathway", "Alzheimer disease-presenilin pathway" in EE2-induced DEGs. Single nucleotide polymorphism (SNP) and insertion-deletion (Indel) analysis found no significant differences in mutation rates with either BPA or EE2 treatments. Taken together, global gene expression differences in testes of medaka during early stages of gametogenesis were responsive to chronic BPA and EE2 exposure.
    MeSH term(s) Animals ; Benzhydryl Compounds/toxicity ; Endocrine Disruptors/metabolism ; Estrogens/metabolism ; Ethinyl Estradiol/metabolism ; Ethinyl Estradiol/toxicity ; Female ; Gene Expression Profiling ; Larva/drug effects ; Male ; Oryzias/physiology ; Phenols/toxicity ; Reproduction/drug effects ; Testis/drug effects ; Testis/physiology ; Water Pollutants, Chemical/toxicity
    Chemical Substances Benzhydryl Compounds ; Endocrine Disruptors ; Estrogens ; Phenols ; Water Pollutants, Chemical ; Ethinyl Estradiol (423D2T571U) ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2020-06-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 782699-0
    ISSN 1879-1514 ; 0166-445X
    ISSN (online) 1879-1514
    ISSN 0166-445X
    DOI 10.1016/j.aquatox.2020.105553
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  10. Article ; Online: Endocrine disruptors: Manmade and natural oestrogens: opposite effects on assisted reproduction.

    vom Saal, Frederick S / Welshons, Wade V

    Nature reviews. Endocrinology

    2016  Volume 12, Issue 5, Page(s) 251–252

    MeSH term(s) Benzhydryl Compounds/urine ; Diet ; Female ; Humans ; Phenols/urine ; Pregnancy ; Pregnancy Outcome ; Reproductive Techniques, Assisted ; Soy Foods
    Chemical Substances Benzhydryl Compounds ; Phenols
    Language English
    Publishing date 2016-05
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/nrendo.2016.38
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