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Article: Should We Use Unilateral or Bilateral Tasks to Assess Maximal and Explosive Knee Extensor Strength in Patients with Knee Osteoarthritis? A Cross-Sectional Study.

Pfeifle, Jonas / Hasler, David / Maffiuletti, Nicola A

2021 Volume 10, Issue 19

Abstract: Deficits in maximal and explosive knee extensor strength, which are usually assessed with unilateral tasks, are substantial in patients with knee osteoarthritis (KOA). The aim of this study was to investigate the clinical relevance of unilateral vs. ... ...

Abstract	Deficits in maximal and explosive knee extensor strength, which are usually assessed with unilateral tasks, are substantial in patients with knee osteoarthritis (KOA). The aim of this study was to investigate the clinical relevance of unilateral vs. bilateral tasks for assessing knee extensor strength in patients with KOA. This was achieved primarily by comparing unilateral and bilateral inter-limb strength asymmetries and secondarily by examining the relationship between unilaterally and bilaterally measured strength, and performance-based and self-reported function. Twenty-four patients with unilateral KOA (mean age: 65 ± 7 years) performed isometric gradual and explosive maximal voluntary contractions to assess, respectively their maximal and explosive strength. Performance-based and self-reported function were also evaluated with standard functional tests and questionnaires, respectively. Inter-limb asymmetries of maximal and explosive strength did not differ significantly between unilateral (mean asymmetry: 26 ± 15%) and bilateral tasks (22 ± 21%). In the same way, the relationships between knee extensor strength-measured either unilaterally or bilaterally-and performance-based or self-reported function were not influenced by the type of task. In conclusion, it does not seem to make a difference in terms of clinical relevance whether maximal and explosive knee extensor strength are evaluated with unilateral or bilateral tasks in KOA patients.
Language	English
Publishing date	2021-09-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10194353
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Book ; Thesis: Autoantikörper im Serum von Patienten mit rheumatischen Erkrankungen

Pfeifle, Joachim

Charakterisierung d. Autoantigene

1987

Keywords	Autoantigens ; Autoantibodies ; Rheumatic Diseases / immunology
Size	Getr. Zählung : Ill.
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Tübingen, Univ., Diss., 1987
Note	Enth. 3 Sonderabdr. aus verschiedenen Zeitschr.
HBZ-ID	HT003183405
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Does the intraoperative 3D-flat panel control of the planned implant position lead to an optimization and increased in safety in the anatomically demanding region C1/2?

Jarvers, J-S / Spiegl, U A J / Pieroh, P / von der Höh, N / Völker, A / Pfeifle, C / Glasmacher, S / Heyde, C E

BMC surgery

2023 Volume 23, Issue 1, Page(s) 37

Abstract: Background: The aim of this study was to evaluate the applicability and advantages of intraoperative imaging using a 3D flat panel in the treatment of C1/2 instabilities.: Materials: Prospective single-centered study including surgeries at the upper ... ...

Abstract	Background: The aim of this study was to evaluate the applicability and advantages of intraoperative imaging using a 3D flat panel in the treatment of C1/2 instabilities. Materials: Prospective single-centered study including surgeries at the upper cervical spine between 06/2016 and 12/2018. Intraoperatively thin K-wires were placed under 2D fluoroscopic control. Then an intraoperative 3D-scan was carried out. The image quality was assessed based on a numeric analogue scale (NAS) from 0 to 10 (0 = worst quality, 10 = perfect quality) and the time for the 3D-scan was measured. Additionally, the wire positions were evaluated regarding malpositions. Results: A total of 58 patients were included (33f, 25 m, average age 75.2 years, r.:18-95) with pathologies of C2: 45 type II fractures according to Anderson/D'Alonzo with or without arthrosis of C1/2, 2 Unhappy triad of C1/2 (Odontoid fracture Type II, anterior or posterior C1 arch-fracture, Arthrosis C1/2) 4 pathological fractures, 3 pseudarthroses, 3 instabilities of C1/2 because of rheumatoid arthritis, 1 C2 arch fracture). 36 patients were treated from anterior [29 AOTAF (combined anterior odontoid and transarticular C1/2 screw fixation), 6 lag screws, 1 cement augmented lag screw] and 22 patients from posterior (regarding to Goel/Harms). The median image quality was 8.2 (r.: 6-10). In 41 patients (70.7%) the image quality was 8 or higher and in none of the patients below 6. All of those 17 patients the image quality below 8 (NAS 7 = 16; 27.6%, NAS 6 = 1, 1.7%), had dental implants. A total of 148 wires were analyzed. 133 (89.9%) showed a correct positioning. In the other 15 (10.1%) cases a repositioning had to be done (n = 8; 5.4%) or it had to be drawn back (n = 7; 4.7%). A repositioning was possible in all cases. The implementation of an intraoperative 3D-Scan took an average of 267 s (r.: 232-310 s). No technical problems occurred. Conclusion: Intraoperative 3D imaging in the upper cervical spine is fast and easy to perform with sufficient image quality in all patients. Potential malposition of the primary screw canal can be detected by initial wire positioning before the Scan. The intraoperative correction was possible in all patients. Trial registration German Trials Register (Registered 10 August 2021, DRKS00026644-Trial registration: German Trials Register (Registered 10 August 2021, DRKS00026644- https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00026644 ).
MeSH term(s)	Aged ; Humans ; Bone Cements ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Fractures, Bone ; Odontoid Process/injuries ; Osteoarthritis ; Prospective Studies ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/surgery ; Spinal Fusion/methods
Chemical Substances	Bone Cements
Language	English
Publishing date	2023-02-18
Publishing country	England
Document type	Evaluation Study ; Journal Article
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-023-01934-7
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Article ; Online: An unusual presentation of cutaneous metastatic lobular breast carcinoma.

Nahhas, Amanda F / Scales, Andrew T / Pfeifle, Julie / Stephenson, Sean R

Cutis

2021 Volume 107, Issue 1, Page(s) E23–E26

Abstract: Breast cancer is the most common malignancy to metastasize to the skin in women. Cutaneous breast carcinoma may arise as cutaneous metastasis or secondary to direct tumor extension to the skin. This report describes an unusual presentation of cutaneous ... ...

Abstract	Breast cancer is the most common malignancy to metastasize to the skin in women. Cutaneous breast carcinoma may arise as cutaneous metastasis or secondary to direct tumor extension to the skin. This report describes an unusual presentation of cutaneous metastatic lobular breast carcinoma that involved diffuse cutaneous lesions and rapid progression from onset of breast mass to development of clinically apparent metastatic skin lesions.
MeSH term(s)	Breast ; Breast Neoplasms/diagnosis ; Carcinoma, Lobular/diagnosis ; Female ; Humans ; Skin ; Skin Neoplasms/diagnosis
Language	English
Publishing date	2021-08-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	391840-3
ISSN	2326-6929 ; 0011-4162 ; 0151-9522
ISSN (online)	2326-6929
ISSN	0011-4162 ; 0151-9522
DOI	10.12788/cutis.0162
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Zs.B 1315: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Successful conversion of simulation-based interprofessional education in a pandemic.

Romito, Laura M / Pfeifle, Andrea L / Weber, Zachary A / Daulton, Brittany J

Journal of dental education

2020

Keywords	covid19
Language	English
Publishing date	2020-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	410579-5
ISSN	1930-7837 ; 0022-0337
ISSN (online)	1930-7837
ISSN	0022-0337
DOI	10.1002/jdd.12328
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Zs.A 428: Show issues

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Article ; Online: Pursuing Scholarship: Creating Effective Conference Submissions.

Culmer, Nathan / Drowos, Joanna / DeMasi, Monica / Kenyon, Tina / Figueroa, Edgar / Pfeifle, Andrea / Malaty, John / Schneider, F David / Hartmark-Hill, Jennifer

PRiMER (Leawood, Kan.)

2024 Volume 8, Page(s) 13

Abstract: Medical educators are expected to disseminate peer-reviewed scholarly work for academic promotion and tenure. However, developing submissions for presentations at national meetings can be confusing and sometimes overwhelming. Awareness and use of some ... ...

Abstract	Medical educators are expected to disseminate peer-reviewed scholarly work for academic promotion and tenure. However, developing submissions for presentations at national meetings can be confusing and sometimes overwhelming. Awareness and use of some best practices can demystify the process and maximize opportunities for acceptance for a variety of potential submission categories. This article outlines logistical steps and best practices for each stage of the conference submission process that faculty should consider when preparing submissions. These include topic choice, team composition, consideration of different submission types, and strategies for effectively engaging participants.
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Journal Article
ISSN	2575-7873
ISSN (online)	2575-7873
DOI	10.22454/PRiMER.2024.345782
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Article ; Online: Reliability of Peer Review of Abstracts Submitted to Academic Family Medicine Meetings.

Fenton, Joshua J / Tapp, Hazel / Thakur, Netra M / Pfeifle, Andrea L

Journal of the American Board of Family Medicine : JABFM

2020 Volume 33, Issue 6, Page(s) 986–991

Abstract: Purpose: To assess the reliability of peer review of abstracts submitted to academic family medicine meetings in North America.: Methods: We analyzed reviewer ratings of abstracts submitted: 1) as oral presentations to the North American Primary Care ...

Abstract	Purpose: To assess the reliability of peer review of abstracts submitted to academic family medicine meetings in North America. Methods: We analyzed reviewer ratings of abstracts submitted: 1) as oral presentations to the North American Primary Care Research Group (NAPCRG) meeting from 2016 to 2019, as well as 2019 poster session or workshop submissions; and 2) in 12 categories to the Society of Teachers of Family Medicine (STFM) Spring 2018 meeting. In each category and year, we used a multi-level mixed model to estimate the abstract-level intraclass correlation coefficient (ICC) and the reliability of initial review (using the abstract-level ICC and the number of reviewers per abstract). Results: We analyzed review data for 1554 NAPCRG oral presentation abstracts, 418 NAPCRG poster or workshop abstracts, and 1145 STFM abstracts. Across all years, abstract-level ICCs for NAPCRG oral presentations were below 0.20 (range, 0.10 in 2019 to 0.18 in 2016) and were even lower for posters and workshops (range, 0.00-0.10). After accounting for the number of reviewers per abstract, reliabilities of initial review for NAPCRG oral presentations ranged from 0.24 in 2019 to 0.30 in 2016 and 0.00 to 0.18 for posters and workshops in 2019. Across 12 STFM submission categories, the median abstract-level ICC was 0.21 (range, 0.12-0.50) and the median reliability was 0.42 (range, 0.25-0.78). Conclusions: For abstracts submitted to North American academic family medicine meetings, inter-reviewer agreement is often low, compromising initial review reliability. For many submission categories, program committees should supplement initial review with independent postreview assessments.
MeSH term(s)	Family Practice ; Humans ; Peer Review ; Reproducibility of Results ; Societies, Medical
Language	English
Publishing date	2020-10-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2239939-2
ISSN	1558-7118 ; 1557-2625
ISSN (online)	1558-7118
ISSN	1557-2625
DOI	10.3122/jabfm.2020.06.200123
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Zs.A 2626: Show issues

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Article ; Online: Intrahepatic mucinous cholangiocarcinoma with recurrent colic in a horse: case report and literature review of cholangiocarcinoma in horses.

Barrantes Murillo, Daniel Felipe / Cattley, Russell C / Cullen, John M / Withers, Cornelius / Towns, Jordan / Pfeifle, Rachel / Wooldridge, Anne / Neto, Rachel L A L T

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

2024 , Page(s) 10406387241245775

Abstract: A 17-y-old Arabian mare was presented to the Auburn Large Animal Veterinary Teaching Hospital with a long-term history of intermittent mild recurrent colic that responded to medical treatment. CBC revealed mild lymphopenia; serum biochemistry findings ... ...

Abstract	A 17-y-old Arabian mare was presented to the Auburn Large Animal Veterinary Teaching Hospital with a long-term history of intermittent mild recurrent colic that responded to medical treatment. CBC revealed mild lymphopenia; serum biochemistry findings were of increased gamma-glutamyl transferase and creatine kinase activities, hyperferremia, hyperglycemia, hypomagnesemia, and hypokalemia. Abdominocentesis was compatible with low-protein transudate. Due to the progression and duration of clinical signs, the owner elected euthanasia. Postmortem examination and histopathology confirmed a cholangiocarcinoma. The neoplastic cells were arranged in large cysts containing lakes of mucin that comprised 90% of the tumor volume; thus, a mucinous variant was determined. The neoplastic cells had strong cytoplasmic immunolabeling for cytokeratin 19 and lacked immunolabeling for hepatocyte paraffin 1, supporting bile duct origin. Cholangiocarcinomas are infrequent tumors in horses with nonspecific and slow progressive clinical signs, including recurrent colic. Mucinous cholangiocarcinomas are seldom reported in veterinary medicine and, to our knowledge, have not been reported previously in horses.
Language	English
Publishing date	2024-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/10406387241245775
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Article ; Online: Impact of Multifidus Muscle Atrophy on the Occurrence of Secondary Symptomatic Adjacent Osteoporotic Vertebral Compression Fractures.

Osterhoff, Georg / Asatryan, Garnik / Spiegl, Ulrich J A / Pfeifle, Christian / Jarvers, Jan-Sven / Heyde, Christoph-E

Calcified tissue international

2021 Volume 110, Issue 4, Page(s) 421–427

Abstract: To assess the potential influence of multifidus atrophy and fatty degeneration on the incidence of adjacent vertebral compression fractures within one year after the index fracture. In a retrospective cohort study, patients who underwent surgery for an ... ...

Abstract	To assess the potential influence of multifidus atrophy and fatty degeneration on the incidence of adjacent vertebral compression fractures within one year after the index fracture. In a retrospective cohort study, patients who underwent surgery for an OVCF were identified and baseline characteristics, fracture patterns and the occurrence of secondary adjacent fractures within one year were obtained by chart review. Multifidus muscle atrophy and fatty degeneration were determined on preoperative MRI or CT scans. In this analysis of 191 patients (mean age 77 years, SD 8, 116 female), OF type 3 was the most common type of OVCF (49.2%). Symptomatic adjacent OVCFs within one year after index fracture were observed in 23/191 patients (12%) at mean 12, SD 12 weeks (range 1-42 weeks) postoperatively. The mean multifidus muscle area was 264, SD 53 mm
MeSH term(s)	Aged ; Female ; Fractures, Compression/complications ; Humans ; Kyphoplasty/adverse effects ; Male ; Muscular Atrophy/complications ; Osteoporotic Fractures/complications ; Osteoporotic Fractures/epidemiology ; Paraspinal Muscles ; Retrospective Studies ; Spinal Fractures/complications ; Spinal Fractures/epidemiology ; Treatment Outcome
Language	English
Publishing date	2021-10-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304266-2
ISSN	1432-0827 ; 0944-0747 ; 0008-0594 ; 0171-967X
ISSN (online)	1432-0827
ISSN	0944-0747 ; 0008-0594 ; 0171-967X
DOI	10.1007/s00223-021-00925-1
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Zs.A 317: Show issues

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Article ; Online: Does time-to-surgery affect mortality in patients with acute osteoporotic vertebral compression fractures?

Pfeifle, Christian / Kohut, Petr / Jarvers, Jan-Sven / Spiegl, Ulrich J / Heyde, Christoph-Eckhard / Osterhoff, Georg

BMC geriatrics

2021 Volume 21, Issue 1, Page(s) 714

Abstract: Introduction: Osteoporotic vertebral compression fractures (VCFs) are common. An increase in mortality associated with osteoporotic VCFs has been well documented. The purpose of this study was to assess the impact of time to surgery on 1-year survival ... ...

Abstract	Introduction: Osteoporotic vertebral compression fractures (VCFs) are common. An increase in mortality associated with osteoporotic VCFs has been well documented. The purpose of this study was to assess the impact of time to surgery on 1-year survival in patients with osteoporotic vertebral compression fractures. Methods: In a retrospective cohort study with prospective mortality follow-up, consecutive patients aged ≥ 60 years who had operative treatment of a low-energy fracture of a thoracolumbar vertebra and had undergone surgical stabilization between January 2015 and December 2018 were identified from our institutional database. By chart review, additional information on hospitalization time, comorbidities (expressed as ASA - American Society of Anesthesiologists Scale), complications and revision surgery was obtained. Time-to-surgery was defined as the time between admission and surgery. Mortality data was assessed by contacting the patients by phone, mail or the national social insurance database. Results: Two hundred sixty patients (mean age 78 years, SD 7 years, range, 60 to 93; 172 female) were available for final analysis. Mean follow-up was 40 months (range, 12 to 68 months). Fifty-nine patients (22.7%) had died at final follow-up and 27/260 patients (10.4%) had died within 1 year after the surgery. Time-to-surgery was not different for patients who died within 1 year after the surgery and those who survived (p = .501). In-hospital complications were seen in 40/260 (15.4%) patients. Time-to-surgery showed a strong correlation with hospitalization time (Pearson's r = .614, p < .001), but only a very weak correlation with the time spent in hospital after the surgery (Pearson's r = .146, p = .018). Conclusions: In contrast to patients with proximal femur factures, time-to-surgery had no significant effect on one-year mortality in geriatric patients with osteoporotic vertebral compression fractures. Treatment decisions for these fractures in the elderly should be individualized.
MeSH term(s)	Aged ; Female ; Fractures, Compression/surgery ; Humans ; Osteoporotic Fractures/surgery ; Prospective Studies ; Retrospective Studies ; Spinal Fractures/surgery ; Spine ; Treatment Outcome
Language	English
Publishing date	2021-12-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-021-02682-0
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