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Article: Jia-ga-song-tang protection against alcoholic liver and intestinal damage.

Fang, Jiamin / Wu, Yuhuan / Gan, Changlian / Ruan, Shufang / He, Xiaoliang / Wang, Bixia / Wang, Ying / Yu, Jingtao / Sang, Chuanlan / Zeren, Dawa / Xiong, Tianqin

Frontiers in pharmacology

2022 Volume 13, Page(s) 981706

Abstract: ... We investigated whether the beneficial effects and underlying mechanisms of Jia-ga-song Tang (JGST) against ALD ... the relationship between Jia-Ga-Song-Tang (JGST) and alcoholic liver disease (ALD) was designed by Network ...

Abstract	Gut-liver axis and cellular homeostasis play key roles in alcohol liver disease (ALD). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a stress-sensitive guarantor of cellular homeostasis. We investigated whether the beneficial effects and underlying mechanisms of Jia-ga-song Tang (JGST) against ALD were associated with gut-liver axis and cellular homeostasis. A predictive network depicting the relationship between Jia-Ga-Song-Tang (JGST) and alcoholic liver disease (ALD) was designed by Network pharmacology. Next, 5% v/v Lieber-DeCarli alcohol liquid diet was used to establish the ALD. JGST protected the liver damage, repaired the intestines to alleviate the Two-hit on the liver, and balanced the cellular homeostasis. It was manifested in repairing the liver and intestinal pathological structure, reducing serum ALT, AST, and liver TG, TC, MDA, CAT, and increasing liver GSH, and intestine GSH-Px. JGST mainly inhibited the liver mRNA levels of HO-1, NQO1, GCLC, FASN, and PPARα and activated the intestinal mRNA levels of HO-1 and NQO1, while inhibiting the liver protein levels of HO-1, NQO1. Furthermore, LPS and LBP in the plasma and the expression of inflammatory factors such as IL-1β, TNF-α, IL-6, TGFβ1, CD14, and Myd88 were reduced after treatment to prove that JGST protects the liver from Two-hit. Ethanol was used to intervene in HepG2 and IEC-6 to establish an ALD cell model and treated by Germacrone, ML385, and TBHQ. repaired the intestinal barrier, and inhibited Nrf2 in IEC-6, but protect the HepG2 by activating Nrf2 to balance cellular homeostasis. Our results reinforce that JGST provides an effective protective method for alcoholic liver disease (ALD) by regulating Gut-liver axis and cellular homeostasis.
Language	English
Publishing date	2022-09-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.981706
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Article ; Online: The risk of uveitis in patients with JIA receiving etanercept: the challenges of analysing real-world data.

Davies, Rebecca / De Cock, Diederik / Kearsley-Fleet, Lianne / Southwood, Taunton / Baildam, Eileen / Beresford, Michael W / Foster, Helen E / Thomson, Wendy / Ramanan, Athimalaipet V / Hyrich, Kimme L

Rheumatology (Oxford, England)

2019 Volume 59, Issue 6, Page(s) 1391–1397

Abstract: Objectives: To describe and compare the occurrence of newly diagnosed uveitis in children with JIA ... within UK JIA registries (British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study ... to compare the rate of new onset uveitis across the three main anti-TNF therapies used in JIA, a new ...

Abstract	Objectives: To describe and compare the occurrence of newly diagnosed uveitis in children with JIA receiving MTX, etanercept, adalimumab and infliximab. Methods: This on-drug analysis included patients within UK JIA registries (British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study and Biologics for Children with Rheumatic Diseases) with non-systemic disease, registered at MTX or biologic start with no history of uveitis. Follow-up began from date of first treatment, continuing until first uveitis, discontinuation of registered drug, most recent follow-up up or death, whichever came first. Hazard ratios comparing risk of uveitis between drugs were calculated using propensity-adjusted Cox regression. Results: A total of 2294 patients were included (943 MTX, 304 adalimumab/infliximab, 1047 etanercept). There were 44 reported cases of uveitis (27 MTX, 16 etanercept, 1 adalimumab). Unadjusted hazard ratio showed a reduced risk of uveitis in biologic cohorts compared with MTX. After adjusting for propensity deciles, there was no significant difference in the risk of uveitis between patients receiving etanercept or MTX [hazard ratio 0.5 (0.2-1.1)]. Fully adjusted comparisons were not possible for adalimumab/infliximab as there were too few events. Conclusions: In this first paper to compare the rate of new onset uveitis across the three main anti-TNF therapies used in JIA, a new diagnosis of uveitis is less common among patients starting biologics compared with MTX, although this did not reach statistical significance. The suggested protective effect of etanercept is likely explained by confounding, whereby patients in the MTX cohort are younger and earlier in disease, and therefore at greater risk of developing uveitis compared with etanercept patients.
MeSH term(s)	Adalimumab/adverse effects ; Adolescent ; Antirheumatic Agents/adverse effects ; Arthritis, Juvenile/drug therapy ; Biological Products/adverse effects ; Child ; Child, Preschool ; Cohort Studies ; Etanercept/adverse effects ; Female ; Humans ; Infliximab/adverse effects ; Male ; Methotrexate/adverse effects ; Proportional Hazards Models ; Registries ; Risk Factors ; Tumor Necrosis Factor Inhibitors/adverse effects ; United Kingdom/epidemiology ; Uveitis/chemically induced ; Uveitis/epidemiology
Chemical Substances	Antirheumatic Agents ; Biological Products ; Tumor Necrosis Factor Inhibitors ; Infliximab (B72HH48FLU) ; Adalimumab (FYS6T7F842) ; Etanercept (OP401G7OJC) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2019-10-11
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kez449
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Article ; Online: Homaliodendron pulchrum L. Y. Pei & Y. Jia, new to Guizhou Province, China

ZHANG Yongchang / LI Dandan / HUANG Ruoling / HE Lin / GUO Shuiliang

Journal of Shanghai Normal University (Natural Sciences), Vol 49, Iss 4, Pp 394-

2020 Volume 397

Abstract: Homaliodendron pulchrum L. Y. Pei & Y. Jia was described as a new species from Guangxi, Hunan and ...

Abstract	Homaliodendron pulchrum L. Y. Pei & Y. Jia was described as a new species from Guangxi, Hunan and Sichuan Provinces, China in 2011.We found the species was new to Guizhou Province based on a specimen collected from the Maolan National Nature Reserve.Detailed descriptions and an ink drawing of the species are provided, and a key on Homaliodendron in Guizhou was also presented.
Keywords	bryophyte ; new record ; homaliodendron pulchrum ; guizhou ; maolan ; Science (General) ; Q1-390
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	Academic Journals Center of Shanghai Normal University
Document type	Article ; Online
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Article ; Online: Treatment prescribing patterns in patients with juvenile idiopathic arthritis (JIA): Analysis from the UK Childhood Arthritis Prospective Study (CAPS).

Davies, Rebecca / Carrasco, Roberto / Foster, Helen E / Baildam, Eileen M / Chieng, S E Alice / Davidson, Joyce E / Ioannou, Yiannis / Wedderburn, Lucy R / Thomson, Wendy / Hyrich, Kimme L

Seminars in arthritis and rheumatism

2016 Volume 46, Issue 2, Page(s) 190–195

Abstract: Objective: Initial treatment of juvenile idiopathic arthritis (JIA) is largely based on the extent ... of joint involvement, disease severity and ILAR category. The licensing of biologic therapies for JIA has ... expanded treatment options. The aims of the study are (1) to describe treatment prescribing patterns in JIA ...

Abstract	Objective: Initial treatment of juvenile idiopathic arthritis (JIA) is largely based on the extent of joint involvement, disease severity and ILAR category. The licensing of biologic therapies for JIA has expanded treatment options. The aims of the study are (1) to describe treatment prescribing patterns in JIA over the first 3 years following first presentation to paediatric rheumatology and (2) to determine whether patterns of treatment have changed as biologics have become more widely available. Methods: Children with at least 3 years of follow-up within the Childhood Arthritis Prospective Study (CAPS) were included. For analysis, children were placed into one of five groups according to their initial presentation to paediatric rheumatology: oligoarthritis (oJIA), polyarthritis (pJIA), systemic (sJIA), enthesitis-related arthritis (ERA) and psoriatic arthritis (PsA). Treatment patterns over 3 years were described. Results: Of 1051 children, 58% received synthetic disease-modifying anti-rheumatic drugs (sDMARD) and 20% received biologics over the 3 years. Use of sDMARDs and biologics was higher in more severe disease presentations (sJIA and pJIA); however, 35% and 10% who presented with oJIA were also treated with sDMARDs and biologics, respectively. The number of children receiving sDMARD after 2006 was higher (p = 0.02); however, there was no difference in biologic prescribing before and after 2006 (p = 0.4). Conclusions: A high proportion of children presenting with JIA received sDMARDs plus/minus biologics during 3 years of follow-up. This was most common for patients with severe JIA but was also prescribed for patients with oligoarticular disease, despite the lack of evidence for effectiveness in this category.
MeSH term(s)	Adolescent ; Antirheumatic Agents/therapeutic use ; Arthritis, Juvenile/diagnosis ; Arthritis, Juvenile/drug therapy ; Biological Products/therapeutic use ; Child ; Child, Preschool ; Drug Prescriptions ; Female ; Humans ; Male ; Practice Patterns, Physicians' ; Prospective Studies ; Severity of Illness Index ; Treatment Outcome ; United Kingdom
Chemical Substances	Antirheumatic Agents ; Biological Products
Language	English
Publishing date	2016-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120247-9
ISSN	1532-866X ; 0049-0172
ISSN (online)	1532-866X
ISSN	0049-0172
DOI	10.1016/j.semarthrit.2016.06.001
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Article: Fluoreszenzoptisches Bildgebungssystem Xiralite zur Einschätzung der Therapieeffizienz bei JIA

Horneff, G. / Werner, S. G. / Langer, H. E. / Backhaus, M.

Arthritis + Rheuma

2012 Volume 32, Issue 1, Page(s) 42

Language	German
Document type	Article
ZDB-ID	605764-0
ISSN	0176-5167
Database	Current Contents Medicine

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Article: Fluoreszenzoptisches Bildgebungssystem Xiralite® zur Einschätzung der Therapieeffizienz bei JIA

Horneff, G. / Werner, S. G. / Langer, H. E. / Backhaus, M.

Arthritis und Rheuma

2012 Volume 32, Issue 01, Page(s) 42–44

Language	German
Publishing date	2012-01-01
Publisher	Schattauer GmbH
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2223481-0
ISSN	2567-5753 ; 0176-5167
ISSN (online)	2567-5753
ISSN	0176-5167
DOI	10.1055/s-0037-1618103
Database	Thieme publisher's database

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Article ; Online: Estimating Forest Aboveground Carbon Storage in Hang-Jia-Hu Using Landsat TM/OLI Data and Random Forest Model

Meng Zhang / Huaqiang Du / Guomo Zhou / Xuejian Li / Fangjie Mao / Luofan Dong / Junlong Zheng / Hua Liu / Zihao Huang / Shaobai He

Forests, Vol 10, Iss 11, p

2019 Volume 1004

Abstract: ... Forest (RF) algorithm to estimate the forest aboveground carbon (AGC) in a forest area in China (Hang-Jia ...

Abstract	Dynamic monitoring of carbon storage in forests resources is important for tracking ecosystem functionalities and climate change impacts. In this study, we used multi-year Landsat data combined with a Random Forest (RF) algorithm to estimate the forest aboveground carbon (AGC) in a forest area in China (Hang-Jia-Hu) and analyzed its spatiotemporal changes during the past two decades. Maximum likelihood classification was applied to make land-use maps. Remote sensing variables, such as the spectral band, vegetation indices, and derived texture features, were extracted from 20 Landsat TM and OLI images over five different years (2000, 2004, 2010, 2015, and 2018). These variables were subsequently selected according to their importance and subsequently used in the RF algorithm to build an estimation model of forest AGC. The results showed the following: (1) Verification of classification results showed maximum likelihood can extract land information effectively. Our land cover classification yielded overall accuracies between 86.86% and 89.47%. (2) Additionally, our RF models showed good performance in predicting forest AGC, with R 2 from 0.65 to 0.73 in the training and testing phase and a RMSE range between 3.18 and 6.66 Mg/ha. RMSEr in the testing phase ranged from 20.27 to 22.27 with a low model error. (3) The estimation results indicated that forest AGC in the past two decades increased with density at 10.14 Mg/ha, 21.63 Mg/ha, 26.39 Mg/ha, 29.25 Mg/ha, and 44.59 Mg/ha in 2000, 2004, 2010, 2015, and 2018. The total forest AGC storage had a growth rate of 285%. (4) Our study showed that, although forest area decreased in the study area during the time period under study, the total forest AGC increased due to an increment in forest AGC density. However, such an effect is overridden in the vicinity of cities by intense urbanization and the loss of forest covers. Our study demonstrated that the combined use of remote sensing data and machine learning techniques can improve our ability to track the forest changes ...
Keywords	landsat dataset ; forest agc estimation ; random forest ; spatiotemporal evolution ; Plant ecology ; QK900-989
Subject code	333
Language	English
Publishing date	2019-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Estimating Forest Aboveground Carbon Storage in Hang-Jia-Hu Using Landsat TM/OLI Data and Random Forest Model

Zhang, Meng / Du, Huaqiang / Zhou, Guomo / Li, Xuejian / Mao, Fangjie / Dong, Luofan / Zheng, Junlong / Liu, Hua / Huang, Zihao / He, Shaobai

Forests. 2019 Nov. 09, v. 10, no. 11

2019

Abstract: ... Forest (RF) algorithm to estimate the forest aboveground carbon (AGC) in a forest area in China (Hang-Jia ...

Abstract	Dynamic monitoring of carbon storage in forests resources is important for tracking ecosystem functionalities and climate change impacts. In this study, we used multi-year Landsat data combined with a Random Forest (RF) algorithm to estimate the forest aboveground carbon (AGC) in a forest area in China (Hang-Jia-Hu) and analyzed its spatiotemporal changes during the past two decades. Maximum likelihood classification was applied to make land-use maps. Remote sensing variables, such as the spectral band, vegetation indices, and derived texture features, were extracted from 20 Landsat TM and OLI images over five different years (2000, 2004, 2010, 2015, and 2018). These variables were subsequently selected according to their importance and subsequently used in the RF algorithm to build an estimation model of forest AGC. The results showed the following: (1) Verification of classification results showed maximum likelihood can extract land information effectively. Our land cover classification yielded overall accuracies between 86.86% and 89.47%. (2) Additionally, our RF models showed good performance in predicting forest AGC, with R2 from 0.65 to 0.73 in the training and testing phase and a RMSE range between 3.18 and 6.66 Mg/ha. RMSEr in the testing phase ranged from 20.27 to 22.27 with a low model error. (3) The estimation results indicated that forest AGC in the past two decades increased with density at 10.14 Mg/ha, 21.63 Mg/ha, 26.39 Mg/ha, 29.25 Mg/ha, and 44.59 Mg/ha in 2000, 2004, 2010, 2015, and 2018. The total forest AGC storage had a growth rate of 285%. (4) Our study showed that, although forest area decreased in the study area during the time period under study, the total forest AGC increased due to an increment in forest AGC density. However, such an effect is overridden in the vicinity of cities by intense urbanization and the loss of forest covers. Our study demonstrated that the combined use of remote sensing data and machine learning techniques can improve our ability to track the forest changes in support of regional natural resource management practices.
Keywords	Landsat ; algorithms ; artificial intelligence ; carbon ; carbon sequestration ; cities ; climate change ; ecosystems ; forests ; land cover ; land use ; models ; monitoring ; prediction ; remote sensing ; spatial data ; statistical analysis ; texture ; urbanization ; vegetation index ; China
Language	English
Dates of publication	2019-1109
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f10111004
Database	NAL-Catalogue (AGRICOLA)

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Article: [The clinical study on decompensatory cirrhotic patients treated by Bie Jia Jian].

Wang, Yong-Ze / Yang, Hong-Zhi / Lin, Bing-Liang / Xie, He-Ping / Li, Yong-Wei / Dai, Min

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

2007 Volume 30, Issue 6, Page(s) 755–757

Abstract: ... by Bie Jia Jian.: Methods: 98 decompensatory cirrhotic patients were randomly divided into two groups ... western medicine of protecting and supporting liver. Except that, treatment group were treated by Bie Jia ... than those in control group (P < 0. 05).: Conclusion: Bie Jia Jian is effective in treating decompesatory cirrhotic ...

Abstract	Objective: To observe the clinical curative effect on decompensatory cirrhotic patients treated by Bie Jia Jian. Methods: 98 decompensatory cirrhotic patients were randomly divided into two groups: 49 patients in treatment group and 49 in control group. Both groups were treated with the same western medicine of protecting and supporting liver. Except that, treatment group were treated by Bie Jia Jian. Results: The Contents of AST, ALT, total bilirubin (TB), direct bilirubin (DB), hyaluronic acid (HA), Laminin (LN) , procollagen III (pc III), and type IV collagen (IV.C) in both groups decreased after treatment, and prothrombin time activity (PTA) increased. Among them, the decrease of TB, DB, HA, LN, PC-III and IV-C, and the increase of PTA in treatment group were more obvious than those in control group (P < 0. 05). Conclusion: Bie Jia Jian is effective in treating decompesatory cirrhotic patients.
MeSH term(s)	Adult ; Alanine Transaminase/blood ; Aspartate Aminotransferases/blood ; Biomarkers/blood ; Collagen Type III/blood ; Drug Combinations ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Hyaluronic Acid/blood ; Laminin/blood ; Liver Cirrhosis/blood ; Liver Cirrhosis/drug therapy ; Liver Function Tests ; Male ; Middle Aged ; Phytotherapy ; Treatment Outcome
Chemical Substances	Biomarkers ; Collagen Type III ; Drug Combinations ; Drugs, Chinese Herbal ; Laminin ; bie jia jian ; Hyaluronic Acid (9004-61-9) ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2)
Language	Chinese
Publishing date	2007-06
Publishing country	China
Document type	English Abstract ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	1001-4454
ISSN	1001-4454
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Article: Type and extent of enamel defects in juvenile idiopathic arthritis (JIA).

Welbury, R R / Thomason, J M / Fitzgerald, J L / Steen, I N / Foster, H E

European journal of paediatric dentistry

2002 Volume 3, Issue 4, Page(s) 217–221

Abstract: ... with Juvenile Idiopathic Arthritis (JIA) in patients in the North of England.: Study design: clinical examination of subjects and ... of defects and no greater extent of them in subjects with JIA compared with age and sex matched controls. ...

Abstract	Aim: To establish whether there is an increased prevalence and extent of enamel defects associated with Juvenile Idiopathic Arthritis (JIA) in patients in the North of England. Study design: clinical examination of subjects and age and sex matched controls. Methods: The labial surfaces of all erupted permanent teeth in subjects, as well as age and sex matched controls, were examined. They were classified for type and extent of defects according to the Modified DDE index. The records of 146 subjects and 142 controls were available for analysis. Statistics: defects were expressed as the percentage of subjects or controls with or without any defects or specific types of defect. Fisher's exact test was used to compare the prevalence of disease in the two groups with significance being accepted at the 5% level. In addition, 95% confidence intervals for the relative risk of disease in the two groups were derived. Results: There was no significant difference between subjects and controls for the presence of any type of defect (p=0.48), demarcated opacities (p=0.39), diffuse opacities (p=0.71), or hypoplasias (p=0.19). There was no significant increase in severity of defects in subjects compared with controls. There was also no significant difference when comparing the group diagnosed before the age of 4 (0-3) and the group diagnosed after the age of 4 (>4) years. Conclusion: There was no greater overall prevalence of enamel defects or specific type of defects and no greater extent of them in subjects with JIA compared with age and sex matched controls.
Language	English
Publishing date	2002-07-24
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2035588-9
ISSN	2035-648X ; 1591-996X
ISSN (online)	2035-648X
ISSN	1591-996X
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