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Article ; Online: Novel interactive text-messaging curriculum for endocrinology board review.

Majety, Priyanka / Ajayi, Ayodele / Modest, Anna M / Vamvini, Maria / Freed, Jason A

Journal of clinical & translational endocrinology

2023 Volume 34, Page(s) 100326

Abstract: Background: The ABIM certification exam is one of the measures to ensure that physicians have the clinical skills for good care delivery. The 5-year average pass rate for ABIM Endocrinology exam is 82%. The pass rate significantly decreased to a nadir ... ...

Abstract	Background: The ABIM certification exam is one of the measures to ensure that physicians have the clinical skills for good care delivery. The 5-year average pass rate for ABIM Endocrinology exam is 82%. The pass rate significantly decreased to a nadir of 74% in 2021 and 2022, lowest of all medicine subspecialties. Objectives: To assess the feasibility of text messaging curriculum for fellows and its utility in improving their test performance. Methods: In 2021, endocrinology fellows from 51 programs across the country were invited to participate in our curriculum. They completed a pre-test, joined a texting group via Remind application and received 1 multiple choice question daily (total n = 78). After 15 weeks, they completed a post-test and survey. Paired results from pre- and post-test were compared. Results: A total of 89 fellows from 27 programs responded. Of these, 82 fellows, predominantly females (n = 60; 73 %), filled out the pre-test. On an average, 42 fellows (SD = 12) responded to the questions daily and 57 % of them answered the questions within 24 h. Thirty fellows completed the post-test. The median number of correct responses on the pre-test was 5 (IQR 3-6), compared to 8 (IQR 6-9) in the post-test. There was a significant improvement (p-value < 0.0001) in fellows' performance in the post-test when compared with the pre-test following our intervention. Conclusions: Text-messaging based curriculum for exam preparation is feasible and can improve test performance. Fellows find receiving a daily high yield multiple choice question via text-message as a useful tool for exam preparation.
Language	English
Publishing date	2023-09-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2834222-7
ISSN	2214-6237 ; 2214-6237
ISSN (online)	2214-6237
ISSN	2214-6237
DOI	10.1016/j.jcte.2023.100326
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Characteristics and Diabetes Control in Adults With Type 1 Diabetes Admitted With COVID-19 Infection.

Vamvini, Maria / Lioutas, Vasileios-Arsenios / Middelbeek, Roeland J W

Diabetes care

2020 Volume 43, Issue 10, Page(s) e120–e122

MeSH term(s)	Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Diabetes Mellitus, Type 1 ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-08-07
Publishing country	United States
Document type	Research Support, N.I.H., Extramural ; Journal Article
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc20-1540
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1434: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 365: Show issues

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Article ; Online: Moderate-intensity endurance training improves late phase β-cell function in adults with type 2 diabetes.

Zhang, Hui / Simpson, Laura K / Carbone, Nicholas P / Hirshman, Michael F / Nigro, Pasquale / Vamvini, Maria / Goodyear, Laurie J / Middelbeek, Roeland J W

iScience

2023 Volume 26, Issue 7, Page(s) 107226

Abstract: Physical activity is important for type 2 diabetes treatment, yet the underlying mechanisms for these beneficial effects of exercise are not fully understood. Here, we investigated the effects of exercise training on biphasic β-cell insulin secretory ... ...

Abstract	Physical activity is important for type 2 diabetes treatment, yet the underlying mechanisms for these beneficial effects of exercise are not fully understood. Here, we investigated the effects of exercise training on biphasic β-cell insulin secretory function, a key factor regulating blood glucose. Adults with type 2 diabetes (7F/3M, age 49 ± 5 years, BMI 30 ± 3 kg/m
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.107226
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Exercise Training and Cold Exposure Trigger Distinct Molecular Adaptations to Inguinal White Adipose Tissue.

Vamvini, Maria / Nigro, Pasquale / Caputo, Tiziana / Stanford, Kristin I / Hirshman, Michael F / Middelbeek, Roeland J W / Goodyear, Laurie J

bioRxiv : the preprint server for biology

2023

Abstract: Exercise training and cold exposure both improve systemic metabolism, but the mechanisms are not well-established. We tested the hypothesis that adaptations to inguinal white adipose tissue (iWAT) are critical for these beneficial effects by determining ... ...

Abstract	Exercise training and cold exposure both improve systemic metabolism, but the mechanisms are not well-established. We tested the hypothesis that adaptations to inguinal white adipose tissue (iWAT) are critical for these beneficial effects by determining the impact of exercise-trained and cold-exposed iWAT on systemic glucose metabolism and the iWAT proteome and secretome. Transplanting trained iWAT into sedentary mice improved glucose tolerance, while cold-exposed iWAT transplantation showed no such benefit. Compared to training, cold led to more pronounced alterations in the iWAT proteome and secretome, downregulating >2,000 proteins but also boosting iWAT's thermogenic capacity. In contrast, only training increased extracellular space and vesicle transport proteins, and only training upregulated proteins that correlate with favorable fasting glucose, suggesting fundamental changes in trained iWAT that mediate tissue-to-tissue communication. This study defines the unique exercise training- and cold exposure-induced iWAT proteomes, revealing distinct mechanisms for the beneficial effects of these interventions on metabolic health.
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.16.562635
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Article ; Online: Novel interactive text-messaging curriculum for endocrinology board review

Priyanka Majety / Ayodele Ajayi / Anna M. Modest / Maria Vamvini / Jason A. Freed

Journal of Clinical & Translational Endocrinology, Vol 34, Iss , Pp 100326- (2023)

2023

Abstract	Background: The ABIM certification exam is one of the measures to ensure that physicians have the clinical skills for good care delivery. The 5-year average pass rate for ABIM Endocrinology exam is 82%. The pass rate significantly decreased to a nadir of 74% in 2021 and 2022, lowest of all medicine subspecialties. Objectives: To assess the feasibility of text messaging curriculum for fellows and its utility in improving their test performance. Methods: In 2021, endocrinology fellows from 51 programs across the country were invited to participate in our curriculum. They completed a pre-test, joined a texting group via Remind application and received 1 multiple choice question daily (total n = 78). After 15 weeks, they completed a post-test and survey. Paired results from pre- and post-test were compared. Results: A total of 89 fellows from 27 programs responded. Of these, 82 fellows, predominantly females (n = 60; 73 %), filled out the pre-test. On an average, 42 fellows (SD = 12) responded to the questions daily and 57 % of them answered the questions within 24 h. Thirty fellows completed the post-test. The median number of correct responses on the pre-test was 5 (IQR 3–6), compared to 8 (IQR 6–9) in the post-test. There was a significant improvement (p-value < 0.0001) in fellows’ performance in the post-test when compared with the pre-test following our intervention. Conclusions: Text-messaging based curriculum for exam preparation is feasible and can improve test performance. Fellows find receiving a daily high yield multiple choice question via text-message as a useful tool for exam preparation.
Keywords	Text-messaging ; Board review ; Medicine fellows ; Endocrinology ; ABIM exam ; Exam preparation ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
Subject code	150
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Characteristics and Diabetes Control in Adults With Type 1 Diabetes Admitted With COVID-19 Infection

Vamvini, Maria / Lioutas, Vasileios-Arsenios / Middelbeek, Roeland J W

Diabetes Care

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #707430
Database	COVID19

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Article: Virtually Better Diabetes Care?

Vamvini, Maria T / Dushay, Joanne R / Abrahamson, Martin J

Clinical diabetes : a publication of the American Diabetes Association

2018 Volume 37, Issue 3, Page(s) 284–286

Language	English
Publishing date	2018-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025953-3
ISSN	0891-8929
ISSN	0891-8929
DOI	10.2337/cd18-0052
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Zs.A 2591: Show issues

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Article ; Online: Anti-Insulin Receptor Antibody for Malignant Insulinoma and Refractory Hypoglycemia.

Osataphan, Soravis / Vamvini, Maria / Rosen, Evan D / Pei, Lei / Erlikh, Natanie / Singh, Gurcharan / Dhorajiya, Poojaben / Parker, J Anthony / Dreyfuss, Jonathan M / Rattani, Ahmed / Patti, Mary-Elizabeth

The New England journal of medicine

2023 Volume 389, Issue 8, Page(s) 767–769

MeSH term(s)	Humans ; Antibodies/immunology ; Hypoglycemia/etiology ; Hypoglycemia/therapy ; Insulinoma/complications ; Insulinoma/immunology ; Insulinoma/therapy ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/immunology ; Pancreatic Neoplasms/therapy ; Insulin/immunology ; Insulin Antagonists/immunology ; Insulin Antagonists/therapeutic use
Chemical Substances	Antibodies ; Insulin ; Insulin Antagonists
Language	English
Publishing date	2023-08-23
Publishing country	United States
Document type	Letter
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2307576
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Article ; Online: Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix.

Nigro, Pasquale / Vamvini, Maria / Yang, Jiekun / Caputo, Tiziana / Ho, Li-Lun / Carbone, Nicholas P / Papadopoulos, Danae / Conlin, Royce / He, Jie / Hirshman, Michael F / White, Joseph D / Robidoux, Jacques / Hickner, Robert C / Nielsen, Søren / Pedersen, Bente K / Kellis, Manolis / Middelbeek, Roeland J W / Goodyear, Laurie J

Cell reports

2023 Volume 42, Issue 4, Page(s) 112392

Abstract: Inguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training on metabolic health. The underlying mechanisms for these effects are not fully understood, and here, we test the hypothesis that exercise training results ... ...

Abstract	Inguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training on metabolic health. The underlying mechanisms for these effects are not fully understood, and here, we test the hypothesis that exercise training results in a more favorable iWAT structural phenotype. Using biochemical, imaging, and multi-omics analyses, we find that 11 days of wheel running in male mice causes profound iWAT remodeling including decreased extracellular matrix (ECM) deposition and increased vascularization and innervation. We identify adipose stem cells as one of the main contributors to training-induced ECM remodeling, show that the PRDM16 transcriptional complex is necessary for iWAT remodeling and beiging, and discover neuronal growth regulator 1 (NEGR1) as a link between PRDM16 and neuritogenesis. Moreover, we find that training causes a shift from hypertrophic to insulin-sensitive adipocyte subpopulations. Exercise training leads to remarkable adaptations to iWAT structure and cell-type composition that can confer beneficial changes in tissue metabolism.
MeSH term(s)	Male ; Mice ; Animals ; Motor Activity ; Adipose Tissue, White/metabolism ; Adaptation, Physiological/physiology ; Acclimatization/physiology ; Transcription Factors/metabolism ; Adipose Tissue, Brown/metabolism ; Adipose Tissue/metabolism ; Mice, Inbred C57BL ; Cell Adhesion Molecules, Neuronal/metabolism
Chemical Substances	Transcription Factors ; NEGR1 protein, mouse ; Cell Adhesion Molecules, Neuronal
Language	English
Publishing date	2023-04-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2023.112392
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Moderate-intensity endurance training improves late phase β-cell function in adults with type 2 diabetes

Hui Zhang / Laura K. Simpson / Nicholas P. Carbone / Michael F. Hirshman / Pasquale Nigro / Maria Vamvini / Laurie J. Goodyear / Roeland J.W. Middelbeek

iScience, Vol 26, Iss 7, Pp 107226- (2023)

2023

Abstract: Summary: Physical activity is important for type 2 diabetes treatment, yet the underlying mechanisms for these beneficial effects of exercise are not fully understood. Here, we investigated the effects of exercise training on biphasic β-cell insulin ... ...

Abstract	Summary: Physical activity is important for type 2 diabetes treatment, yet the underlying mechanisms for these beneficial effects of exercise are not fully understood. Here, we investigated the effects of exercise training on biphasic β-cell insulin secretory function, a key factor regulating blood glucose. Adults with type 2 diabetes (7F/3M, age 49 ± 5 years, BMI 30 ± 3 kg/m2) completed a 10-week moderate-intensity exercise program and multiple components of glucose homeostasis were measured. Training improved glycemic control, insulin sensitivity, and processing of proinsulin-to-insulin. Training increased late phase β-cell function by 38% (p = 0.01), which was correlated with changes in VO2peak suggesting training response-dependent effects. Ras-Responsive Element Binding Protein 1 (RREB1) concentrations, a protein postulated to increase type 2 diabetes risk, were inversely correlated with increases in training-induced late-phase disposition index, consistent with an inhibitory role of RREB1 on insulin secretion. Moderate-intensity exercise training improves late-phase β-cell function and glycemic control in adults with type 2 diabetes.
Keywords	Kinesiology ; Human metabolism ; Science ; Q
Subject code	571 ; 796
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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