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Article ; Online: Engineered Extracellular Vesicles in Chronic Kidney Diseases: A Comprehensive Review.

Xue, Kaming / Mi, Bobin

2024 Volume 19, Page(s) 2377–2393

Abstract: Chronic kidney diseases (CKD) present a formidable global health challenge, characterized by a deficiency of effective treatment options. Extracellular vesicles (EVs), recognized as multifunctional drug delivery systems in biomedicine, have gained ... ...

Abstract	Chronic kidney diseases (CKD) present a formidable global health challenge, characterized by a deficiency of effective treatment options. Extracellular vesicles (EVs), recognized as multifunctional drug delivery systems in biomedicine, have gained accumulative interest. Specifically, engineered EVs have emerged as a promising therapeutic approach for targeted drug delivery, potentially addressing the complexities of CKD management. In this review, we systematically dissect EVs, elucidating their classification, biogenesis, composition, and cargo molecules. Furthermore, we explore techniques for EV engineering and strategies for their precise renal delivery, focusing on cargo loading and transportation, providing a comprehensive perspective. Moreover, this review also discusses and summarizes the diverse therapeutic applications of engineered EVs in CKD, emphasizing their anti-inflammatory, immunomodulatory, renoprotective, and tissue-regenerating effects. It critically evaluates the challenges and limitations in translating EV therapies from laboratory settings to clinical applications, while outlining future prospects and emerging trends.
MeSH term(s)	Humans ; Extracellular Vesicles ; Drug Delivery Systems/methods ; Renal Insufficiency, Chronic/therapy ; Kidney ; Anti-Inflammatory Agents
Chemical Substances	Anti-Inflammatory Agents
Language	English
Publishing date	2024-03-07
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S452393
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Article ; Online: Macrophage-mediated fracture healing: Unraveling molecular mechanisms and therapeutic implications using hydrogel-based interventions.

Mi, Bobin / Xiong, Yuan / Lu, Li / Liao, Jiewen / Liu, Guohui / Zhao, Yanli

Biomaterials

2024 Volume 305, Page(s) 122461

Abstract: Fracture healing is a complex biological process that involves the orchestrated interplay of various cells and molecular signaling pathways. Among the key players, macrophages have emerged as critical regulators of fracture repair, influencing ... ...

Abstract	Fracture healing is a complex biological process that involves the orchestrated interplay of various cells and molecular signaling pathways. Among the key players, macrophages have emerged as critical regulators of fracture repair, influencing inflammation, tissue remodeling, and angiogenesis. Recent advances in hydrogel-based therapeutics have provided exciting opportunities to leverage the modulatory effects of macrophages for improving fracture healing outcomes. In the present study, we review the importance of macrophages in fracture repair and their potential therapeutic role in hydrogel-based interventions. We discuss the molecular mechanisms underlying macrophage-mediated effects on fracture healing, and how hydrogels can be utilized as a platform for macrophage modulation. Furthermore, we highlight the translation of hydrogel-based therapies from bench to bedside, including preclinical and clinical studies, and the challenges and opportunities in harnessing the therapeutic potential of macrophages in fracture repair. Overall, understanding the importance of macrophages in fracture healing and the potential of hydrogel-based therapeutics to modulate macrophage responses can pave the way for developing innovative approaches to improve fracture healing outcomes.
MeSH term(s)	Humans ; Fracture Healing ; Hydrogels/pharmacology ; Macrophages/metabolism ; Inflammation/metabolism ; Fractures, Bone
Chemical Substances	Hydrogels
Language	English
Publishing date	2024-01-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2023.122461
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Article ; Online: Engineered Extracellular Vesicles in Wound Healing: Design, Paradigms, and Clinical Application.

Liao, Yuheng / Zhang, Zhenhe / Ouyang, Lizhi / Mi, Bobin / Liu, Guohui

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 20, Issue 7, Page(s) e2307058

Abstract: The severe quality of life and economic burden imposed by non-healing skin wounds, infection risks, and treatment costs are affecting millions of patients worldwide. To mitigate these challenges, scientists are relentlessly seeking effective treatment ... ...

Abstract	The severe quality of life and economic burden imposed by non-healing skin wounds, infection risks, and treatment costs are affecting millions of patients worldwide. To mitigate these challenges, scientists are relentlessly seeking effective treatment measures. In recent years, extracellular vesicles (EVs) have emerged as a promising cell-free therapy strategy, attracting extensive attention from researchers. EVs mediate intercellular communication, possessing excellent biocompatibility and stability. These features make EVs a potential tool for treating a plethora of diseases, including those related to wound repair. However, there is a growing focus on the engineering of EVs to overcome inherent limitations such as low production, relatively fixed content, and targeting capabilities of natural EVs. This engineering could improve both the effectiveness and specificity of EVs in wound repair treatments. In light of this, the present review will introduce the latest progress in the design methods and experimental paradigms of engineered EVs applied in wound repair. Furthermore, it will comprehensively analyze the current clinical research status and prospects of engineered EVs within this field.
MeSH term(s)	Humans ; Quality of Life ; Cell Communication ; Cell- and Tissue-Based Therapy ; Extracellular Vesicles ; Wound Healing
Language	English
Publishing date	2023-10-08
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202307058
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Predicting overall survival in chordoma patients using machine learning models: a web-app application.

Cheng, Peng / Xie, Xudong / Knoedler, Samuel / Mi, Bobin / Liu, Guohui

Journal of orthopaedic surgery and research

2023 Volume 18, Issue 1, Page(s) 652

Abstract: Objective: The goal of this study was to evaluate the efficacy of machine learning (ML) techniques in predicting survival for chordoma patients in comparison with the standard Cox proportional hazards (CoxPH) model.: Methods: Using a Surveillance, ... ...

Abstract	Objective: The goal of this study was to evaluate the efficacy of machine learning (ML) techniques in predicting survival for chordoma patients in comparison with the standard Cox proportional hazards (CoxPH) model. Methods: Using a Surveillance, Epidemiology, and End Results database of consecutive newly diagnosed chordoma cases between January 2000 and December 2018, we created and validated three ML survival models as well as a traditional CoxPH model in this population-based cohort study. Randomly, the dataset was divided into training and validation datasets. Tuning hyperparameters on the training dataset involved a 1000-iteration random search with fivefold cross-validation. Concordance index (C-index), Brier score, and integrated Brier score were used to evaluate the performance of the model. The receiver operating characteristic (ROC) curves, calibration curves, and area under the ROC curves (AUC) were used to assess the reliability of the models by predicting 5- and 10-year survival probabilities. Results: A total of 724 chordoma patients were divided into training (n = 508) and validation (n = 216) cohorts. Cox regression identified nine significant prognostic factors (p < 0.05). ML models showed superior performance over CoxPH model, with DeepSurv having the highest C-index (0.795) and the best discrimination for 5- and 10-year survival (AUC 0.84 and 0.88). Calibration curves revealed strong correlation between DeepSurv predictions and actual survival. Risk stratification by DeepSurv model effectively discriminated high- and low-risk groups (p < 0.01). The optimized DeepSurv model was implemented into a web application for clinical use that can be found at https://hust-chengp-ml-chordoma-app-19rjyr.streamlitapp.com/ . Conclusion: ML algorithms based on time-to-event results are effective in chordoma prediction, with DeepSurv having the best discrimination performance and calibration.
MeSH term(s)	Humans ; Chordoma/diagnosis ; Cohort Studies ; Mobile Applications ; Reproducibility of Results ; Machine Learning
Language	English
Publishing date	2023-09-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-023-04105-9
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Article ; Online: Correction for: Inhibition of circulating exosomal microRNA-15a-3p accelerates diabetic wound repair.

Xiong, Yuan / Chen, Lang / Yu, Tao / Yan, Chenchen / Zhou, Wu / Cao, Faqi / You, Xiaomeng / Zhang, Yingqi / Sun, Yun / Liu, Jing / Xue, Hang / Hu, Yiqiang / Chen, Dong / Mi, Bobin / Liu, Guohui

Aging

2024 Volume 16, Issue 7, Page(s) 6627–6628

Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article ; Published Erratum
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205514
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A distinct "repair" role of regulatory T cells in fracture healing.

Wu, Tingting / Wang, Lulu / Jian, Chen / Zhang, Zhenhe / Zeng, Ruiyin / Mi, Bobin / Liu, Guohui / Zhang, Yu / Shi, Chen

Frontiers of medicine

2024

Abstract: Regulatory T cells (Tregs) suppress immune responses and inflammation. Here, we described the distinct nonimmunological role of Tregs in fracture healing. The recruitment from the circulation pool, peripheral induction, and local expansion rapidly ... ...

Abstract	Regulatory T cells (Tregs) suppress immune responses and inflammation. Here, we described the distinct nonimmunological role of Tregs in fracture healing. The recruitment from the circulation pool, peripheral induction, and local expansion rapidly enriched Tregs in the injured bone. The Tregs in the injured bone displayed superiority in direct osteogenesis over Tregs from lymphoid organs. Punctual depletion of Tregs compromised the fracture healing process, which leads to increased bone nonunion. In addition, bone callus Tregs showed unique T-cell receptor repertoires. Amphiregulin was the most overexpressed protein in bone callus Tregs, and it can directly facilitate the proliferation and differentiation of osteogenic precursor cells by activation of phosphatidylinositol 3-kinase/protein kinase B signaling pathways. The results of loss- and gain-function studies further evidenced that amphiregulin can reverse the compromised healing caused by Treg dysfunction. Tregs also enriched in patient bone callus and amphiregulin can promote the osteogenesis of human pre-osteoblastic cells. Our findings indicate the distinct and nonredundant role of Tregs in fracture healing, which will provide a new therapeutic target and strategy in the clinical treatment of fractures.
Language	English
Publishing date	2024-03-16
Publishing country	China
Document type	Journal Article
ZDB-ID	2617113-2
ISSN	2095-0225 ; 2095-0217
ISSN (online)	2095-0225
ISSN	2095-0217
DOI	10.1007/s11684-023-1024-8
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Article: [Research on Locating Device for the Entry Point of Intramedullary Nail Based on Inertial Navigation].

Guo, Chu / Mi, Bobin / Wang, Junwen / Jiao, Jing / Wu, Shilei / Xia, Tian / Li, Jingfeng / Liu, Guohui / Liu, Mengxing

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation

2024 Volume 48, Issue 2, Page(s) 179–183

Abstract: Objective: To introduce a locating device for the entry point of intramedullary nail based on the inertial navigation technology, which utilizes multi-dimensional angle information to assist in rapid and accurate positioning of the ideal direction of ... ...

Abstract	Objective: To introduce a locating device for the entry point of intramedullary nail based on the inertial navigation technology, which utilizes multi-dimensional angle information to assist in rapid and accurate positioning of the ideal direction of femoral anterograde intramedullary nails' entry point, and to verify its clinical value through clinical tests. Methods: After matching the locating module with the developing board, which are the two components of the locating device, they were placed on the skin surface of the proximal femur of the affected side. Anteroposterior fluoroscopy was performed. The developing angle corresponding to the ideal direction of entry point was selected based on the X-ray image, and then the yaw angle of the locating module was reset to zero. After resetting, the locating module was combined with the surgical instrument to guide the insertion angle of the guide wire. The ideal direction of entry point was accurately located based on the angle guidance. By setting up an experimental group and a control group for clinical surgical operations, the number of guide wire insertion times, surgical time, fluoroscopy frequency, and intraoperative blood loss with or without the locating device was recorded. Results: Compared to the control group, the experimental group showed significant improvement in the number of guide wire insertion times, surgical time, fluoroscopy frequency, and intraoperative blood loss, with a statistically significant difference ( Conclusion: The locating device can assist doctors in quickly locating the entry point of intramedullary nail, effectively reducing the fluoroscopy frequency and surgical time by improving the success rate of the guide wire insertion with one shot, improving surgical efficiency, and possessing certain clinical value.
MeSH term(s)	Humans ; Bone Nails ; Blood Loss, Surgical ; Fluoroscopy/methods ; Fracture Fixation, Intramedullary/methods ; Surgery, Computer-Assisted/methods
Language	Chinese
Publishing date	2024-01-19
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1671-7104
ISSN	1671-7104
DOI	10.12455/j.issn.1671-7104.230432
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Functionalized multidimensional biomaterials for bone microenvironment engineering applications: Focus on osteoimmunomodulation.

Lv, Bin / Wu, Juntao / Xiong, Yuan / Xie, Xudong / Lin, Ze / Mi, Bobin / Liu, Guohui

Frontiers in bioengineering and biotechnology

2022 Volume 10, Page(s) 1023231

Abstract: As bone biology develops, it is gradually recognized that bone regeneration is a pathophysiological process that requires the simultaneous participation of multiple systems. With the introduction of osteoimmunology, the interplay between the immune ... ...

Abstract	As bone biology develops, it is gradually recognized that bone regeneration is a pathophysiological process that requires the simultaneous participation of multiple systems. With the introduction of osteoimmunology, the interplay between the immune system and the musculoskeletal diseases has been the conceptual framework for a thorough understanding of both systems and the advancement of osteoimmunomodulaty biomaterials. Various therapeutic strategies which include intervention of the surface characteristics or the local delivery systems with the incorporation of bioactive molecules have been applied to create an ideal bone microenvironment for bone tissue regeneration. Our review systematically summarized the current research that is being undertaken in the field of osteoimmunomodulaty bone biomaterials on a case-by-case basis, aiming to inspire more extensive research and promote clinical conversion.
Language	English
Publishing date	2022-11-04
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2022.1023231
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Article ; Online: Recent advances in carboxymethyl chitosan-based materials for biomedical applications.

Geng, Yongtao / Xue, Hang / Zhang, Zhenhe / Panayi, Adriana C / Knoedler, Samuel / Zhou, Wu / Mi, Bobin / Liu, Guohui

Carbohydrate polymers

2023 Volume 305, Page(s) 120555

Abstract: Chitosan (CS) and its derivatives have been applied extensively in the biomedical field owing to advantageous characteristics including biodegradability, biocompatibility, antibacterial activity and adhesive properties. The low solubility of CS at ... ...

Abstract	Chitosan (CS) and its derivatives have been applied extensively in the biomedical field owing to advantageous characteristics including biodegradability, biocompatibility, antibacterial activity and adhesive properties. The low solubility of CS at physiological pH limits its use in systems requiring higher dissolving ability and a suitable drug release rate. Besides, CS can result in fast drug release because of its high swelling degree and rapid water absorption in aqueous media. As a water-soluble derivative of CS, carboxymethyl chitosan (CMC) has certain improved properties, rendering it a more suitable candidate for wound healing, drug delivery and tissue engineering applications. This review will focus on the antibacterial, anticancer and antitumor, antioxidant and antifungal bioactivities of CMC and the most recently described applications of CMC in wound healing, drug delivery, tissue engineering, bioimaging and cosmetics.
MeSH term(s)	Chitosan/chemistry ; Drug Delivery Systems/methods ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Chemical Phenomena ; Antifungal Agents
Chemical Substances	Chitosan (9012-76-4) ; Anti-Bacterial Agents ; Antifungal Agents
Language	English
Publishing date	2023-01-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2023.120555
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Article ; Online: Recent Advances in Enhancement Strategies for Osteogenic Differentiation of Mesenchymal Stem Cells in Bone Tissue Engineering

Kangkang Zha / Yue Tian / Adriana C. Panayi / Bobin Mi / Guohui Liu

Frontiers in Cell and Developmental Biology, Vol

2022 Volume 10

Abstract: Although bone is an organ that displays potential for self-healing after damage, bone regeneration does not occur properly in some cases, and it is still a challenge to treat large bone defects. The development of bone tissue engineering provides a new ... ...

Abstract	Although bone is an organ that displays potential for self-healing after damage, bone regeneration does not occur properly in some cases, and it is still a challenge to treat large bone defects. The development of bone tissue engineering provides a new approach to the treatment of bone defects. Among various cell types, mesenchymal stem cells (MSCs) represent one of the most promising seed cells in bone tissue engineering due to their functions of osteogenic differentiation, immunomodulation, and secretion of cytokines. Regulation of osteogenic differentiation of MSCs has become an area of extensive research over the past few years. This review provides an overview of recent research progress on enhancement strategies for MSC osteogenesis, including improvement in methods of cell origin selection, culture conditions, biophysical stimulation, crosstalk with macrophages and endothelial cells, and scaffolds. This is favorable for further understanding MSC osteogenesis and the development of MSC-based bone tissue engineering.
Keywords	mesenchymal stem cell ; osteogenesis ; bone defect ; bone healing ; tissue engineering ; Biology (General) ; QH301-705.5
Subject code	616 ; 571
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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