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  1. Article ; Online: Author response: Carotid plaques and detection of atrial fibrillation in embolic stroke of undetermined source.

    Ntaios, George

    Neurology

    2020  Volume 94, Issue 19, Page(s) 850

    MeSH term(s) Atrial Fibrillation ; Humans ; Intracranial Embolism ; Stroke
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000009427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.153: Show issues Location:
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  2. Article ; Online: Author response: Carotid plaques and detection of atrial fibrillation in embolic stroke of undetermined source.

    Ntaios, George

    Neurology

    2020  Volume 94, Issue 19, Page(s) 851

    MeSH term(s) Atrial Fibrillation ; Humans ; Intracranial Embolism ; Stroke
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000009429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Embolic Stroke of Undetermined Source: JACC Review Topic of the Week.

    Ntaios, George

    Journal of the American College of Cardiology

    2020  Volume 75, Issue 3, Page(s) 333–340

    Abstract: The term embolic stroke of undetermined source (ESUS) was introduced in 2014 to describe patients with a nonlacunar ischemic stroke and no convincing etiology. The terms ESUS and cryptogenic stroke are not synonyms, as the latter also includes patients ... ...

    Abstract The term embolic stroke of undetermined source (ESUS) was introduced in 2014 to describe patients with a nonlacunar ischemic stroke and no convincing etiology. The terms ESUS and cryptogenic stroke are not synonyms, as the latter also includes patients with multiple stroke etiologies or incomplete diagnostic work-up. ESUS involves approximately 17% of all ischemic stroke patients, and these patients are typically younger with mild strokes and an annual rate of stroke recurrence of 4% to 5%. It was hypothesized that oral anticoagulation may decrease the risk of stroke recurrence in ESUS, which was tested in 2 large randomized controlled trials: the NAVIGATE ESUS (Rivaroxaban Versus Aspirin in Secondary Prevention of Stroke and Prevention of Systemic Embolism in Patients With Recent Embolic Stroke of Undetermined Source) and the RE-SPECT ESUS (Dabigatran Etexilate for Secondary Stroke Prevention in Patients With Embolic Stroke of Undetermined Source). The present review discusses the trials of anticoagulation in patients with ESUS, suggests potential explanations for their neutral results, and highlights the rationale that supports ongoing and future research in this population aiming to reduce the associated risk for stroke recurrence.
    MeSH term(s) Anticoagulants/therapeutic use ; Clinical Trials as Topic/methods ; Embolism/diagnosis ; Embolism/epidemiology ; Embolism/therapy ; Humans ; Platelet Aggregation Inhibitors/therapeutic use ; Stroke/diagnosis ; Stroke/physiopathology ; Stroke/therapy
    Chemical Substances Anticoagulants ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2020-02-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2019.11.024
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  4. Article ; Online: The obesity paradigm on outcome in heart failure with reduced ejection fraction.

    Doehner, Wolfram / Akyea, Ralph Kwame / Ntaios, George

    European heart journal

    2024  Volume 45, Issue 16, Page(s) 1484–1485

    MeSH term(s) Humans ; Stroke Volume ; Heart Failure/therapy ; Ventricular Dysfunction, Left ; Obesity/complications ; Obesity/epidemiology ; Ventricular Function, Left
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad761
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  5. Article ; Online: Beyond antithrombotics: recent advances in pharmacological risk factor management for secondary stroke prevention.

    Sagris, Dimitrios / Ntaios, George / Milionis, Haralampos

    Journal of neurology, neurosurgery, and psychiatry

    2024  Volume 95, Issue 3, Page(s) 264–272

    Abstract: Patients with ischaemic stroke represent a diverse group with several cardiovascular risk factors and comorbidities, which classify them as patients at very high risk of stroke recurrence, cardiovascular adverse events or death. In addition to ... ...

    Abstract Patients with ischaemic stroke represent a diverse group with several cardiovascular risk factors and comorbidities, which classify them as patients at very high risk of stroke recurrence, cardiovascular adverse events or death. In addition to antithrombotic therapy, which is important for secondary stroke prevention in most patients with stroke, cardiovascular risk factor assessment and treatment also contribute significantly to the reduction of mortality and morbidity. Dyslipidaemia, diabetes mellitus and hypertension represent common and important modifiable cardiovascular risk factors among patients with stroke, while early recognition and treatment may have a significant impact on patients' future risk of major cardiovascular events. In recent years, there have been numerous advancements in pharmacological agents aimed at secondary cardiovascular prevention. These innovations, combined with enhanced awareness and interventions targeting adherence and persistence to treatment, as well as lifestyle modifications, have the potential to substantially alleviate the burden of cardiovascular disease, particularly in patients who have experienced ischaemic strokes. This review summarises the evidence on the contemporary advances on pharmacological treatment and future perspectives of secondary stroke prevention beyond antithrombotic treatment.
    MeSH term(s) Humans ; Stroke/drug therapy ; Stroke/etiology ; Stroke/prevention & control ; Fibrinolytic Agents/therapeutic use ; Brain Ischemia/drug therapy ; Risk Factors ; Diabetes Mellitus ; Secondary Prevention
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2022-329149
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  6. Article ; Online: Diagnostic Challenges and Uncertainties of Embolic Strokes of Undetermined Source in Young Adults.

    Ntaios, George / Omran, Setareh Salehi

    JAMA neurology

    2022  Volume 79, Issue 5, Page(s) 444–447

    MeSH term(s) Embolic Stroke ; Humans ; Intracranial Embolism/diagnostic imaging ; Intracranial Embolism/etiology ; Risk Factors ; Stroke/diagnostic imaging ; Stroke/etiology ; Young Adult
    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2022.0058
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  7. Article ; Online: Anticoagulation for Thromboprophylaxis in Patients with Intracerebral Hemorrhage: Less Room for Skepticism.

    Proietti, Marco / Ntaios, George

    Thrombosis and haemostasis

    2022  Volume 122, Issue 7, Page(s) 1071–1074

    MeSH term(s) Anticoagulants/adverse effects ; Blood Coagulation ; Cerebral Hemorrhage/drug therapy ; Humans ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-04-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 518294-3
    ISSN 2567-689X ; 0340-6245
    ISSN (online) 2567-689X
    ISSN 0340-6245
    DOI 10.1055/a-1834-4923
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  8. Article ; Online: Embolic stroke of undetermined source and atrial cardiopathy: Towards a personalized antithrombotic strategy for secondary stroke prevention.

    Ntaios, George / Korompoki, Eleni

    European journal of internal medicine

    2022  Volume 99, Page(s) 24–25

    MeSH term(s) Embolic Stroke ; Fibrinolytic Agents/therapeutic use ; Heart Diseases/complications ; Heart Diseases/drug therapy ; Humans ; Secondary Prevention ; Stroke/drug therapy ; Stroke/prevention & control
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2022-02-19
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2022.02.016
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    Zs.A 2608: Show issues Location:
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  9. Article ; Online: Obesity, metabolic health and clinical outcomes after incident cardiovascular disease: A nationwide population-based cohort study.

    Akyea, Ralph K / Ntaios, George / Doehner, Wolfram

    Journal of cachexia, sarcopenia and muscle

    2023  Volume 14, Issue 6, Page(s) 2653–2662

    Abstract: Background: The association between metabolic syndrome and increased cardiovascular disease (CVD) risk is well-established. However, in patients with incident CVD, the relationship between obesity, metabolic health, and subsequent CVD and mortality ... ...

    Abstract Background: The association between metabolic syndrome and increased cardiovascular disease (CVD) risk is well-established. However, in patients with incident CVD, the relationship between obesity, metabolic health, and subsequent CVD and mortality outcomes are less well-established. This study investigated the association between body mass index (BMI), metabolic health and the risk of subsequent cardiovascular mortality and morbidity outcomes in patients with incident CVD events.
    Methods: This cohort study identified 130 685 patients from the nationwide Clinical Practice Research Datalink (CPRD GOLD) and Hospital Episode Statistics (HES) databases in the United Kingdom. Patients were ≥18 years with incident CVD [coronary heart disease (CHD), stroke, or peripheral vascular disease (PVD)] between 1 January 1998 and 31 December 2017. BMI (in kg/m
    Results: During a median follow-up of 13.0 years, a higher BMI was associated with reduced risk for stroke, PVD, CVD-mortality and all-cause mortality within each metabolic risk category, while increasing metabolic RFs within each BMI subgroup accounted for increasing risks. When compared with patients with normal BMI and no RF, CVD-mortality risk in overweight patients with no RF was 0.76 (0.70-0.84), and in obese patients with no RF was 0.85 (0.76-0.96). The respective risk for all-cause mortality in patients with overweight and no RF was 0.69 (0.65-0.72), and in obese patients with no RF was 0.75 (0.70-0.79). Subsequent outcomes of stroke and PVD showed similar trends. In contrast, the risk of subsequent non-fatal CHD events and incident HF increased with higher BMI and with incremental metabolic risk factors within each BMI category. Underweight was constantly associated with increased risk for all outcomes regardless of the presence of metabolic RFs except for non-fatal CHD events.
    Conclusions: In patients with incident CVD, overweight and obesity were related to a more favourable prognosis for subsequent stroke, PVD and mortality (CVD-related and all-cause) irrespective of the presence of other metabolic risk factors.
    MeSH term(s) Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Overweight ; Cohort Studies ; Thinness/complications ; Thinness/epidemiology ; Obesity/complications ; Obesity/epidemiology ; Stroke/epidemiology ; Stroke/etiology
    Language English
    Publishing date 2023-10-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1002/jcsm.13340
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  10. Article ; Online: Interaction between age and efficacy of dual antiplatelet therapy in non-cardioembolic minor acute ischemic stroke or high-risk transient ischemic attack.

    Kyriakoulis, Konstantinos G / Menti, Ariadni / Korompoki, Eleni / Ntaios, George / Kollias, Anastasios

    European journal of internal medicine

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2024.04.001
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