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  1. Article ; Online: Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State.

    Arentz, Matt / Yim, Eric / Klaff, Lindy / Lokhandwala, Sharukh / Riedo, Francis X / Chong, Maria / Lee, Melissa

    JAMA

    2020  Volume 323, Issue 16, Page(s) 1612–1614

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Coronavirus Infections/therapy ; Critical Illness ; Female ; Hospitalization ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Respiration, Artificial ; Respiratory Distress Syndrome/complications ; SARS-CoV-2 ; Treatment Outcome ; Washington
    Keywords covid19
    Language English
    Publishing date 2020-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.4326
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  2. Article: Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State

    Arentz, Matt / Yim, Eric / Klaff, Lindy / Lokhandwala, Sharukh / Riedo, Francis X / Chong, Maria / Lee, Melissa

    JAMA

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #10527
    Database COVID19

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  3. Article ; Online: Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State

    Arentz, Matt / Yim, Eric / Klaff, Lindy / Lokhandwala, Sharukh / Riedo, Francis X. / Chong, Maria / Lee, Melissa

    JAMA

    2020  Volume 323, Issue 16, Page(s) 1612

    Keywords General Medicine ; covid19
    Language English
    Publisher American Medical Association (AMA)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.4326
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  4. Article ; Online: A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection.

    Sinclair, Jane E / Zhu, Yanshan / Xu, Gang / Ma, Wei / Shi, Haiyan / Ma, Kun-Long / Cao, Chun-Feng / Kong, Ling-Xi / Wan, Ke-Qiang / Liao, Juan / Wang, Hai-Qiang / Arentz, Matt / Redd, Meredith A / Gallo, Linda A / Short, Kirsty R

    iScience

    2021  Volume 24, Issue 4, Page(s) 102264

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyze the association of host co-morbidities (chronic respiratory illnesses, cardiovascular ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyze the association of host co-morbidities (chronic respiratory illnesses, cardiovascular disease [CVD], hypertension or diabetes mellitus [DM]) with the acute cardiovascular complications associated with SARS-CoV-2 infection. Individual analyses of the majority of studies found median age was higher by ~10 years in patients with cardiovascular complications. Pooled analyses showed development of SARS-CoV-2 cardiovascular complications was significantly increased in patients with chronic respiratory illness (odds ratio (OR): 1.67 [1.48, 1.88]), CVD (OR: 3.37 [2.57, 4.43]), hypertension (OR: 2.68 [2.11, 3.41]), DM (OR: 1.60 [1.31, 1.95]) and male sex (OR: 1.31 [1.21, 1.42]), findings that were mostly conserved during sub-analysis of studies stratified into global geographic regions. Age, chronic respiratory illness, CVD, hypertension, DM, and male sex may represent prognostic factors for the development of cardiovascular complications in COVID-19 disease, highlighting the need for a multidisciplinary approach to chronic disease patient management.
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2021.102264
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  5. Article ; Online: A meta-analysis on the role of pre-existing chronic disease in the cardiac complications of SARS-CoV-2 infection

    Jane E. Sinclair / Yanshan Zhu / Gang Xu / Wei Ma / Haiyan Shi / Kun-Long Ma / Chun-Feng Cao / Ling-Xi Kong / Ke-Qiang Wan / Juan Liao / Hai-Qiang Wang / Matt Arentz / Meredith A. Redd / Linda A. Gallo / Kirsty R. Short

    iScience, Vol 24, Iss 4, Pp 102264- (2021)

    2021  

    Abstract: Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyze the association of host co-morbidities (chronic respiratory illnesses, ... ...

    Abstract Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with multiple direct and indirect cardiovascular complications. We sought to analyze the association of host co-morbidities (chronic respiratory illnesses, cardiovascular disease [CVD], hypertension or diabetes mellitus [DM]) with the acute cardiovascular complications associated with SARS-CoV-2 infection. Individual analyses of the majority of studies found median age was higher by ~10 years in patients with cardiovascular complications. Pooled analyses showed development of SARS-CoV-2 cardiovascular complications was significantly increased in patients with chronic respiratory illness (odds ratio (OR): 1.67 [1.48, 1.88]), CVD (OR: 3.37 [2.57, 4.43]), hypertension (OR: 2.68 [2.11, 3.41]), DM (OR: 1.60 [1.31, 1.95]) and male sex (OR: 1.31 [1.21, 1.42]), findings that were mostly conserved during sub-analysis of studies stratified into global geographic regions. Age, chronic respiratory illness, CVD, hypertension, DM, and male sex may represent prognostic factors for the development of cardiovascular complications in COVID-19 disease, highlighting the need for a multidisciplinary approach to chronic disease patient management.
    Keywords Virology ; Omics ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The role of pre-existing chronic disease in cardiac complications from SARS-CoV-2 infection: A systematic review and meta-analysis

    Sinclair, Jane E / Zhu, Yanshan / Xu, Gang / Ma, Wei / Shi, Haiyan / Ma, Kun-Long / Cao, Chun-Feng / Kong, Ling-Xi / Wan, Ke-Qiang / Liao, Juan / Wang, Hai-Qiang / Arentz, Matt / Redd, Meredith / Gallo, Linda A / Short, Kirsty R

    medRxiv

    Abstract: ABSTRACT Importance: SARS-CoV-2 is associated with multiple direct and indirect effects to the heart. It is not yet well defined whether patient groups at increased risk of severe respiratory disease due to SARS-CoV-2 infection also experience a ... ...

    Abstract ABSTRACT Importance: SARS-CoV-2 is associated with multiple direct and indirect effects to the heart. It is not yet well defined whether patient groups at increased risk of severe respiratory disease due to SARS-CoV-2 infection also experience a heightened incidence of cardiac complications. Objective: We sought to analyse the role of pre-existing chronic disease (chronic respiratory illness, cardiovascular disease (CVD), hypertension and diabetes mellitus) in the development of cardiac complications from SARS-CoV-2. Data Sources: We retrospectively investigated published (including pre-prints), publicly released, de-identified, data made available between Dec 1, 2019, and May 11, 2020. Information was accessed from PubMed, Embase, medRxiv and SSRN. Study Selection: 379 full-text articles were reviewed and 321 excluded for lack of original research, irrelevance to outcome, inappropriate cohort, or small patient numbers (case reports of <10 patients). Data were extracted from two studies and the remaining 56 contacted to request appropriate data, to which three responded with data contributions. A final of five studies were included. Data Extraction and Synthesis: This systematic review was conducted based on PRISMA and MOOSE statements. Included studies were critically appraised using Newcastle Ottawa Quality Assessment Scale (NOS). Data were extracted independently by multiple observers. A fixed-effects model was selected for the meta-analysis based on relatively low heterogeneity between the studies (I<sup>2</sup><50%). Main Outcome and Measures: Cardiac complications were determined via blood levels of cardiac biomarkers above the 99th percentile of the upper reference limit, abnormalities in electrocardiography, and/or abnormalities in echocardiography. Results: SARS-CoV-2-infected patients who developed cardiac complications were, on average, 10 years older than those that did not. Pooled analyses showed the development of cardiac complications from SARS-CoV-2 was significantly increased in patients with underlying chronic respiratory illness (OR 2.88[1.45,5.71]), CVD (OR 5.12[3.09,8.48]), hypertension (OR 4.37[2.99,6.39]) and diabetes mellitus (OR 2.61[1.67,4.09]). Conclusions and Relevance: Older age and pre-existing chronic respiratory illness, CVD, hypertension, and diabetes mellitus may represent prognostic factors for the development of additional cardiac complications in COVID-19, highlighting the need for a multidisciplinary approach to chronic disease patient management and providing justification for a larger scale observational study.
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.06.21.20136622
    Database COVID19

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  7. Article ; Online: Correlation between atrial fibrillation driver locations and complex fractionated atrial electrograms in patients with persistent atrial fibrillation.

    Ammar-Busch, Sonia / Reents, Tilko / Knecht, Sebastien / Rostock, Thomas / Arentz, Thomas / Duytschaever, Mattias / Neumann, Thomas / Cauchemez, Bruno / Albenque, Jean-Paul / Hessling, Gabriele / Deisenhofer, Isabel

    Pacing and clinical electrophysiology : PACE

    2018  Volume 41, Issue 10, Page(s) 1279–1285

    Abstract: Introduction: The aim of this study was to evaluate a spatial correlation between active atrial fibrillation (AF) drivers measured by electrocardiographic imaging and complex fractionated atrial electrograms (CFAEs) in patients with persistent AF.: ... ...

    Abstract Introduction: The aim of this study was to evaluate a spatial correlation between active atrial fibrillation (AF) drivers measured by electrocardiographic imaging and complex fractionated atrial electrograms (CFAEs) in patients with persistent AF.
    Methods: Sixteen patients with persistent AF were included. A biatrial geometry relative to an array of 252-body-surface-electrodes was obtained from a noncontrast computed tomography scan. The reconstructed unipolar AF electrograms were signal-processed (ECVUE™, CardioInsight Technologies Inc., Cleveland, OH, USA) to identify AF drivers. Before driver ablation, a biatrial mapping using the NavX system (St. Jude Medical, St. Paul, MN, USA) was performed to identify CFAEs. CFAE and driver regions were then quantified and compared.
    Results: AF was terminated by driver ablation in 11/16 (70%) patients. The mean number of ablated driver regions was 4 ± 1 per patient. The most frequent driver locations were the inferior left atrium and coronary sinus, the right pulmonary veins, and the right atrium. In 49/63 (78%) of the driver locations, more than 75% of the driver site showed CFAEs. The mean ablated driver area was 58 ± 24 cm
    Conclusions: There is a significant overlap between AF driver regions identified by the ECVUE™ system and CFAE areas identified by the NavX system. AF driver regions are smaller and mostly embedded in larger CFAE areas. Selective ablation of drivers in CFAE areas seems sufficient to terminate persistent AF in the majority of patients.
    MeSH term(s) Aged ; Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Body Surface Potential Mapping ; Catheter Ablation/methods ; Electrocardiography/methods ; Female ; Humans ; Male ; Middle Aged ; Signal Processing, Computer-Assisted ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2018-09-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 424437-0
    ISSN 1540-8159 ; 0147-8389
    ISSN (online) 1540-8159
    ISSN 0147-8389
    DOI 10.1111/pace.13483
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  8. Article ; Online: Multicentre evaluation of non-invasive biatrial mapping for persistent atrial fibrillation ablation: the AFACART study.

    Knecht, Sébastien / Sohal, Manav / Deisenhofer, Isabelle / Albenque, Jean-Paul / Arentz, Thomas / Neumann, Thomas / Cauchemez, Bruno / Duytschaever, Mattias / Ramoul, Khaled / Verbeet, Thierry / Thorsten, Sonia / Jadidi, Amir / Combes, Stephane / Tavernier, René / Vandekerckhove, Yves / Ernst, Sabine / Packer, Douglas / Rostock, Thomas

    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

    2017  Volume 19, Issue 8, Page(s) 1302–1309

    Abstract: Aims: Non-invasive electrocardiogram (ECG) mapping allows the activation of the entire atrial epicardium to be recorded simultaneously, potentially identifying mechanisms critical for atrial fibrillation (AF) persistence. We sought to evaluate the ... ...

    Abstract Aims: Non-invasive electrocardiogram (ECG) mapping allows the activation of the entire atrial epicardium to be recorded simultaneously, potentially identifying mechanisms critical for atrial fibrillation (AF) persistence. We sought to evaluate the utility of ECG mapping as a practical tool prior to ablation of persistent AF (PsAF) in centres with no practical experience of the system.
    Methods and results: A total of 118 patients with continuous AF duration <1 year were prospectively studied at 8 European centres. Patients were on a median of 1 antiarrhythmic drug (AAD) that had failed to restore sinus rhythm. Electrocardiogram mapping (ECVUE™, CardioInsight, USA) was performed prior to ablation to map AF drivers (local re-entrant circuits or focal breakthroughs). Ablation targeted drivers depicted by the system, followed by pulmonary vein (PV) isolation, and finally left atrial linear ablation if AF persisted. The primary endpoint was AF termination. Totally, 4.9 ± 1.0 driver sites were mapped per patient with a cumulative mapping time of 16 ± 2 s. Of these, 53% of drivers were located in the left atrium, 27% in the right atrium, and 20% in the anterior interatrial groove. Driver-only ablation resulted in AF termination in 75 of the 118 patients (64%) with a mean radiofrequency (RF) duration of 46 ± 28 min. Acute termination rates were not significantly different amongst all 8 centres (P = 0.672). Ten additional patients terminated with PV isolation and lines resulting in a total AF termination rate of 72%. Total RF duration was 75 ± 27 min. At 1-year follow-up, 78% of the patients were off AADs and 77% of the patients were free from AF recurrence. Of the patients with no AF recurrence, 49% experienced at least one episode of atrial tachycardia (AT) which required either continued AAD therapy, cardioversion, or repeat ablation.
    Conclusion: Non-invasive mapping identifies biatrial drivers that are critical in PsAF. This is validated by successful AF termination in the majority of patients treated in centres with no experience of the system. Ablation targeting these drivers results in favourable AF-free survival at 1 year, albeit with a significant rate of AT recurrence requiring further management.
    MeSH term(s) Action Potentials ; Aged ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/surgery ; Body Surface Potential Mapping/instrumentation ; Body Surface Potential Mapping/methods ; Catheter Ablation/adverse effects ; Disease-Free Survival ; Europe ; Feasibility Studies ; Female ; Heart Rate ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; Pulmonary Veins/physiopathology ; Pulmonary Veins/surgery ; Recurrence ; Reproducibility of Results ; Risk Factors ; Tachycardia, Supraventricular/diagnosis ; Tachycardia, Supraventricular/etiology ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2017-02-08
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1449879-0
    ISSN 1532-2092 ; 1099-5129
    ISSN (online) 1532-2092
    ISSN 1099-5129
    DOI 10.1093/europace/euw168
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