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Article: Evaluation of the Reliability of Electrocardiographic Criteria for Cardiac Hypertrophy Based on Echocardiographic Data.

Augustaitytė, Agnė / Kalinauskienė, Eglė

2022 Volume 29, Issue 1, Page(s) 91–99

Abstract: Background: Left ventricular hypertrophy (LVH) regardless of other risk factors may be associated with an increased risk of mortality from cardiovascular diseases. Therefore, timely diagnosis for LVH is important in order to avoid possible complications. ...

Abstract	Background: Left ventricular hypertrophy (LVH) regardless of other risk factors may be associated with an increased risk of mortality from cardiovascular diseases. Therefore, timely diagnosis for LVH is important in order to avoid possible complications. One of the simplest and cheapest methods to diagnose LVH is electrocardiography (ECG). Although a number of ECG criteria for LVH is known, their reliability varies in many studies. Aim: To evaluate the reliability of ECG criteria for LVH based on transthoracic echocardiography (TTE) data. Methods: The study included all consecutive patients in Kaunas Clinical Hospital Department of Cardiology from December 2019 until March 2020 and from September until October 2020, after applying the inclusion and exclusion criteria. The sensitivity and specificity of the ECG criteria for LVH were assessed based on TTE measurements performed during the same inpatient setting. The reliability of the ECG criteria for LVH was assessed using ROC curves. Reliability differences in gender, age and nutritional status groups were assessed using ANOVA statistical method. Results: Data from 95 patients were analyzed (63.2% were women and 36.8% were men). The sensitivity, specificity and AUC of Sokolow-Lyon criterion were 9.38%, 85.71% and 0.44 (p = 0.034), R in aVL - 6.25%, 90.48% and 0.51 (p = 0.038), Cornell - 21.88%, 100 % and0.69 (p = 0.084), Cornell product - 31.25%, 95.24% and 0.72 (p = 0.070), Peguero-Lo Presti - 31.25%, 85.71% and 0.68 (p = 0.053), respectively. No statistically significant differences were observed among the individual gender, age and nutritional status groups. Conclusions: Sokolow-Lyon and RaVL criteria were not statistically significantly reliable in LVH diagnosis compared to TTE, unlike the Cornell, Cornell product, and Peguero-Lo Presti criteria.
Language	English
Publishing date	2022-07-26
Publishing country	Lithuania
Document type	Journal Article
ZDB-ID	1291937-8
ISSN	2029-4174 ; 1392-0138
ISSN (online)	2029-4174
ISSN	1392-0138
DOI	10.15388/Amed.2021.29.1.12
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Article ; Online: Evaluation of the Reliability of Electrocardiographic Criteria for Cardiac Hypertrophy Based on Echocardiographic Data

Agnė Augustaitytė / Eglė Kalinauskienė

Acta Medica Lituanica, Vol 29, Iss

2022 Volume 1

Abstract: Background. Left ventricular hypertrophy (LVH) regardless of other risk factors may be associated with an increased risk of mortality from cardiovascular diseases. Therefore, timely diagnosis for LVH is important in order to avoid possible complications. ...

Abstract	Background. Left ventricular hypertrophy (LVH) regardless of other risk factors may be associated with an increased risk of mortality from cardiovascular diseases. Therefore, timely diagnosis for LVH is important in order to avoid possible complications. One of the simplest and cheapest methods to diagnose LVH is electrocardiography (ECG). Although a number of ECG criteria for LVH is known, their reliability varies in many studies. Aim. To evaluate the reliability of ECG criteria for LVH based on transthoracic echocardiography (TTE) data. Methods. The study included all consecutive patients in Kaunas Clinical Hospital Department of Cardiology from December 2019 until March 2020 and from September until October 2020, after applying the inclusion and exclusion criteria. The sensitivity and specificity of the ECG criteria for LVH were assessed based on TTE measurements performed during the same inpatient setting. The reliability of the ECG criteria for LVH was assessed using ROC curves. Reliability differences in gender, age and nutritional status groups were assessed using ANOVA statistical method. Results. Data from 95 patients were analyzed (63.2% were women and 36.8% were men). The sensitivity, specificity and AUC of Sokolow–Lyon criterion were 9.38%, 85.71% and 0.44 (p = 0.034), R in aVL – 6.25%, 90.48% and 0.51 (p = 0.038), Cornell – 21.88%, 100 % and0.69 (p = 0.084), Cornell product – 31.25%, 95.24% and 0.72 (p = 0.070), Peguero–Lo Presti – 31.25%, 85.71% and 0.68 (p = 0.053), respectively. No statistically significant differences were observed among the individual gender, age and nutritional status groups. Conclusions. Sokolow–Lyon and RaVL criteria were not statistically significantly reliable in LVH diagnosis compared to TTE, unlike the Cornell, Cornell product, and Peguero–Lo Presti criteria.
Keywords	ECG criteria ; left ventricular hypertrophy ; transthoracic echocardiography ; Medicine ; R
Subject code	610
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Vilnius University Press
Document type	Article ; Online
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Article ; Online: A De Novo 8q22.2q22.3 Interstitial Microdeletion in a Girl with Developmental Delay and Congenital Defects.

Kalinauskiene, Ruta / Brazdziunaite, Deimante / Burokiene, Neringa / Dirsė, Vaidas / Morkuniene, Ausra / Utkus, Algirdas / Preiksaitiene, Egle

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 6

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Female ; Humans ; Chromosome Deletion ; Abnormalities, Multiple/genetics ; Synostosis/genetics ; Intellectual Disability/genetics ; Phenotype
Language	English
Publishing date	2023-06-15
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59061156
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Article ; Online: Early repolarization pattern on ECG predicts worse outcomes in patients hospitalized due to chronic heart failure decompensation.

Ališauskas, Andrius / Naudžiūnas, Albinas / Sadauskas, Saulius / Jankauskienė, Laima / Kalinauskienė, Eglė / Jucevičius, Jonas / Vanagaitė, Giedrė

Journal of electrocardiology

2023 Volume 78, Page(s) 49–57

Abstract: Background: To improve the outcomes of patients with chronic heart failure (CHF), it is important to identify reliable prognostic tools. Early repolarization pattern (ER) on 12‑lead electrocardiogram (ECG) is a predictor of worse outcomes, which has ... ...

Abstract	Background: To improve the outcomes of patients with chronic heart failure (CHF), it is important to identify reliable prognostic tools. Early repolarization pattern (ER) on 12‑lead electrocardiogram (ECG) is a predictor of worse outcomes, which has been widely researched in the general population but not in the CHF population. Objective: To evaluate the incidence and prognostic value of ER and compare its prognostic significance with other non-invasive diagnostic methods for CHF outcomes and hospital readmissions. Methods: The study included 301 patients (166 men and 135 women) hospitalized for CHF decompensation. CHF diagnosis was confirmed according to the current guidelines. The patients underwent standard tests and impedance cardiography (ICG) at enrollment and on the day of discharge. Results: Thirty-one confirmed ER cases (10.3%) were enrolled. During a median follow-up period of 18 months, 128 cardiac-related deaths were observed (42.5%), with 23 (74.2%) and 105 (38.9%) patients in the ER and non-ER groups, respectively (p < 0.001). The ER group had more readmissions than the non-ER group did at 6-months (2 [1, 2] vs. 1 [1, 2]; p=0.04) and 12-months (3 [2-4] vs. 2 [1-3]; p<0.001). ER on ECG (hazard ratio [HR] 2.59; 95% confidence interval [CI] 1.64-4.07; p<0.001), N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels ≥425.5 pmoL/L (HR 5.1; 95% CI 3.33-7.83; p < 0.001), thoracic fluid content (TFC) ≥36.9 1/kΩ (HR 4.6; 95% CI 2.7-7.85, p < 0.001), and left ventricular ejection fraction (LVEF) ≤40% (HR 4.94; 95% CI 2.83-8.65; p < 0.001) were independently and significantly associated with cardiac death. Conclusions: The combination of ER, LVEF ≤40%, NT-proBNP, or TFC provides an incremental prognostic value for cardiac-related death in patients with CHF.
MeSH term(s)	Male ; Humans ; Female ; Ventricular Function, Left ; Stroke Volume ; Electrocardiography ; Heart Failure/diagnosis ; Heart Failure/complications ; Natriuretic Peptide, Brain ; Prognosis ; Peptide Fragments ; Chronic Disease ; Biomarkers
Chemical Substances	Natriuretic Peptide, Brain (114471-18-0) ; Peptide Fragments ; Biomarkers
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	410286-1
ISSN	1532-8430 ; 0022-0736
ISSN (online)	1532-8430
ISSN	0022-0736
DOI	10.1016/j.jelectrocard.2023.01.014
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Article ; Online: A De Novo 8q22.2q22.3 Interstitial Microdeletion in a Girl with Developmental Delay and Congenital Defects

Ruta Kalinauskiene / Deimante Brazdziunaite / Neringa Burokiene / Vaidas Dirsė / Ausra Morkuniene / Algirdas Utkus / Egle Preiksaitiene

Medicina, Vol 59, Iss 1156, p

2023 Volume 1156

Abstract: Background and Objectives: Only nine patients with interstitial de novo 8q22.2q22.3 microdeletions have been reported to date. The objective of this report is to present clinical features of a new patient with an 8q22.2q22.3 microdeletion, to compare her ...

Abstract	Background and Objectives: Only nine patients with interstitial de novo 8q22.2q22.3 microdeletions have been reported to date. The objective of this report is to present clinical features of a new patient with an 8q22.2q22.3 microdeletion, to compare her phenotype to other previously reported patients, and to further expand the phenotype associated with this microdeletion. Materials and Methods: We describe an 8½-year-old girl with developmental delay, congenital hip dysplasia, a bilateral foot deformity, bilateral congenital radioulnar synostosis, a congenital heart defect, and minor facial anomalies. Results: Chromosomal microarray analysis revealed a 4.9 Mb deletion in the 8q22.2q22.3 region. De novo origin was confirmed by real-time PCR analysis. Conclusions: Microdeletions in the 8q22.2q22.3 region are characterized by moderate to severe intellectual disability, seizures, distinct facial features and skeletal abnormalities. In addition to one already reported individual with an 8q22.2q22.3 microdeletion and unilateral radioulnar synostosis, this report of a child with bilateral radioulnar synostosis provides additional evidence, that radioulnar synostosis is not an incidental finding in individuals with an 8q22.2q22.3 microdeletion. Additional patients with similar microdeletions would be of a great importance for more accurate phenotypic description and further analysis of the genotypic-phenotypic relationship.
Keywords	8q22.2q22.3 microdeletion ; intellectual disability ; radioulnar synostosis ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Nine times measure, 10th cut away.

Kalinauskiene, Egle

Journal of electrocardiology

2010 Volume 43, Issue 3, Page(s) 220

MeSH term(s)	Electrocardiography/standards ; Humans ; Myocardial Ischemia/diagnosis ; Practice Guidelines as Topic ; United States
Language	English
Publishing date	2010-05
Publishing country	United States
Document type	Letter
ZDB-ID	410286-1
ISSN	1532-8430 ; 0022-0736
ISSN (online)	1532-8430
ISSN	0022-0736
DOI	10.1016/j.jelectrocard.2009.11.007
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Article ; Online: Comparison of the improvement in myocardial perfusion and function in cases of rapid and slow electrocardiographic stage dynamics between patients with TIMI-3 flow after primary angioplasty for acute myocardial infarction.

Kalinauskienė, Eglė / Naudžiūnas, Albinas

Medicina (Kaunas, Lithuania)

2015 Volume 51, Issue 4, Page(s) 217–221

Abstract: Background and objective: Post-PCI TIMI flow grade 3 in infarct-related artery not always is associated with follow-up improvement in myocardial perfusion and function. We compared the improvement in myocardial perfusion and function in cases of rapid ... ...

Abstract	Background and objective: Post-PCI TIMI flow grade 3 in infarct-related artery not always is associated with follow-up improvement in myocardial perfusion and function. We compared the improvement in myocardial perfusion and function in cases of rapid and slow electrocardiographic (ECG) stage dynamics between patients with TIMI-3 flow after primary angioplasty for acute myocardial infarction (MI). Materials and methods: Ten patients with post-PCI TIMI-3 flow were divided into group A (n=50, no rapid change of ECG stages) and group B (n=50, with a ≥2 ECG stages per 2 days change rate). Results: There were no significant changes after 3 months in scintigraphic (ejection fraction 44.6±9.3% vs. 42.0±3.4%, P=0.4; perfusion deficit severity 3.0±0.7 vs. 2.3±0.8, P=0.1) and echocardiographic (dysfunction score 1.9±0.2 vs. 1.6±0.5, P=0.2) data in group A. Scintigraphic data improved (ejection fraction 34.6±3.9% vs. 52.0±7.3, P=0.03; perfusion deficit severity 2.8±0.6 vs. 1.5±0.8, P=0.03) and changes in echocardiographic data were of borderline significance (dysfunction score 1.8±0.2 vs. 1.4±0.4, P=0.06) in group B. Conclusions: There was not any change in myocardial perfusion and function in a case of slow change of ECG stages after reached post-PCI TIMI flow grade 3, while myocardial perfusion improved and function tended to improve in a case of the rate at least two ECG stages in 2 days after primary angioplasty for acute MI.
MeSH term(s)	Aged ; Angioplasty ; Electrocardiography ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/physiopathology ; Myocardial Infarction/surgery ; Myocardial Perfusion Imaging ; Myocardial Reperfusion ; Percutaneous Coronary Intervention ; Prospective Studies ; Stroke Volume ; Technetium Tc 99m Sestamibi
Chemical Substances	Technetium Tc 99m Sestamibi (971Z4W1S09)
Language	English
Publishing date	2015
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.1016/j.medici.2015.04.003
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Article ; Online: Differences in the Selvester QRS score after primary PCI strategy and conservative treatment for STEMI patients with negative T waves.

Kalinauskiene, Egle / Gerviene, Dalia / Bacharova, Ljuba / Krivosikova, Zora / Naudziunas, Albinas

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc

2019 Volume 24, Issue 6, Page(s) e12684

Abstract: Background: According to current guidelines, the main indications for PCI in patients with STEMI are ST-segment deviations and defined time from the onset of symptoms. Negative T wave at admission can be a sign of prolonged ischemia or spontaneous ... ...

Abstract	Background: According to current guidelines, the main indications for PCI in patients with STEMI are ST-segment deviations and defined time from the onset of symptoms. Negative T wave at admission can be a sign of prolonged ischemia or spontaneous reperfusion. In both situations, the urgent intervention is questionable. We evaluated the infarct size and in-hospital mortality in STEMI patients with negative T wave in cases of primary PCI strategy compared with conservative treatment. Methods: A retrospective analysis of 116 STEMI patients with negative T wave at the presenting ECG was performed. Sixty-eight patients (59%) underwent primary PCI strategy (PCI group), and 48 (41%) were treated conservatively (non-PCI group). The infarct size estimated by using the Selvester score, and in-hospital mortality were evaluated. Results: The difference between Selvester score values at admission and at discharge in the non-PCI group was statistically significant (1.48; 95% CI 0.694-2.27), while no significant difference was observed in the PCI group (-0.07; 95% CI -0.546-0.686). The in-hospital mortality was higher in the non-PCI group; however, the numbers were relatively small: PCI 2 (2.9%) and non-PCI 5 (10.4%). Conclusion: In this study, we showed a reduction in the infarct size estimated by Selvester score in STEMI patients with negative T wave who were treated conservatively, while there was no significant change in the infarct size after primary PCI strategy. The higher mortality in patients treated conservatively could be attributed to higher age and comorbidities in the non-PCI group. It seems that conservative treatment strategy might be an option in STEMI patients with negative T wave.
MeSH term(s)	Aged ; Aged, 80 and over ; Conservative Treatment/methods ; Electrocardiography/methods ; Female ; Hospital Mortality ; Humans ; Male ; Percutaneous Coronary Intervention/methods ; Retrospective Studies ; ST Elevation Myocardial Infarction/physiopathology ; ST Elevation Myocardial Infarction/therapy ; Severity of Illness Index ; Treatment Outcome
Language	English
Publishing date	2019-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1325530-7
ISSN	1542-474X ; 1082-720X
ISSN (online)	1542-474X
ISSN	1082-720X
DOI	10.1111/anec.12684
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Article ; Online: Comparison of the improvement in myocardial perfusion and function in cases of rapid and slow electrocardiographic stage dynamics between patients with TIMI-3 flow after primary angioplasty for acute myocardial infarction

Eglė Kalinauskienė / Albinas Naudžiūnas

Medicina, Vol 51, Iss 4, Pp 217-

2015 Volume 221

Abstract	Background and objective: Post-PCI TIMI flow grade 3 in infarct-related artery not always is associated with follow-up improvement in myocardial perfusion and function. We compared the improvement in myocardial perfusion and function in cases of rapid and slow electrocardiographic (ECG) stage dynamics between patients with TIMI-3 flow after primary angioplasty for acute myocardial infarction (MI). Materials and methods: Ten patients with post-PCI TIMI-3 flow were divided into group A (n = 50, no rapid change of ECG stages) and group B (n = 50, with a ≥2 ECG stages per 2 days change rate). Results: There were no significant changes after 3 months in scintigraphic (ejection fraction 44.6 ± 9.3% vs. 42.0 ± 3.4%, P = 0.4; perfusion deficit severity 3.0 ± 0.7 vs. 2.3 ± 0.8, P = 0.1) and echocardiographic (dysfunction score 1.9 ± 0.2 vs. 1.6 ± 0.5, P = 0.2) data in group A. Scintigraphic data improved (ejection fraction 34.6 ± 3.9% vs. 52.0 ± 7.3, P = 0.03; perfusion deficit severity 2.8 ± 0.6 vs. 1.5 ± 0.8, P = 0.03) and changes in echocardiographic data were of borderline significance (dysfunction score 1.8 ± 0.2 vs. 1.4 ± 0.4, P = 0.06) in group B. Conclusions: There was not any change in myocardial perfusion and function in a case of slow change of ECG stages after reached post-PCI TIMI flow grade 3, while myocardial perfusion improved and function tended to improve in a case of the rate at least two ECG stages in 2 days after primary angioplasty for acute MI.
Keywords	Electrocardiogram ; Myocardial infarction ; Percutaneous coronary intervention ; Echocardiography ; Tc-99m-sestamibi scintigraphy ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: A Comparison of Electronic and Traditional Stethoscopes in the Heart Auscultation of Obese Patients

Kalinauskienė, Eglė / Razvadauskas, Haroldas / Morse, Dan J / Maxey, Gail E / Naudžiūnas, Albinas

Medicina (Kaunas, Lithuania)

2019 Volume 55, Issue 4

Abstract: Background and objectives: ...

Abstract	Background and objectives:
MeSH term(s)	Age Factors ; Aged ; Aged, 80 and over ; Body Mass Index ; Cardiologists ; Echocardiography ; Female ; Hearing Loss, High-Frequency ; Heart Auscultation/instrumentation ; Heart Murmurs/complications ; Heart Murmurs/diagnosis ; Humans ; Male ; Middle Aged ; Obesity/complications ; Obesity/physiopathology ; Sensitivity and Specificity ; Stethoscopes
Language	English
Publishing date	2019-04-05
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina55040094
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