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  1. Book ; Online: Chapter The power of photovoice

    He, Xuan / Sun, Shuai / Lin, Xiaoling

    AI support provides voicing opportunities for children in sex education

    2023  

    Keywords Product design ; Photovoice ; Sex education for children ; Artificial intelligence for care ; Participatory action research, Participatory design with family
    Language English
    Size 1 electronic resource (4 pages)
    Publisher Academia Press
    Publishing place Ghent
    Document type Book ; Online
    Note English
    HBZ-ID HT030644876
    ISBN 9789401496476 ; 9401496471
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Harmonious bilingual experience and child wellbeing: a conceptual framework.

    Sun, He

    Frontiers in psychology

    2023  Volume 14, Page(s) 1282863

    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1282863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Unveiling the magic of mega-city block environments: investigating the intriguing mechanisms shaping children's spontaneous play preferences.

    Wang, Yin / Sun, Yinan / Sun, Yihao / He, Ting

    Frontiers in psychology

    2024  Volume 15, Page(s) 1354236

    Abstract: Introduction: This study delves into the spatial preferences of children for play spaces within high-density urban block environments, specifically targeting the area of Baihua Second Road in Shenzhen, China.: Methods: Recognizing the critical role ... ...

    Abstract Introduction: This study delves into the spatial preferences of children for play spaces within high-density urban block environments, specifically targeting the area of Baihua Second Road in Shenzhen, China.
    Methods: Recognizing the critical role of play in children's development, and the unique challenges posed by dense urban settings, this research employs multiclass logistic regression models and negative binomial regression models to construct a detailed mathematical analysis of neighborhood spatial elements and children's play space preferences. Data was meticulously gathered through both objective observations of 14 different types of spaces within the block, and subjective assessments via children's responses to a series of environment photos, capturing the essence of over 3,000 child participants' interactions and choices.
    Results: Key findings reveal a pronounced preference among children for soft facility features and visually appealing spatial experiences, suggesting a nuanced understanding of play space needs beyond traditional playground designs. Notably, the study identifies that while cartoon-style designs in play facilities might increase moderate attractiveness, ordinary designs hold broader appeal, indicating a preference for diversity in play space aesthetics. These insights offer profound implications for urban planners and designers, advocating for a child-centered approach in the creation of urban play environments that prioritize aesthetic diversity, and the integration of natural elements.
    Conclusion: Moreover, the study situates Baihua Second Road as a paradigmatic case, illustrating the methodology and analytical framework applied in addressing the complex interplay between children's play preferences and urban spatial configurations. By incorporating a comprehensive data-driven analysis, this research contributes significantly to the discourse on child-friendly urban design, offering valuable strategies for cultivating inclusive and engaging urban play spaces for children amidst the constraints of high-density city living.
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2024.1354236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: AFM is used to study the biophysics of hypertension-induced tachyarrhythmia.

    He, Yin / Sun, Zhifu / He, Xiaonan / Mi, Yuhong

    Microscopy research and technique

    2023  Volume 86, Issue 9, Page(s) 1099–1107

    Abstract: Patients with long-lasting hypertension often suffer from atrial or ventricular arrhythmias. Evidence suggests that mechanical stimulation can change the refractory period and dispersion of the ventricular myocyte action potential through stretch- ... ...

    Abstract Patients with long-lasting hypertension often suffer from atrial or ventricular arrhythmias. Evidence suggests that mechanical stimulation can change the refractory period and dispersion of the ventricular myocyte action potential through stretch-activated ion channels (SACs) and influence cellular calcium transients, thus increasing susceptibility to ventricular arrhythmias. However, the specific pathogenesis of hypertension-induced arrhythmias is unknown. In this study, through clinical data, we found that a short-term increase in blood pressure leads to a rise in tachyarrhythmias in patients with clinical hypertension. We investigated the mechanism of this phenomenon using a combined imaging system(AC) of atomic force microscopy (AFM) and laser scanning confocal microscopy. After mechanical distraction to stimulate ventricular myocytes isolated from Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR), we synchronously monitored cardiomyocyte stiffness and intracellular calcium changes. This method can reasonably simulate cardiomyocytes' mechanics and ion changes when blood pressure rises rapidly. Our results indicated that the stiffness value of cardiomyocytes in SHR was significantly more extensive than that of normal controls, and cardiomyocytes were more sensitive to mechanical stress; In addition, intracellular calcium increased rapidly and briefly in rats with spontaneous hypertension. After intervention with streptomycin, a SAC blocker, ventricular myocytes are significantly less sensitive to mechanical stimuli. Thus, SAC is involved in developing and maintaining ventricular arrhythmias induced by hypertension. The increased stiffness of ventricular myocytes caused by hypertension leads to hypersensitivity of cellular calcium flow to mechanical stimuli is one of the mechanisms that cause arrhythmias. The AC system is a new research method to study the mechanical properties of cardiomyocytes. This study provides new techniques and ideas for developing new anti-arrhythmic drugs. HIGHLIGHT: The mechanism of hypertension-induced tachyarrhythmia is not precise. Through this study, it is found that the biophysical properties of myocardial abnormalities, the myocardium is excessively sensitive to mechanical stimulation, and the calcium flow appears to transient explosive changes, leading to tachyarrhythmia.
    Language English
    Publishing date 2023-07-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099714-3
    ISSN 1097-0029 ; 1059-910X
    ISSN (online) 1097-0029
    ISSN 1059-910X
    DOI 10.1002/jemt.24365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2251: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Examining influencing factors of express delivery stations' spatial distribution using the gradient boosting decision trees: A case study of Nanjing, China.

    He, Qianhui / Sun, Shijie

    PloS one

    2023  Volume 18, Issue 7, Page(s) e0288716

    Abstract: Online shopping has promoted the development of logistics and express delivery businesses. Express delivery stations are closely related to residents' daily lives, and it is an important topic for the study of urban consumption space and commercial ... ...

    Abstract Online shopping has promoted the development of logistics and express delivery businesses. Express delivery stations are closely related to residents' daily lives, and it is an important topic for the study of urban consumption space and commercial service space. This paper analyzed the factors influencing the spatial distribution of terminal logistics space (express delivery stations) in the process of online shopping. The gradient boosting decision trees (GBDT) was selected for analyzing the factors influencing the distribution of express delivery stations. The results demonstrated that express delivery stations' distribution is mainly influenced by commercial retail and residential neighborhoods, showing a clustering toward consumer spaces and residential areas. This paper studied the association between express delivery stations and other functional spaces in the city, and established an analytical framework for the factors influencing the spatial distribution of express delivery stations. The research results help to improve the rationality and effectiveness of the setting and management of the terminal logistics space in the online shopping process.
    MeSH term(s) China ; Cities ; Residence Characteristics ; Decision Trees
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0288716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Understanding consumers' purchase intentions of single-use plastic products.

    Sun, Ying / He, Haonan

    Frontiers in psychology

    2023  Volume 14, Page(s) 1105959

    Abstract: Human health and marine life are facing the hazards and threats of plastic waste. China is the world's largest producer and consumer of disposable plastic products, thus paying more attention to the threats and challenges of single-use plastics products ... ...

    Abstract Human health and marine life are facing the hazards and threats of plastic waste. China is the world's largest producer and consumer of disposable plastic products, thus paying more attention to the threats and challenges of single-use plastics products in China is urgent. This study aims to explore the intention to purchase single-use plastic products based on the theory of planned behavior. Data collection using self-reported questionnaires, and 402 valid questionnaires were obtained, thus analyzed using Amos 22.0 and SPSS 18.0 software. Results indicate that attitude, perceived behavioral control, normative social influence, informational social influence, and positive anticipated emotion positively affect intention to purchase single-use plastic products. Meanwhile, positive anticipated emotion positively moderates the relationship between normative social influence and intention to purchase single-use plastic products, but negatively moderates the relationship between informational social influence and intention to purchase single-use plastic products. This research provides some theoretical and policy implications to help relevant agencies design targeted interventions to address environmental issues related to single-use plastic consumption.
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1105959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: From PROTAC to TPD: Advances and Opportunities in Targeted Protein Degradation.

    Wang, Siqi / He, Fuchu / Tian, Chunyan / Sun, Aihua

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 1

    Abstract: PROTAC is a rapidly developing engineering technology for targeted protein degradation using the ubiquitin-proteasome system, which has promising applications for inflammatory diseases, neurodegenerative diseases, and malignant tumors. This paper gives a ...

    Abstract PROTAC is a rapidly developing engineering technology for targeted protein degradation using the ubiquitin-proteasome system, which has promising applications for inflammatory diseases, neurodegenerative diseases, and malignant tumors. This paper gives a brief overview of the development and design principles of PROTAC, with a special focus on PROTAC-based explorations in recent years aimed at achieving controlled protein degradation and improving the bioavailability of PROTAC, as well as TPD technologies that use other pathways such as autophagy and lysosomes to achieve targeted protein degradation.
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17010100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Path analysis of regional logistics and economy coordinated development: An fsQCA approach.

    An, Zhiyuan / He, Enqiu / Du, Xue / Sun, Bo

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0297441

    Abstract: The coordinated development of regional logistics and the economy is crucial for regional economic progress and for reducing regional development disparities. This study applies regional coordinated development theory and coupling theory, utilizing the ... ...

    Abstract The coordinated development of regional logistics and the economy is crucial for regional economic progress and for reducing regional development disparities. This study applies regional coordinated development theory and coupling theory, utilizing the Coupling Coordination Degree Model (CCDM) to analyze data from 31 provinces and cities in China in 2021, with the analysis results serving as the outcome variable. Additionally, we use data from four dimensions: infrastructure investment (II), technological innovation (TI), industrial structure (IS), and human capital (HC), as the conditional variables, conducting a multi-factor configurational analysis using fsQCA. Three paths with high coupling coordination and one path with non-high coupling coordination are identified, and the reasons for each path are analyzed. The results indicate that: 1) there are significant regional disparities in China regarding economic development, logistics development, and the degree of their coupling and coordination, with the eastern regions exhibiting higher levels and the western regions and other remote areas exhibiting lower levels. 2) The three paths with high coupling coordination are: "Infrastructure Investment-Technological Innovation", "Technological Innovation-Industrial Structure-Human Capital", and "Infrastructure Investment-Fundamental Innovation-Industrial Structure". These three types facilitate the well-coordinated progress of regional logistics and the economy. The article concludes by highlighting policy suggestions that underscore the significance of fortifying the bond between the logistics industry and the economy, alongside earnest efforts to enhance regional logistics standards. This will foster a mutually reinforcing and co-developing situation, further promoting coordinated development among regions, achieving high-quality regional development, and reducing the imbalances in logistics and economic development among different regions.
    MeSH term(s) Humans ; Economic Development ; Investments ; China ; Cities ; Factor Analysis, Statistical
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Global research status and frontiers on autophagy in hepatocellular carcinoma:a comprehensive bibliometric and visualized analysis.

    He, Tao / Zou, Jieyu / Sun, Ke / Yang, Juan

    International journal of surgery (London, England)

    2024  

    Abstract: Background: An extensive body of research has explored the role of autophagy in hepatocellular carcinoma (HCC), revealing its critical involvement in the disease's pathogenesis, progression, and therapeutic targeting. However, there is a discernible ... ...

    Abstract Background: An extensive body of research has explored the role of autophagy in hepatocellular carcinoma (HCC), revealing its critical involvement in the disease's pathogenesis, progression, and therapeutic targeting. However, there is a discernible deficit in quantitative, analytical studies concerning autophagy in the context of HCC. Accordingly, this investigation endeavored to meticulously assess the evolution of autophagy research, employing bibliometric citation analysis to offer a comprehensive evaluation of the findings in this field.
    Methods: We conducted a literature search on August 2, 2023, to extract relevant publications spanning from 2013 to 2022, indexed in the Science Citation Index-Expanded (SCIE) of the Web of Science Core Collection (WOSCC). Subsequently, we performed a bibliometric assessment of the compiled documents using visualization tools such as CiteSpace and VOSviewer.
    Results: The search yielded 734 publications penned by 4,699 authors, encompassing contributions from 41 countries and 909 institutions, disseminated across 272 journals, and comprising 26,295 co-cited references from 2,667 journals. Notably, China led in publication volume with 264 articles (amounting to 35.9%) and exhibited the most robust collaboration with the United States. The mechanisms underlying autophagy's influence on the emergence and advancement of HCC, as well as the implicated proteins and genes, have garnered significant attention. In recent years, investigations of targeting autophagy and the resistance to sorafenib have surfaced as pivotal themes and emerging frontiers in this domain.
    Conclusion: This study rigorously collated and distilled the prevailing research narratives and novel insights on autophagy in HCC. The resultant synthesis provides a substantive foundation for medical professionals and researchers, as well as pivotal implications for future investigative endeavors in this arena.
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000001202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6502: Show issues Location:
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  10. Article ; Online: NSD family proteins: Rising stars as therapeutic targets.

    He, Lin / Cao, Yiping / Sun, Luyang

    Cell insight

    2024  Volume 3, Issue 2, Page(s) 100151

    Abstract: Epigenetic modifications, including DNA methylation and histone post-translational modifications, intricately regulate gene expression patterns by influencing DNA accessibility and chromatin structure in higher organisms. These modifications are ... ...

    Abstract Epigenetic modifications, including DNA methylation and histone post-translational modifications, intricately regulate gene expression patterns by influencing DNA accessibility and chromatin structure in higher organisms. These modifications are heritable, are independent of primary DNA sequences, undergo dynamic changes during development and differentiation, and are frequently disrupted in human diseases. The reversibility of epigenetic modifications makes them promising targets for therapeutic intervention and drugs targeting epigenetic regulators (e.g., tazemetostat, targeting the H3K27 methyltransferase EZH2) have been applied in clinical therapy for multiple cancers. The NSD family of H3K36 methyltransferase enzymes-including NSD1 (KMT3B), NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1)-are now receiving drug development attention, with the exciting advent of an NSD2 inhibitor (KTX-1001) advancing to Phase I clinical trials for relapsed or refractory multiple myeloma. NSD proteins recognize and catalyze methylation of histone lysine marks, thereby regulating chromatin integrity and gene expression. Multiple studies have implicated NSD proteins in human disease, noting impacts from translocations, aberrant expression, and various dysfunctional somatic mutations. Here, we review the biological functions of NSD proteins, epigenetic cooperation related to NSD proteins, and the accumulating evidence linking these proteins to developmental disorders and tumorigenesis, while additionally considering prospects for the development of innovative epigenetic therapies.
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2772-8927
    ISSN (online) 2772-8927
    DOI 10.1016/j.cellin.2024.100151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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