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Article ; Online: A New Mission Awaits: Machine Learning to Predict COVID-19-Related Complications.

Shi, Shaobo / Cao, Qiqi

JACC advances

2022 Volume 1, Issue 2, Page(s) 100045

Language	English
Publishing date	2022-05-08
Publishing country	United States
Document type	Editorial
ISSN	2772-963X
ISSN (online)	2772-963X
DOI	10.1016/j.jacadv.2022.100045
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Engineering Surface Passivation and Hole Transport Layer on Hematite Photoanodes Enabling Robust Photoelectrocatalytic Water Oxidation.

Xie, Huimin / Song, Yurou / Jiao, Yuye / Gao, Lihua / Shi, Shaobo / Wang, Chen / Hou, Jungang

ACS nano

2024

Abstract: Regulation of charge transport at the molecular level is essential to elucidating the kinetics of junction photoelectrodes across the heterointerface for photoelectrochemical (PEC) water oxidation. Herein, an integrated photoanode as the prototype was ... ...

Abstract	Regulation of charge transport at the molecular level is essential to elucidating the kinetics of junction photoelectrodes across the heterointerface for photoelectrochemical (PEC) water oxidation. Herein, an integrated photoanode as the prototype was constructed by use of a 5,10,15,20-tetrakis(4-carboxyphenyl) porphyrin-cobalt molecule (CoTCPP) and ZnO on hematite (α-Fe
Language	English
Publishing date	2024-02-11
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c11638
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Machine Learning-based Development and Validation of a Cell Senescence Predictive and Prognostic Signature in Intrahepatic Cholangiocarcinoma.

Yang, Ruida / Sun, Feidi / Shi, Yu / Wang, Huanhuan / Fan, Yangwei / Wu, Yinying / Fan, Ruihan / Wu, Shaobo / Sun, Liankang

Journal of Cancer

2024 Volume 15, Issue 9, Page(s) 2810–2828

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-03-25
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.92698
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Article ; Online: MCPIP1 alleviates depressive‑like behaviors in mice by inhibiting the TLR4/TRAF6/NF‑κB pathway to suppress neuroinflammation.

An, Qi / Xia, Jiejing / Pu, Fanchun / Shi, Shaobo

Molecular medicine reports

2023 Volume 29, Issue 1

Abstract: Lipopolysaccharide‑induced (LPS) neuroinflammation serves an important role in the development of depression. Monocyte chemotactic protein‑1‑induced protein 1 (MCPIP1, also known as ZC3H12A and Regnase‑1) possesses endoribonuclease and deubiquitinase ... ...

Abstract	Lipopolysaccharide‑induced (LPS) neuroinflammation serves an important role in the development of depression. Monocyte chemotactic protein‑1‑induced protein 1 (MCPIP1, also known as ZC3H12A and Regnase‑1) possesses endoribonuclease and deubiquitinase activities. In the present study, the effects of MCPIP1 on LPS‑induced depression were assessed. A mouse model of hippocampal neuroinflammation was established by intraperitoneal injection of LPS. Microglia were treated with LPS, MCPIP1 overexpression vector, MCPIP1 knockdown vector or TLR4 inhibitor. MCPIP1 alleviated LPS‑induced depressive‑like behaviors. MCPIP1 facilitated M2 polarization of microglia. MCPIP1 attenuated the inflammatory response in microglia via inhibition of the TLR4/TNF receptor associated factor 6 (TRAF6)/NF‑κB signaling pathway. The results indicated that MCPIP1 accelerated M2‑polarization of microglia and alleviated depressive‑like behaviors of mice via the inhibition of the TLR4/TRAF6/NF‑κB signaling pathway.
MeSH term(s)	Animals ; Mice ; Lipopolysaccharides/pharmacology ; Microglia/metabolism ; Neuroinflammatory Diseases ; NF-kappa B/metabolism ; TNF Receptor-Associated Factor 6/genetics ; TNF Receptor-Associated Factor 6/metabolism ; Toll-Like Receptor 4/genetics ; Toll-Like Receptor 4/metabolism
Chemical Substances	Lipopolysaccharides ; NF-kappa B ; TNF Receptor-Associated Factor 6 ; Toll-Like Receptor 4 ; TRAF6 protein, mouse ; Tlr4 protein, mouse ; Zc3h12a protein, mouse (EC 3.1.-)
Language	English
Publishing date	2023-11-17
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2023.13129
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Article: In Situ Nano-SiO

Shi, Luwei / Zhang, Longxing / Yang, Yanping / Zhang, Haipeng / Yao, Ruijie / Yuan, Caoquan / Cheng, Shaobo

Nanomaterials (Basel, Switzerland)

2023 Volume 13, Issue 7

Abstract: Polyethylene oxide (PEO)-based composite polymer electrolytes (CPEs) containing in situ ... ...

Abstract	Polyethylene oxide (PEO)-based composite polymer electrolytes (CPEs) containing in situ SiO
Language	English
Publishing date	2023-04-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano13071294
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Article ; Online: Self-powered SnS

Chen, Jing / Xu, Jianping / Kong, Lina / Shi, Shaobo / Xu, Jianghua / Gao, Songyao / Zhang, Xiaosong / Li, Lan

Journal of colloid and interface science

2024 Volume 663, Page(s) 336–344

Abstract: In this work, we report the design and fabrication of self-powered binary response PDs based on II-type heterostructures consisting of ... ...

Abstract	In this work, we report the design and fabrication of self-powered binary response PDs based on II-type heterostructures consisting of SnS
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2024.02.154
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Article ; Online: LINC00632 relates to milder Th1/Th2 imbalance, attenuated nasal symptoms, and better response to therapy in allergic rhinitis patients.

Shi, Yanan / Zhang, Guimin / Ji, Ran / Zhang, Shengchi / Shen, Shaobo

Allergologia et immunopathologia

2023 Volume 51, Issue 2, Page(s) 120–125

Abstract: Objective: Long intergenic noncoding RNA 00632 (LINC00632) regulates nasal inflammation and CD4: Methods: In total, 120 AR patients, 20 non-atopic obstructive snoring patients as disease controls (DCs), and 20 healthy controls (HCs) were recruited. ... ...

Abstract	Objective: Long intergenic noncoding RNA 00632 (LINC00632) regulates nasal inflammation and CD4 Methods: In total, 120 AR patients, 20 non-atopic obstructive snoring patients as disease controls (DCs), and 20 healthy controls (HCs) were recruited. Their LINC00632 expressions in peripheral blood mononuclear cells were detected by RT-qPCR. Results: LINC00632 expression was declined in AR patients compared with DCs and HCs (both Conclusion: LINC00632 relates to milder Th1/Th2 imbalance, attenuated nasal symptoms, and better response during 4-week therapy in AR patients.
MeSH term(s)	Animals ; Humans ; Cytokines/metabolism ; Disease Models, Animal ; Leukocytes, Mononuclear/metabolism ; Nasal Mucosa/metabolism ; Rhinitis, Allergic/drug therapy ; Th1 Cells ; Th2 Cells
Chemical Substances	Cytokines
Language	English
Publishing date	2023-03-01
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193144-1
ISSN	1578-1267 ; 0301-0546
ISSN (online)	1578-1267
ISSN	0301-0546
DOI	10.15586/aei.v51i2.728
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1165: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: The progress of research on the application of redox nanomaterials in disease therapy.

Shi, Xiaolu / Tian, Ye / Zhai, Shaobo / Liu, Yang / Chu, Shunli / Xiong, Zhengrong

Frontiers in chemistry

2023 Volume 11, Page(s) 1115440

Abstract: Redox imbalance can trigger cell dysfunction and damage and plays a vital role in the origin and progression of many diseases. Maintaining the balance between oxidants and ... ...

Abstract	Redox imbalance can trigger cell dysfunction and damage and plays a vital role in the origin and progression of many diseases. Maintaining the balance between oxidants and antioxidants
Language	English
Publishing date	2023-02-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711776-5
ISSN	2296-2646
ISSN	2296-2646
DOI	10.3389/fchem.2023.1115440
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Article ; Online: Integrating network pharmacology, experimental validation and molecular docking to reveal the alleviation of Yinhuang granule on idiopathic pulmonary fibrosis.

Wu, Zeqi / Shi, Ruijia / Yan, Shihao / Zhang, Shaobo / Lu, Bin / Huang, Zhenlin / Ji, Lili

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 128, Page(s) 155368

Abstract: Background: Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by the abnormal proliferation of fibroblast and excessive deposition of extracellular matrix (ECM), accompanied by inflammation and ultimately respiratory failure. ... ...

Abstract	Background: Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by the abnormal proliferation of fibroblast and excessive deposition of extracellular matrix (ECM), accompanied by inflammation and ultimately respiratory failure. Yinhuang granule (YHG), with clinical properties of clearing heat, detoxifying and anti-inflammation, is commonly used to heal upper respiratory diseases in China for decades. Purpose: To explore the improvement of YHG on bleomycin (BLM)-induced IPF in mice and its possible engaged mechanism. Methods: The mortality rate was recorded, lung function was determined and hematoxylin-eosin (H&E) staining was carried out to explore the alleviation of YHG on BLM-caused IPF in mice. Hydroxyproline, collagen I and collagen III contents were detected, and Sirius red and Masson staining were conducted to evaluate YHG's alleviation on lung fibrosis. The underlying mechanism was predicted by network pharmacology, and confirmed by Real-time polymerase chain reaction (RT-PCR), Western-blot (WB) and enzyme linked immunosorbent assay (ELISA). The binding affinity between related key proteins and active compounds in YHG was calculated by using molecular docking, and further validated by cellular thermal shift assay (CESTA). Results: YHG (400, 800 mg/kg) weakened lung damage and pulmonary fibrosis in mice induced by BLM. Network pharmacology and experimental validation displayed that inflammation and angiogenesis participated in the YHG-provided improvement on IPF, and key involved molecules included tumor necrosis factor-α (TNFα), vascular endothelial growth factor-A (VEGFA), interleukine-6 (IL-6), etc. The data of molecular docking presented that some main active compounds from YHG had a high binding affinity with TNFR1 or VEGFR2, and some of them were further validated by CESTA. Conclusion: YHG effectively improved the BLM-induced IPF in mice via reducing inflammation and angiogenesis.
Language	English
Publishing date	2024-01-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155368
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Zs.A 4115: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods.

Shi, Zhen / Wang, Yazhen / Dong, Shaobo / Lan, Tianyu

RSC advances

2021 Volume 11, Issue 34, Page(s) 20670–20678

Abstract: In this paper, two methods were used to prepare the magnetic targeting drug carrier ... ...

Abstract	In this paper, two methods were used to prepare the magnetic targeting drug carrier Fe
Language	English
Publishing date	2021-06-09
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d1ra04256d
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