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  1. Article ; Online: Initial data from the COVID-19 Global Rheumatology Alliance provider registries - Authors' reply.

    Gianfrancesco, Milena A

    The Lancet Rheumatology

    2020  Volume 2, Issue 6, Page(s) e317

    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(20)30125-9
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  2. Article ; Online: Changing COVID-19 outcomes in patients with rheumatic disease-are we really getting better at this?

    Gianfrancesco, Milena A / Robinson, Philip C

    The Lancet. Rheumatology

    2021  Volume 3, Issue 2, Page(s) e88–e90

    Language English
    Publishing date 2021-01-28
    Publishing country England
    Document type Journal Article
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(21)00008-4
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  4. Article ; Online: Where There's Smoke, There's a Joint: Passive Smoking and Rheumatoid Arthritis.

    Gianfrancesco, Milena A / Crowson, Cynthia S

    Arthritis & rheumatology (Hoboken, N.J.)

    2021  Volume 73, Issue 12, Page(s) 2161–2162

    MeSH term(s) Arthritis, Rheumatoid/etiology ; Humans ; Smoke ; Smoking ; Tobacco Smoke Pollution/adverse effects
    Chemical Substances Smoke ; Tobacco Smoke Pollution
    Language English
    Publishing date 2021-10-26
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.41940
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  5. Article ; Online: Initial data from the COVID-19 Global Rheumatology Alliance provider registries – Authors' reply

    Gianfrancesco, Milena A

    The Lancet Rheumatology

    2020  Volume 2, Issue 6, Page(s) e317

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2665-9913
    DOI 10.1016/s2665-9913(20)30125-9
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: A narrative review on the validity of electronic health record-based research in epidemiology.

    Gianfrancesco, Milena A / Goldstein, Neal D

    BMC medical research methodology

    2021  Volume 21, Issue 1, Page(s) 234

    Abstract: Electronic health records (EHRs) are widely used in epidemiological research, but the validity of the results is dependent upon the assumptions made about the healthcare system, the patient, and the provider. In this review, we identify four overarching ... ...

    Abstract Electronic health records (EHRs) are widely used in epidemiological research, but the validity of the results is dependent upon the assumptions made about the healthcare system, the patient, and the provider. In this review, we identify four overarching challenges in using EHR-based data for epidemiological analysis, with a particular emphasis on threats to validity. These challenges include representativeness of the EHR to a target population, the availability and interpretability of clinical and non-clinical data, and missing data at both the variable and observation levels. Each challenge reveals layers of assumptions that the epidemiologist is required to make, from the point of patient entry into the healthcare system, to the provider documenting the results of the clinical exam and follow-up of the patient longitudinally; all with the potential to bias the results of analysis of these data. Understanding the extent of as well as remediating potential biases requires a variety of methodological approaches, from traditional sensitivity analyses and validation studies, to newer techniques such as natural language processing. Beyond methods to address these challenges, it will remain crucial for epidemiologists to engage with clinicians and informaticians at their institutions to ensure data quality and accessibility by forming multidisciplinary teams around specific research projects.
    MeSH term(s) Bias ; Delivery of Health Care ; Electronic Health Records ; Health Services Needs and Demand ; Humans
    Language English
    Publishing date 2021-10-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2041362-2
    ISSN 1471-2288 ; 1471-2288
    ISSN (online) 1471-2288
    ISSN 1471-2288
    DOI 10.1186/s12874-021-01416-5
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  7. Article: Practical Considerations for Developing Clinical Natural Language Processing Systems for Population Health Management and Measurement.

    Tamang, Suzanne / Humbert-Droz, Marie / Gianfrancesco, Milena / Izadi, Zara / Schmajuk, Gabriela / Yazdany, Jinoos

    JMIR medical informatics

    2023  Volume 11, Page(s) e37805

    Abstract: Experts have noted a concerning gap between clinical natural language processing (NLP) research and real-world applications, such as clinical decision support. To help address this gap, in this viewpoint, we enumerate a set of practical considerations ... ...

    Abstract Experts have noted a concerning gap between clinical natural language processing (NLP) research and real-world applications, such as clinical decision support. To help address this gap, in this viewpoint, we enumerate a set of practical considerations for developing an NLP system to support real-world clinical needs and improve health outcomes. They include determining (1) the readiness of the data and compute resources for NLP, (2) the organizational incentives to use and maintain the NLP systems, and (3) the feasibility of implementation and continued monitoring. These considerations are intended to benefit the design of future clinical NLP projects and can be applied across a variety of settings, including large health systems or smaller clinical practices that have adopted electronic medical records in the United States and globally.
    Language English
    Publishing date 2023-01-03
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2798261-0
    ISSN 2291-9694
    ISSN 2291-9694
    DOI 10.2196/37805
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  8. Article ; Online: The racial/ethnic and sociocultural aspects of the pandemic in rheumatology.

    Taylor, Tiffany / Yazdany, Jinoos / Gianfrancesco, Milena A

    Best practice & research. Clinical rheumatology

    2021  Volume 35, Issue 1, Page(s) 101665

    Abstract: The disproportionate impact of coronavirus-2019 (COVID-19) on communities of color is gaining global attention. Current research demonstrates that historically marginalized populations are experiencing disproportionate levels of SARS-Cov-2 infection and ... ...

    Abstract The disproportionate impact of coronavirus-2019 (COVID-19) on communities of color is gaining global attention. Current research demonstrates that historically marginalized populations are experiencing disproportionate levels of SARS-Cov-2 infection and adverse clinical outcomes. However, research examining whether COVID-19 outcomes vary by race and ethnicity within the rheumatic disease population is limited. This paper will review data showing how SARS-CoV-2 infection has differentially affected racial and ethnic minorities in the general population and those with rheumatic disease. We will also highlight disparities in rheumatic disease risk and severity that existed prior to the pandemic, and discuss recent work examining severe outcomes of COVID-19 in rheumatic disease patients by race and ethnicity. Finally, we propose several actionable steps for the rheumatology community to address COVID-19 health disparities, which may have long-term effects on patients with rheumatic disease.
    MeSH term(s) COVID-19 ; Ethnicity ; Health Status Disparities ; Humans ; Pandemics ; Rheumatology ; SARS-CoV-2
    Language English
    Publishing date 2021-02-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2021.101665
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    Se 1036: Show issues Location:
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  9. Article ; Online: Relationship Between Body Mass Index, Disease Activity, and Exercise in Ankylosing Spondylitis.

    Liew, Jean W / Gianfrancesco, Milena A / Heckbert, Susan R / Gensler, Lianne S

    Arthritis care & research

    2022  Volume 74, Issue 8, Page(s) 1287–1293

    Abstract: Objective: Ankylosing spondylitis (AS) is associated with elevated cardiovascular risk, and obesity is a common, modifiable risk factor. Our aims were to assess the relationship of body mass index (BMI) with disease activity in AS patients and to assess ...

    Abstract Objective: Ankylosing spondylitis (AS) is associated with elevated cardiovascular risk, and obesity is a common, modifiable risk factor. Our aims were to assess the relationship of body mass index (BMI) with disease activity in AS patients and to assess the extent to which the effect is mediated through exercise.
    Methods: We used data from a prospective AS cohort with a median follow-up of 7 years. To determine the association of BMI (kg/m
    Results: There were 183 subjects with available BMI and disease activity data (77% male, 70% White, mean ± SD age 40.8 ± 13.3 years). Higher BMI was significantly associated with higher disease activity over time; on average, for a 1 kg/m
    Conclusion: Higher BMI was associated with higher disease activity in a prospective AS cohort. We found that being overweight/obese largely influenced disease activity directly rather than indirectly through exercise. Other mechanisms, such as increased inflammation, may better explain the obesity-disease activity association.
    MeSH term(s) Adult ; Body Mass Index ; Female ; Humans ; Male ; Middle Aged ; Obesity/complications ; Obesity/diagnosis ; Obesity/epidemiology ; Overweight/complications ; Prospective Studies ; Severity of Illness Index ; Spondylitis, Ankylosing/complications ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/epidemiology
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 645059-3
    ISSN 2151-4658 ; 0893-7524 ; 2151-464X
    ISSN (online) 2151-4658
    ISSN 0893-7524 ; 2151-464X
    DOI 10.1002/acr.24565
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  10. Article ; Online: More on Covid-19 in Immune-Mediated Inflammatory Diseases.

    Briggs, Farren B S / Gianfrancesco, Milena A / George, Michaela F

    The New England journal of medicine

    2020  Volume 383, Issue 8, Page(s) 796–797

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Inflammation ; New York ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2018011
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