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Article ; Online: ADAD2 interacts with RNF17 in P-bodies to repress the Ping-pong cycle in pachytene piRNA biogenesis.

Xiong, Mengneng / Yin, Lisha / Gui, Yiqian / Lv, Chunyu / Ma, Xixiang / Guo, Shuangshuang / Wu, Yanqing / Feng, Shenglei / Fan, Xv / Zhou, Shumin / Wang, Lingjuan / Wen, Yujiao / Wang, Xiaoli / Xie, Qingzhen / Namekawa, Satoshi H / Yuan, Shuiqiao

The Journal of cell biology

2023 Volume 222, Issue 5

Abstract: ... pachytene piRNA biogenesis with regard to the lack of a secondary amplification process known as the Ping ... pong cycle. However, the underlying molecular mechanism and the venue for the suppression of the Ping ... family member protein RNF17 and is associated with P-bodies. Importantly, ADAD2 directs RNF17 to repress Ping ...

Abstract	Pachytene piRNA biogenesis is a hallmark of the germline, distinct from another wave of pre-pachytene piRNA biogenesis with regard to the lack of a secondary amplification process known as the Ping-pong cycle. However, the underlying molecular mechanism and the venue for the suppression of the Ping-pong cycle remain elusive. Here, we showed that a testis-specific protein, ADAD2, interacts with a TDRD family member protein RNF17 and is associated with P-bodies. Importantly, ADAD2 directs RNF17 to repress Ping-pong activity in pachytene piRNA biogenesis. The P-body localization of RNF17 requires the intrinsically disordered domain of ADAD2. Deletion of Adad2 or Rnf17 causes the mislocalization of each other and subsequent Ping-pong activity derepression, secondary piRNAs overproduced, and disruption of P-body integrity at the meiotic stage, thereby leading to spermatogenesis arrested at the round spermatid stage. Collectively, by identifying the ADAD2-dependent mechanism, our study reveals a novel function of P-bodies in suppressing Ping-pong activity in pachytene piRNA biogenesis.
MeSH term(s)	Male ; Meiotic Prophase I ; Piwi-Interacting RNA ; Processing Bodies ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Spermatogenesis/genetics
Chemical Substances	Piwi-Interacting RNA ; RNA, Small Interfering
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.202206067
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Article ; Online: NMR-based metabolomic approach to understanding Zeng-Sheng-Ping-induced hepatotoxicity, and identifying possible toxic constituents by LC-MS profiles.

Wu, Yan / Wang, Jia-Qi / Wang, Ya-Nan / Pang, Xiao-Xia / Bao, Jie / Guan, Xiao-Bing / Wang, Su-Juan

Journal of pharmaceutical and biomedical analysis

2022 Volume 217, Page(s) 114833

Abstract: Zeng-Sheng-Ping (ZSP) tablets, made from six Chinese herbs, are widely used in the chemoprevention ...

Abstract	Zeng-Sheng-Ping (ZSP) tablets, made from six Chinese herbs, are widely used in the chemoprevention and treatment of precancerous lesions in patients with gastrointestinal cancer. However, sporadic cases of liver injury have occurred. Herein, the serum metabolites in hamsters with ZSP-induced liver damage were analyzed by NMR-based metabolomics. Twelve metabolites associated with ZSP-induced hepatoxicity were identified. Amino acid metabolism and the urea cycle were significantly altered, and three associated amino acid metabolic enzymes (PAH, GS, and GLS) were further validated by ELISA. Therefore, 12 metabolites and 3 amino acid metabolic enzymes were proposed as potential biomarkers in ZSP-induced liver injury. The chemical constituents of ZSP tablets were profiled using liquid chromatography-mass spectrometry. The furanoids in two herbs, Dioscorea bulbifera L. and Dictamnus dasycarpus Turcz., were proposed to be the major hepatotoxic constituents in ZSP, leading to an improved preparation method with low hepatotoxicity for ZSP.
MeSH term(s)	Amino Acids/metabolism ; Chemical and Drug Induced Liver Injury/metabolism ; Chromatography, Liquid ; Humans ; Liver/metabolism ; Metabolomics/methods ; Tandem Mass Spectrometry
Chemical Substances	Amino Acids
Language	English
Publishing date	2022-05-14
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2022.114833
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Article ; Online: Mechanisms and molecular targets of the Yu-Ping-Feng powder for allergic rhinitis, based on network pharmacology.

Yang, Shasha / Fu, Qinwei / Deng, Hua / Liu, Zhiqing / Zhong, Juan / Zhu, Xiaoyu / Wang, Qian / Sun, Chuanhui / Wu, Jing

Medicine

2021 Volume 100, Issue 35, Page(s) e26929

Abstract: Abstract: In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat ...

Abstract	Abstract: In traditional Chinese medicine (TCM), Yu-Ping-Feng powder (YPFP) has been used to treat allergic rhinitis (AR) for centuries. However, the mechanisms underlying its effects or its molecular targets in AR treatment are yet to be elucidated. Therefore, the active compounds of YPFP and their targets were collected and identified from the Traditional Chinese Medicine Systems Pharmacology database. Moreover, AR-associated targets were acquired from the GeneCards and Online Mendelian Inheritance in Man database. Proteins interactions network of YPFP presumed targets and AR-associated targets were examined and merged to reveal the candidate YPFP targets against AR.Cytoscape software and BisoGenet Database were employed to perform the Visualization and Integrated Discovery (Cluster Profiler R package, version: 3.8.1). Kyoto Encyclopedia of Genes and Genomes and genome pathway analyses. To identify the key target genes, a gene-pathway network has been constructed.We identified 44 effective active compounds and 622 YPFP targets. Also 1324 target genes related to AR were identified. Twenty pathways, including those of AGE-RAGE signaling, fluid shear stress, atherosclerosis, PI3K-Akt signaling, and tumor necrosis factor signaling was enriched significantly. MAPK1 was identified as the core gene, while others including RELA, AKT1, NFKBIA, IL6, and JUN, were also important in the gene-pathway network. Clearly, network pharmacology can be applied in revealing the molecular targets and mechanisms of action of complex herbal preparations.These findings suggested that YPFP could treat AR by regulating immunological functions, diminishing inflammation, and improving immunity through different pathways.
MeSH term(s)	Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Pharmacology/methods ; Protein Interaction Maps/drug effects ; Rhinitis, Allergic/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; yu ping feng san
Language	English
Publishing date	2021-09-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000026929
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Article: Yu-Ping-Feng Formula Exerts Antilung Cancer Effects by Remodeling the Tumor Microenvironment through Regulating Myeloid-Derived Suppressor Cells.

Wang, Yuli / Sun, Ningyang / Luo, Yingbin / Fang, Zhihong / Fang, Yuan / Tian, Jianhui / Yu, Yongchun / Wu, Jianchun / Li, Yan

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 6624461

Abstract: Yu-Ping-Feng (YPF) formula is a classical prescription used for enhancing the body's immunity ...

Abstract	Yu-Ping-Feng (YPF) formula is a classical prescription used for enhancing the body's immunity function in traditional Chinese medicine (TCM). In clinical practice, the YPF formula has been reported to exhibit antilung cancer and immunomodulatory effect. However, the relationship between them remains unclear. The present study aimed to investigate the antilung cancer effect of the YPF formula and its immune-related mechanisms. The C57BL/6 tumor-bearing mice model was established and randomly divided into the YPF group and the control group. Tumor volume, spleen weight, and survival in both groups were measured and evaluated during 28 days of consecutive intervention. Flow cytometry was used to detect the proportion of immune cell subsets. Myeloid-derived suppressor cells (MDSCs) were induced in vitro from bone marrow cells. After intervention by the YPF formula, CCK-8 and flow cytometry analyses were performed to detect proliferation and apoptosis of MDSCs. A coculture system containing T cells and MDSCs was established to further study the role of MDSCs in the regulation of T-cell subsets proportion by the YPF formula. The expressions of MDSCs-related genes and proteins were detected by RT-PCR and Western blotting. The results showed the YPF formula inhibited tumor growth, reduced spleen weight, and prolonged the survival of mice. Besides, the proportions of MDSCs subsets and Regulatory
Language	English
Publishing date	2021-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/6624461
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Article ; Online: Effects of Different LED Light Qualities on Plant Growth and Flower Traits of Chrysanthemum Ping Pong

Honghui LUO / Qing WU / Junxiao HOU / Zeyu LI / Jingwen LI / Fenglan WANG / Hougao ZHOU

Guangdong nongye kexue, Vol 49, Iss 12, Pp 44-

2022 Volume 54

Abstract: ... of 'Pink Ping Pong'and Purple Ping Pong, the LED white light treatment was used as the CK group, the total ... Ping Pong and 70-day-treatment Purple Ping Pong under RBFR treatment increased by 18.3% and 27.3 ... leaf dry weight of the 70-day-treatment Purple Ping Pong under RBFR treatment were 18.6%, 5.8%, 25.6 ...

Abstract	【Objective】Due to the instability of flower color and some other growth traits of chrysanthemums growing in high temperature environment in South China, effective LED light combinations were investigated to regulate the growth and flower color of chrysanthemums in order to provide theoretical references of LED light cultivation technology for the production of chrysanthemums.【Method】Different LED light combination treatments of RBFR (the photosynthetic photon flux density PPFD ratio of red ∶ blue ∶ far-red light ≈ 10 ∶ 7 ∶ 2.5), RBUV (red ∶ blue ∶ ultraviolet light ≈ 10 ∶ 6 ∶ 0.5) and WB (white ∶ blue ≈ 10 ∶ 4.8) were performed on 35-day-old potted seedlings of commercially popular chrysanthemum cultivars of 'Pink Ping Pong'and Purple Ping Pong, the LED white light treatment was used as the CK group, the total light intensity of each group was set to be about 240 μmol·m-2s-1, and all treatments lasted for 80 days. The changes of growth trait indicators of the chrysanthemums growing from seedling to mature flowering were observed and photographed.【Result】(1) Compared with CK group, the plant heights of 80-day-treatment Pink Ping Pong and 70-day-treatment Purple Ping Pong under RBFR treatment increased by 18.3% and 27.3% respectively, the stem thicknesses increased by 14.1% and 38.1% respectively, the petiole lengths increased by 0.4% and 34.8% respectively; and the mean values of leaf length, leaf width, leaf fresh weight and leaf dry weight of the 70-day-treatment Purple Ping Pong under RBFR treatment were 18.6%, 5.8%, 25.6% and 45.5% higher than those of CK group, respectively; values of the above growth trait indicators were the highest among all treatment groups. (2) In terms of flowering trait indicators of the 70-day-treatment Ping Pong, mean values of peduncle length, peduncle diameter, petal length and petal width of the top capitulum and diameter of side capitulum of 'Pink Ping Pong'under WB treatment were the highest among all treatment groups, which were 4.5%, 2.3%, 10.9%, 17.3%, and 19.1% higher than ...
Keywords	chrysanthemum 'ping pong' ; led light combination ; far-red to red-blue light ; plant growth ; white blue light ; flower color ; flower quality ; Agriculture ; S
Subject code	580
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Guangdong Academy of Agricultural Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The Mechanisms of Yu Ping Feng San in Tracking the Cisplatin-Resistance by Regulating ATP-Binding Cassette Transporter and Glutathione S-Transferase in Lung Cancer Cells.

Du, Yingqing / Zheng, Yuzhong / Yu, Ciel Xiaomei / Zhong, Lishan / Li, Yafang / Wu, Baomeng / Hu, Weihui / Zhu, Elsa Wanyi / Xie, Venus Wei / Xu, Qitian / Zhan, Xingri / Huang, Yamiao / Zeng, Liyi / Zhang, Zhenxia / Liu, Xi / Yin, Jiachuan / Zha, Guangcai / Chan, Kelvin / Tsim, Karl Wah Keung

Frontiers in pharmacology

2021 Volume 12, Page(s) 678126

Abstract: ... however, the chemotherapeutic drug resistance is still a major obstacle of cisplatin in treating cancers. Yu Ping Feng San (YPFS ...

Abstract	Cisplatin is one of the first line anti-cancer drugs prescribed for treatment of solid tumors; however, the chemotherapeutic drug resistance is still a major obstacle of cisplatin in treating cancers. Yu Ping Feng San (YPFS), a well-known ancient Chinese herbal combination formula consisting of Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix, is prescribed as a herbal decoction to treat immune disorders in clinic. To understand the fast-onset action of YPFS as an anti-cancer drug to fight against the drug resistance of cisplatin, we provided detailed analyses of intracellular cisplatin accumulation, cell viability, and expressions and activities of ATP-binding cassette transporters and glutathione S-transferases (GSTs) in YPFS-treated lung cancer cell lines. In cultured A549 or its cisplatin-resistance A549/DDP cells, application of YPFS increased accumulation of intracellular cisplatin, resulting in lower cell viability. In parallel, the activities and expressions of ATP-binding cassette transporters and GSTs were down-regulated in the presence of YPFS. The expression of p65 subunit of NF-κB complex was reduced by treating the cultures with YPFS, leading to a high ratio of Bax/Bcl-2, i.e. increasing the rate of cell death. Prim-O-glucosylcimifugin, one of the abundant ingredients in YPFS, modulated the activity of GSTs, and then elevated cisplatin accumulation, resulting in increased cell apoptosis. The present result supports the notion of YPFS in reversing drug resistance of cisplatin in lung cancer cells by elevating of intracellular cisplatin, and the underlying mechanism may be down regulating the activities and expressions of ATP-binding cassette transporters and GSTs.
Language	English
Publishing date	2021-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.678126
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Article: Discussion on the sedimentary structure, geochemical characteristics and sedimentary environment of Ping Chau formation at Tung Ping Chau, Hong Kong.

Wang, Lulin / Tian, Mingzhong / Wu, Fadong

Journal of environmental biology

2015 Volume 36 Spec No, Page(s) 777–788

Abstract: Ping Chau Formation has long been regarded as the youngest formation in Hong Kong ... since its emergence from Tung Ping Chau, an island on the northeast of Mirs Bay of New Territories. On the basis ... sedimentary environment of Ping Chau Formation at Tung Ping Chau. Furthermore, with combination of geochemical ...

Abstract	Ping Chau Formation has long been regarded as the youngest formation in Hong Kong since its emergence from Tung Ping Chau, an island on the northeast of Mirs Bay of New Territories. On the basis of field survey, the present study re-collates and re-stipulates typical sedimentary structure and sedimentary environment of Ping Chau Formation at Tung Ping Chau. Furthermore, with combination of geochemical laboratory methods for the first time a systematic analysis of the major and trace elements of Ping Chau Formation, and geochemical characteristics of rare earth elements were studied. The results showed that: Ping Chau Formation was formed in a passive continental margin structural environment; the study area belonged to transition facies ranging from brackish water to fresh water, with salinity increase from bottom to top on the profile showing a tendency of gradual salinization, The sedimentary environment of Ping Chau Formation had an anoxic reducing environment; The study concluded that Ping Chau Formation was formed in a reducing environment of brackish water or shore-shallow lake with low salinity.
MeSH term(s)	Geologic Sediments/chemistry ; Geological Phenomena ; Hong Kong
Language	English
Publishing date	2015-07
Publishing country	India
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	0254-8704
ISSN	0254-8704
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Article ; Online: Chemical Constituents, Quantitative Analysis, Anti-SARS-CoV-2 and Antioxidant Activities of Herbal Formula “Ping An Fang Yu Yin”

Yun-Chen Tsai / Ming-Chung Lee / Yu-Hui Hsieh / Kun-Teng Wang / Chao-Yu Chen / Wu-Chang Chuang / Jih-Jung Chen

Processes, Vol 10, Iss 2213, p

2022 Volume 2213

Abstract: ... coronavirus 2 (SARS-CoV-2). The herbal formula, Ping An Fang Yu Yin (PAFYY), has been used to prevent ...

Abstract	COVID-19 is a global pandemic infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The herbal formula, Ping An Fang Yu Yin (PAFYY), has been used to prevent respiratory viral infections for many years. This study aims to evaluate the effect of PAFYY on SARS-CoV-2 infection, oxidative stress, and inflammation via in vitro, investigate the chemical composition by full constituent quantitative analysis, and verify its anti-viral potential against SARS-CoV-2 using in silico. In this study, a total of eleven compounds, twenty amino acids, saccharide compositions, and trace elements were found and quantitatively determined by chromatographic techniques. PAFYY displayed free radical scavenging activity (DPPH, SC 50 : 1.24 ± 0.09 mg/mL), SOD activity (68.71 ± 1.28%), inhibition of lipoxygenase activity (75.96 ± 7.64 mg/mL) and interfered the interaction of SARS-CoV-2 spike protein and angiotensin-converting enzyme 2 (48.04 ± 3.18%). Furthermore, in-silico analysis results supported that liquiritin, 3,5-dicaffeoylquinic acid, and luteolin-7- O -glucoside with the highest affinity between SARS-CoV-2 RBD and human angiotensin-converting enzyme II (hACE2) receptor. Our findings suggest that PAFYY has the potential for anti-SARS-CoV-2 infection, anti-oxidation stress, and anti-inflammation, and may be used as supplements for amelioration or prevention of COVID-19 symptoms, as well as the representative compounds can be used for quality control of PAFYY in the future.
Keywords	Ping An Fang Yu Yin ; anti-SARS-CoV-2 ; antioxidant ; chromatographic techniques ; fingerprints analysis ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	572
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Yu-Ping-Feng Formula Exerts Antilung Cancer Effects by Remodeling the Tumor Microenvironment through Regulating Myeloid-Derived Suppressor Cells

Yuli Wang / Ningyang Sun / Yingbin Luo / Zhihong Fang / Yuan Fang / Jianhui Tian / Yongchun Yu / Jianchun Wu / Yan Li

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: Yu-Ping-Feng (YPF) formula is a classical prescription used for enhancing the body’s immunity ...

Abstract	Yu-Ping-Feng (YPF) formula is a classical prescription used for enhancing the body’s immunity function in traditional Chinese medicine (TCM). In clinical practice, the YPF formula has been reported to exhibit antilung cancer and immunomodulatory effect. However, the relationship between them remains unclear. The present study aimed to investigate the antilung cancer effect of the YPF formula and its immune-related mechanisms. The C57BL/6 tumor-bearing mice model was established and randomly divided into the YPF group and the control group. Tumor volume, spleen weight, and survival in both groups were measured and evaluated during 28 days of consecutive intervention. Flow cytometry was used to detect the proportion of immune cell subsets. Myeloid-derived suppressor cells (MDSCs) were induced in vitro from bone marrow cells. After intervention by the YPF formula, CCK-8 and flow cytometry analyses were performed to detect proliferation and apoptosis of MDSCs. A coculture system containing T cells and MDSCs was established to further study the role of MDSCs in the regulation of T-cell subsets proportion by the YPF formula. The expressions of MDSCs-related genes and proteins were detected by RT-PCR and Western blotting. The results showed the YPF formula inhibited tumor growth, reduced spleen weight, and prolonged the survival of mice. Besides, the proportions of MDSCs subsets and Regulatory T (Treg) in the YPF group decreased, whereas those of CD4+T and CD8+T increased both in vitro and in vivo. CCK-8 and flow cytometry demonstrated that the YPF formula could inhibit proliferation and promote apoptosis of MDSCs. The coculture experiments further confirmed that MDSCs served a critical role in regulating the tumor microenvironment by the YPF formula. RT-PCR and Western blotting indicated that the levels of MDSCs’ activation and proliferation-related proteins and genes were downregulated in the YPF group. Therefore, our results demonstrated that the YPF formula could promote apoptosis and inhibit the proliferation of ...
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Xiao-ai-ping injection adjunct with platinum-based chemotherapy for advanced non-small-cell lung cancer: a systematic review and meta-analysis.

Feng, Fanchao / Huang, Jingyi / Wang, Zhichao / Zhang, Jiarui / Han, Di / Wu, Qi / He, Hailang / Zhou, Xianmei

BMC complementary medicine and therapies

2020 Volume 20, Issue 1, Page(s) 3

Abstract: Background: Xiao-ai-ping injection (XAPI), as patented Chinese medicine, has shown promising ...

Abstract	Background: Xiao-ai-ping injection (XAPI), as patented Chinese medicine, has shown promising outcomes in non-small-cell lung cancer (NSCLC) patients. This meta-analysis investigated the efficacy and safety of XAPI in combination with platinum-based chemotherapy. Methods: A comprehensive literature search was conducted to identify relevant studies in Pubmed, EMBASE, the Cochrane Library, Chinese National Knowledge Infrastructure, Wangfang Database, VIP Database, and Chinese Biology Medical Database from the date of their inception to September 2018. The RevMan 5.3 software was applied to calculate the risk ratio (RR) and mean difference (MD) with 95% confidence interval (CI). Results: We included and analyzed 24 randomized controlled trials. The meta-analysis showed that XAPI adjunctive to platinum-based chemotherapy had better outcomes in objective tumor response rate (ORR) (RR: 1.27, 95% CI, 1.14-1.40); improved Karnofsky performance scores (KPS) (RR: 1.70, 95% CI, 1.48-1.95); reduction in occurrence of grade 3/4 leukopenia (RR: 0.49, 95% CI, 0.38-0.64), anemia (RR: 0.63, 95% CI, 0.46-0.87) and thrombocytopenia (RR: 0.53, 95% CI, 0.38-0.73), nausea and vomiting (RR: 0.57, 95% CI, 0.36-0.90); and enhanced immune function (CD8 Conclusions: Our meta-analyses demonstrated that XAPI in combination with platinum-based chemotherapy had a better tumor response, improved the quality of life, attenuated adverse side effects, and enhanced immune function, which suggests that it might be used for advanced NSCLC. Moreover, low dosage (< 60 ml/d) and long-term treatment of XAPI might be a choice for advanced NSCLC patients.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Injections ; Karnofsky Performance Status ; Lung Neoplasms/drug therapy ; Medicine, Chinese Traditional ; Platinum Compounds/therapeutic use ; Randomized Controlled Trials as Topic
Chemical Substances	Drugs, Chinese Herbal ; Marsdeniae tenacissimae extract ; Platinum Compounds
Language	English
Publishing date	2020-01-13
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-019-2795-y
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