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  1. Article ; Online: Seronegative HIV-1 infection in a Japanese man presenting with Pneumocystis pneumonia: Analysis of long-term antibody response and literature review.

    Seto, Nayuta / Fukuchi, Takahiko / Kawakami, Mamiyo / Nagashima, Mami / Sadamasu, Kenji / Hatakeyama, Shuji

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2024  

    Abstract: Seronegative human immunodeficiency virus (HIV) infection, where an HIV-specific antibody response is lacking even in chronic or late-stage HIV infections, is extremely rare. Here, we report the case of a 50-year-old Japanese man presenting with ... ...

    Abstract Seronegative human immunodeficiency virus (HIV) infection, where an HIV-specific antibody response is lacking even in chronic or late-stage HIV infections, is extremely rare. Here, we report the case of a 50-year-old Japanese man presenting with Pneumocystis pneumonia who did not produce antibodies against HIV-1 until the initiation of antiretroviral therapy (ART). Fourth-generation antigen-antibody testing temporarily reverted from weakly positive to negative soon after initiating ART, likely due to a reduction in viral load (assessed by p24 antigen levels). His HIV-1 antibody titers remained low or indeterminate even after four years of ART. A literature review suggested that the absence of HIV-1-specific antibody production may be associated with unimpeded HIV replication and rapid CD4
    Language English
    Publishing date 2024-02-06
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2024.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: NMR assignment and dynamics of the dimeric form of soluble C-terminal domain major ampullate spidroin 2 from Latrodectus hesperus.

    Oktaviani, Nur Alia / Malay, Ali D / Goto, Mami / Nagashima, Toshio / Hayashi, Fumiaki / Numata, Keiji

    Biomolecular NMR assignments

    2023  Volume 17, Issue 2, Page(s) 249–255

    Abstract: Spider dragline silk has attracted great interest due to its outstanding mechanical properties, which exceed those of man-made synthetic materials. Dragline silk, which is composed of at least major ampullate spider silk protein 1 and 2 (MaSp1 and MaSp2), ...

    Abstract Spider dragline silk has attracted great interest due to its outstanding mechanical properties, which exceed those of man-made synthetic materials. Dragline silk, which is composed of at least major ampullate spider silk protein 1 and 2 (MaSp1 and MaSp2), contains a long repetitive domain flanked by N-terminal and C-terminal domains (NTD and CTD). Despite the small size of the CTD, this domain plays a crucial role as a molecular switch that regulates and directs spider silk self-assembly. In this study, we report the
    MeSH term(s) Humans ; Animals ; Nuclear Magnetic Resonance, Biomolecular ; Fibroins/chemistry ; Silk/chemistry ; Silk/metabolism ; Magnetic Resonance Spectroscopy ; Spiders/metabolism
    Chemical Substances spidroin 2 (147883-43-0) ; Fibroins (9007-76-5) ; Silk
    Language English
    Publishing date 2023-09-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2388861-1
    ISSN 1874-270X ; 1874-2718
    ISSN (online) 1874-270X
    ISSN 1874-2718
    DOI 10.1007/s12104-023-10150-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Characteristics of the SARS-CoV-2 omicron HK.3 variant harbouring the FLip substitution.

    Kosugi, Yusuke / Plianchaisuk, Arnon / Putri, Olivia / Uriu, Keiya / Kaku, Yu / Hinay, Alfredo A / Chen, Luo / Kuramochi, Jin / Sadamasu, Kenji / Yoshimura, Kazuhisa / Asakura, Hiroyuki / Nagashima, Mami / Ito, Jumpei / Sato, Kei

    The Lancet. Microbe

    2024  Volume 5, Issue 4, Page(s) e313

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2/genetics
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Letter
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(23)00373-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Performance evaluation of Novaplex SARS-CoV-2 variants assay kit series for SARS-CoV-2 detection using single nucleotide polymorphisms.

    Ogihara, Shinji / Aoki, Kotaro / Nagashima, Mami / Sadamasu, Kenji / Ishii, Yoshikazu / Tateda, Kazuhiro

    Access microbiology

    2022  Volume 4, Issue 10, Page(s) acmi000447

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have received increasing attention globally because of their increased transmissibility and potential to escape immunity. Although whole-genome sequencing is the gold standard method ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have received increasing attention globally because of their increased transmissibility and potential to escape immunity. Although whole-genome sequencing is the gold standard method for SARS-CoV-2 mutation detection and lineage determination, it is costly and time-consuming. However, SARS-CoV-2 variants can be identified based on select variant-specific single nucleotide polymorphisms (SNPs) in the spike protein-encoding gene (
    Language English
    Publishing date 2022-10-27
    Publishing country England
    Document type Journal Article
    ISSN 2516-8290
    ISSN (online) 2516-8290
    DOI 10.1099/acmi.0.000447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Assessment of the frequency of SARS-CoV-2 Omicron variant escape from RNA-dependent RNA polymerase inhibitors and 3C-like protease inhibitors.

    Takashita, Emi / Fujisaki, Seiichiro / Morita, Hiroko / Nagata, Shiho / Miura, Hideka / Nagashima, Mami / Watanabe, Shinji / Takeda, Makoto / Kawaoka, Yoshihiro / Hasegawa, Hideki

    Antiviral research

    2023  Volume 216, Page(s) 105671

    Abstract: The emergence and spread of antiviral-resistant SARS-CoV-2 is of great concern. In this study, we evaluated the propensity of Omicron variants to escape from RNA-dependent RNA polymerase (RdRP) inhibitors and 3C-like protease (3CLpro) inhibitors. SARS- ... ...

    Abstract The emergence and spread of antiviral-resistant SARS-CoV-2 is of great concern. In this study, we evaluated the propensity of Omicron variants to escape from RNA-dependent RNA polymerase (RdRP) inhibitors and 3C-like protease (3CLpro) inhibitors. SARS-CoV-2 Delta and Omicron variants were serially passaged in vitro in the presence of RdRP inhibitors (remdesivir and molnupiravir) and 3CLpro inhibitors (nirmatrelvir and lufotrelvir) to detect SARS-CoV-2 escape mutants. After five passages with 3CLpro inhibitors, mutant viruses that escaped from 3CLpro inhibitors emerged; however, in the presence of RdRP inhibitors all variants disappeared within 2-4 passages. Our findings suggest that the frequency of SARS-CoV-2 mutant escape from RdRP inhibitors is lower than that from 3CLpro inhibitors. We also found that Delta variants were more likely to acquire amino acid substitutions associated with resistance to 3CLpro inhibitors under the selective pressure of this drug compared with Omicron variants.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2/genetics ; Antiviral Agents/pharmacology ; Leucine ; RNA-Dependent RNA Polymerase/genetics ; Protease Inhibitors/pharmacology
    Chemical Substances Antiviral Agents ; Leucine (GMW67QNF9C) ; RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Protease Inhibitors
    Language English
    Publishing date 2023-07-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2023.105671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Correction: SARS-CoV-2 suppression depending on the pH of graphene oxide nanosheets.

    Islam, Md Saidul / Fukuda, Masahiro / Hossain, Md Jakir / Rabin, Nurun Nahar / Tagawa, Ryuta / Nagashima, Mami / Sadamasu, Kenji / Yoshimura, Kazuhisa / Sekine, Yoshihiro / Ikeda, Terumasa / Hayami, Shinya

    Nanoscale advances

    2023  Volume 5, Issue 11, Page(s) 3115

    Abstract: This corrects the article DOI: 10.1039/D3NA00084B.]. ...

    Abstract [This corrects the article DOI: 10.1039/D3NA00084B.].
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Published Erratum
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d3na90044d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Antiviral efficacy of the SARS-CoV-2 XBB breakthrough infection sera against omicron subvariants including EG.5.

    Kaku, Yu / Kosugi, Yusuke / Uriu, Keiya / Ito, Jumpei / Hinay, Alfredo A / Kuramochi, Jin / Sadamasu, Kenji / Yoshimura, Kazuhisa / Asakura, Hiroyuki / Nagashima, Mami / Sato, Kei

    The Lancet. Infectious diseases

    2023  Volume 23, Issue 10, Page(s) e395–e396

    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Letter
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(23)00553-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: SARS-CoV-2 suppression depending on the pH of graphene oxide nanosheets.

    Islam, Md Saidul / Fukuda, Masahiro / Hossain, Md Jakir / Rabin, Nurun Nahar / Tagawa, Ryuta / Nagashima, Mami / Sadamasu, Kenji / Yoshimura, Kazuhisa / Sekine, Yoshihiro / Ikeda, Terumasa / Hayami, Shinya

    Nanoscale advances

    2023  Volume 5, Issue 9, Page(s) 2413–2417

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivation of pH-dependent graphene oxide (GO) nanosheets is presented. The observed virus inactivation using an authentic virus (Delta variant) and different GO dispersions at pH 3, 7, and ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivation of pH-dependent graphene oxide (GO) nanosheets is presented. The observed virus inactivation using an authentic virus (Delta variant) and different GO dispersions at pH 3, 7, and 11 suggests that the higher pH of the GO dispersion yields a better performance compared to that of GO at neutral or lower pH. The current findings can be ascribed to the pH-driven functional group change and the overall charge of GO, favorable for the attachment between GO nanosheets and virus particles.
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d3na00084b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Examination of Efficient HIV Confirmatory Testing Protocols Using an HIV-1/2 Antibody Differentiation Assay.

    Nagashima, Mami / Kumagai, Ryota / Kitamura, Yurie / Matsuoka, Saori / Imamura, Akifumi / Chiba, Takashi / Sadamasu, Kenji

    Japanese journal of infectious diseases

    2020  Volume 73, Issue 2, Page(s) 173–175

    MeSH term(s) Clinical Laboratory Techniques/methods ; HIV Antibodies/blood ; HIV Infections/diagnosis ; HIV Infections/immunology ; HIV-1/immunology ; HIV-2/immunology ; Humans ; Immunoassay ; Reagent Kits, Diagnostic/standards ; Sensitivity and Specificity ; Tokyo
    Chemical Substances HIV Antibodies ; Reagent Kits, Diagnostic
    Language English
    Publishing date 2020-02-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1478383-6
    ISSN 1884-2836 ; 1344-6304
    ISSN (online) 1884-2836
    ISSN 1344-6304
    DOI 10.7883/yoken.JJID.2019.447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.409: Show issues Location:
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  10. Article: A conventional PCR-based method to detect the E2 gene of the rubella virus for epidemiological analysis.

    Mori, Kohji / Suzuki, Ai / Kumagai, Ryota / Harada, Sachiko / Kasuya, Fumi / Amano, Arisa / Kosugi, Tomohiro / Hasegawa, Michiya / Nagashima, Mami / Suzuki, Jun / Sadamasu, Kenji

    Virusdisease

    2023  Volume 34, Issue 1, Page(s) 92–96

    Abstract: To eliminate the rubella virus (RV), genetic characterization is vital for its detection, identification of endemic transmission, and diagnosis of imported cases. The 739-nucleotide region in the E1 gene has primarily been used for genotyping for ... ...

    Abstract To eliminate the rubella virus (RV), genetic characterization is vital for its detection, identification of endemic transmission, and diagnosis of imported cases. The 739-nucleotide region in the E1 gene has primarily been used for genotyping for epidemiological analysis. However, in the 2018-2019 RV outbreak, identical sequences were observed in patients who were not epidemiologically linked. Additionally, the 739 nt sequences from the outbreak in Tokyo in 2018-2019 were identical to RV identified in China in 2019. This suggests that this region may be insufficient to identify the detected RV strains as endemic or imported. In 62.4% of the specimens, the E1 gene sequences of the 1E RV genotype were identical. Additionally, the observed discordance of sequences from the mainly detected identical sequence in the 739-nt sequence of the E1 gene were one (31.0%), two (3.5%), three (2.6%), and four (0.23%). Moreover, a comparison of the complete structural protein-coding region suggests that the E2 gene is more diverse than the E1 and the capsid gene. Thus, conventional polymerase chain reaction (PCR) primers were developed to detect the E2 gene and improve epidemiological analysis. A comparison of the sequences identified during the RV outbreak in Tokyo revealed genetic differences in the sequences (15 of the 18 specimens). These results suggest that additional information could be obtained by simultaneously analyzing the E2 and the E1 region. The identified sequences can potentially aid in evaluating the RV strains detected during epidemiological analysis.
    Language English
    Publishing date 2023-02-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 2846993-8
    ISSN 2347-3517 ; 2347-3584
    ISSN (online) 2347-3517
    ISSN 2347-3584
    DOI 10.1007/s13337-023-00810-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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