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  1. Book: Hearing impairment

    Suzuki, Jun-Ichi

    an invisible disability ; how you can live with a hearing impairment

    2004  

    Author's details J. Suzuki ... (ed.)
    Keywords Hörschädigung ; Hörgerät
    Subject Hörhilfe ; Hörbehinderung ; Hörschaden ; Gehörschaden ; Gehörschädigung
    Language English
    Size XXVI, 580 S. : Ill., graph. Darst., 24 cm
    Publisher Springer
    Publishing place Tokyo u.a.
    Publishing country Japan
    Document type Book
    Note Literaturangaben
    HBZ-ID HT014159604
    ISBN 4-431-22326-6 ; 978-4-431-22326-9
    Database Catalogue ZB MED Medicine, Health

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  2. Book: Reconstructive surgery of the middle ear

    Suzuki, Jun-Ichi

    1999  

    Author's details by Jun-Ichi Suzuki
    Keywords Mittelohr ; Wiederherstellungschirurgie
    Subject Rekonstruktionschirurgie ; Auris media
    Language English
    Size XVI, 184 S. : zahlr. Ill., graph. Darst.
    Edition 1. ed.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT011076121
    ISBN 0-444-50207-6 ; 978-0-444-50207-0
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Unified Interpretations of Two Kinds of Needle-Shaped Precipitates Using Transmission Electron Microscopy and Small-Angle Neutron Scattering in Aged Al-Mg

    Kaharudin, Amalina Aina / Ohnuma, Masato / Lee, Seungwon / Tsuchiya, Taiki / Asada, Yuuki / Ikeda, Ken-Ichi / Ohishi, Kazuki / Suzuki, Jun-Ichi / Matsuda, Kenji / Homma, Tomoyuki

    Nanomaterials (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: This study investigates the nanostructural properties of pseudo-binary Al-1 ... ...

    Abstract This study investigates the nanostructural properties of pseudo-binary Al-1.0Mg
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano14020176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Association Between NUDT15 R139C Genotype and Neutropenia During Antiviral Therapy in Patients With Congenital Cytomegalovirus Infection.

    Yamaguchi, Makoto / Iwata, Ken-Ichi / Fukuda, Yuto / Haruta, Kazunori / Suzuki, Takako / Torii, Yuka / Ito, Yoshinori / Kawada, Jun-Ichi

    The Pediatric infectious disease journal

    2023  Volume 42, Issue 7, Page(s) e256–e257

    MeSH term(s) Humans ; Genotype ; Neutropenia ; Cytomegalovirus Infections/drug therapy ; Antiviral Agents/adverse effects
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Formation Processes of a Solid Electrolyte Interphase at a Silicon/Sulfide Electrolyte Interface in a Model All-Solid-State Li-Ion Battery.

    Asano, Sho / Hata, Jun-Ichi / Watanabe, Kenta / Shimizu, Keisuke / Matsui, Naoki / Yamada, Norifumi L / Suzuki, Kota / Kanno, Ryoji / Hirayama, Masaaki

    ACS applied materials & interfaces

    2024  Volume 16, Issue 6, Page(s) 7189–7199

    Abstract: Understanding the electrochemical reactions at the interface between a Si anode and a solid sulfide electrolyte is essential in improving the cycle stabilities of Si anodes in all-solid-state batteries (ASSBs). Highly dense Si films with very low ... ...

    Abstract Understanding the electrochemical reactions at the interface between a Si anode and a solid sulfide electrolyte is essential in improving the cycle stabilities of Si anodes in all-solid-state batteries (ASSBs). Highly dense Si films with very low roughnesses of <1 nm were fabricated at room temperature via cathodic arc plasma deposition, which led to the formation of a Si/sulfide electrolyte model interface. Li (de)alloying through the model interface hardly occurred during the first cycle, whereas it proceeded stably in subsequent cycles. Hard X-ray photoelectron spectroscopy and neutron reflectometry directly revealed that the reduction or oxidation of the interfacial component or Li
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c16862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Miliary Tuberculosis during R-MPV Therapy in an Elderly Patient with Primary Central Nerve System Lymphoma: A Case Report.

    Take, Yushiro / Shirahata, Mitsuaki / Sakai, Jun / Kubota, Yuichi / Suzuki, Tomonari / Adachi, Jun-Ichi / Maesaki, Shigefumi / Mishima, Kazuhiko / Nishikawa, Ryo

    Case reports in oncology

    2023  Volume 16, Issue 1, Page(s) 1054–1059

    Abstract: Most elderly patients with tuberculosis (TB) have previously been infected ... ...

    Abstract Most elderly patients with tuberculosis (TB) have previously been infected with
    Language English
    Publishing date 2023-09-29
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2458961-5
    ISSN 1662-6575
    ISSN 1662-6575
    DOI 10.1159/000530711
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Crystal structure of the motor domain of centromere-associated protein E in complex with a non-hydrolysable ATP analogue.

    Shibuya, Asuka / Suzuki, Akira / Ogo, Naohisa / Sawada, Jun-Ichi / Asai, Akira / Yokoyama, Hideshi

    FEBS letters

    2023  Volume 597, Issue 8, Page(s) 1138–1148

    Abstract: Centromere-associated protein E (CENP-E) is a kinesin motor protein essential for mitosis and a new target for anticancer agents with less side effects. To rationally design anticancer drug candidates based on structure, it is important to determine the ... ...

    Abstract Centromere-associated protein E (CENP-E) is a kinesin motor protein essential for mitosis and a new target for anticancer agents with less side effects. To rationally design anticancer drug candidates based on structure, it is important to determine the three-dimensional structure of the CENP-E motor domain bound to its inhibitor. Here, we report the first crystal structure of the CENP-E motor domain in complex with a non-hydrolysable ATP analogue, adenylyl-imidodiphosphate (AMPPNP). Furthermore, the structure is compared with the ADP-bound form of the CENP-E motor domain as well as the AMPPNP-bound forms of other kinesins. This study indicates that helix α4 of CENP-E participates in the slow binding of CENP-E to microtubules. These results will contribute to the development of anticancer drugs targeting CENP-E.
    MeSH term(s) Adenylyl Imidodiphosphate/analysis ; Adenylyl Imidodiphosphate/metabolism ; Microtubules/metabolism ; Mitosis ; Antineoplastic Agents/pharmacology ; Centromere/metabolism
    Chemical Substances Adenylyl Imidodiphosphate (25612-73-1) ; Antineoplastic Agents
    Language English
    Publishing date 2023-03-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: MicroRNA expression profiling of urine exosomes in children with congenital cytomegalovirus infection.

    Torii, Yuka / Suzuki, Takako / Fukuda, Yuto / Haruta, Kazunori / Yamaguchi, Makoto / Horiba, Kazuhiro / Kawada, Jun-Ichi / Ito, Yoshinori

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5475

    Abstract: Congenital cytomegalovirus (cCMV) infection can damage the central nervous system in infants; however, its prognosis cannot be predicted from clinical evaluations at the time of birth. Urinary exosomes can be used to analyze neuronal damage in neuronal ... ...

    Abstract Congenital cytomegalovirus (cCMV) infection can damage the central nervous system in infants; however, its prognosis cannot be predicted from clinical evaluations at the time of birth. Urinary exosomes can be used to analyze neuronal damage in neuronal diseases. To investigate the extent of neuronal damage in patients with cCMV, exosomal miRNA expression in the urine was investigated in cCMV-infected infants and controls. Microarray analysis of miRNA was performed in a cohort of 30 infants, including 11 symptomatic cCMV (ScCMV), 7 asymptomatic cCMV (AScCMV), and one late-onset ScCMV cases, and 11 healthy controls (HC). Hierarchical clustering analysis revealed the distinct expression profile of ScCMV. The patient with late-onset ScCMV was grouped into the ScCMV cluster. Pathway enrichment analysis of the target mRNAs differed significantly between the ScCMV and HC groups; this analysis also revealed that pathways related to brain development were linked to upregulated pathways. Six miRNAs that significantly different between groups (ScCMV vs. HC and ScCMV vs. AScCMV) were selected for digital PCR in another cohort for further validation. Although these six miRNAs seemed insufficient for predicting ScCMV, expression profiles of urine exosomal miRNAs can reveal neurological damage in patients with ScCMV compared to those with AcCMV or healthy infants.
    MeSH term(s) Child ; Infant ; Humans ; Exosomes/genetics ; Body Fluids ; MicroRNAs/genetics ; Central Nervous System ; Cytomegalovirus Infections/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56106-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Clinical significance and pitfalls of human chorionic gonadotropin-related tumor markers for intracranial germinomas.

    Suzuki, Tomonari / Shirahata, Mitsuaki / Adachi, Jun-Ichi / Mishima, Kazuhiko / Nishikawa, Ryo

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2023  Volume 39, Issue 4, Page(s) 901–907

    Abstract: Purpose: Measuring serum and cerebrospinal fluid human chorionic gonadotropin (hCG) is essential for the diagnosis of intracranial germ cell tumors. There are three types of hCG-related markers in clinical use: hCGβ, intact hCG, and total hCG. The best ... ...

    Abstract Purpose: Measuring serum and cerebrospinal fluid human chorionic gonadotropin (hCG) is essential for the diagnosis of intracranial germ cell tumors. There are three types of hCG-related markers in clinical use: hCGβ, intact hCG, and total hCG. The best marker for the diagnosis of intracranial germ cell tumors, especially germinoma, is currently unknown. This study aimed to evaluate the usefulness of these hCG-related markers.
    Methods: We investigated 19 serum samples obtained from 6 patients with histologically diagnosed germinoma treated in our institute. Serum hCGβ, intact hCG, and total hCG values were measured before, during, and after treatment. Samples with hCG values above the lower limits were considered positive.
    Results: The positivity rates of serum hCGβ, intact hCG, and total hCG were 6% (1/17), 47% (7/15), and 42% (8/19), respectively, with the latter two having significantly higher positivity rates than hCGβ (p = 0.041). Both intact and total hCGs showed similar values. The median values of hCGβ, intact hCG, and total hCG before treatment were 0.1 ng/mL, 4.6 mIU/mL, and 4.5 mIU/mL, respectively.
    Conclusion: Serum intact and total hCGs have higher detection rates than hCGβ in patients with germinoma using available commercial measurement tools.
    MeSH term(s) Humans ; Biomarkers, Tumor ; Clinical Relevance ; Chorionic Gonadotropin/cerebrospinal fluid ; Chorionic Gonadotropin, beta Subunit, Human/cerebrospinal fluid ; Germinoma/diagnosis ; Brain Neoplasms/diagnosis
    Chemical Substances Biomarkers, Tumor ; Chorionic Gonadotropin ; Chorionic Gonadotropin, beta Subunit, Human
    Language English
    Publishing date 2023-02-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-023-05856-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Crystal structure of the motor domain of centromere‐associated protein E in complex with a non‐hydrolysable ATP analogue

    Shibuya, Asuka / Suzuki, Akira / Ogo, Naohisa / Sawada, Jun‐ichi / Asai, Akira / Yokoyama, Hideshi

    FEBS Letters. 2023 Apr., v. 597, no. 8 p.1138-1148

    2023  

    Abstract: Centromere‐associated protein E (CENP‐E) is a kinesin motor protein essential for mitosis and a new target for anticancer agents with less side effects. To rationally design anticancer drug candidates based on structure, it is important to determine the ... ...

    Abstract Centromere‐associated protein E (CENP‐E) is a kinesin motor protein essential for mitosis and a new target for anticancer agents with less side effects. To rationally design anticancer drug candidates based on structure, it is important to determine the three‐dimensional structure of the CENP‐E motor domain bound to its inhibitor. Here, we report the first crystal structure of the CENP‐E motor domain in complex with a non‐hydrolysable ATP analogue, adenylyl‐imidodiphosphate (AMPPNP). Furthermore, the structure is compared with the ADP‐bound form of the CENP‐E motor domain as well as the AMPPNP‐bound forms of other kinesins. This study indicates that helix α4 of CENP‐E participates in the slow binding of CENP‐E to microtubules. These results will contribute to the development of anticancer drugs targeting CENP‐E.
    Keywords antineoplastic agents ; crystal structure ; kinesin ; microtubules ; mitosis ; molecular motor proteins
    Language English
    Dates of publication 2023-04
    Size p. 1138-1148.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14602
    Database NAL-Catalogue (AGRICOLA)

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