LIVIVO - Search results -

Search results

Result 1 - 10 of total 238

Search options

Article ; Online: Passive array micro-magnetic stimulation device based on multi-carrier wireless flexible control for magnetic neuromodulation.

Tian, Lei / Zhao, Tong / Dong, Lei / Liu, Qiwen / Zheng, Yu

2023 Volume 20, Issue 5

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Brain ; Hippocampus ; Magnetic Fields ; Movement ; Neuronal Plasticity
Language	English
Publishing date	2023-09-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2170901-4
ISSN	1741-2552 ; 1741-2560
ISSN (online)	1741-2552
ISSN	1741-2560
DOI	10.1088/1741-2552/acfa23
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6071: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Protective effects and mechanism of curcumin in animal models of pulmonary fibrosis: a preclinical systematic review and meta-analysis.

Hanyu, Fang / Zheng, Hong / Jiaqi, Wang / Tairan, Dong / Yiyuanzi, Zhao / Qiwen, Yang / Ying, Liu / Hongchun, Zhang / Lu, Liu

Frontiers in pharmacology

2023 Volume 14, Page(s) 1258885

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-10-13
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1258885
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: An Efficient Fisher Matrix Approximation Method for Large-Scale Neural Network Optimization.

Yang, Minghan / Xu, Dong / Cui, Qiwen / Wen, Zaiwen / Xu, Pengxiang

IEEE transactions on pattern analysis and machine intelligence

2023 Volume 45, Issue 5, Page(s) 5391–5403

Abstract: Although the shapes of the parameters are not crucial for designing first-order optimization methods in large scale empirical risk minimization problems, they have important impact on the size of the matrix to be inverted when developing second-order ... ...

Abstract	Although the shapes of the parameters are not crucial for designing first-order optimization methods in large scale empirical risk minimization problems, they have important impact on the size of the matrix to be inverted when developing second-order type methods. In this article, we propose an efficient and novel second-order method based on the parameters in the real matrix space [Formula: see text] and a matrix-product approximate Fisher matrix (MatFisher) by using the products of gradients. The size of the matrix to be inverted is much smaller than that of the Fisher information matrix in the real vector space [Formula: see text]. Moreover, by utilizing the matrix delayed update and the block diagonal approximation techniques, the computational cost can be controlled and is comparable with first-order methods. A global convergence and a superlinear local convergence analysis are established under mild conditions. Numerical results on image classification with ResNet50, quantum chemistry modeling with SchNet, and data-driven partial differential equations solution with PINN illustrate that our method is quite competitive to the state-of-the-art methods.
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Journal Article
ISSN	1939-3539
ISSN (online)	1939-3539
DOI	10.1109/TPAMI.2022.3213654
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Molecular eidemiology of carbapenem-resistant Enterobacter cloacae complex in a tertiary hospital in Shandong, China.

Hu, Shengnan / Xie, Wenyan / Cheng, Qiwen / Zhang, Xiaoning / Dong, Xiutao / Jing, Huaiqi / Wang, Jiazheng

BMC microbiology

2023 Volume 23, Issue 1, Page(s) 177

Abstract: Background: The increasing incidence and prevalence of carbapenem-resistant Enterobacter cloacae complex (CREC) poses great challenges to infection prevention and disease treatment. However, much remains unknown about the clinical characteristics of ... ...

Abstract	Background: The increasing incidence and prevalence of carbapenem-resistant Enterobacter cloacae complex (CREC) poses great challenges to infection prevention and disease treatment. However, much remains unknown about the clinical characteristics of CREC isolates. Our objective was to characterize antimicrobial resistance and, carbapenemase production in CREC with 36 CREC isolates collected from a tertiary hospital in Shandong, China. Results: Three types of carbapenemases (NDM, IMP and VIM) were detected in these isolates. Among them, NDM carbapenemases were most prevalent, with a 61.2% (22/36) detection rate for NDM-1, 27.8% (10/36) for NDM-5 and 2.8% (1/36) for NDM-7. IMP-4 was found in two isolates and VIM-1 in only one isolate. The MLST analysis identified 12 different sequence types (STs), of which ST171 (27.8%) was the most prevalent, followed by ST418 (25.0%). ST171 isolates had significantly higher rates of resistance than other STs to gentamicin and tobramycin (Ps < 0.05), and lower rates of resistance to aztreonam than ST418 and other STs (Ps < 0.05). Among 17 carbapenemase-encoding genes, the bla Conclusion: NDM-5 produced by ST171 and NDM-1 carbapenemase produced by ST418 were the leading cause of CREC in this hospital. This study enhances the understanding of CREC strains and helps improve infection control and treatment in hospitals.
MeSH term(s)	Humans ; Enterobacter cloacae/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Carbapenems/pharmacology ; Tertiary Care Centers ; Multilocus Sequence Typing ; Enterobacteriaceae Infections/epidemiology ; beta-Lactamases/genetics ; Bacterial Proteins/genetics ; Carbapenem-Resistant Enterobacteriaceae/genetics ; China/epidemiology ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents ; Carbapenems ; beta-Lactamases (EC 3.5.2.6) ; Bacterial Proteins
Language	English
Publishing date	2023-07-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041505-9
ISSN	1471-2180 ; 1471-2180
ISSN (online)	1471-2180
ISSN	1471-2180
DOI	10.1186/s12866-023-02913-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Design, Synthesis, Formulation, and Bioevaluation of Trisubstituted Triazines as Highly Selective mTOR Inhibitors for the Treatment of Human Breast Cancer.

Sun, Qiwen / Chu, Yuxiu / Zhang, Nana / Chen, Rui / Wang, Lili / Wu, Jiangxia / Dong, Yongxi / Li, Hongliang / Wang, Ling / Tang, Lei / Zhan, Changyou / Zhang, Ji-Quan

Journal of medicinal chemistry

2024

Abstract: The aberrant activation of the PI3K/mTOR signaling pathway is implicated in various human cancers. Thus, the development of inhibitors targeting mTOR has attracted considerable attention. In this study, we used a structure-based drug design strategy to ... ...

Abstract	The aberrant activation of the PI3K/mTOR signaling pathway is implicated in various human cancers. Thus, the development of inhibitors targeting mTOR has attracted considerable attention. In this study, we used a structure-based drug design strategy to discover a highly potent and kinase-selective mTOR inhibitor
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.4c00173
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The clinical value of Delphian lymph node metastasis in papillary thyroid carcinoma.

He, Qiwen / Zhu, Qinsheng / Dong, Jian / Wu, Yijun

Asian journal of surgery

2020 Volume 43, Issue 12, Page(s) 1180–1181

MeSH term(s)	Adult ; Female ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis/pathology ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Thyroid Cancer, Papillary/pathology ; Thyroid Cancer, Papillary/surgery ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/surgery ; Thyroidectomy
Language	English
Publishing date	2020-09-26
Publishing country	China
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2020.09.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2831: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The Role of Distribution Forms of Fe-Cr-C Cladding Layer in the Impact Abrasive Wear Performance of Hadfield Steel.

Pan, Zhang / Dong, Xuanpu / Cao, Huatang / Huang, Qiwen

Materials (Basel, Switzerland)

2020 Volume 13, Issue 8

Abstract: To investigate the role of different distribution forms of Fe-Cr-C cladding layer in the impact abrasive wear performance of Hadfield steel, the over-lapped Fe-Cr-C cladding layer and dot-shaped Fe-Cr-C cladding layer were deposited, respectively, by ... ...

Abstract	To investigate the role of different distribution forms of Fe-Cr-C cladding layer in the impact abrasive wear performance of Hadfield steel, the over-lapped Fe-Cr-C cladding layer and dot-shaped Fe-Cr-C cladding layer were deposited, respectively, by plasma transferred arc (PTA) cladding on Hadfield steel. The microstructure, microhardness and impact abrasive wear performance of the two cladding layers under the impact of glass sand, granite and quartz sand were investigated. The results showed that both microstructures of the cladding layers were hypoeutectic Fe-Cr-C microstructures. The average microhardness of the over-lapped cladding layer and dot-shaped cladding layer was around 560 HV
Language	English
Publishing date	2020-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma13081818
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: CXCL14 as a potential marker for immunotherapy response prediction in renal cell carcinoma.

Pan, Qiwen / Liu, Ruiqi / Zhang, Xinyue / Cai, Lingling / Li, Yilin / Dong, Pei / Gao, Jianming / Liu, Yang / He, Liru

Therapeutic advances in medical oncology

2023 Volume 15, Page(s) 17588359231217966

Abstract: Background: Epigenetic mechanisms play vital roles in the activation, differentiation, and effector function of immune cells. The breast and kidney-expressed chemokine (CXCL14) mainly contributes to the regulation of immune cells. However, its role in ... ...

Abstract	Background: Epigenetic mechanisms play vital roles in the activation, differentiation, and effector function of immune cells. The breast and kidney-expressed chemokine (CXCL14) mainly contributes to the regulation of immune cells. However, its role in shaping the tumor immune microenvironment (TIME) is yet to be elucidated in renal cell carcinoma (RCC). Objectives: This study aimed to elucidate the role of CXCL14 in predicting the efficacy of immunotherapy in patients with RCC. Methods: CXCL14 expression and RNA-sequencing, single-cell RNA-sequencing (scRNA-seq), and survival datasets of RCC from public databases were analyzed, and survival was compared between different CXCL14 levels. The correlation between CXCL14 and immune infiltration and human leukocyte antigen (HLA) gene expression was analyzed with TIMER2.0 and gene expression profiling interactive analysis. Institutional scRNA-seq and immunohistochemical staining analyses were used to verify the relationship between CXCL14 expression level and the efficacy of immunotherapy. Results: CXCL14 was expressed in fibroblast and malignant cells in RCC, and higher expression was associated with better survival. Enrichment analysis revealed that CXCL14 is involved in immune activation, primarily in antigen procession, antigen presentation, and major histocompatibility complex assemble. CXCL14 expression was positively correlated with T-cell infiltration as well as HLA-related gene expression. Among the RCC cohort receiving nivolumab in Checkmate 025, the patients with CXCL14 high expression had better overall survival than those with CXCL14 low expression after immunotherapy. scRNA-seq revealed a cluster of CXCL14+ fibroblast in immunotherapy responders. Immunohistochemistry analysis verified that the patients with high CXCL14 expression had an increased proportion of high CD8 expression simultaneously. The expression level of CXCL14 was associated with CXCR4 expression in RCC. Conclusion: CXCL14 expression is associated with immunotherapy response in RCC. It is a promising biomarker for immunotherapy response prediction and may be an effective epigenetic modulator in combination with immunotherapy approaches.
Language	English
Publishing date	2023-12-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2503443-1
ISSN	1758-8359 ; 1758-8340
ISSN (online)	1758-8359
ISSN	1758-8340
DOI	10.1177/17588359231217966
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues.

Smith, Kyle R / Paul, Somnath / Dong, Qiwen / Anannya, Orchi / Oldenburg, Darby G / Forrest, J Craig / McBride, Kevin M / Krug, Laurie T

mSphere

2023 Volume 8, Issue 5, Page(s) e0027823

Abstract: Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian uracil-DNA glycosylases (UNG) excise deleterious uracil residues from their ... ...

Abstract	Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian uracil-DNA glycosylases (UNG) excise deleterious uracil residues from their genomic DNA. Each herpesvirus UNG studied to date has demonstrated conservation of the enzymatic function to excise uracil residues from DNA. We previously reported that a murine gammaherpesvirus (MHV68) with a stop codon in
MeSH term(s)	Animals ; Mice ; Uracil-DNA Glycosidase/genetics ; Uracil-DNA Glycosidase/metabolism ; Virus Replication ; DNA Replication ; DNA, Viral/genetics ; Rhadinovirus/genetics ; Rhadinovirus/metabolism ; Gammaherpesvirinae/genetics ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; Uracil ; Mammals
Chemical Substances	Uracil-DNA Glycosidase (EC 3.2.2.-) ; DNA, Viral ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; Uracil (56HH86ZVCT)
Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Intramural ; Research Support, N.I.H., Extramural
ISSN	2379-5042
ISSN (online)	2379-5042
DOI	10.1128/msphere.00278-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: A Recombinant Antibody For Tracking Murine Gammaherpesvirus 68 Uracil DNA Glycosylase Expression.

Mu, Yunxiang / Plummer, Joshua B / Zelazowska, Monika A / Paul, Somnath / Dong, Qiwen / Chen, Zaowen / Krug, Laurie T / McBride, Kevin M

bioRxiv : the preprint server for biology

2023

Abstract: Antibodies are powerful tools to detect expressed proteins. However off-target recognition can confound their use. Therefore, careful characterization is needed to validate specificity in distinct applications. Here we report the sequence and ... ...

Abstract	Antibodies are powerful tools to detect expressed proteins. However off-target recognition can confound their use. Therefore, careful characterization is needed to validate specificity in distinct applications. Here we report the sequence and characterization of a mouse recombinant antibody that specifically detects ORF46 of murine gammaherpesvirus 68 (MHV68). This ORF encodes the viral uracil DNA glycosylase (vUNG). The antibody does not recognize murine uracil DNA glycosylase and is useful in detecting vUNG expressed in virally infected cells. It can detect expressed vUNG in cells via immunostaining and microscopy or flow cytometry analysis. The antibody can detect vUNG from lysates of expressing cells via immunoblot under native conditions but not denaturing conditions. This suggests it recognizes a confirmational based epitope. Altogether this manuscript describes the utility of the anti-vUNG antibody and suitability for use in studies of MHV68 infected cells.
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.17.541089
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED