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Article: A water quality assessment method based on an improved grey relational analysis and particle swarm optimization multi-classification support vector machine.

Gai, Rongli / Guo, Zhibin

2023 Volume 14, Page(s) 1099668

Abstract: Most of the water quality indicators that affect the results of river water quality assessment are gray and localized, thus the correlation between water quality indicators can be calculated using gray correlation analysis (GRA).However, GRA takes equal ... ...

Abstract	Most of the water quality indicators that affect the results of river water quality assessment are gray and localized, thus the correlation between water quality indicators can be calculated using gray correlation analysis (GRA).However, GRA takes equal weighting for water quality indicators and does not take into account the weighting of the indicators. Therefore, this paper proposes a river water quality assessment method based on improved grey correlation analysis (ACGRA) andparticle swarm optimization multi-classification support vector machine (PSO-MSVM) for assessing river water environment quality. Firstly, the combination weights of water quality indicators were calculated using Analytic Hierarchy Process (AHP)AHP and Criteria Importance Though Intercrieria Correlation (CRITIC)CRITIC, and then the correlation between water quality indicators was calculated for feature selection. Secondly, the PSO-MSVM model was established using the water quality indicators obtained by ACGRA as input parameters for water environment quality assessment. The river water environment assessment methods of ACGRA and PSO-MSVM were applied to the evaluation of water environment quality in different watersheds in the country. Accuracy, precision, recall and root mean square errorRMSE were also introduced as model evaluation criteria. The results show that the river water environment assessment methods based on ACGRA and PSO-MSVM can evaluate the water environment quality more accurately.
Language	English
Publishing date	2023-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1099668
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Article: Surgical results and quality of life after single-stage posterior transpedicular approach for circumferential epidural decompression in patients with thoracolumbar spine metastasis.

Niu, Jianfang / Zhao, Zhiqing / Wang, Jichuan / Yan, Taiqiang / Guo, Wei / Yang, Rongli / Tang, Xiaodong

Journal of Cancer

2023 Volume 14, Issue 11, Page(s) 2145–2151

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2023-07-09
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2573318-7
ISSN	1837-9664
ISSN	1837-9664
DOI	10.7150/jca.85939
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Article ; Online: In Situ Growth 3D GDY-NCNTs Nanocomposites for High-Performance Supercapacitors.

Xing, Enhao / Cui, Rongli / Guo, Xihong / Liu, Jiali / Wang, Dongmei / Chai, Yuru / Wang, Xue / Chen, Yajing / Dong, Jinquan / Sun, Baoyun

ACS applied materials & interfaces

2024

Abstract: New binary carbon composites (GDY-NCNTs and GDY-CNTs) with a three-dimensional porous structure, which are synthesized by an in situ growth method, are adopted in this article. The GDY-NCNTs composites exhibit excellent specific capacitance performance ( ... ...

Abstract	New binary carbon composites (GDY-NCNTs and GDY-CNTs) with a three-dimensional porous structure, which are synthesized by an in situ growth method, are adopted in this article. The GDY-NCNTs composites exhibit excellent specific capacitance performance (679 F g
Language	English
Publishing date	2024-04-26
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.4c02112
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Article: Integrated single-cell RNA-seq analysis reveals the vital cell types and dynamic development signature of atherosclerosis.

Shao, Xiuli / Hou, Xiuyang / Zhang, Xiaolin / Zhang, Ruijia / Zhu, Rongli / Qi, He / Zheng, Jianling / Guo, Xiaoling / Feng, Rui

Frontiers in physiology

2023 Volume 14, Page(s) 1118239

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1118239
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Article ; Online: One step accurate phase demodulation from a closed fringe pattern with the convolutional neural network HRUnet.

Guo, Rongli / Lu, Shuaidong / Zhang, Miaomiao / Li, Zhaoxin / Li, Dangjuan / Wang, Fan / Hu, XiaoYing / Wu, Shenjiang

Applied optics

2024 Volume 63, Issue 7, Page(s) B59–B69

Abstract: Retrieving a phase map from a single closed fringe pattern is a challenging task in optical interferometry. In this paper, a convolutional neural network (CNN), HRUnet, is proposed to demodulate phase from a closed fringe pattern. The HRUnet, derived ... ...

Abstract	Retrieving a phase map from a single closed fringe pattern is a challenging task in optical interferometry. In this paper, a convolutional neural network (CNN), HRUnet, is proposed to demodulate phase from a closed fringe pattern. The HRUnet, derived from the Unet model, adopts a high resolution network (HRnet) module to extract high resolution feature maps of the data and employs residual blocks to erase the gradient vanishing in the network. With the trained network, the unwrapped phase map can be directly obtained by feeding a scaled fringe pattern. The high accuracy of the phase map obtained from HRUnet is demonstrated by demodulation of both simulated data and actual fringe patterns. Compared results between HRUnet and two other CNNS are also provided, and the results proved that the performance of HRUnet in accuracy is superior to the two other counterparts.
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.506877
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Article ; Online: Phosphorylation of G3BP1 is involved in the regulation of PDCoV-induced inflammatory response.

Zhang, Baotai / Li, Siyuan / Chen, Zhuoqi / Fan, Liyuan / Wang, Wei / Guo, Rongli / Fan, Baochao / Li, Jizong / Li, Bin

Veterinary microbiology

2024 Volume 293, Page(s) 110070

Abstract: Stress granules (SGs), the main component is GTPase-activating protein-binding protein 1 (G3BP1), which are assembled during viral infection and function to sequester host and viral mRNAs and proteins, are part of the antiviral responses. In this study, ... ...

Abstract	Stress granules (SGs), the main component is GTPase-activating protein-binding protein 1 (G3BP1), which are assembled during viral infection and function to sequester host and viral mRNAs and proteins, are part of the antiviral responses. In this study, we found that porcine deltacoronavirus (PDCoV) infection induced stable formation of robust SGs in cells through a PERK (protein kinase R-like endoplasmic reticulum kinase)-dependent mechanism. Overexpression of SGs marker proteins G3BP1 significantly reduced PDCoV replication in vitro, while inhibition of endogenous G3BP1 enhanced PDCoV replication. Moreover, PDCoV infected LLC-PK1 cells raise the phosphorylation level of G3BP1. By overexpression of the G3BP1 phosphorylated protein or the G3BP1 dephosphorylated protein, we found that phosphorylation of G3BP1 is involved in the regulation of PDCoV-induced inflammatory response. Taken together, our study presents a vital aspect of the host innate response to invading pathogens and reveals attractive host targets for antiviral target.
Language	English
Publishing date	2024-04-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2024.110070
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Article ; Online: The efficacy and safety of vincristine, irinotecan and anlotinib in Epithelioid Sarcoma.

Xie, Lu / Sun, Xin / Xu, Jie / Liang, Xin / Liu, Kuisheng / Sun, Kunkun / Yang, Rongli / Tang, Xiaodong / Guo, Wei

BMC cancer

2024 Volume 24, Issue 1, Page(s) 172

Abstract: Background: Epithelioid sarcoma is a rare soft tissue sarcoma characterized by SMARCB1/INI1 deficiency. Much attention has been paid to the selective EZH2 inhibitor tazemetostat, where other systemic treatments are generally ignored. To explore ... ...

Abstract	Background: Epithelioid sarcoma is a rare soft tissue sarcoma characterized by SMARCB1/INI1 deficiency. Much attention has been paid to the selective EZH2 inhibitor tazemetostat, where other systemic treatments are generally ignored. To explore alternative treatment options, we studied the effects of irinotecan-based chemotherapy in a series of epithelioid sarcoma patients. Methods: We retrospectively reviewed data from patients with metastatic or unresectable epithelioid sarcoma at the Peking University People's Hospital treated with irinotecan (50 mg/m Results: A total of 54 courses were administered. With a median follow up of 21.2 months (95% CI, 12.2, 68.1), the 5-year overall survival rate was 83.3%. Five of eight (62.5%) patients presented with unresectable localized lesions, including local tumor thrombosis and lymphatic metastasis. The other patients had unresectable pulmonary metastases. Six of eight (75%) patients had progressed following two lines of systemic therapy. The objective response rate reached 37.5% (three of eight patients) while stabilized disease was observed in 62.5% (five of eight) of patients. No patient had progressed at initial evaluation. At the last follow up, two patients were still using the combination and three patients had ceased the therapy due to toxicities such as diarrhea, nausea, and emesis. One patient changed to tazemetostat for maintenance and one patient stopped treatment due to coronavirus disease 2019 (COVID-19). Another patient stopped therapy as residual lesions had been radiated. Conclusions: The combination of irinotecan and Anlotinib as a salvage regimen may be considered another effective treatment option for refractory epithelioid sarcoma. Trial registration: This study was approved in the Medical Ethics Committee of Peking University People's Hospital on October 28, 2022 (No.: 2022PHD015-002). The study was registered in Clinicaltrials.gov with identifier no. NCT05656222.
MeSH term(s)	Humans ; Irinotecan/therapeutic use ; Vincristine/therapeutic use ; Retrospective Studies ; Sarcoma/pathology ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Biphenyl Compounds ; Benzamides ; Morpholines ; Quinolines ; Indoles ; Pyridones
Chemical Substances	Irinotecan (7673326042) ; Vincristine (5J49Q6B70F) ; tazemetostat (Q40W93WPE1) ; anlotinib ; Biphenyl Compounds ; Benzamides ; Morpholines ; Quinolines ; Indoles ; Pyridones
Language	English
Publishing date	2024-02-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-024-11921-7
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Article ; Online: In vitro suppression of porcine epidemic diarrhea virus by Panax notoginseng saponins: assessing antiviral potential.

Hu, Yiyi / Li, Yunchuan / Zhu, Haodan / Wang, Dandan / Zhou, Junming / Ni, Yanxiu / Guo, Rongli / Fan, Baochao / Li, Bin

Archives of virology

2024 Volume 169, Issue 5, Page(s) 89

Abstract: Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea and high mortality in neonatal suckling piglets, leading to significant economic losses to the swine industry. Panax notoginseng saponins (PNS) are bioactive extracts derived from the P. ... ...

Abstract	Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea and high mortality in neonatal suckling piglets, leading to significant economic losses to the swine industry. Panax notoginseng saponins (PNS) are bioactive extracts derived from the P. notoginseng plant. In this study, we investigated the anti-PEDV effect of PNS by employing various methodologies to assess their impact on PEDV in Vero cells. Using a CCK-8 (Cell Counting Kit-8) assay, we found that PNS had no significant cytotoxicity below the concentration of 128 µg/mL in Vero cells. Using immunofluorescence assays (IFAs), an enzyme-linked immunosorbent assay (ELISA), and plaque formation assays, we observed a dose-dependent inhibition of PEDV infection by PNS within 24-48 hours postinfection. PNS exerts its anti-PEDV activity specifically at the genome replication stage, and mRNA-seq analysis demonstrated that treatment with PNS resulted in increased expression of various genes, including IFIT1 (interferon-induced protein with tetratricopeptide repeats 1), IFIT3 (interferon-induced protein with tetratricopeptide repeats 3), CFH (complement factor H), IGSF10 (immunoglobulin superfamily member 10), ID2 (inhibitor of DNA binding 2), SPP1 (secreted phosphoprotein 1), PLCB4 (phospholipase C beta 4), and FABP4 (fatty acid binding protein 4), but it resulted in decreased expression of IL1A (interleukin 1 alpha), TNFRSF19 (TNF receptor superfamily member 19), CDH8 (cadherin 8), DDIT3 (DNA damage inducible transcript 3), GADD45A (growth arrest and DNA damage inducible alpha), PTPRG (protein tyrosine phosphatase receptor type G), PCK2 (phosphoenolpyruvate carboxykinase 2), and ADGRA2 (adhesion G protein-coupled receptor A2). This study provides insights into the potential mechanisms underlying the antiviral effects of PNS. Taken together, the results suggest that the PNS might effectively regulate the defense response to the virus and have potential to be used in antiviral therapies.
MeSH term(s)	Chlorocebus aethiops ; Animals ; Swine ; Saponins/pharmacology ; Vero Cells ; Porcine epidemic diarrhea virus/genetics ; Panax notoginseng ; Interferons ; Antiviral Agents/pharmacology ; Coronavirus Infections ; Swine Diseases/drug therapy
Chemical Substances	Saponins ; Interferons (9008-11-1) ; Antiviral Agents
Language	English
Publishing date	2024-04-02
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-024-06020-8
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Article: Limited-angle tomographic phase microscopy utilizing confocal scanning fluorescence microscopy.

Guo, Rongli / Barnea, Itay / Shaked, Natan T

Biomedical optics express

2021 Volume 12, Issue 4, Page(s) 1869–1881

Abstract: We present a multimodal imaging technique, combining tomographic phase microscopy with limited angular projection range and number, and two-channel spinning-disk confocal scanning fluorescence microscopy. This technique allows high-accuracy 3D refractive ...

Abstract	We present a multimodal imaging technique, combining tomographic phase microscopy with limited angular projection range and number, and two-channel spinning-disk confocal scanning fluorescence microscopy. This technique allows high-accuracy 3D refractive index (RI) profiling of live cells in spite of the missing projections. The cellular outer shape and its interior organelles measured by the confocal fluorescence imaging not only specify the cell in molecular levels, but also provide the 3D distributions of the whole cell as well as its organelles. We take these additional 3D morphological details as constraints in Gerchberg-Papoulis-based optical diffraction tomography algorithm. We then obtain an accurate 3D RI tomogram, even with a sparse angular range having a small number of perspective projections, otherwise providing low-accuracy RI reconstruction. Then, we obtain both cellular molecular specificity and inner RI values of the cell and its organelles. We compare the reconstructed 3D RI profiles of various samples, demonstrating the superiority of the proposed technique.
Language	English
Publishing date	2021-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2572216-5
ISSN	2156-7085
ISSN	2156-7085
DOI	10.1364/BOE.419598
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Article ; Online: Lipidomics reveals the significance and mechanism of the cellular ceramide metabolism for rotavirus replication.

Tao, Ran / Cheng, Xi / Gu, Laqiang / Zhou, Jinzhu / Zhu, Xuejiao / Zhang, Xuehan / Guo, Rongli / Wang, Wei / Li, Bin

Journal of virology

2024 Volume 98, Issue 4, Page(s) e0006424

Abstract: As one of the most important causative agents of severe gastroenteritis in children, piglets, and other young animals, species A rotaviruses have adversely impacted both human health and the global swine industry. Vaccines against rotaviruses (RVs) are ... ...

Abstract	As one of the most important causative agents of severe gastroenteritis in children, piglets, and other young animals, species A rotaviruses have adversely impacted both human health and the global swine industry. Vaccines against rotaviruses (RVs) are insufficiently effective, and no specific treatment is available. To understand the relationships between porcine RV (PoRV) infection and enterocytes in terms of the cellular lipid metabolism, we performed an untargeted liquid chromatography mass spectrometry (LC-MS) lipidomics analysis of PoRV-infected IPEC-J2 cells. Herein, a total of 451 lipids (263 upregulated lipids and 188 downregulated lipids), spanning sphingolipid, glycerolipid, and glycerophospholipids, were significantly altered compared with the mock-infected group. Interestingly, almost all the ceramides among these lipids were upregulated during PoRV infection. LC-MS analysis was used to validated the lipidomics data and demonstrated that PoRV replication increased the levels of long-chain ceramides (C16-ceramide, C18-ceramide, and C24-ceramide) in cells. Furthermore, we found that these long-chain ceramides markedly inhibited PoRV infection and that their antiviral actions were exerted in the replication stage of PoRV infection. Moreover, downregulation of endogenous ceramides with the ceramide metabolic inhibitors enhanced PoRV propagation. Increasing the levels of ceramides by the addition of C6-ceramide strikingly suppressed the replication of diverse RV strains. We further found that the treatment with an apoptotic inhibitor could reverse the antiviral activity of ceramide against PoRV replication, demonstrating that ceramide restricted RV infection by inducing apoptosis. Altogether, this study revealed that ceramides played an antiviral role against RV infection, providing potential approaches for the development of antiviral therapies.IMPORTANCERotaviruses (RVs) are among the most important zoonosis viruses, which mainly infected enterocytes of the intestinal epithelium causing diarrhea in children and the young of many mammalian and avian species. Lipids play an essential role in viral infection. A comprehensive understanding of the interaction between RV and lipid metabolism in the enterocytes will be helpful to control RV infection. Here, we mapped changes in enterocyte lipids following porcine RV (PoRV) infection using an untargeted lipidomics approach. We found that PoRV infection altered the metabolism of various lipid species, especially ceramides (derivatives of the sphingosine). We further demonstrated that PoRV infection increased the accumulation of ceramides and that ceramides exerted antiviral effects on RV replication by inducing apoptosis. Our findings fill a gap in understanding the alterations of lipid metabolism in RV-infected enterocytes and highlight the antiviral effects of ceramides on RV infection, suggesting potential approaches to control RV infection.
MeSH term(s)	Animals ; Ceramides/metabolism ; Lipid Metabolism ; Lipidomics ; Rotavirus/physiology ; Swine ; Enterocytes/metabolism ; Enterocytes/virology ; Rotavirus Infections/metabolism ; Cell Line
Chemical Substances	Ceramides
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.00064-24
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