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  1. Book ; Online ; E-Book: PI3K and AKT isoforms in immunity

    Dominguez-Villar, Margarita

    mechanisms and therapeutic opportunities

    (Current topics in microbiology and immunology ; 436)

    2022  

    Author's details Margarita Dominguez-Villar editor
    Series title Current topics in microbiology and immunology ; 436
    Collection
    Language English
    Size 1 Online-Ressource (vii, 466 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021575237
    ISBN 978-3-031-06566-8 ; 9783031065651 ; 3-031-06566-2 ; 3031065654
    DOI 10.1007/978-3-031-06566-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Host protection by two memory-like MAIT subsets.

    Dominguez-Villar, Margarita

    Nature cell biology

    2023  Volume 25, Issue 6, Page(s) 802–804

    MeSH term(s) CD8-Positive T-Lymphocytes
    Language English
    Publishing date 2023-05-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-023-01149-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 12: Show issues

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  3. Article ; Online: TKT deficiency puts T

    Dominguez-Villar, Margarita

    Nature metabolism

    2022  Volume 4, Issue 5, Page(s) 503–504

    MeSH term(s) Humans ; Metabolic Diseases
    Language English
    Publishing date 2022-05-23
    Publishing country Germany
    Document type Journal Article ; Comment
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-022-00574-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Antigen-Specific Regulatory T Cell Therapy in Autoimmune Diseases and Transplantation.

    Selck, Claudia / Dominguez-Villar, Margarita

    Frontiers in immunology

    2021  Volume 12, Page(s) 661875

    Abstract: Regulatory T (Treg) cells are a heterogenous population of immunosuppressive T cells whose therapeutic potential for the treatment of autoimmune diseases and graft rejection is currently being explored. While clinical trial results thus far support the ... ...

    Abstract Regulatory T (Treg) cells are a heterogenous population of immunosuppressive T cells whose therapeutic potential for the treatment of autoimmune diseases and graft rejection is currently being explored. While clinical trial results thus far support the safety and efficacy of adoptive therapies using polyclonal Treg cells, some studies suggest that antigen-specific Treg cells are more potent in regulating and improving immune tolerance in a disease-specific manner. Hence, several approaches to generate and/or expand antigen-specific Treg cells
    MeSH term(s) Animals ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Autoimmunity ; Cell- and Tissue-Based Therapy/methods ; Drug Evaluation, Preclinical ; Genetic Engineering ; Humans ; Immune Tolerance ; Immunotherapy, Adoptive/methods ; Immunotherapy, Adoptive/statistics & numerical data ; Mice ; Organ Transplantation ; T-Lymphocytes, Regulatory/immunology
    Language English
    Publishing date 2021-05-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.661875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Subolesin knockdown in tick cells provides insights into vaccine protective mechanisms.

    Artigas-Jerónimo, Sara / Villar, Margarita / Estrada-Peña, Agustín / Alberdi, Pilar / de la Fuente, José

    Vaccine

    2024  Volume 42, Issue 11, Page(s) 2801–2809

    Abstract: Ticks as obligate blood-feeding arthropod vectors of pathogenic viruses, bacteria, protozoa and helminths associated with prevalent tick-borne diseases (TBDs) worldwide. These arthropods constitute the second vector after mosquitoes that transmit ... ...

    Abstract Ticks as obligate blood-feeding arthropod vectors of pathogenic viruses, bacteria, protozoa and helminths associated with prevalent tick-borne diseases (TBDs) worldwide. These arthropods constitute the second vector after mosquitoes that transmit pathogens to humans and the first vector in domestic animals. Vaccines constitute the safest and more effective approach to control tick infestations and TBDs, but research is needed to identify new antigens and improve vaccine formulations. The tick protein Subolesin (Sub) is a well-known vaccine protective antigen with a highly conserved sequence at both gene and protein levels in the Ixodidae and among arthropods and vertebrates. In this study, transcriptomics and proteomics analyses were conducted together with graph theory data analysis in wild type and Sub knockdown (KD) tick ISE6 cells in order to identify and characterize the functional implications of Sub in tick cells. The results support a key role for Sub in the regulation of gene expression in ticks and the relevance of this antigen in vaccine development against ticks and TBDs. Proteins with differential representation in response to Sub KD provide insights into vaccine protective mechanisms and candidate tick protective antigens.
    MeSH term(s) Animals ; Humans ; Ticks/microbiology ; Mosquito Vectors ; Vaccines ; Antigens ; Tick Infestations/prevention & control ; Arthropod Proteins/genetics ; Tick-Borne Diseases/prevention & control
    Chemical Substances Vaccines ; Antigens ; Arthropod Proteins
    Language English
    Publishing date 2024-03-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2024.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1930: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 458: Show issues

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  6. Article ; Online: Fatty Acid Metabolism and T Cells in Multiple Sclerosis.

    Pompura, Saige L / Hafler, David A / Dominguez-Villar, Margarita

    Frontiers in immunology

    2022  Volume 13, Page(s) 869197

    Abstract: Cellular metabolic remodeling is intrinsically linked to the development, activation, differentiation, function, and survival of T cells. T cells transition from a catabolic, naïve state to an anabolic effector state upon T cell activation. Subsequently, ...

    Abstract Cellular metabolic remodeling is intrinsically linked to the development, activation, differentiation, function, and survival of T cells. T cells transition from a catabolic, naïve state to an anabolic effector state upon T cell activation. Subsequently, specialization of T cells into T helper (Th) subsets, including regulatory T cells (T
    MeSH term(s) Fatty Acids/metabolism ; Humans ; Lipids ; Lymphocyte Activation ; Multiple Sclerosis/metabolism ; T-Lymphocyte Subsets
    Chemical Substances Fatty Acids ; Lipids
    Language English
    Publishing date 2022-05-04
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.869197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Control of CD4

    Cameron, Benjamin / Zaheer, Syed Aymaan / Dominguez-Villar, Margarita

    Current topics in microbiology and immunology

    2022  Volume 436, Page(s) 197–216

    Abstract: The phosphoinositide-3-kinase (PI3K) pathway is a highly conserved intracellular signaling pathway involving numerous key effectors which, in response to diverse extracellular stimuli, modulate the phenotype and function of most mammalian cell types in a ...

    Abstract The phosphoinositide-3-kinase (PI3K) pathway is a highly conserved intracellular signaling pathway involving numerous key effectors which, in response to diverse extracellular stimuli, modulate the phenotype and function of most mammalian cell types in a pleiotropic manner. PI3K signaling plays a critical role in the development, activation, and differentiation of lymphocytes. In particular, the PI3Kδ and PI3Kγ isoforms have been shown to carry out essential, non-redundant roles in T cells, and therefore, tight regulation of the PI3K pathway is important to maintain the balance between immune tolerance and inflammation. Recent and ongoing efforts to manipulate the biology of T helper cell subsets in the treatment of autoimmune conditions, inflammatory disorders, as well as cancer have shown promising results, and targeting the PI3K pathway may be beneficial in these contexts. However, more insight as to the precise function of individual PI3K isoforms in pathogenic and protective immune cell subsets is still required, and how exactly PI3K signaling is regulated and integrated with classical immune pathways. This chapter provides an overview of the role of PI3K isoforms in the differentiation and function of T helper cell subsets, within the broader context of targeting this pathway to potentially alleviate immunopathology.
    MeSH term(s) Animals ; Cell Differentiation ; Mammals/metabolism ; Phosphatidylinositol 3-Kinase ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositols/metabolism ; Protein Isoforms/genetics ; T-Lymphocytes, Helper-Inducer/metabolism
    Chemical Substances Phosphatidylinositols ; Protein Isoforms ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137)
    Language English
    Publishing date 2022-10-15
    Publishing country Germany
    Document type Journal Article
    ISSN 0070-217X
    ISSN 0070-217X
    DOI 10.1007/978-3-031-06566-8_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Einzelsignatur: Show issues

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  8. Article ; Online: Editorial: Control of Regulatory T Cell Stability, Plasticity, and Function in Health and Disease.

    Piconese, Silvia / Walker, Lucy S K / Dominguez-Villar, Margarita

    Frontiers in immunology

    2021  Volume 11, Page(s) 611591

    MeSH term(s) Animals ; Cardiovascular Diseases/immunology ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/pathology ; Cell Differentiation ; Cell Lineage ; Cell Plasticity ; Cellular Microenvironment ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Humans ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Phenotype ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; T-Lymphocytes, Regulatory/pathology
    Language English
    Publishing date 2021-01-27
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.611591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Akirin/Subolesin regulatory mechanisms at host/tick-pathogen interactions.

    de la Fuente, José / Artigas-Jerónimo, Sara / Villar, Margarita

    microLife

    2021  Volume 3, Page(s) uqab012

    Abstract: Ticks and tick-borne pathogens such ... ...

    Abstract Ticks and tick-borne pathogens such as
    Language English
    Publishing date 2021-11-11
    Publishing country England
    Document type Journal Article
    ISSN 2633-6693
    ISSN (online) 2633-6693
    DOI 10.1093/femsml/uqab012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: HTLV-1 induces an inflammatory CD4+CD8+ T cell population in HTLV-1-associated myelopathy.

    Maher, Allison K / Aristodemou, Aris / Giang, Nicolas / Tanaka, Yuetsu / Bangham, Charles Rm / Taylor, Graham P / Dominguez-Villar, Margarita

    JCI insight

    2024  Volume 9, Issue 1

    Abstract: Human T cell leukemia virus type 1 (HTLV-1) is a retrovirus with preferential CD4+ T cell tropism that causes a range of conditions spanning from asymptomatic infection to adult T cell leukemia and HTLV-1-associated myelopathy (HAM), an inflammatory ... ...

    Abstract Human T cell leukemia virus type 1 (HTLV-1) is a retrovirus with preferential CD4+ T cell tropism that causes a range of conditions spanning from asymptomatic infection to adult T cell leukemia and HTLV-1-associated myelopathy (HAM), an inflammatory disease of the CNS. The mechanisms by which HTLV-1 induces HAM are poorly understood. By directly examining the ex vivo phenotype and function of T cells from asymptomatic carriers and patients with HAM, we show that patients with HAM have a higher frequency of CD4+CD8+ double-positive (DP) T cells, which are infected with HTLV-1 at higher rates than CD4+ T cells. Displaying both helper and cytotoxic phenotypes, these DP T cells are highly proinflammatory and contain high frequencies of HTLV-1-specific cells. Mechanistically, we demonstrate that DP T cells arise by direct HTLV-1 infection of CD4+ and CD8+ T cells. High levels of CD49d and CXCR3 expression suggest that DP T cells possess the ability to migrate to the CNS, and when cocultured with astrocytes, DP T cells induce proinflammatory astrocytes that express high levels of CXCL10, IFN-γ, and IL-6. These results demonstrate the potential of DP T cells to directly contribute to CNS pathology.
    MeSH term(s) Humans ; Astrocytes ; Bone Marrow Diseases ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Human T-lymphotropic virus 1 ; Paraparesis, Tropical Spastic
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.173738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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