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Article: WITHDRAWN: Oncogenic KRAS

Lasse-Opsahl, Emily / Baliira, Rachael / Barravecchia, Ivana / McLintock, Elyse / Lee, Jennifer M / Ferris, Sarah F / Espinoza, Carlos E / Hinshaw, Rachael / Cavanaugh, Sophia / Robotti, Marzia / Brown, Kristee / Donahue, Katelyn / Abdelmalak, Kristena Y / Galban, Craig J / Frankel, Timothy L / Zhang, Yaqing / di Magliano, Marina Pasca / Galban, Stefanie

bioRxiv : the preprint server for biology

2024

Abstract: This manuscript has been withdrawn by the authors due to a dispute over co-first authorship that is currently being arbitrated by the medical school at our institution. Therefore, the authors do not wish this work to be cited as reference for the project. ...

Abstract	This manuscript has been withdrawn by the authors due to a dispute over co-first authorship that is currently being arbitrated by the medical school at our institution. Therefore, the authors do not wish this work to be cited as reference for the project. Upon completion of the arbitration process, we will take steps to revert the current withdrawn status. If you have any questions, please contact the corresponding author.
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.16.568090
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Selection of Multidrug-Resistant Bacteria in Medicated Animal Feeds.

Brown, Emily E F / Cooper, Ashley / Carrillo, Catherine / Blais, Burton

Frontiers in microbiology

2019 Volume 10, Page(s) 456

Abstract: Exposure to antimicrobial resistant (AMR) bacteria is a major public health issue which may, in part, have roots in food production practices that are conducive to the selection of AMR bacteria ultimately impacting the human microbiome through food ... ...

Abstract	Exposure to antimicrobial resistant (AMR) bacteria is a major public health issue which may, in part, have roots in food production practices that are conducive to the selection of AMR bacteria ultimately impacting the human microbiome through food consumption. Of particular concern is the prophylactic use of antibiotics in animal husbandry, such as the medication of feeds with sulfonamides and other antibiotics not considered clinically relevant, but which may nonetheless co-select for multi-drug resistant (MDR) bacteria harboring resistance to medically important antibiotics. Using a MDR
Language	English
Publishing date	2019-03-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2019.00456
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Obesity and metabolic dysfunction correlate with background parenchymal enhancement in premenopausal women.

Brown, Justin C / Ligibel, Jennifer A / Crane, Tracy E / Kontos, Despina / Yang, Shengping / Conant, Emily F / Mack, Julie A / Ahima, Rexford S / Schmitz, Kathryn H

Obesity (Silver Spring, Md.)

2023 Volume 31, Issue 2, Page(s) 479–486

Abstract: Objective: This study tested the hypothesis that obesity and metabolic abnormalities correlate with background parenchymal enhancement (BPE), the volume and intensity of enhancing fibroglandular breast tissue on dynamic contrast-enhanced magnetic ... ...

Abstract	Objective: This study tested the hypothesis that obesity and metabolic abnormalities correlate with background parenchymal enhancement (BPE), the volume and intensity of enhancing fibroglandular breast tissue on dynamic contrast-enhanced magnetic resonance imaging. Methods: Participants included 59 premenopausal women at high risk of breast cancer. Obesity was defined as BMI ≥ 30 kg/m Results: BMI was positively correlated with BPE (r = 0.69; p < 0.001); participants with obesity had higher BPE than those without obesity (404.9 ± 189.6 vs. 261.8 ± 143.8 cm Conclusions: In premenopausal women at high risk of breast cancer, increased BPE is associated with obesity, insulin resistance, leptin, and adiponectin.
MeSH term(s)	Humans ; Female ; Leptin ; Adiponectin ; Insulin Resistance ; Obesity/metabolism ; Breast Neoplasms ; Lipids ; Inflammation
Chemical Substances	Leptin ; Adiponectin ; Lipids
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.23649
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Zs.A 4061: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 87: Show issues

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Article ; Online: Invasion of phagocytic Galectin 3 expressing macrophages in the diabetic brain disrupts vascular repair.

Mehina, Eslam M F / Taylor, Stephanie / Boghozian, Roobina / White, Emily / Choi, Sun Eui / Cheema, Manjinder S / Korbelin, Jakob / Brown, Craig E

Science advances

2021 Volume 7, Issue 34

Abstract: The cellular events that dictate the repair of damaged vessels in the brain, especially in those with vascular risk factors such as diabetes, is poorly understood. Here, we dissected the role of resident microglia and infiltrative macrophages in ... ...

Abstract	The cellular events that dictate the repair of damaged vessels in the brain, especially in those with vascular risk factors such as diabetes, is poorly understood. Here, we dissected the role of resident microglia and infiltrative macrophages in determining the repair of ruptured cerebral microvessels. Using in vivo time-lapse imaging, gene expression analysis, and immunohistochemistry, we identified a unique population of phagocytic Galectin 3 (Gal3) expressing macrophages, distinct from resident microglia, which infiltrated and aggregated at the site of injury in diabetic mice and were associated with the elimination of microvessels. Depletion of these infiltrative macrophages in diabetic mice attenuated phagocytic activity and prevented the loss of blood vessels after injury. These findings highlight a previously unknown role for infiltrative Gal3 expressing macrophages in promoting vessel elimination after brain injury and provide impetus for future studies to determine whether depleting these cells can facilitate vascular repair in at risk populations.
MeSH term(s)	Animals ; Brain/metabolism ; Diabetes Mellitus, Experimental/genetics ; Galectin 3/genetics ; Galectin 3/metabolism ; Macrophages/metabolism ; Mice ; Microglia/metabolism
Chemical Substances	Galectin 3
Language	English
Publishing date	2021-08-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.abg2712
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Article ; Online: Using simulation to accelerate autonomous experimentation: A case study using mechanics.

Gongora, Aldair E / Snapp, Kelsey L / Whiting, Emily / Riley, Patrick / Reyes, Kristofer G / Morgan, Elise F / Brown, Keith A

iScience

2021 Volume 24, Issue 4, Page(s) 102262

Abstract: Autonomous experimentation (AE) accelerates research by combining automation and machine learning to perform experiments intelligently and rapidly in a sequential fashion. While AE systems are most needed to study properties that cannot be predicted ... ...

Abstract	Autonomous experimentation (AE) accelerates research by combining automation and machine learning to perform experiments intelligently and rapidly in a sequential fashion. While AE systems are most needed to study properties that cannot be predicted analytically or computationally, even imperfect predictions can in principle be useful. Here, we investigate whether imperfect data from simulation can accelerate AE using a case study on the mechanics of additively manufactured structures. Initially, we study resilience, a property that is well-predicted by finite element analysis (FEA), and find that FEA can be used to build a Bayesian prior and experimental data can be integrated using discrepancy modeling to reduce the number of needed experiments ten-fold. Next, we study toughness, a property not well-predicted by FEA and find that FEA can still improve learning by transforming experimental data and guiding experiment selection. These results highlight multiple ways that simulation can improve AE through transfer learning.
Language	English
Publishing date	2021-03-02
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2021.102262
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Article: "We forgot about the donkeys!" An institutional analysis of the shift in animal welfare from direct implementation towards advocacy-based programming.

Haddy, Emily / Proops, Leanne / Burden, Faith / Raw, Zoe / Kaminski, Juliane / Brown, Julia

Animal welfare (South Mimms, England)

2024 Volume 33, Page(s) e9

Abstract: Shifts from direct implementation to advocacy-based programming have been documented across many non-governmental organisation (NGO) sectors, including animal welfare. Semi-structured interviews with 32 staff from different positions within animal ... ...

Abstract	Shifts from direct implementation to advocacy-based programming have been documented across many non-governmental organisation (NGO) sectors, including animal welfare. Semi-structured interviews with 32 staff from different positions within animal welfare NGOs explored recent programming changes. Maintaining a balance between direct implementation and advocacy-based activities emerged as a strong theme. The findings suggest that risks are associated with both the direct implementation
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ISSN	0962-7286
ISSN	0962-7286
DOI	10.1017/awf.2024.11
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Article: Coronary Microvascular Function Following Severe Preeclampsia.

Honigberg, Michael C / Economy, Katherine E / Pabón, Maria A / Wang, Xiaowen / Castro, Claire / Brown, Jenifer M / Divakaran, Sanjay / Weber, Brittany N / Barrett, Leanne / Perillo, Anna / Sun, Anina Y / Antoine, Tajmara / Farrohi, Faranak / Docktor, Brenda / Lau, Emily S / Yeh, Doreen DeFaria / Natarajan, Pradeep / Sarma, Amy A / Weisbrod, Robert M /

Hamburg, Naomi M / Ho, Jennifer E / Roh, Jason D / Wood, Malissa J / Scott, Nandita S / Carli, Marcelo F Di

medRxiv : the preprint server for health sciences

2024

Abstract: Background: Preeclampsia is a pregnancy-specific hypertensive disorder associated with an imbalance in circulating pro- and anti-angiogenic proteins. Preclinical evidence implicates microvascular dysfunction as a potential mediator of preeclampsia- ... ...

Abstract	Background: Preeclampsia is a pregnancy-specific hypertensive disorder associated with an imbalance in circulating pro- and anti-angiogenic proteins. Preclinical evidence implicates microvascular dysfunction as a potential mediator of preeclampsia-associated cardiovascular risk. Methods: Women with singleton pregnancies complicated by severe antepartum-onset preeclampsia and a comparator group with normotensive deliveries underwent cardiac positron emission tomography (PET) within 4 weeks of delivery. A control group of pre-menopausal, non-postpartum women was also included. Myocardial flow reserve (MFR), myocardial blood flow (MBF), and coronary vascular resistance (CVR) were compared across groups. Soluble fms-like tyrosine kinase receptor-1 (sFlt-1) and placental growth factor (PlGF) were measured at imaging. Results: The primary cohort included 19 women with severe preeclampsia (imaged at a mean 16.0 days postpartum), 5 with normotensive pregnancy (mean 14.4 days postpartum), and 13 non-postpartum female controls. Preeclampsia was associated with lower MFR ( Conclusions: In this exploratory study, we observed reduced coronary microvascular function in the early postpartum period following severe preeclampsia, suggesting that systemic microvascular dysfunction in preeclampsia involves the coronary microcirculation. Further research is needed to establish interventions to mitigate risk of preeclampsia-associated cardiovascular disease.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.04.24303728
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Article ; Online: Coronary Microvascular Function Following Severe Preeclampsia.

Honigberg, Michael C / Economy, Katherine E / Pabón, Maria A / Wang, Xiaowen / Castro, Claire / Brown, Jenifer M / Divakaran, Sanjay / Weber, Brittany N / Barrett, Leanne / Perillo, Anna / Sun, Anina Y / Antoine, Tajmara / Farrohi, Faranak / Docktor, Brenda / Lau, Emily S / DeFaria Yeh, Doreen / Natarajan, Pradeep / Sarma, Amy A / Weisbrod, Robert M /

Hamburg, Naomi M / Ho, Jennifer E / Roh, Jason D / Wood, Malissa J / Scott, Nandita S / Di Carli, Marcelo F

Hypertension (Dallas, Tex. : 1979)

2024

Abstract: Background: Preeclampsia is a pregnancy-specific hypertensive disorder associated with an imbalance in circulating proangiogenic and antiangiogenic proteins. Preclinical evidence implicates microvascular dysfunction as a potential mediator of ... ...

Abstract	Background: Preeclampsia is a pregnancy-specific hypertensive disorder associated with an imbalance in circulating proangiogenic and antiangiogenic proteins. Preclinical evidence implicates microvascular dysfunction as a potential mediator of preeclampsia-associated cardiovascular risk. Methods: Women with singleton pregnancies complicated by severe antepartum-onset preeclampsia and a comparator group with normotensive deliveries underwent cardiac positron emission tomography within 4 weeks of delivery. A control group of premenopausal, nonpostpartum women was also included. Myocardial flow reserve, myocardial blood flow, and coronary vascular resistance were compared across groups. sFlt-1 (soluble fms-like tyrosine kinase receptor-1) and PlGF (placental growth factor) were measured at imaging. Results: The primary cohort included 19 women with severe preeclampsia (imaged at a mean of 15.3 days postpartum), 5 with normotensive pregnancy (mean, 14.4 days postpartum), and 13 nonpostpartum female controls. Preeclampsia was associated with lower myocardial flow reserve (β, -0.67 [95% CI, -1.21 to -0.13]; Conclusions: In this exploratory cross-sectional study, we observed reduced coronary microvascular function in the early postpartum period following preeclampsia, suggesting that systemic microvascular dysfunction in preeclampsia involves coronary microcirculation. Further research is needed to establish interventions to mitigate the risk of preeclampsia-associated cardiovascular disease.
Language	English
Publishing date	2024-04-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	423736-5
ISSN	1524-4563 ; 0194-911X ; 0362-4323
ISSN (online)	1524-4563
ISSN	0194-911X ; 0362-4323
DOI	10.1161/HYPERTENSIONAHA.124.22905
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Zs.A 1488: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Using simulation to accelerate autonomous experimentation

Aldair E. Gongora / Kelsey L. Snapp / Emily Whiting / Patrick Riley / Kristofer G. Reyes / Elise F. Morgan / Keith A. Brown

iScience, Vol 24, Iss 4, Pp 102262- (2021)

A case study using mechanics

2021

Abstract: Summary: Autonomous experimentation (AE) accelerates research by combining automation and machine learning to perform experiments intelligently and rapidly in a sequential fashion. While AE systems are most needed to study properties that cannot be ... ...

Abstract	Summary: Autonomous experimentation (AE) accelerates research by combining automation and machine learning to perform experiments intelligently and rapidly in a sequential fashion. While AE systems are most needed to study properties that cannot be predicted analytically or computationally, even imperfect predictions can in principle be useful. Here, we investigate whether imperfect data from simulation can accelerate AE using a case study on the mechanics of additively manufactured structures. Initially, we study resilience, a property that is well-predicted by finite element analysis (FEA), and find that FEA can be used to build a Bayesian prior and experimental data can be integrated using discrepancy modeling to reduce the number of needed experiments ten-fold. Next, we study toughness, a property not well-predicted by FEA and find that FEA can still improve learning by transforming experimental data and guiding experiment selection. These results highlight multiple ways that simulation can improve AE through transfer learning.
Keywords	Mechanical Property ; Computational Method in Materials Science ; Simulation in Materials Science ; Science ; Q
Subject code	501
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Assessment of Parent-Child Interaction Is Important With Infants in Rehabilitation and Can Use High-Tech or Low-Tech Methods.

Dusing, Stacey C / Marcinowski, Emily C / Rocha, Nelci A C F / Tripathi, Tanya / Brown, Shaaron E

Physical therapy

2019 Volume 99, Issue 6, Page(s) 658–665

Abstract: Parents are their infant's first teachers and play a very important role in early development. Early intervention strives to enhance infant participation in the family, and regulations require the engagement of families in assessment and intervention. ... ...

Abstract	Parents are their infant's first teachers and play a very important role in early development. Early intervention strives to enhance infant participation in the family, and regulations require the engagement of families in assessment and intervention. Infants born preterm or with motor impairments demonstrate altered social engagements that can influence parent-child interaction and the efficacy of therapy services. However, in research focused on the efficacy of interventions or in clinical practice, therapists rarely assess or report on the quality of parent-infant interaction. Understanding these interactions can help determine what perceptual motor opportunities parents provide that can enhance learning. This Perspective article will: (1) present evidence on the need for early assessment and ongoing measurement of parent-infant interaction; (2) describe an example of each of 3 methods for assessment of parent-child interaction-low-tech, low-resource (Dyadic Mutuality Code), low-tech, high-resource (Parent Children Early Relational Assessment), and high-tech, high-resource (customized behavioral coding); (3) compare 3 approaches theoretically highlighting the strengths and weaknesses of each assessment; and (4) reflect on the challenges and value of adding these measures to future research on the efficacy of interventions and clinical practice.
MeSH term(s)	Child Development/physiology ; Early Intervention (Education)/methods ; Female ; Humans ; Infant Behavior/physiology ; Infant, Newborn ; Infant, Premature/physiology ; Male ; Parent-Child Relations ; Parents/psychology ; Prospective Studies
Language	English
Publishing date	2019-04-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	415886-6
ISSN	1538-6724 ; 0031-9023
ISSN (online)	1538-6724
ISSN	0031-9023
DOI	10.1093/ptj/pzz021
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