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Article ; Online: ＜Editors' Choice＞ The relationship between preoperative foot alignment and postoperative outcomes in patients who underwent initial total knee arthroplasty.

Hishida, Aika / Hiraiwa, Hideki / Kadono, Izumi / Yamaguchi, Hidetoshi / Okada, Takashi / Terai, Chiaki / Kayamoto, Azusa / Nishida, Yoshihiro

Nagoya journal of medical science

2024 Volume 86, Issue 1, Page(s) 91–103

Abstract: We compared the relationship between foot alignments and quality of life in patients who underwent initial total knee arthroplasty (TKA). Among the patients with knee osteoarthritis (KOA) who underwent TKA from May 2015 to May 2017 at our hospital, we ... ...

Abstract	We compared the relationship between foot alignments and quality of life in patients who underwent initial total knee arthroplasty (TKA). Among the patients with knee osteoarthritis (KOA) who underwent TKA from May 2015 to May 2017 at our hospital, we focused on those in whom weight-bearing foot radiographs had been evaluated preoperatively. The hallux valgus angle and Meary angle were measured by preoperative radiography, and those with hallux valgus angles of 20 degrees or more were classified into the hallux valgus (HV) group, and those with Meary angles of 4 degrees or more into the high arch (HA) group. Also knee and ankle range of motion, knee pain Visual Analog Scale, and the 36-item short-form health survey (SF-36) were measured preoperatively and at discharge, and the amount of these changes was compared in the presence/absence of HV and HA. Regarding HV, there were no significant differences in any of these items between the HV and non-HV groups. However, the SF-physical function was significantly lower in the HA group than in the normal group. In addition, ankle dorsiflexion was lower in the HA group than that in the normal group, although this difference was not statistically significant. There was little improvement of the ankle dorsiflexion, and it was associated with deterioration of the physical function items of SF-36. In total knee arthroplasty patients with HA, physical therapy of the ankles and feet, as well as of the knees, was considered to enhance the improvement of physical function.
Language	English
Publishing date	2024-03-05
Publishing country	Japan
Document type	Journal Article
ZDB-ID	193148-9
ISSN	2186-3326 ; 0027-7622
ISSN (online)	2186-3326
ISSN	0027-7622
DOI	10.18999/nagjms.86.1.91
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Article: Clinical Efficacy and Future Prospects of Immunotherapy in Lung Cancer.

Kinoshita, Tomonari / Terai, Hideki / Yaguchi, Tomonori

Life (Basel, Switzerland)

2021 Volume 11, Issue 10

Abstract: The three major conventional treatments: surgery, chemotherapy, and radiation therapy, have been commonly performed for lung cancer. However, lung cancer is still the leading cause of cancer-related mortality. Immunotherapy has recently emerged as a very ...

Abstract	The three major conventional treatments: surgery, chemotherapy, and radiation therapy, have been commonly performed for lung cancer. However, lung cancer is still the leading cause of cancer-related mortality. Immunotherapy has recently emerged as a very effective new treatment modality, and there is now growing enthusiasm for cancer immunotherapy worldwide. However, the results of clinical studies using immunotherapy are not always favorable. Understanding the steps involved in the recognition and eradication of cancer cells by the immune system seems essential to understanding why past immunotherapies have failed and how current therapies can be optimally utilized. In addition, the combination of immunotherapies, such as cancer vaccines and immune checkpoint inhibitors, as well as the combination of these therapies with three conventional therapies, may pave the way for personalized immunotherapy. In this review, we summarize the results of immunotherapies used in phase III clinical trials, including immune checkpoint inhibitors, and discuss the future prospects of immunotherapies in lung cancer treatment.
Language	English
Publishing date	2021-09-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life11101029
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Article ; Online: Clinical Efficacy and Future Prospects of Immunotherapy in Lung Cancer

Tomonari Kinoshita / Hideki Terai / Tomonori Yaguchi

Life, Vol 11, Iss 1029, p

2021 Volume 1029

Abstract	The three major conventional treatments: surgery, chemotherapy, and radiation therapy, have been commonly performed for lung cancer. However, lung cancer is still the leading cause of cancer-related mortality. Immunotherapy has recently emerged as a very effective new treatment modality, and there is now growing enthusiasm for cancer immunotherapy worldwide. However, the results of clinical studies using immunotherapy are not always favorable. Understanding the steps involved in the recognition and eradication of cancer cells by the immune system seems essential to understanding why past immunotherapies have failed and how current therapies can be optimally utilized. In addition, the combination of immunotherapies, such as cancer vaccines and immune checkpoint inhibitors, as well as the combination of these therapies with three conventional therapies, may pave the way for personalized immunotherapy. In this review, we summarize the results of immunotherapies used in phase III clinical trials, including immune checkpoint inhibitors, and discuss the future prospects of immunotherapies in lung cancer treatment.
Keywords	lung cancer ; immunotherapy ; immune checkpoint inhibitor ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: A qualitative systematic review of the significance of adjuvant therapy in patients with low-risk endometrial cancer presenting positive peritoneal cytology: a relevant study to the guideline update for endometrial cancer by the Japan society of gynecologic oncology guideline committee.

Shigeta, Shogo / Konno, Yosuke / Terai, Yoshito / Morisada, Tohru / Tokunaga, Hideki / Baba, Tsukasa / Kobayashi, Yoichi / Nagase, Satoru

Japanese journal of clinical oncology

2023 Volume 54, Issue 2, Page(s) 217–220

Abstract: In association with an update of the Japan Society of Gynecologic Oncology clinical practice guidelines for endometrial cancer in 2023, a systematic review was conducted about the therapeutic benefit of adjuvant therapy on patients with early-stage ... ...

Abstract	In association with an update of the Japan Society of Gynecologic Oncology clinical practice guidelines for endometrial cancer in 2023, a systematic review was conducted about the therapeutic benefit of adjuvant therapy on patients with early-stage endometrial carcinoma, who presented positive peritoneal cytology (PPC) without the risk factors for recurrence. The systematic review only included two eligible retrospective studies. Both studies included patients with risk factors for recurrence. A nationwide study in the United States reported that adjuvant chemotherapy was associated with the reduced risk of death among patients with stages I-II endometrial cancer with PPC by multivariate, propensity score-adjusted analysis. Another single-center study in Japan reported no association between adjuvant chemotherapy and relapse-free survival among patients with stage IA endometrial cancer by univariate analysis. This systematic review identified that evidence was limited with conflicting results. Continuous evaluation is warranted to address this clinical question.
MeSH term(s)	Humans ; Female ; Prognosis ; Retrospective Studies ; Neoplasm Staging ; Japan ; Cytology ; Neoplasm Recurrence, Local/pathology ; Endometrial Neoplasms/pathology ; Chemotherapy, Adjuvant
Language	English
Publishing date	2023-11-01
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyad140
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Zs.A 1298: Show issues

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Article ; Online: Protocol improvement and multisite validation of a digital soft agar colony formation assay for tumorigenic transformed cells intermingled in cell therapy products.

Bando, Kiyoko / Kusakawa, Shinji / Adachi, Hideki / Yamamoto, Mika / Iwata, Miki / Kitanaka, Atsushi / Ogimura, Eiichiro / Osada, Tomoharu / Tamura, Maya / Terai, Orie / Watanabe, Takeshi / Yoda, Tomomi / Yotsumoto, Takafumi / Zaizen, Kinuko / Sato, Yoji

Cytotherapy

2024

Abstract: Background aims: The administration of human cell-processed therapeutic products (hCTPs) is associated with a risk of tumorigenesis due to the transformed cellular contaminants. To mitigate this risk, these impurities should be detected using sensitive ... ...

Abstract	Background aims: The administration of human cell-processed therapeutic products (hCTPs) is associated with a risk of tumorigenesis due to the transformed cellular contaminants. To mitigate this risk, these impurities should be detected using sensitive and validated assays. The digital soft agar colony formation (D-SAC) assay is an ultrasensitive in vitro test for detecting tumorigenic transformed cells in hCTPs. Methods: In this study, we first evaluated the colony formation efficiency (CFE) precision of tumorigenic reference cells in positive control samples according to a previously reported D-SAC assay protocol (Protocol I) from multiple laboratories. However, the CFE varied widely among laboratories. Thus, we improved and optimized the test protocol as Protocol II to reduce variability in the CFE of tumorigenic reference cells. Subsequently, the improved protocol was validated at multiple sites. Human mesenchymal stromal cells (hMSCs) were used as model cells, and positive control samples were prepared by spiking them with HeLa cells. Results: Based on the previously reported protocol, the CFE was estimated using an ultra-low concentration (0.0001%) of positive control samples in multiple plates. Next, we improved the protocol to reduce the CFE variability. Based on the CFE results, we estimated the sample size as the number of wells (Protocol II) and assessed the detectability of 0.0001% HeLa cells in hMSCs to validate the protocol at multiple sites. Using Protocol I yielded low CFEs (mean: 30%) and high variability between laboratories (reproducibility coefficient of variance [CV]: 72%). In contrast, Protocol II, which incorporated a relatively high concentration (0.002%) of HeLa cells in the positive control samples, resulted in higher CFE values (mean: 63%) and lower variability (reproducibility CV: 18%). Moreover, the sample sizes for testing were estimated as the number of wells per laboratory (314-570 wells) based on the laboratory-specific CFE (42-76%). Under these conditions, all laboratories achieved a detection limit of 0.0001% HeLa cells in hMSCs in a predetermined number of wells. Moreover, colony formation was not observed in the wells seeded with hMSCs alone. Conclusions: The D-SAC assay is a highly sensitive and robust test for detecting malignant cells as impurities in hCTPs. In addition, optimal assay conditions were established to test tumorigenic impurities in hCTPs with high sensitivity and an arbitrary false negative rate.
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2039821-9
ISSN	1477-2566 ; 1465-3249
ISSN (online)	1477-2566
ISSN	1465-3249
DOI	10.1016/j.jcyt.2024.03.005
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Zs.A 5601: Show issues

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Article ; Online: Observation of peripheral airways using ultra-thin fiberscope.

Kinoshita, Tomonari / Terai, Hideki / Ikemura, Shinnosuke / Takada, Nao / Fukui, Takahiro / Irie, Hidehiro / Miyazawa, Raita / Funatsu, Yohei / Okamura, Teppei / Koh, Hidefumi / Yamamoto, Tatsuya / Shigematsu, Risa / Ohgino, Keiko / Oka, Kiyoshi

Respirology (Carlton, Vic.)

2023 Volume 28, Issue 9, Page(s) 881–884

MeSH term(s)	Humans ; Bronchoscopy ; Respiratory System
Language	English
Publishing date	2023-07-05
Publishing country	Australia
Document type	Letter
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.14547
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Zs.A 4957: Show issues

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Article ; Online: Usefulness of Prophylactic Administration of Pegfilgrastim for Esophageal Cancer Chemotherapy: A Single-center Retrospective Study.

Okamoto, Koichi / Ninomiya, Itasu / Saito, Hiroto / Shimada, Mari / Yamaguchi, Takahisa / Terai, Shiro / Moriyama, Hideki / Kinoshita, Jun / Nakamura, Keishi / Inaki, Noriyuki

Anticancer research

2022 Volume 42, Issue 5, Page(s) 2783–2790

Abstract: Background/aim: To evaluate the impact of prophylactic administration of pegfilgrastim in esophageal cancer (EC) patients treated with chemotherapy consisted of docetaxel, cisplatin, and fluorouracil (DCF).: Patients and methods: Among 102 patients ... ...

Abstract	Background/aim: To evaluate the impact of prophylactic administration of pegfilgrastim in esophageal cancer (EC) patients treated with chemotherapy consisted of docetaxel, cisplatin, and fluorouracil (DCF). Patients and methods: Among 102 patients who received neoadjuvant or induction DCF for primary advanced EC, 65 received prophylactic pegfilgrastim and 37 did not. The association of pegfilgrastim with adverse events and clinicopathological outcomes was retrospectively analyzed. Results: In the pegfilgrastim group, the incidence of grade >3 neutropenia was lower (30.8% vs. 62.2%) and more patients avoided dose reduction or discontinuation of chemotherapy (32.3% vs. 70.3%). The radiological (PR≤) and histopathological (grade 1b≤) response rates were significantly higher (69.2% vs. 43.2% and 59.2% vs. 35.7%). Three-year overall survival and progression-free survival rates were significantly higher (65.0% vs. 48.6%, p=0.033; 56.1% vs. 35.1%, p=0.007, respectively). Conclusion: Prophylactic pegfilgrastim in DCF may relieve adverse events and improve the oncologic outcome of EC patients.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Cisplatin ; Docetaxel ; Esophageal Neoplasms/pathology ; Filgrastim ; Fluorouracil ; Humans ; Lymphoma, Follicular ; Neutropenia/chemically induced ; Neutropenia/prevention & control ; Polyethylene Glycols ; Retrospective Studies
Chemical Substances	Docetaxel (15H5577CQD) ; pegfilgrastim (3A58010674) ; Polyethylene Glycols (3WJQ0SDW1A) ; Filgrastim (PVI5M0M1GW) ; Cisplatin (Q20Q21Q62J) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2022-04-27
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.15758
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Zs.A 1642: Show issues

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Article ; Online: Clinical features of Japanese patients with gastrointestinal long-COVID symptoms.

Yagi, Kazuma / Asakura, Takanori / Terai, Hideki / Ohgino, Keiko / Masaki, Katsunori / Namkoong, Ho / Chubachi, Shotaro / Miyata, Jun / Kawada, Ichiro / Kodama, Nobuhiro / Sakamoto, Satoshi / Umeda, Akira / Ishiguro, Takashi / Ishii, Makoto / Fukunaga, Koichi

JGH open : an open access journal of gastroenterology and hepatology

2023 Volume 7, Issue 12, Page(s) 998–1002

Abstract: Gastrointestinal (GI) long-COVID symptoms, including diarrhea and abdominal pain, have been reported in patients with long-COVID. However, the clinical features of patients with GI long-COVID symptoms remain unclear. We conducted a large-scale ... ...

Abstract	Gastrointestinal (GI) long-COVID symptoms, including diarrhea and abdominal pain, have been reported in patients with long-COVID. However, the clinical features of patients with GI long-COVID symptoms remain unclear. We conducted a large-scale prospective cohort study focusing on the clinical characteristics of patients with GI long-COVID symptoms in Japan. Among 943 COVID-19 patients, 58 patients (6.2%) had GI long-COVID symptoms. The health-related quality of life (QOL) parameters (the Short Form-8 [SF-8] and Euro Quality of Life 5 Dimensions 5 level [EQ-5D-5L]) at 12 months after diagnosis in patients with GI long-COVID symptoms were significantly lower than in those without GI long-COVID symptoms (
Language	English
Publishing date	2023-12-06
Publishing country	Australia
Document type	Journal Article
ISSN	2397-9070
ISSN (online)	2397-9070
DOI	10.1002/jgh3.13006
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Article: Lorlatinib-induced visual and auditory hallucinations: A case report.

Hakamata, Jun / Nakada, Hideo / Muramatsu, Hiroshi / Masuzawa, Keita / Terai, Hideki / Ikemura, Shinnosuke / Fukunaga, Koichi / Aomori, Tohru

Clinical case reports

2021 Volume 9, Issue 8

Abstract: Lorlatinib can cause visual and auditory hallucinations. And, it is necessary to keep in mind that hallucinations can persist even after discontinuation in patients who develop hallucinations while receiving lorlatinib. ...

Abstract	Lorlatinib can cause visual and auditory hallucinations. And, it is necessary to keep in mind that hallucinations can persist even after discontinuation in patients who develop hallucinations while receiving lorlatinib.
Language	English
Publishing date	2021-04-07
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.4040
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Article ; Online: Upper Respiratory Symptoms as Long COVID: Insight from a Multicenter Cohort Study.

Okada, Masahiko / Ishida, Noriyuki / Kanzaki, Sho / Kawada, Ichiro / Nagashima, Kengo / Terai, Hideki / Hiruma, Gaku / Namkoong, Ho / Asakura, Takanori / Masaki, Katsunori / Ohgino, Keiko / Miyata, Jun / Chubachi, Shotaro / Kodama, Nobuhiro / Maeda, Shunsuke / Sakamoto, Satoshi / Okamoto, Masaki / Nagasaki, Yoji / Umeda, Akira /

Miyagawa, Kazuya / Shimada, Hisato / Minami, Kazuhiro / Hagiwara, Rie / Ishii, Makoto / Sato, Yasunori / Fukunaga, Koichi

OTO open

2024 Volume 8, Issue 1, Page(s) e120

Abstract: Objective: This study aimed to investigate the clinical features of long COVID cases presenting with upper respiratory symptoms, a topic not yet fully elucidated.: Study design: Prospective cohort study.: Setting: A multicenter study involving 26 ... ...

Abstract	Objective: This study aimed to investigate the clinical features of long COVID cases presenting with upper respiratory symptoms, a topic not yet fully elucidated. Study design: Prospective cohort study. Setting: A multicenter study involving 26 medical facilities in Japan. Methods: Inclusion criteria were patients aged ≥18 years old with a confirmed COVID-19 diagnosis via severe acute respiratory syndrome coronavirus 2 polymerase chain reaction or antigen testing, who were hospitalized at the participating medical facilities. Analyzing clinical information and patient-reported outcomes from 1009 patients were analyzed. The outcome measured the degree of initial symptoms for taste or olfactory disorders and assessed the likelihood of these symptoms persisting as long COVID, as well as the impact on quality of life if the upper respiratory symptoms persisted as long COVID. Results: Patients with high albumin, low C-reactive protein, and low lactate dehydrogenase in laboratory tests tended to experience taste or olfactory disorders as part of long COVID. Those with severe initial symptoms had a higher risk of experiencing residual symptoms at 3 months, with an odds ratio of 2.933 (95% confidence interval [CI], 1.282-6.526) for taste disorders and 3.534 (95% CI, 1.382-9.009) for olfactory disorders. Presence of upper respiratory symptoms consistently resulted in lower quality of life scores. Conclusion: The findings from this cohort study suggest that severe taste or olfactory disorders as early COVID-19 symptoms correlate with an increased likelihood of persistent symptoms in those disorders as long COVID.
Language	English
Publishing date	2024-03-03
Publishing country	United States
Document type	Journal Article
ISSN	2473-974X
ISSN (online)	2473-974X
DOI	10.1002/oto2.120
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