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Article ; Online: Sm and Gd Contacts in 2D Semiconductors for High-Performance Electronics and Spintronics.

Wang, Dong / Tan, Chao / Wang, Shaoyuan / Yang, Zhihao / Yang, Lei / Wang, Zegao

ACS applied materials & interfaces

2024 Volume 16, Issue 11, Page(s) 14064–14071

Abstract: Two-dimensional (2D) semiconductors have attracted great attention due to their rich electronic properties and even been considered to have the potential to extend Moore's Law. However, the Schottky barrier between the metal and 2D semiconductor is ... ...

Abstract	Two-dimensional (2D) semiconductors have attracted great attention due to their rich electronic properties and even been considered to have the potential to extend Moore's Law. However, the Schottky barrier between the metal and 2D semiconductor is formed due to the metal-induced gap states (MIGS), which greatly hinder the development of 2D semiconductor transistors in large-scale integrated circuits. Meanwhile, most air-stable 2D semiconductors are nonmagnetic, limiting the possibility of spintronic application. Here, we report a new strategy to suppress the MIGS and reduce the Schottky barrier height on 2D semiconductors (MoS
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c19260
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Article ; Online: ASO Visual Abstract: Development and Validation of PET/CT-Based Nomogram for Preoperative Prediction of Lymph Node Status in Esophageal Squamous Cell Carcinoma.

Zhang, Shaoyuan / Sun, Linyi / Cai, Danjie / Liu, Guobing / Jiang, Dongxian / Yin, Jun / Fang, Yong / Wang, Hao / Shen, Yaxing / Hou, Yingyong / Shi, Hongcheng / Tan, Lijie

Annals of surgical oncology

2024

Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-13841-5
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Zs.A 4042: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Telocytes protect against lung tissue fibrosis through hexokinase 2-dependent pathway by secreting hepatocyte growth factor.

Zhang, Shaoyuan / Sun, Linyi / Chen, Borong / Lin, Siyun / Gu, Jianmin / Tan, Lijie / Lin, Miao

Clinical and experimental pharmacology & physiology

2023 Volume 50, Issue 12, Page(s) 964–972

Abstract: Pulmonary fibrosis (PF) is one of the common manifestations of end-stage lung disease. Chronic lung failure after lung transplantation is mainly caused by bronchiolitis obliterans syndrome (BOS) and is mainly characterized by lung tissue fibrosis. ... ...

Abstract	Pulmonary fibrosis (PF) is one of the common manifestations of end-stage lung disease. Chronic lung failure after lung transplantation is mainly caused by bronchiolitis obliterans syndrome (BOS) and is mainly characterized by lung tissue fibrosis. Pulmonary epithelial-mesenchymal transformation (EMT) is crucial for pulmonary fibrosis. Telocytes (TCs), a new type of mesenchymal cells, play a protective role in various acute injuries. For exploring the anti-pulmonary fibrosis effect of TCs in the BOS model in vitro and the related mechanism, rat tracheal epithelial (RTE) cells were treated with transforming growth factor-β (TGF-β) to simulate lung tissue fibrosis in vitro. The RTE cells were then co-cultured with TCs primarily extracted from rat lung tissue. Western blot, Seahorse XF Analysers and enzyme-linked immunosorbent assay were used to detect the level of EMT and aerobic respiration of RTE cells. Furthermore, anti-hepatocyte growth factor (anti-HGF) antibody was exogenously added to the cultured cells to explore further mechanisms. Moreover, hexokinase 2 (HK2) in RTE cells was knocked down to assess whether it influences the blocking effect of the anti-HGF antibody. TGF-β could induce lung tissue fibrosis in RTE cells in vitro. Nevertheless, TCs co-culture decreased the level of EMT, glucose metabolic indicators (lactate and ATP) and oxygen levels. Furthermore, TCs released hepatocyte growth factor (HGF). Therefore, the exogenous addition of anti-HGF antibody in the co-culture system blocked the anti-lung tissue fibrosis effect. However, HK2 knockdown attenuated the blocking effect of the anti-HGF antibody. In conclusion, TCs can protect against lung tissue fibrosis by releasing HGF, a process dependent on HK2.
MeSH term(s)	Animals ; Rats ; Fibrosis ; Hepatocyte Growth Factor/metabolism ; Hexokinase ; Lung/metabolism ; Pulmonary Fibrosis/metabolism ; Telocytes/metabolism ; Transforming Growth Factor beta/metabolism ; Transforming Growth Factor beta1/metabolism
Chemical Substances	Hepatocyte Growth Factor (67256-21-7) ; Hexokinase (EC 2.7.1.1) ; Transforming Growth Factor beta ; Transforming Growth Factor beta1 ; Hgf protein, rat
Language	English
Publishing date	2023-09-16
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	189277-0
ISSN	1440-1681 ; 0305-1870 ; 0143-9294
ISSN (online)	1440-1681
ISSN	0305-1870 ; 0143-9294
DOI	10.1111/1440-1681.13823
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Zs.A 990: Show issues

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Article ; Online: Strong Anisotropic Two-Dimensional In₂Se₃ for Light Intensity and Polarization Dual-Mode High-Performance Detection

Wang, Shaoyuan / Yang, Zhihao / Wang, Dong / Tan, Chao / Yang, Lei / Wang, Zegao

ACS Applied Materials & Interfaces. 2023 Jan. 04, v. 15, no. 2 p.3357-3364

2023

Abstract: Detecting the light from different freedom is of great significance to gain more information. Two-dimensional (2D) materials with low intrinsic carrier concentration and highly tunable electronic structure have been considered as the promising candidate ... ...

Abstract	Detecting the light from different freedom is of great significance to gain more information. Two-dimensional (2D) materials with low intrinsic carrier concentration and highly tunable electronic structure have been considered as the promising candidate for future room-temperature multi-functional photodetectors. However, current investigations mainly focus on intensity-sensitive detection; the multi-dimensional photodetection such as polarization-sensitive photodetection is still in its early stage. Herein, the intensity- and polarization-sensitive photodetection based on α-In₂Se₃ is studied. By using angle-resolved polarized Raman spectroscopy, it is demonstrated that α-In₂Se₃ shows an anisotropic phonon vibration property indicating its asymmetric structure. The α-In₂Se₃-based photodetector has a photoelectric performance with a responsivity of 1936 A/W and a specific detectivity of 2.1 × 10¹³ Jones under 0.2 mW/cm² power density at 400 nm. Moreover, by studying the polarized angle-resolved photoelectrical effect, it is found that the ratio of maximum and minimum photocurrent (dichroic ratio) reaches 1.47 at 650 nm suggesting good polarization-sensitive detection. After post-annealing, α-In₂Se₃ in situ converts to β-In₂Se₃ which has similar in-plane anisotropic crystallinity and exhibits a dichroic ratio of 1.41. It is found that the responsivity of β-In₂Se₃ is 6 A/W, much lower than that of α-In₂Se₃. The high-performance light intensity- and polarization-detection of α-In₂Se₃ enlarges the 2D anisotropic materials family and provides new opportunities for future dual-mode photodetection.
Keywords	Raman spectroscopy ; ambient temperature ; anisotropy ; crystal structure ; electric current ; light intensity ; vibration ; polarization detection ; intensity detection ; In2Se3 ; photodetector ; dual-mode
Language	English
Dates of publication	2023-0104
Size	p. 3357-3364.
Publishing place	American Chemical Society
Document type	Article ; Online
ISSN	1944-8252
DOI	10.1021/acsami.2c19660
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A novel strategy to attenuate porcine reproductive and respiratory syndrome virus by inhibiting viral replication in the target pulmonary alveolar macrophages via hematopoietic-specific miR-142.

Tan, Shaoyuan / Wu, Weixin / Ge, Xinna / Zhang, Yongning / Han, Jun / Guo, Xin / Zhou, Lei / Yang, Hanchun

One health advances

2023 Volume 1, Issue 1, Page(s) 3

Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen for the global pork industry. Although modified live virus (MLV) vaccines are commonly used for PRRSV prevention and control, they still carry a risk of ... ...

Abstract	Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen for the global pork industry. Although modified live virus (MLV) vaccines are commonly used for PRRSV prevention and control, they still carry a risk of infecting the host and replicating in target cells, thereby increasing the likehood of virus recombination and reversion to virulence. In this study, we inserted the target sequence of miR-142 into the nsp2 hypervariable region of PRRSV to inhibit viral replication in its host cells of pigs, with the aim of achieving virus attenuation. The chimeric virus RvJX-miR-142t was successfully rescued and retained its growth characteristics in MARC-145 cells. Furthermore, it did not replicate in MARC-145 cells transfected with miRNA-142 mimic. We also observed limited replication ability of RvJX-miR-142t in pulmonary alveolar macrophages, which are the main cell types that PRRSV infects. Our animal inoculation study showed that pigs infected with RvJX-miR-142t displayed less severe clinical symptoms, lower viremia titers, lighter lung lesions, and significantly lower mortality rates during the first 7 days post-inoculation, in comparison to pigs infected with the backbone virus RvJXwn. We detected a partially deletion of the miR-142 target sequence in the RvJX-miR-142t genome at 14 dpi. It is highly possible that the reversion of viral virulence observed in the later timepoints of our animal experiment was caused by that. Our study provided a new strategy for attenuating PRRSV and confirmed its effectiveness. However, further studies are necessary to increase the stability of this virus under host selection pressure.
Language	English
Publishing date	2023-03-30
Publishing country	England
Document type	Journal Article
ISSN	2731-9970
ISSN (online)	2731-9970
DOI	10.1186/s44280-023-00002-2
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Article ; Online: Characterization of Emerging Swine Viral Diseases through Oxford Nanopore Sequencing Using Senecavirus A as a Model.

Tan, Shaoyuan / Dvorak, Cheryl M T / Murtaugh, Michael P

Viruses

2020 Volume 12, Issue 10

Abstract: Emerging viral infectious diseases present a major threat to the global swine industry. Since 2015, Senecavirus A (SVA) has been identified as a cause of vesicular disease in different countries and is considered an emerging disease. Despite the growing ... ...

Abstract	Emerging viral infectious diseases present a major threat to the global swine industry. Since 2015, Senecavirus A (SVA) has been identified as a cause of vesicular disease in different countries and is considered an emerging disease. Despite the growing concern about SVA, there is a lack of preventive and diagnostic strategies, which is also a problem for all emerging infectious diseases. Using SVA as a model, we demonstrated that Oxford Nanopore MinION sequencing could be used as a robust tool for the investigation and surveillance of emerging viral diseases. Our results identified that MinION sequencing allowed for rapid, unbiased pathogen detection at the species and strain level for clinical cases. SVA whole genome sequences were generated using both direct RNA sequencing and PCR-cDNA sequencing methods, with an optimized consensus accuracy of 94% and 99%, respectively. The advantages of direct RNA sequencing lie in its shorter turnaround time, higher analytical sensitivity and its quantitative relationship between input RNA and output sequencing reads, while PCR-cDNA sequencing excelled at creating highly accurate sequences. This study developed whole genome sequencing methods to facilitate the control of SVA and provide a reference for the timely detection and prevention of other emerging infectious diseases.
MeSH term(s)	Animals ; Communicable Diseases, Emerging/veterinary ; Communicable Diseases, Emerging/virology ; Genome, Viral/genetics ; Molecular Diagnostic Techniques ; Nanopore Sequencing/methods ; Picornaviridae/genetics ; Picornaviridae Infections/diagnosis ; Picornaviridae Infections/veterinary ; Sequence Analysis, RNA ; Swine/virology ; Swine Diseases/diagnosis ; Swine Diseases/virology ; Whole Genome Sequencing/methods
Keywords	covid19
Language	English
Publishing date	2020-10-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v12101136
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Article ; Online: Publisher Correction: Neoadjuvant adebrelimab in locally advanced resectable esophageal squamous cell carcinoma: a phase 1b trial.

Yin, Jun / Yuan, Jingnan / Li, Yunjin / Fang, Yong / Wang, Ruoxi / Jiao, Heng / Tang, Han / Zhang, Shaoyuan / Lin, Siyun / Su, Feng / Gu, Jianmin / Jiang, Tian / Lin, Dong / Huang, Zhiliang / Du, Chaoxiang / Wu, Kui / Tan, Lijie / Zhou, Qing

Nature medicine

2023 Volume 29, Issue 9, Page(s) 2376

Language	English
Publishing date	2023-07-31
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-023-02511-4
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Zs.A 4212: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 39: Show issues

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Article ; Online: Celastrol inhibits angiogenesis and the biological processes of MDA-MB-231 cells via the DEGS1/S1P signaling pathway.

Jia, Lulu / Zhu, Shengnan / Zhu, Mingfei / Nie, Rongrong / Huang, Lingyue / Xu, Siyuan / Luo, Yuqin / Su, Huazhen / Huang, Shaoyuan / Tan, Qinyou

Biological chemistry

2023 Volume 405, Issue 4, Page(s) 267–281

Abstract: Celastrol (Cel) shows potent antitumor activity in various experimental models. This study examined the relationship between Cel's antivascular and antitumor effects and sphingolipids. CCK-8 assay, transwell assay, Matrigel, PCR-array/RT-PCR/western ... ...

Abstract	Celastrol (Cel) shows potent antitumor activity in various experimental models. This study examined the relationship between Cel's antivascular and antitumor effects and sphingolipids. CCK-8 assay, transwell assay, Matrigel, PCR-array/RT-PCR/western blotting/immunohistochemistry assay, ELISA and HE staining were used to detect cell proliferation, migration and invasion, adhesion and angiogenesis, mRNA and protein expression, S1P production and tumor morphology. The results showed that Cel could inhibit proliferation, migration or invasion, adhesion and angiogenesis of human umbilical vein endothelial cells (HUVECs) and MDA-MB-231 cells by downregulating the expression of degenerative spermatocyte homolog 1 (DEGS1). Transfection experiments showed that downregulation of DEGS1 inhibited the above processes and sphingosine-1-phosphate (S1P) production of HUVECs and MDA-MB-231 cells, while upregulation of DEGS1 had the opposite effects. Coculture experiments showed that HUVECs could promote proliferation, migration and invasion of MDA-MB-231 cells through S1P/sphingosine-1-phosphate receptor (S1PR) signaling pathway, while Cel inhibited these processes in MDA-MB-231 cells induced by HUVECs. Animal experiments showed that Cel could inhibit tumor growth in nude mice. Western blotting, immunohistochemistry and ELISA assay showed that Cel downregulated the expression of DEGS1, CD146, S1PR1-3 and S1P production. These data confirm that DEGS1/S1P signaling pathway may be related to the antivascular and antitumor effects of cel.
MeSH term(s)	Mice ; Animals ; Humans ; Receptors, Lysosphingolipid/genetics ; Receptors, Lysosphingolipid/metabolism ; MDA-MB-231 Cells ; Angiogenesis ; Mice, Nude ; Signal Transduction ; Human Umbilical Vein Endothelial Cells/metabolism ; Sphingosine/pharmacology ; Sphingosine/metabolism ; Sphingosine/analogs & derivatives ; Lysophospholipids/pharmacology ; Lysophospholipids/metabolism ; Biological Phenomena ; Pentacyclic Triterpenes
Chemical Substances	celastrol (L8GG98663L) ; Receptors, Lysosphingolipid ; sphingosine 1-phosphate (26993-30-6) ; Sphingosine (NGZ37HRE42) ; Lysophospholipids ; Pentacyclic Triterpenes
Language	English
Publishing date	2023-12-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1334659-3
ISSN	1437-4315 ; 1431-6730 ; 1432-0355
ISSN (online)	1437-4315
ISSN	1431-6730 ; 1432-0355
DOI	10.1515/hsz-2023-0324
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Uc I Zs.50: Show issues

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Article: Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population.

Zhang, Shaoyuan / Fang, Yong / Su, Feng / Jiang, Tian / Yu, Jinjie / Lin, Siyun / Lv, Lu / Long, Tao / Pan, Huiwen / Qi, Junqing / Zhou, Qiang / Tang, Weifeng / Ding, Guowen / Wang, Liming / Tan, Lijie / Yin, Jun

Journal of oncology

2023 Volume 2023, Page(s) 6922909

Abstract: Introduction: LAMA1, also known as laminin subunit : Method: 2,186 participants were collected retrospectively between October 2008 and January 2017, including 1,043 ESCC patients and 1,143 noncancer patients. A 2 mL blood sample was obtained ... ...

Abstract	Introduction: LAMA1, also known as laminin subunit Method: 2,186 participants were collected retrospectively between October 2008 and January 2017, including 1,043 ESCC patients and 1,143 noncancer patients. A 2 mL blood sample was obtained intravenously for the LDR for SNP analysis. The 6 SNP loci of Results: In the rs62081531 G > A locus, genotype GA was a protective factor for ESCC compared with GG (OR: 0.830, Conclusion: The
Language	English
Publishing date	2023-02-14
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2461349-6
ISSN	1687-8469 ; 1687-8450
ISSN (online)	1687-8469
ISSN	1687-8450
DOI	10.1155/2023/6922909
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Article: The β6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection.

Smith, Maria / Meliopoulos, Victoria / Tan, Shaoyuan / Bub, Theresa / Brigleb, Pamela H / Sharp, Bridgett / Crawford, Jeremy Chase / Prater, Mollie S / Pruett-Miller, Shondra M / Schultz-Cherry, Stacey

bioRxiv : the preprint server for biology

2023

Abstract: Integrins are essential surface receptors that sense extracellular changes to initiate various intracellular signaling cascades. The rapid activation of the epithelial-intrinsic β6 integrin during influenza A virus (IAV) infection has been linked to ... ...

Abstract	Integrins are essential surface receptors that sense extracellular changes to initiate various intracellular signaling cascades. The rapid activation of the epithelial-intrinsic β6 integrin during influenza A virus (IAV) infection has been linked to innate immune impairments. Yet, how β6 regulates epithelial immunity remains undefined. Here, we identify the role of β6 in mediating the Toll-like receptor 7 (TLR7) through the regulation of intracellular trafficking. We demonstrate that deletion of the β6 integrin in lung epithelial cells significantly enhances the TLR7-mediated activation of the type I interferon (IFN) response during homeostasis and respiratory infection. IAV-induced β6 facilitates TLR7 trafficking to lysosome-associated membrane protein (LAMP2a) components, leading to a reduction in endosomal compartments and associated TLR7 signaling. Our findings reveal an unappreciated role of β6-induced autophagy in influencing epithelial immune responses during influenza virus infection.
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.28.555098
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