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  1. Article ; Online: APOL1-G2 accelerates nephrocyte cell death by inhibiting the autophagy pathway

    Jun-yi Zhu / Jin-Gu Lee / Yulong Fu / Joyce van de Leemput / Patricio E. Ray / Zhe Han

    Disease Models & Mechanisms, Vol 16, Iss

    2023  Volume 12

    Keywords apol1 ; podocyte ; nephrocyte ; drosophila ; endocytosis ; autophagy ; Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Commentary: Referral for Lung Transplantation Should Be Carefully Decided for Patients with COVID-19 Acute Respiratory Distress Syndrome.

    Lee, Jin Gu

    Journal of chest surgery

    2022  Volume 56, Issue 1, Page(s) 14–15

    Language English
    Publishing date 2022-12-31
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2765-1606
    ISSN 2765-1606
    DOI 10.5090/jcs.22.159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identification of the Porcine Vascular Endothelial Cell-Specific Promoter ESAM1.0 Using Transcriptome Analysis.

    Kim, Sang Eun / Sun, Wu-Sheng / Oh, Miae / Lee, Seunghoon / No, Jin-Gu / Lee, Haesun / Lee, Poongyeon / Oh, Keon Bong

    Genes

    2023  Volume 14, Issue 10

    Abstract: The vascular endothelium of xenografted pig organs represents the initial site of rejection after exposure to recipient immune cells. In this study, we aimed to develop a promoter specific to porcine vascular endothelial cells as a step toward overcoming ...

    Abstract The vascular endothelium of xenografted pig organs represents the initial site of rejection after exposure to recipient immune cells. In this study, we aimed to develop a promoter specific to porcine vascular endothelial cells as a step toward overcoming xenograft rejection. Transcriptome analysis was performed on porcine aortic endothelial cells (PAECs), ear skin fibroblasts isolated from
    MeSH term(s) Animals ; Swine/genetics ; Humans ; Endothelial Cells/metabolism ; Cells, Cultured ; Animals, Genetically Modified ; Promoter Regions, Genetic ; Gene Expression Profiling
    Language English
    Publishing date 2023-10-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14101928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes

    Jin-Gu Lee / Yulong Fu / Jun-yi Zhu / Pei Wen / Joyce van de Leemput / Patricio E. Ray / Zhe Han

    Cell & Bioscience, Vol 13, Iss 1, Pp 1-

    2023  Volume 14

    Abstract: Abstract Background People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA ... ...

    Abstract Abstract Background People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate CKD remain elusive, hindering the development of potential treatments. Results Using a Drosophila genetic modifier screen, we found that SNARE proteins (Syx7, Ykt6, and Syb) play an important role in preventing APOL1 cytotoxicity. Reducing the expression of these SNARE proteins significantly increased APOL1 cytotoxicity in fly nephrocytes, the equivalent of mammalian podocytes, whereas overexpression of Syx7, Ykt6, or Syb attenuated their toxicity in nephrocytes. These SNARE proteins bound to APOL1-G0 with higher affinity than APOL1-G1/G2, and attenuated APOL1-G0 cytotoxicity to a greater extent than either APOL1-RA. Conclusions Using a Drosophila screen, we identified SNARE proteins (Syx7, Ykt6, and Syb) as antagonists of APOL1-induced cytotoxicity by directly binding APOL1. These data uncovered a new potential protective role for certain SNARE proteins in the pathogenesis of APOL1-CKD and provide novel therapeutic targets for APOL1-associated nephropathies.
    Keywords SNARE proteins ; SNARE protective pool ; APOL1 ; Renal toxicity ; Nephrocytes ; Serum resistance-associated (SRA) protein ; Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Effect of Propofol versus Sevoflurane Anesthesia on Acute Kidney Injury after Lung Transplantation Surgery: A Prospective Randomized Controlled Trial.

    Song, Young / Paik, Hyo-Chae / Kim, Namo / Jung, Heejae / Lee, Jin-Gu / Yoo, Young-Chul

    Journal of clinical medicine

    2022  Volume 11, Issue 22

    Abstract: This prospective randomized controlled trial aimed to compare the effects of sevoflurane and propofol anesthesia on the occurrence of acute kidney injury (AKI) following lung transplantation (LTx) surgery. Sixty adult patients undergoing bilateral LTx ... ...

    Abstract This prospective randomized controlled trial aimed to compare the effects of sevoflurane and propofol anesthesia on the occurrence of acute kidney injury (AKI) following lung transplantation (LTx) surgery. Sixty adult patients undergoing bilateral LTx were randomized to receive either inhalation of sevoflurane or continuous infusion of propofol for general anesthesia. The primary outcomes were AKI incidence according to the Acute Kidney Injury Network (AKIN) criteria and blood biomarker of kidney injury, including neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C levels within 48 h of surgery. Serum interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and superoxide dismutase were measured before and after surgery. The post-operative 30-day morbidity and long-term mortality were also assessed. Significantly fewer patients in the propofol group developed AKI compared with the sevoflurane group (13% vs. 38%,
    Language English
    Publishing date 2022-11-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11226862
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Relationship between skin greasiness and cuticular wax in harvested "Hongro" apples.

    Lee, Jeong Gu / Eum, Hyang Lan / Lee, Eun Jin

    Food chemistry

    2024  Volume 450, Page(s) 139334

    Abstract: We investigated the ripening and skin greasiness of "Hongro" apples during storage at 20 °C. Postharvest treatment using 100 ... ...

    Abstract We investigated the ripening and skin greasiness of "Hongro" apples during storage at 20 °C. Postharvest treatment using 100 μLL
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 243123-3
    ISSN 1873-7072 ; 0308-8146
    ISSN (online) 1873-7072
    ISSN 0308-8146
    DOI 10.1016/j.foodchem.2024.139334
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    In stock of ZB MED Bonn / Germany

    Z 3634: Show issues

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  7. Article: A SNARE protective pool antagonizes APOL1 renal toxicity in Drosophila nephrocytes.

    Lee, Jin-Gu / Fu, Yulong / Zhu, Jun-Yi / Wen, Pei / van de Leemput, Joyce / Ray, Patricio E / Han, Zhe

    Cell & bioscience

    2023  Volume 13, Issue 1, Page(s) 199

    Abstract: Background: People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate ... ...

    Abstract Background: People of Sub-Saharan African ancestry are at higher risk of developing chronic kidney disease (CKD), attributed to the Apolipoprotein L1 (APOL1) gene risk alleles (RA) G1 and G2. The underlying mechanisms by which the APOL1-RA precipitate CKD remain elusive, hindering the development of potential treatments.
    Results: Using a Drosophila genetic modifier screen, we found that SNARE proteins (Syx7, Ykt6, and Syb) play an important role in preventing APOL1 cytotoxicity. Reducing the expression of these SNARE proteins significantly increased APOL1 cytotoxicity in fly nephrocytes, the equivalent of mammalian podocytes, whereas overexpression of Syx7, Ykt6, or Syb attenuated their toxicity in nephrocytes. These SNARE proteins bound to APOL1-G0 with higher affinity than APOL1-G1/G2, and attenuated APOL1-G0 cytotoxicity to a greater extent than either APOL1-RA.
    Conclusions: Using a Drosophila screen, we identified SNARE proteins (Syx7, Ykt6, and Syb) as antagonists of APOL1-induced cytotoxicity by directly binding APOL1. These data uncovered a new potential protective role for certain SNARE proteins in the pathogenesis of APOL1-CKD and provide novel therapeutic targets for APOL1-associated nephropathies.
    Language English
    Publishing date 2023-11-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-023-01147-8
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  8. Article ; Online: APOL1-G2 accelerates nephrocyte cell death by inhibiting the autophagy pathway.

    Zhu, Jun-Yi / Lee, Jin-Gu / Fu, Yulong / van de Leemput, Joyce / Ray, Patricio E / Han, Zhe

    Disease models & mechanisms

    2023  Volume 16, Issue 12

    Abstract: People of African ancestry who carry the APOL1 risk alleles G1 or G2 are at high risk of developing kidney diseases through not fully understood mechanisms that impair the function of podocytes. It is also not clear whether the APOL1-G1 and APOL1-G2 risk ...

    Abstract People of African ancestry who carry the APOL1 risk alleles G1 or G2 are at high risk of developing kidney diseases through not fully understood mechanisms that impair the function of podocytes. It is also not clear whether the APOL1-G1 and APOL1-G2 risk alleles affect these cells through similar mechanisms. Previously, we have developed transgenic Drosophila melanogaster lines expressing either the human APOL1 reference allele (G0) or APOL1-G1 specifically in nephrocytes, the cells homologous to mammalian podocytes. We have found that nephrocytes that expressed the APOL1-G1 risk allele display accelerated cell death, in a manner similar to that of cultured human podocytes and APOL1 transgenic mouse models. Here, to compare how the APOL1-G1 and APOL1-G2 risk alleles affect the structure and function of nephrocytes in vivo, we generated nephrocyte-specific transgenic flies that either expressed the APOL1-G2 or both G1 and G2 (G1G2) risk alleles on the same allele. We found that APOL1-G2- and APOL1-G1G2-expressing nephrocytes developed more severe changes in autophagic pathways, acidification of organelles and the structure of the slit diaphragm, compared to G1-expressing nephrocytes, leading to their premature death. We conclude that both risk alleles affect similar key cell trafficking pathways, leading to reduced autophagy and suggesting new therapeutic targets to prevent APOL1 kidney diseases.
    MeSH term(s) Animals ; Mice ; Humans ; Drosophila melanogaster/metabolism ; Apolipoprotein L1/genetics ; Apolipoprotein L1/metabolism ; Kidney Diseases ; Cell Death ; Mice, Transgenic ; Autophagy/genetics ; Mammals/metabolism
    Chemical Substances Apolipoprotein L1 ; APOL1 protein, human
    Language English
    Publishing date 2023-12-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mono-UFMylation promotes misfolding-associated secretion of α-synuclein.

    Wang, Lihui / Xu, Yue / Fukushige, Tetsunari / Saidi, Layla / Wang, Xiaorong / Yu, Clinton / Lee, Jin-Gu / Krause, Michael / Huang, Lan / Ye, Yihong

    Science advances

    2024  Volume 10, Issue 11, Page(s) eadk2542

    Abstract: Stressed cells secret misfolded proteins lacking signaling sequence via an unconventional protein secretion (UcPS) pathway, but how misfolded proteins are targeted selectively in UcPS is unclear. Here, we report that misfolded UcPS clients are subject to ...

    Abstract Stressed cells secret misfolded proteins lacking signaling sequence via an unconventional protein secretion (UcPS) pathway, but how misfolded proteins are targeted selectively in UcPS is unclear. Here, we report that misfolded UcPS clients are subject to modification by a ubiquitin-like protein named ubiquitin-fold modifier 1 (UFM1). Using α-synuclein (α-Syn) as a UcPS model, we show that mutating the UFMylation sites in α-Syn or genetic inhibition of the UFMylation system mitigates α-Syn secretion, whereas overexpression of UFBP1, a component of the endoplasmic reticulum-associated UFMylation ligase complex, augments α-Syn secretion in mammalian cells and in model organisms. UFM1 itself is cosecreted with α-Syn, and the serum UFM1 level correlates with that of α-Syn. Because UFM1 can be directly recognized by ubiquitin specific peptidase 19 (USP19), a previously established UcPS stimulator known to associate with several chaperoning activities, UFMylation might facilitate substrate engagement by USP19, allowing stringent and regulated selection of misfolded proteins for secretion and proteotoxic stress alleviation.
    MeSH term(s) Animals ; Humans ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism ; Protein Transport/physiology ; Endoplasmic Reticulum/metabolism ; Mammals/metabolism ; Endopeptidases/metabolism
    Chemical Substances alpha-Synuclein ; USP19 protein, human (EC 3.4.-) ; Endopeptidases (EC 3.4.-)
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adk2542
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  10. Article ; Online: Analysis of Changes in Sleep Quality and Patterns after Hip Fracture Using Real Evidence of Artificial Intelligence Linked (REAL) Hip Cohort Data.

    Cha, Yonghan / Kim, Jung-Taek / Kim, Jin-Woo / Lee, Jin-Gu / Lee, Sang-Yeob / Kim, Hyun-Bin / Kang, Yang Jae / Choy, Won-Sik / Yoo, Jun-Il

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 12

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Female ; Aged ; Male ; Sleep Quality ; Quality of Life ; Artificial Intelligence ; Hip Fractures/complications ; Hip Fractures/epidemiology ; Hip Fractures/surgery ; Sleep ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/etiology
    Language English
    Publishing date 2023-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59122125
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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