LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 103

Search options

  1. Article ; Online: Human settlements and sustainability

    Mele Caterina

    E3S Web of Conferences, Vol 119, p

    a crucial and open issue

    2019  Volume 00012

    Abstract: The human habitation of the surface of the planet has led, especially since the mid-twentieth century, to an enormous increase in the built up area. This phenomenon concerns both the oldest industrialised countries, such as European Union and the United ... ...

    Abstract The human habitation of the surface of the planet has led, especially since the mid-twentieth century, to an enormous increase in the built up area. This phenomenon concerns both the oldest industrialised countries, such as European Union and the United States, and the so-called emerging countries in Asia, Africa and Latin America.The urbanised built area has increased in different ways, but has led everywhere to the destruction of large portions of virgin soil, the loss of biodiversity in the number and type of species in fauna and flora, and often the total or partial impairment of ecosystem functions of enormous environmental value (such as the evapotransportive mechanisms of soil and vegetation). Although the curve of global population growth is slowing, the growth of urban areas continues to expand, even in countries which have long been industrialised, where the spread of building has given rise to cities dispersed over a territory so that there is no longer a recognisable clear division between the city and the countryside. In fact, contemporary cities are the main consumers of all environmental resources, from water to food, including energy and environmental stressors, and are responsible for 80% of CO2 emissions into the atmosphere. The ecosystem surface required to sustain a large city on the planet today canbe about 200 times larger than its physical size. The urban civilisation of the 21st century, which at a superficial glance may appear as a symbol of the human capacity to radically adapt and transform the natural habitat toits own needs, is also a witness to the unsustainability of the human footprint on earth. Radically rethinking cities and human settlements entails an equally radical rethinking of our economic and development model, but it is a necessary and strategic task if we really want to face the challenge of sustainability with appropriate instruments.
    Keywords Environmental sciences ; GE1-350
    Subject code 333 ; 910
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  2. Article ; Online: Urban Issues and Sustainability

    Mele Caterina

    E3S Web of Conferences, Vol 2, p

    2014  Volume 03004

    Abstract: This paper’s focus is to reflect on the global growth of urban areas, according to number and size of inhabitants and also according to the environmental, social, cultural and economic impact of this phenomenon. If city growth is an issue which addresses ...

    Abstract This paper’s focus is to reflect on the global growth of urban areas, according to number and size of inhabitants and also according to the environmental, social, cultural and economic impact of this phenomenon. If city growth is an issue which addresses mainly developing countries such as China, India or the states in South America, the features acquired by urbanisation in the OCSE countries, currently undergoing economic and demographic contraction, lead towards a territorial dispersion of the built up areas with serious consequences especially in terms of soil use, pollution and loss of site identity. Thus, the solutions proposed by the various national and supranational programmes intended to guide global urbanisation to a greater sustainability must be differentiated between countries with fully developed economies from those whose economy is currently on the rise, and must also actively involve the local communities.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2014-03-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  3. Article ; Online: Olive Oil Phenols Prevent Mercury-Induced Phosphatidylserine Exposure and Morphological Changes in Human Erythrocytes Regardless of Their Different Scavenging Activity.

    Notariale, Rosaria / Perrone, Pasquale / Mele, Luigi / Lettieri, Gennaro / Piscopo, Marina / Manna, Caterina

    International journal of molecular sciences

    2022  Volume 23, Issue 10

    Abstract: Phosphatidylserine (PS) translocation to the external membrane leaflet represents a key mechanism in the pathophysiology of human erythrocytes (RBC) acting as an "eat me" signal for the removal of aged/stressed cells. Loss of physiological membrane ... ...

    Abstract Phosphatidylserine (PS) translocation to the external membrane leaflet represents a key mechanism in the pathophysiology of human erythrocytes (RBC) acting as an "eat me" signal for the removal of aged/stressed cells. Loss of physiological membrane asymmetry, however, can lead to adverse effects on the cardiovascular system, activating a prothrombotic activity. The data presented indicate that structurally related olive oil phenols prevent cell alterations induced in intact human RBC exposed to HgCl
    MeSH term(s) Erythrocytes/metabolism ; Glutathione/metabolism ; Humans ; Mercury/pharmacology ; Olive Oil/pharmacology ; Phenols/metabolism ; Phenols/pharmacology ; Phosphatidylserines/metabolism
    Chemical Substances Olive Oil ; Phenols ; Phosphatidylserines ; Mercury (FXS1BY2PGL) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2022-05-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23105693
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: A Retrospective Study on Statins and Post-stroke Patients: What About Functional Outcome and Follow-Up in a Stroke Rehabilitation Cohort?

    Mele, Chiara / Maggioni, Giorgio / Giordano, Andrea / Lunardon, Clara / Balsamo, Francesca / Mazzone, Alessandra / Pistarini, Caterina

    Frontiers in neurology

    2021  Volume 12, Page(s) 744732

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2021-10-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.744732
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Olive Oil Phenols Prevent Mercury-Induced Phosphatidylserine Exposure and Morphological Changes in Human Erythrocytes Regardless of Their Different Scavenging Activity

    Rosaria Notariale / Pasquale Perrone / Luigi Mele / Gennaro Lettieri / Marina Piscopo / Caterina Manna

    International Journal of Molecular Sciences, Vol 23, Iss 5693, p

    2022  Volume 5693

    Abstract: Phosphatidylserine (PS) translocation to the external membrane leaflet represents a key mechanism in the pathophysiology of human erythrocytes (RBC) acting as an “eat me” signal for the removal of aged/stressed cells. Loss of physiological membrane ... ...

    Abstract Phosphatidylserine (PS) translocation to the external membrane leaflet represents a key mechanism in the pathophysiology of human erythrocytes (RBC) acting as an “eat me” signal for the removal of aged/stressed cells. Loss of physiological membrane asymmetry, however, can lead to adverse effects on the cardiovascular system, activating a prothrombotic activity. The data presented indicate that structurally related olive oil phenols prevent cell alterations induced in intact human RBC exposed to HgCl 2 (5–40 µM) or Ca 2+ ionophore (5 µM), as measured by hallmarks including PS exposure, reactive oxygen species generation, glutathione depletion and microvesicles formation. The protective effect is observed in a concentration range of 1–30 µM, hydroxytyrosol being the most effective; its in vivo metabolite homovanillic alcohol still retains the biological activity of its dietary precursor. Significant protection is also exerted by tyrosol, in spite of its weak scavenging activity, indicating that additional mechanisms are involved in the protective effect. When RBC alterations are mediated by an increase in intracellular calcium, the protective effect is observed at higher concentrations, indicating that the selected phenols mainly act on Ca 2+ -independent mechanisms, identified as protection of glutathione depletion. Our findings strengthen the nutritional relevance of olive oil bioactive compounds in the claimed health-promoting effects of the Mediterranean Diet.
    Keywords calcium ; endothelium ; erythrocytes ; glutathione ; hydroxytyrosol ; mercury ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 333
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  6. Article ; Online: Efficacy of Eculizumab in Coexisting Complement C3 Glomerulopathy and Atypical Hemolytic Uremic Syndrome.

    Busutti, Marco / Diomedi-Camassei, Francesca / Donadelli, Roberta / Mele, Caterina / Emma, Francesco / Vivarelli, Marina

    Kidney international reports

    2020  Volume 6, Issue 2, Page(s) 534–537

    Language English
    Publishing date 2020-11-10
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2020.10.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article: Epileptiform Activity During Transient Focal Neurologic Episodes in Cerebral Amyloid Angiopathy.

    Mattavelli, Daniele / Mele, Francesco / Bertora, Pierluigi / Rosa, Silvia / Bortolami, Cristina / Nascimbene, Caterina / Osio, Maurizio / Pantoni, Leonardo

    Neurology. Clinical practice

    2021  Volume 11, Issue 1, Page(s) e43–e45

    Language English
    Publishing date 2021-02-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000000781
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Case Report: Tackling Complement Hyperactivation With Eculizumab in Atypical Hemolytic Uremic Syndrome Triggered by COVID-19.

    Leone, Valentina Fanny / Imeraj, Amantia / Gastoldi, Sara / Mele, Caterina / Liguori, Lucia / Condemi, Carmelita / Ruggenenti, Piero / Remuzzi, Giuseppe / Carrara, Camillo

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 842473

    Abstract: Hemolytic uremic syndrome (HUS) is a rare life-threatening disease of unrestrained complement system dysregulation, microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure in genetically predisposed individuals. In this report, we ... ...

    Abstract Hemolytic uremic syndrome (HUS) is a rare life-threatening disease of unrestrained complement system dysregulation, microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure in genetically predisposed individuals. In this report, we describe two cases of SARS-CoV-2-associated HUS treated with eculizumab, a C5-blocking monoclonal antibody reported to be remarkably effective in the treatment of HUS. Detailed biochemical and genetic complement system analysis is reported, and the prompt clinical response after C5 pharmacological blockade is documented. Our report provides the rationale and supports the use of terminal complement pathway inhibition for the treatment of SARS-CoV-2-associated HUS.
    Language English
    Publishing date 2022-02-28
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.842473
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: CFH

    Piras, Rossella / Valoti, Elisabetta / Alberti, Marta / Bresin, Elena / Mele, Caterina / Breno, Matteo / Liguori, Lucia / Donadelli, Roberta / Rigoldi, Miriam / Benigni, Ariela / Remuzzi, Giuseppe / Noris, Marina

    Frontiers in immunology

    2023  Volume 13, Page(s) 1011580

    Abstract: Introduction: Atypical hemolytic uremic syndrome (aHUS) is a rare disease that manifests with microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure, and is associated with dysregulation of the alternative complement pathway. The ... ...

    Abstract Introduction: Atypical hemolytic uremic syndrome (aHUS) is a rare disease that manifests with microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure, and is associated with dysregulation of the alternative complement pathway. The chromosomal region including
    Methods: In this study, we report the results of
    Results: We found uncommon SVs in 8% of patients with primary aHUS: 70% carried rearrangements involving
    Discussion: In conclusion, these data highlight that uncommon
    MeSH term(s) Humans ; Atypical Hemolytic Uremic Syndrome/epidemiology ; Atypical Hemolytic Uremic Syndrome/genetics ; Atypical Hemolytic Uremic Syndrome/drug therapy ; Complement Factor H/genetics ; Prevalence ; DNA Copy Number Variations ; Neoplasm Recurrence, Local ; Genomics
    Chemical Substances Complement Factor H (80295-65-4)
    Language English
    Publishing date 2023-01-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1011580
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: PI3K/PTEN/mTOR pathway dynamic tracking and prognostic value in HR+/HER2- BC patients with residual disease after neoadjuvant chemotherapy: a cohort study.

    Miglietta, Federica / Carraro, Valentina / Amato, Ottavia / Griguolo, Gaia / Bottosso, Michele / Munari, Giada / Zarrilli, Giovanni / Lo Mele, Marcello / Barbieri, Caterina / Dei Tos, Angelo Paolo / Guarneri, Valentina / Dieci, Maria Vittoria / Fassan, Matteo

    Journal of clinical pathology

    2023  

    Abstract: Aims: Hormone receptor-positive (HR)+/HER2- breast cancer (BC) is highly heterogeneous, with PI3K/PTEN/mTOR pathway alterations emerging as possible players within this complexity. We longitudinally tracked PI3K/PTEN/mTOR pathway dynamics from baseline ... ...

    Abstract Aims: Hormone receptor-positive (HR)+/HER2- breast cancer (BC) is highly heterogeneous, with PI3K/PTEN/mTOR pathway alterations emerging as possible players within this complexity. We longitudinally tracked PI3K/PTEN/mTOR pathway dynamics from baseline biopsy to residual disease (RD)-and to metastases in case of relapse-in HR+/HER2- BC patients receiving neoadjuvant chemotherapy (NACT).
    Methods: HR+/HER2- BC patients with RD after NACT were identified. We assessed
    Results: 92 patient were included. The conversion rate of
    Conclusions: We observed that PI3K/PTEN/mTOR pathway is highly dynamic under NACT exposure and the assessment of
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jcp-2023-208856
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top