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  1. Article ; Online: Beyond Borders: Investigating the Mysteries of Cacipacoré, a Lesser-Studied Arbovirus in Brazil.

    Saivish, Marielena V / Nogueira, Maurício L / Rossi, Shannan L / Vasilakis, Nikos

    Viruses

    2024  Volume 16, Issue 3

    Abstract: Cacipacoré virus (CPCV) was discovered in 1977 deep in the Amazon rainforest from the blood of a black-faced ant thrush ( ...

    Abstract Cacipacoré virus (CPCV) was discovered in 1977 deep in the Amazon rainforest from the blood of a black-faced ant thrush (
    MeSH term(s) Animals ; Cattle ; Arboviruses ; Brazil/epidemiology ; Mosquito Vectors ; Aedes ; Culex ; Primates ; Rodentia
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16030336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Zoonotic mosquito-borne arboviruses: Spillover, spillback, and realistic mitigation strategies.

    Campos, Rafael K / Rossi, Shannan L / Tesh, Robert B / Weaver, Scott C

    Science translational medicine

    2023  Volume 15, Issue 718, Page(s) eadj2166

    Abstract: Emerging zoonotic mosquito-borne viruses pose increasing health threats because of growing mosquito population, geographic expansions, and control challenges. We emphasize the need for global preparedness to effectively mitigate the health, societal, and ...

    Abstract Emerging zoonotic mosquito-borne viruses pose increasing health threats because of growing mosquito population, geographic expansions, and control challenges. We emphasize the need for global preparedness to effectively mitigate the health, societal, and economic impacts of spillover by these viruses through proactive measures of prediction, surveillance, prevention, and treatment.
    MeSH term(s) Animals ; Arboviruses ; Arbovirus Infections/prevention & control ; Culicidae
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.adj2166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6941: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Aedes albopictus

    Cecilia, Hélène / Althouse, Benjamin M / Azar, Sasha R / Moehn, Brett A / Yun, Ruimei / Rossi, Shannan L / Vasilakis, Nikos / Hanley, Kathryn A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The contact structure between vertebrate hosts and arthropod vectors plays a key role in the spread of arthropod-borne viruses (arboviruses); thus, it is important to determine whether arbovirus infection of either host or vector alters vector feeding ... ...

    Abstract The contact structure between vertebrate hosts and arthropod vectors plays a key role in the spread of arthropod-borne viruses (arboviruses); thus, it is important to determine whether arbovirus infection of either host or vector alters vector feeding behavior. Here we leveraged a study of the replication dynamics of two arboviruses isolated from their ancestral cycles in paleotropical forests, sylvatic dengue-2 (DENV-2) and Zika (ZIKV), in one non-human primate (NHP) species from the paleotropics (cynomolgus macaques,
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.19.580944
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Testicular pathological alterations associated with SARS-CoV-2 infection.

    Ly, Judy / Campos, Rafael K / Hager-Soto, E Eldridge / Camargos, Vidyleison N / Rossi, Shannan L

    Frontiers in reproductive health

    2023  Volume 5, Page(s) 1229622

    Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the etiologic agent of the coronavirus disease 2019 (COVID-19), which caused one of the pandemics with the highest mortalities with millions of deaths and hundreds of millions of cases to ... ...

    Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the etiologic agent of the coronavirus disease 2019 (COVID-19), which caused one of the pandemics with the highest mortalities with millions of deaths and hundreds of millions of cases to date. Due to its potential for airborne transmission, many studies have focused on SARS-CoV-2 primarily as a respiratory disease. However, the spread of SARS-CoV-2 to non-respiratory organs has been experimentally demonstrated and clinically observed. During autopsy studies, histopathological lesions, and disruption of the blood-testes barrier (BTB) have been observed in the male reproductive tract. Here, we review findings from both autopsy cases and animal models that demonstrate testicular disease due to COVID-19 and present an overview of the pathological alterations that occur in the testes resulting from SARS-CoV-2 infection and explore its potential mechanisms.
    Language English
    Publishing date 2023-06-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-3153
    ISSN (online) 2673-3153
    DOI 10.3389/frph.2023.1229622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: CD8

    Campos, Rafael K / Liang, Yuejin / Azar, Sasha R / Ly, Judy / Camargos, Vidyleison Neves / Hager-Soto, E Eldridge / Eyzaguirre, Eduardo / Sun, Jiaren / Rossi, Shannan L

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Zika virus (ZIKV) causes human testicular inflammation and alterations in sperm parameters and causes testicular damage in mouse models. The involvement of individual immune cells in testicular damage is not fully understood. We detected virus in the ... ...

    Abstract Zika virus (ZIKV) causes human testicular inflammation and alterations in sperm parameters and causes testicular damage in mouse models. The involvement of individual immune cells in testicular damage is not fully understood. We detected virus in the testes of the interferon (IFN) α/β receptor
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.22.575592
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Potential of Ilhéus virus to emerge.

    Plante, Kenneth S / Plante, Jessica A / Azar, Sasha R / Shinde, Divya P / Scharton, Dionna / Versiani, Alice F / Oliveira da Silva, Natalia Ingrid / Strange, Taylor / Sacchetto, Lívia / Fokam, Eric B / Rossi, Shannan L / Weaver, Scott C / Marques, Rafael E / Nogueira, Mauricio L / Vasilakis, Nikos

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e27934

    Abstract: Ilhéus virus (ILHV)( ...

    Abstract Ilhéus virus (ILHV)(
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e27934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Testicular pathological alterations associated with SARS-CoV-2 infection

    Judy Ly / Rafael K. Campos / E. Eldridge Hager-Soto / Vidyleison N. Camargos / Shannan L. Rossi

    Frontiers in Reproductive Health, Vol

    2023  Volume 5

    Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the etiologic agent of the coronavirus disease 2019 (COVID-19), which caused one of the pandemics with the highest mortalities with millions of deaths and hundreds of millions of cases to ... ...

    Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the etiologic agent of the coronavirus disease 2019 (COVID-19), which caused one of the pandemics with the highest mortalities with millions of deaths and hundreds of millions of cases to date. Due to its potential for airborne transmission, many studies have focused on SARS-CoV-2 primarily as a respiratory disease. However, the spread of SARS-CoV-2 to non-respiratory organs has been experimentally demonstrated and clinically observed. During autopsy studies, histopathological lesions, and disruption of the blood-testes barrier (BTB) have been observed in the male reproductive tract. Here, we review findings from both autopsy cases and animal models that demonstrate testicular disease due to COVID-19 and present an overview of the pathological alterations that occur in the testes resulting from SARS-CoV-2 infection and explore its potential mechanisms.
    Keywords SARS-CoV-2 ; testes ; male reproductive tract ; testicular disease ; COVID-19 ; Reproduction ; QH471-489 ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Trade-offs shaping transmission of sylvatic dengue and Zika viruses in monkey hosts.

    Hanley, Kathryn A / Cecilia, Hélène / Azar, Sasha R / Moehn, Brett A / Gass, Jordan T / Oliveira da Silva, Natalia I / Yu, Wanqin / Yun, Ruimei / Althouse, Benjamin M / Vasilakis, Nikos / Rossi, Shannan L

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2682

    Abstract: Mosquito-borne dengue (DENV) and Zika (ZIKV) viruses originated in Old World sylvatic (forest) cycles involving monkeys and canopy-living Aedes mosquitoes. Both viruses spilled over into human transmission and were translocated to the Americas, opening a ...

    Abstract Mosquito-borne dengue (DENV) and Zika (ZIKV) viruses originated in Old World sylvatic (forest) cycles involving monkeys and canopy-living Aedes mosquitoes. Both viruses spilled over into human transmission and were translocated to the Americas, opening a path for spillback into Neotropical sylvatic cycles. Studies of the trade-offs that shape within-host dynamics and transmission of these viruses are lacking, hampering efforts to predict spillover and spillback. We infected a native, Asian host species (cynomolgus macaque) and a novel, American host species (squirrel monkey) with sylvatic strains of DENV-2 or ZIKV via mosquito bite. We then monitored aspects of viral replication (viremia), innate and adaptive immune response (natural killer (NK) cells and neutralizing antibodies, respectively), and transmission to mosquitoes. In both hosts, ZIKV reached high titers that translated into high transmission to mosquitoes; in contrast DENV-2 replicated to low levels and, unexpectedly, transmission occurred only when serum viremia was below or near the limit of detection. Our data reveal evidence of an immunologically-mediated trade-off between duration and magnitude of virus replication, as higher peak ZIKV titers are associated with shorter durations of viremia, and higher NK cell levels are associated with lower peak ZIKV titers and lower anti-DENV-2 antibody levels. Furthermore, patterns of transmission of each virus from a Neotropical monkey suggest that ZIKV has greater potential than DENV-2 to establish a sylvatic transmission cycle in the Americas.
    MeSH term(s) Animals ; Humans ; Zika Virus ; Zika Virus Infection ; Dengue ; Dengue Virus ; Viremia ; Aedes
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46810-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Immunologically mediated trade-offs shaping transmission of sylvatic dengue and Zika viruses in native and novel non-human primate hosts.

    Hanley, Kathryn A / Cecilia, Hélène / Azar, Sasha R / Moehn, Brett / Yu, Wanqin / Yun, Ruimei / Althouse, Benjamin M / Vasilakis, Nikos / Rossi, Shannan L

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Mosquito-borne dengue (DENV) and Zika (ZIKV) viruses originated in Old World sylvatic cycles involving monkey hosts, spilled over into human transmission, and were translocated to the Americas, creating potential for spillback into neotropical sylvatic ... ...

    Abstract Mosquito-borne dengue (DENV) and Zika (ZIKV) viruses originated in Old World sylvatic cycles involving monkey hosts, spilled over into human transmission, and were translocated to the Americas, creating potential for spillback into neotropical sylvatic cycles. Studies of the trade-offs that shape within-host dynamics and transmission of these viruses are lacking, hampering efforts to predict spillover and spillback. We exposed native (cynomolgus macaque) or novel (squirrel monkey) hosts to mosquitoes infected with either sylvatic DENV or ZIKV and monitored viremia, natural killer cells, transmission to mosquitoes, cytokines, and neutralizing antibody titers. Unexpectedly, DENV transmission from both host species occurred only when serum viremia was undetectable or near the limit of detection. ZIKV replicated in squirrel monkeys to much higher titers than DENV and was transmitted more efficiently but stimulated lower neutralizing antibody titers. Increasing ZIKV viremia led to greater instantaneous transmission and shorter duration of infection, consistent with a replication-clearance trade-off.
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.30.547187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Epidemic Alphaviruses: Ecology, Emergence and Outbreaks.

    Azar, Sasha R / Campos, Rafael K / Bergren, Nicholas A / Camargos, Vidyleison N / Rossi, Shannan L

    Microorganisms

    2020  Volume 8, Issue 8

    Abstract: Over the past century, the emergence/reemergence of arthropod-borne zoonotic agents has been a growing public health concern. In particular, agents from the ... ...

    Abstract Over the past century, the emergence/reemergence of arthropod-borne zoonotic agents has been a growing public health concern. In particular, agents from the genus
    Language English
    Publishing date 2020-08-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8081167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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