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  1. Article: Pharmacological Activities of

    Choi, Eunsol / Jang, Eungyeong / Lee, Jang-Hoon

    Evidence-based complementary and alternative medicine : eCAM

    2019  Volume 2019, Page(s) 2943162

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is a rapidly emerging hepatic manifestation of metabolic syndrome. However, its unrevealed mechanism and complicated comorbidities have led to no specific medication, except for weight loss and lifestyle ... ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) is a rapidly emerging hepatic manifestation of metabolic syndrome. However, its unrevealed mechanism and complicated comorbidities have led to no specific medication, except for weight loss and lifestyle modification.
    Language English
    Publishing date 2019-06-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2019/2943162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
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  2. Article ; Online: Pharmacological Activities of Alisma orientale against Nonalcoholic Fatty Liver Disease and Metabolic Syndrome

    Eunsol Choi / Eungyeong Jang / Jang-Hoon Lee

    Evidence-Based Complementary and Alternative Medicine, Vol

    Literature Review

    2019  Volume 2019

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is a rapidly emerging hepatic manifestation of metabolic syndrome. However, its unrevealed mechanism and complicated comorbidities have led to no specific medication, except for weight loss and lifestyle ... ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) is a rapidly emerging hepatic manifestation of metabolic syndrome. However, its unrevealed mechanism and complicated comorbidities have led to no specific medication, except for weight loss and lifestyle modification. Alisma orientale (Sam.) Juzep (A. orientale, Alismataceae) has been increasingly reported on therapeutic effects of A. orientale against NAFLD and metabolic syndrome such as insulin resistance, hyperlipidemia, and obesity. Therefore, this study aimed to review the preclinical efficacy of A. orientale and its chemical constituents including Alisol A 24-acetate, Alisol B 23-acetate, Alisol F, and Alismol against NAFLD and metabolic syndrome. A. orientale prevented hepatic triglyceride accumulation through suppressing de novo lipogenesis and increasing lipid export. In addition, it controlled oxidative stress markers, lipoapoptosis, liver injury panels, and inflammatory and fibrotic mediators, eventually influencing steatohepatitis and liver fibrosis. Moreover, it exhibited pharmacological activities against hyperlipidemia, obesity, and hyperglycemia as well as appetite. These biological actions of A. orientale might contribute to adiponectin activation or a role as a farnesoid X receptor agonist. In particular, Alisol A 24-acetate and Alisol B 23-acetate could be expected as main compounds. Taken together, A. orientale might be an effective candidate agent for the treatment of NAFLD and its comorbidities, although further assessment of its standardization, safety test, and clinical trials is consistently required.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: The Efficacy of Pulmonary Rehabilitation in Patients with Idiopathic Pulmonary Fibrosis.

    Choi, Hee Eun / Kim, Tae Hoon / Jang, Ji Hoon / Jang, Hang-Jea / Yi, Jisook / Jung, So Young / Kim, Dae-Wook / Lee, Jae Ha

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13020403
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  4. Article ; Online: Reciprocal enhancement of SARS-CoV-2 and influenza virus replication in human pluripotent stem cell-derived lung organoids

    Kim, Min Jung / Kim, Sumi / Kim, Heeyeon / Gil, Dayeon / Han, Hyeong-Jun / Thimmulappa, Rajesh K / Choi, Jang-Hoon / Kim, Jung-Hyun

    Emerging microbes & infections

    2023  Volume 12, Issue 1, Page(s) 2211685

    Abstract: Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (FLUAV) coinfections were associated with severe respiratory failure and more deaths. Here, we developed a model for studying SARS-CoV-2 and FLUAV ... ...

    Abstract Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (FLUAV) coinfections were associated with severe respiratory failure and more deaths. Here, we developed a model for studying SARS-CoV-2 and FLUAV coinfection using human pluripotent stem cell-induced alveolar type II organoids (hiAT2). hiAT2 organoids were susceptible to infection by both viruses and had features of severe lung damage. A single virus markedly enhanced the susceptibility to other virus infections. SARS-CoV-2 delta variants upregulated α-2-3-linked sialic acid, while FLUAV upregulated angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). Moreover, coinfection by SARS-CoV-2 and FLUAV caused hyperactivation of proinflammatory and immune-related signaling pathways and cellular damage compared to a respective single virus in hiAT2 organoids. This study provides insight into molecular mechanisms underlying enhanced infectivity and severity in patients with co-infection of SARS-CoV-2 and FLUAV, which may aid in the development of therapeutics for such co-infection cases.
    MeSH term(s) Humans ; SARS-CoV-2 ; Coinfection ; COVID-19 ; Influenza, Human/metabolism ; Lung ; Virus Replication ; Pluripotent Stem Cells ; Organoids
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2023.2211685
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  5. Article ; Online: Explainable Model Using Shapley Additive Explanations Approach on Wound Infection after Wide Soft Tissue Sarcoma Resection: "Big Data" Analysis Based on Health Insurance Review and Assessment Service Hub.

    Choi, Ji-Hye / Choi, Yumin / Lee, Kwang-Sig / Ahn, Ki-Hoon / Jang, Woo Young

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 2

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Male ; Postoperative Complications/etiology ; Risk Factors ; Insurance, Health ; Wound Infection ; Sarcoma/surgery ; Sarcoma/complications ; Soft Tissue Neoplasms/complications ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/surgery ; Retrospective Studies
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60020327
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  6. Article ; Online: Application of Nanoparticles and Melatonin for Cryopreservation of Gametes and Embryos.

    Choi, Hyun-Woo / Jang, Hoon

    Current issues in molecular biology

    2022  Volume 44, Issue 9, Page(s) 4028–4044

    Abstract: Cryopreservation of gametes and embryos, a technique widely applied in human infertility clinics and to preserve desirable genetic traits of livestock, has been developed over 30 years as a component of the artificial insemination process. A number of ... ...

    Abstract Cryopreservation of gametes and embryos, a technique widely applied in human infertility clinics and to preserve desirable genetic traits of livestock, has been developed over 30 years as a component of the artificial insemination process. A number of researchers have conducted studies to reduce cell toxicity during cryopreservation using adjuvants leading to higher gamete and embryo survival rates. Melatonin and Nanoparticles are novel cryoprotectants and recent studies have investigated their properties such as regulating oxidative stresses, lipid peroxidation, and DNA fragmentation in order to protect gametes and embryos during vitrification. This review presented the current status of cryoprotectants and highlights the novel biomaterials such as melatonin and nanoparticles that may improve the survivability of gametes and embryos during this process.
    Language English
    Publishing date 2022-09-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb44090276
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    Zs.A 5122: Show issues Location:
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  7. Article ; Online: Robotic central pancreatectomy: a surgical technique.

    Chong, Eui Hyuk / Jang, Jae Young / Choi, Sung Hoon

    Journal of minimally invasive surgery

    2023  Volume 26, Issue 3, Page(s) 155–161

    Abstract: Robotic central pancreatectomy has not been widely performed because of its rare indications, technical difficulties, and concern about the high complication rate. We reviewed six robotic central pancreatectomy cases between May 2016 and June 2021 at a ... ...

    Abstract Robotic central pancreatectomy has not been widely performed because of its rare indications, technical difficulties, and concern about the high complication rate. We reviewed six robotic central pancreatectomy cases between May 2016 and June 2021 at a single institution. This multimedia article aims to introduce our technique of robotic central pancreatectomy with perioperative and follow-up outcomes. All patients experienced biochemical leakage of postoperative pancreatic fistula, except in one with a grade B pancreatic fistula, which resulted in a pseudocyst formation and was successfully managed by endoscopic internal drainage. All patients achieved completely negative resection margins. There was no new-onset diabetes mellitus or recurrence during the median follow-up period of 13.5 months (range, 10-74 months). With an acceptable complication rate and the preservation of pancreatic function, robotic central pancreatectomy could be a good surgical option for patients with benign and borderline malignant tumors of the pancreatic neck or proximal body.
    Language English
    Publishing date 2023-09-15
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2234-5248
    ISSN (online) 2234-5248
    DOI 10.7602/jmis.2023.26.3.155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Prognostic Impact of Atrial Fibrillation in Patients with Heavily Calcified Coronary Artery Disease Receiving Rotational Atherectomy.

    Jung, Jin / Seo, Yeonjoo / Her, Sung-Ho / Lee, Jae-Hwan / Lee, Kyusup / Yoo, Ki-Dong / Moon, Keon-Woong / Moon, Donggyu / Lee, Su-Nam / Jang, Won-Young / Choi, Ik-Jun / Lee, Jang-Hoon / Lee, Sang-Rok / Lee, Seung-Whan / Yun, Kyeong-Ho / Lee, Hyun-Jong

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 10

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Coronary Artery Disease/complications ; Coronary Artery Disease/surgery ; Atherectomy, Coronary/adverse effects ; Percutaneous Coronary Intervention/adverse effects ; Atrial Fibrillation/complications ; Prognosis ; Treatment Outcome ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2023-10-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59101808
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    Zs.A 6270: Show issues Location:
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  9. Article: Headspace stir-bar sorptive extraction combined with gas chromatography-mass spectrometry for trace analysis of volatile organic compounds in

    Lee, Jae Hoon / Lee, Yun-Yeol / Choi, Yun-Sang / Jang, Hae Won

    Food science & nutrition

    2023  Volume 11, Issue 11, Page(s) 7396–7406

    Abstract: Analyzing volatile organic compounds (VOCs) in food is crucial but challenging. ...

    Abstract Analyzing volatile organic compounds (VOCs) in food is crucial but challenging.
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703010-6
    ISSN 2048-7177
    ISSN 2048-7177
    DOI 10.1002/fsn3.3668
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  10. Article ; Online: Evaluating Z-FA-FMK, a host cathepsin L protease inhibitor, as a potent and broad-spectrum antiviral therapy against SARS-CoV-2 and related coronaviruses.

    Jeong, Ju Hwan / Choi, Jang-Hoon / Kim, Beom Kyu / Min, Seong Cheol / Chokkakula, Santosh / Oh, Sol / Park, Ji-Hyun / Shim, Sang-Mu / Kim, Eung-Gook / Choi, Young Ki / Lee, Joo-Yeon / Baek, Yun Hee / Song, Min-Suk

    Antiviral research

    2023  Volume 216, Page(s) 105669

    Abstract: Even though the World Health Organization announced the end of the COVID-19 pandemic as a global public health emergency on May 5, 2023, SARS-CoV-2 continues to pose a significant health threat worldwide, resulting in substantial numbers of infections ... ...

    Abstract Even though the World Health Organization announced the end of the COVID-19 pandemic as a global public health emergency on May 5, 2023, SARS-CoV-2 continues to pose a significant health threat worldwide, resulting in substantial numbers of infections and fatalities. This study investigated the antiviral potential of Z-FA-FMK (FMK), a novel host cathepsin L protease inhibitor, against SARS-CoV-2 infection using both in vitro and in vivo models. In vitro assessments of FMK against a diverse set of SARS-CoV-2 strains, including the Wuhan-like strain and nine variants, demonstrated potent inhibition with EC
    MeSH term(s) Animals ; Mice ; Humans ; Protease Inhibitors/pharmacology ; Protease Inhibitors/therapeutic use ; SARS-CoV-2 ; Cathepsin L ; Pandemics ; COVID-19 ; Anti-Infective Agents ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Enzyme Inhibitors
    Chemical Substances Protease Inhibitors ; MDL 201053 (1Q2Z3U96CG) ; Cathepsin L (EC 3.4.22.15) ; Anti-Infective Agents ; Antiviral Agents ; Enzyme Inhibitors
    Language English
    Publishing date 2023-07-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2023.105669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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