LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 147

Search options

  1. Article ; Online: Identification of effective control technologies for additive manufacturing.

    Plessis, Johan du / Preez, Sonette du / Stefaniak, Aleksandr B

    Journal of toxicology and environmental health. Part B, Critical reviews

    2022  Volume 25, Issue 5, Page(s) 211–249

    Abstract: Additive manufacturing (AM) refers to several types of processes that join materials to build objects, often layer-by-layer, from a computer-aided design file. Many AM processes release potentially hazardous particles and gases during printing and ... ...

    Abstract Additive manufacturing (AM) refers to several types of processes that join materials to build objects, often layer-by-layer, from a computer-aided design file. Many AM processes release potentially hazardous particles and gases during printing and associated tasks. There is limited understanding of the efficacy of controls including elimination, substitution, administrative, and personal protective technologies to reduce or remove emissions, which is an impediment to implementation of risk mitigation strategies. The Medline, Embase, Environmental Science Collection, CINAHL, Scopus, and Web of Science databases and other resources were used to identify 42 articles that met the inclusion criteria for this review. Key findings were as follows: 1) engineering controls for material extrusion-type fused filament fabrication (FFF) 3-D printers and material jetting printers that included local exhaust ventilation generally exhibited higher efficacy to decrease particle and gas levels compared with isolation alone, and 2) engineering controls for particle emissions from FFF 3-D printers displayed higher efficacy for ultrafine particles compared with fine particles and in test chambers compared with real-world settings. Critical knowledge gaps identified included a need for data: 1) on efficacy of controls for all AM process types, 2) better understanding approaches to control particles over a range of sizes and gas-phase emissions, 3) obtained using a standardized collection approach to facilitate inter-comparison of study results, 4) approaches that go beyond the inhalation exposure pathway to include controls to minimize dermal exposures, and 5) to evaluate not just the engineering tier, but also the prevention-through-design and other tiers of the hierarchy of controls.
    MeSH term(s) Air Pollution, Indoor ; Particulate Matter ; Printing, Three-Dimensional ; Volatile Organic Compounds/analysis
    Chemical Substances Particulate Matter ; Volatile Organic Compounds
    Language English
    Publishing date 2022-06-26
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1415246-0
    ISSN 1521-6950 ; 1093-7404
    ISSN (online) 1521-6950
    ISSN 1093-7404
    DOI 10.1080/10937404.2022.2092569
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: Influence of puff topographies on e-liquid heating temperature, emission characteristics and modeled lung deposition of Puff Bar

    Ranpara, Anand / Stefaniak, Aleksandr B / Fernandez, Elizabeth / Bowers, Lauren N / Arnold, Elizabeth D / LeBouf, Ryan F

    Aerosol science and technology : the journal of the American Association for Aerosol Research

    2023  Volume 57, Issue 5, Page(s) 450–466

    Abstract: ... Puff ... ...

    Abstract Puff Bar
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ISSN 0278-6826
    ISSN 0278-6826
    DOI 10.1080/02786826.2023.2190786
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Effect of Puffing Behavior on Particle Size Distributions and Respiratory Depositions From Pod-Style Electronic Cigarette, or Vaping, Products.

    Ranpara, Anand / Stefaniak, Aleksandr B / Fernandez, Elizabeth / LeBouf, Ryan F

    Frontiers in public health

    2021  Volume 9, Page(s) 750402

    Abstract: The current fourth generation ("pod-style") electronic cigarette, or vaping, products (EVPs) heat a liquid ("e-liquid") contained in a reservoir ("pod") using a battery-powered coil to deliver aerosol into the lungs. A portion of inhaled EVP aerosol is ... ...

    Abstract The current fourth generation ("pod-style") electronic cigarette, or vaping, products (EVPs) heat a liquid ("e-liquid") contained in a reservoir ("pod") using a battery-powered coil to deliver aerosol into the lungs. A portion of inhaled EVP aerosol is estimated as exhaled, which can present a potential secondhand exposure risk to bystanders. The effects of modifiable factors using either a prefilled disposable or refillable pod-style EVPs on aerosol particle size distribution (PSD) and its respiratory deposition are poorly understood. In this study, the influence of up to six puff profiles (55-, 65-, and 75-ml puff volumes per 6.5 and 7.5 W EVP power settings) on PSD was evaluated using a popular pod-style EVP (JUUL
    MeSH term(s) Electronic Nicotine Delivery Systems ; Humans ; Nicotine ; Particle Size ; Vaping
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2021-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2021.750402
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Pulmonary evaluation of whole-body inhalation exposure of polycarbonate (PC) filament 3D printer emissions in rats.

    Farcas, Mariana T / McKinney, Walter / Mandler, W Kyle / Knepp, Alycia K / Battelli, Lori / Friend, Sherri A / Stefaniak, Aleksandr B / Service, Samantha / Kashon, Michael / LeBouf, Ryan F / Thomas, Treye A / Matheson, Joanna / Qian, Yong

    Journal of toxicology and environmental health. Part A

    2024  Volume 87, Issue 8, Page(s) 325–341

    Abstract: During fused filament fabrication (FFF) 3D printing with polycarbonate (PC) filament, a release of ultrafine particles (UFPs) and volatile organic compounds (VOCs) occurs. This study aimed to determine PC filament printing emission-induced toxicity in ... ...

    Abstract During fused filament fabrication (FFF) 3D printing with polycarbonate (PC) filament, a release of ultrafine particles (UFPs) and volatile organic compounds (VOCs) occurs. This study aimed to determine PC filament printing emission-induced toxicity in rats via whole-body inhalation exposure. Male Sprague Dawley rats were exposed to a single concentration (0.529 mg/m
    MeSH term(s) Rats ; Male ; Animals ; Inhalation Exposure ; Rats, Sprague-Dawley ; Lung/metabolism ; Bronchoalveolar Lavage Fluid ; Polycarboxylate Cement
    Chemical Substances polycarbonate (25766-59-0) ; Polycarboxylate Cement
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1413345-3
    ISSN 1528-7394 ; 0098-4108 ; 1087-2620
    ISSN 1528-7394 ; 0098-4108 ; 1087-2620
    DOI 10.1080/15287394.2024.2311170
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Influence of E-Liquid Humectants, Nicotine, and Flavorings on Aerosol Particle Size Distribution and Implications for Modeling Respiratory Deposition.

    Stefaniak, Aleksandr B / Ranpara, Anand C / Virji, Mohammed Abbas / LeBouf, Ryan F

    Frontiers in public health

    2022  Volume 10, Page(s) 782068

    Abstract: Electronic cigarette, or vaping, products are used to heat an e-liquid to form an aerosol (liquid droplets suspended in gas) that the user inhales; a portion of this aerosol deposits in their respiratory tract and the remainder is exhaled, thereby ... ...

    Abstract Electronic cigarette, or vaping, products are used to heat an e-liquid to form an aerosol (liquid droplets suspended in gas) that the user inhales; a portion of this aerosol deposits in their respiratory tract and the remainder is exhaled, thereby potentially creating opportunity for secondhand exposure to bystanders (e.g., in homes, automobiles, and workplaces). Particle size, a critical factor in respiratory deposition (and therefore potential for secondhand exposure), could be influenced by e-liquid composition. Hence, the purposes of this study were to (1) test the influence of laboratory-prepared e-liquid composition [ratio of propylene glycol (PG) to vegetable glycerin (VG) humectants, nicotine, and flavorings] on particle size distribution and (2) model respiratory dosimetry. All e-liquids were aerosolized using a second-generation reference e-cigarette. We measured particle size distribution based on mass using a low-flow cascade impactor (LFCI) and size distribution based on number using real-time mobility sizers. Mass median aerodynamic diameters (MMADs) of aerosol from e-liquids that contained only humectants were significantly larger compared with e-liquids that contained flavorings or nicotine (
    MeSH term(s) Aerosols ; Electronic Nicotine Delivery Systems ; Flavoring Agents ; Humans ; Hygroscopic Agents ; Nicotine ; Particle Size ; Respiratory Physiological Phenomena ; Respiratory System
    Chemical Substances Aerosols ; Flavoring Agents ; Hygroscopic Agents ; Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2022-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2022.782068
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Multi-instrument assessment of fine and ultrafine titanium dioxide aerosols.

    Ranpara, Anand / LeBouf, Ryan F / Nurkiewicz, Timothy R / Yi, Jinghai / Cumpston, Jared L / Stefaniak, Aleksandr B

    Journal of toxicology and environmental health. Part A

    2022  Volume 86, Issue 1, Page(s) 1–22

    Abstract: The measurement of fine (diameter: 100 nanometers-2.5 micrometers) and ultrafine (UF: < 100 nanometers) titanium dioxide ( ... ...

    Abstract The measurement of fine (diameter: 100 nanometers-2.5 micrometers) and ultrafine (UF: < 100 nanometers) titanium dioxide (TiO
    MeSH term(s) Environmental Monitoring/methods ; Occupational Exposure/analysis ; Titanium ; Particle Size ; Aerosols
    Chemical Substances titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE) ; Aerosols
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1413345-3
    ISSN 1528-7394 ; 0098-4108 ; 1087-2620
    ISSN 1528-7394 ; 0098-4108 ; 1087-2620
    DOI 10.1080/15287394.2022.2150730
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Influence of E-Liquid Humectants, Nicotine, and Flavorings on Aerosol Particle Size Distribution and Implications for Modeling Respiratory Deposition

    Aleksandr B. Stefaniak / Anand C. Ranpara / Mohammed Abbas Virji / Ryan F. LeBouf

    Frontiers in Public Health, Vol

    2022  Volume 10

    Abstract: Electronic cigarette, or vaping, products are used to heat an e-liquid to form an aerosol (liquid droplets suspended in gas) that the user inhales; a portion of this aerosol deposits in their respiratory tract and the remainder is exhaled, thereby ... ...

    Abstract Electronic cigarette, or vaping, products are used to heat an e-liquid to form an aerosol (liquid droplets suspended in gas) that the user inhales; a portion of this aerosol deposits in their respiratory tract and the remainder is exhaled, thereby potentially creating opportunity for secondhand exposure to bystanders (e.g., in homes, automobiles, and workplaces). Particle size, a critical factor in respiratory deposition (and therefore potential for secondhand exposure), could be influenced by e-liquid composition. Hence, the purposes of this study were to (1) test the influence of laboratory-prepared e-liquid composition [ratio of propylene glycol (PG) to vegetable glycerin (VG) humectants, nicotine, and flavorings] on particle size distribution and (2) model respiratory dosimetry. All e-liquids were aerosolized using a second-generation reference e-cigarette. We measured particle size distribution based on mass using a low-flow cascade impactor (LFCI) and size distribution based on number using real-time mobility sizers. Mass median aerodynamic diameters (MMADs) of aerosol from e-liquids that contained only humectants were significantly larger compared with e-liquids that contained flavorings or nicotine (p = 0.005). Humectant ratio significantly influenced MMADs; all aerosols from e-liquids prepared with 70:30 PG:VG were significantly larger compared with e-liquids prepared with 30:70 PG:VG (p = 0.017). In contrast to the LFCI approach, the high dilution and sampling flow rate of a fast mobility particle sizer strongly influenced particle size measurements (i.e., all calculated MMAD values were < 75 nm). Dosimetry modeling using LFCI data indicated that a portion of inhaled particles will deposit throughout the respiratory tract, though statistical differences in aerosol MMADs among e-liquid formulations did not translate into large differences in deposition estimates. A portion of inhaled aerosol will be exhaled and could be a source for secondhand exposure. Use of laboratory-prepared e-liquids and a ...
    Keywords electronic cigarette ; vaping ; secondhand or passive exposure ; occupational exposure ; cascade impactor ; Public aspects of medicine ; RA1-1270
    Subject code 600
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  8. Article ; Online: Comment on Strupp papers on beryllium metal toxicity.

    Stefaniak, Aleksandr B

    The Annals of occupational hygiene

    2011  Volume 55, Issue 5, Page(s) 556–7; author reply 558–9

    MeSH term(s) Animals ; Beryllium/toxicity ; Carcinogens/toxicity ; Environmental Exposure ; Eye/drug effects ; Genes, Bacterial/drug effects ; Humans ; Occupational Exposure ; Skin/drug effects
    Chemical Substances Carcinogens ; Beryllium (OW5102UV6N)
    Language English
    Publishing date 2011-06
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 390312-6
    ISSN 1475-3162 ; 0003-4878
    ISSN (online) 1475-3162
    ISSN 0003-4878
    DOI 10.1093/annhyg/mer030
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease.

    Roach, Katherine A / Stefaniak, Aleksandr B / Roberts, Jenny R

    Journal of immunotoxicology

    2019  Volume 16, Issue 1, Page(s) 87–124

    Abstract: The recent surge in incorporation of metallic and metal oxide nanomaterials into consumer products and their corresponding use in occupational settings have raised concerns over the potential for metals to induce size-specific adverse toxicological ... ...

    Abstract The recent surge in incorporation of metallic and metal oxide nanomaterials into consumer products and their corresponding use in occupational settings have raised concerns over the potential for metals to induce size-specific adverse toxicological effects. Although nano-metals have been shown to induce greater lung injury and inflammation than their larger metal counterparts, their size-related effects on the immune system and allergic disease remain largely unknown. This knowledge gap is particularly concerning since metals are historically recognized as common inducers of allergic contact dermatitis, occupational asthma, and allergic adjuvancy. The investigation into the potential for adverse immune effects following exposure to metal nanomaterials is becoming an area of scientific interest since these characteristically lightweight materials are easily aerosolized and inhaled, and their small size may allow for penetration of the skin, which may promote unique size-specific immune effects with implications for allergic disease. Additionally, alterations in physicochemical properties of metals in the nano-scale greatly influence their interactions with components of biological systems, potentially leading to implications for inducing or exacerbating allergic disease. Although some research has been directed toward addressing these concerns, many aspects of metal nanomaterial-induced immune effects remain unclear. Overall, more scientific knowledge exists in regards to the potential for metal nanomaterials to exacerbate allergic disease than to their potential to induce allergic disease. Furthermore, effects of metal nanomaterial exposure on respiratory allergy have been more thoroughly-characterized than their potential influence on dermal allergy. Current knowledge regarding metal nanomaterials and their potential to induce/exacerbate dermal and respiratory allergy are summarized in this review. In addition, an examination of several remaining knowledge gaps and considerations for future studies is provided.
    MeSH term(s) Asthma/chemically induced ; Asthma/immunology ; Dermatitis, Allergic Contact/etiology ; Dermatitis, Allergic Contact/immunology ; Disease Progression ; Environmental Exposure/adverse effects ; Humans ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/toxicity ; Occupational Exposure/adverse effects ; Particle Size ; Permeability ; Respiratory System/drug effects ; Respiratory System/immunology ; Respiratory System/metabolism ; Skin/drug effects ; Skin/immunology ; Skin/metabolism
    Language English
    Publishing date 2019-05-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2205064-4
    ISSN 1547-6901 ; 1547-691X
    ISSN (online) 1547-6901
    ISSN 1547-691X
    DOI 10.1080/1547691X.2019.1605553
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Particle transfer and adherence to human skin compared with cotton glove and pre-moistened polyvinyl alcohol exposure sampling substrates.

    Stefaniak, Aleksandr B / Wade, Eleanor E / Lawrence, Robert B / Arnold, Elizabeth D / Virji, M Abbas

    Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

    2021  Volume 56, Issue 5, Page(s) 585–598

    Abstract: Measurement of skin exposure to particles using interception (e.g., cotton gloves) and removal (e.g., wiping) sampling techniques could be inaccurate because these substrates do not have the same topography and adhesion characteristics as skin. The ... ...

    Abstract Measurement of skin exposure to particles using interception (e.g., cotton gloves) and removal (e.g., wiping) sampling techniques could be inaccurate because these substrates do not have the same topography and adhesion characteristics as skin. The objective of this study was to compare particle transfer and adherence to cotton gloves, cotton gloves with artificial sebum, and a pre-moistened polyvinyl alcohol (PVA) material with bare human skin (fingertip, palm). Experiments were performed with aluminum oxide powder under standardized conditions for three types of surfaces touched, applied loads, contact times, and powder mass levels. In the final mixed model, the fixed effects of substrate, surface type, applied load, and powder mass and their significant two-way interaction terms explained 71% (transfer) and 74% (adherence) of the observed total variance in measurements. For particle mass transfer, compared with bare skin, bias was -77% (cotton glove with sebum) to +197% (PVA material) and for adherence bias ranged from -40% (cotton glove) to +428% (PVA material), which indicated under- and over-sampling by these substrates, respectively. Dermal exposure assessment would benefit from sampling substrates that better reflect human skin characteristics and more accurately estimate exposures. Mischaracterization of dermal exposure has important implications for exposure and risk assessment.
    MeSH term(s) Adhesiveness ; Aluminum Oxide/analysis ; Aluminum Oxide/chemistry ; Aluminum Oxide/metabolism ; Cotton Fiber ; Environmental Exposure/analysis ; Humans ; Polyvinyl Alcohol/chemistry ; Powders/analysis ; Powders/chemistry ; Powders/metabolism ; Skin/metabolism ; Skin Absorption ; Specimen Handling
    Chemical Substances Powders ; Polyvinyl Alcohol (9002-89-5) ; Aluminum Oxide (LMI26O6933)
    Language English
    Publishing date 2021-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 196584-0
    ISSN 1532-4117 ; 0360-1226 ; 1077-1204 ; 1093-4529
    ISSN (online) 1532-4117
    ISSN 0360-1226 ; 1077-1204 ; 1093-4529
    DOI 10.1080/10934529.2021.1899524
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top