LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 97

Search options

  1. Article ; Online: Robust Peak Detection for Holter ECGs by Self-Organized Operational Neural Networks.

    Gabbouj, Moncef / Kiranyaz, Serkan / Malik, Junaid / Zahid, Muhammad Uzair / Ince, Turker / Chowdhury, Muhammad E H / Khandakar, Amith / Tahir, Anas

    IEEE transactions on neural networks and learning systems

    2023  Volume 34, Issue 11, Page(s) 9363–9374

    Abstract: Although numerous R-peak detectors have been proposed in the literature, their robustness and performance levels may significantly deteriorate in low-quality and noisy signals acquired from mobile electrocardiogram (ECG) sensors, such as Holter monitors. ...

    Abstract Although numerous R-peak detectors have been proposed in the literature, their robustness and performance levels may significantly deteriorate in low-quality and noisy signals acquired from mobile electrocardiogram (ECG) sensors, such as Holter monitors. Recently, this issue has been addressed by deep 1-D convolutional neural networks (CNNs) that have achieved state-of-the-art performance levels in Holter monitors; however, they pose a high complexity level that requires special parallelized hardware setup for real-time processing. On the other hand, their performance deteriorates when a compact network configuration is used instead. This is an expected outcome as recent studies have demonstrated that the learning performance of CNNs is limited due to their strictly homogenous configuration with the sole linear neuron model. This has been addressed by operational neural networks (ONNs) with their heterogenous network configuration encapsulating neurons with various nonlinear operators. In this study, to further boost the peak detection performance along with an elegant computational efficiency, we propose 1-D Self-Organized ONNs (Self-ONNs) with generative neurons. The most crucial advantage of 1-D Self-ONNs over the ONNs is their self-organization capability that voids the need to search for the best operator set per neuron since each generative neuron has the ability to create the optimal operator during training. The experimental results over the China Physiological Signal Challenge-2020 (CPSC) dataset with more than one million ECG beats show that the proposed 1-D Self-ONNs can significantly surpass the state-of-the-art deep CNN with less computational complexity. Results demonstrate that the proposed solution achieves a 99.10% F1-score, 99.79% sensitivity, and 98.42% positive predictivity in the CPSC dataset, which is the best R-peak detection performance ever achieved.
    MeSH term(s) Neural Networks, Computer ; Electrocardiography, Ambulatory ; Electrocardiography/methods ; China ; Linear Models
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2022.3158867
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Antigenic comparison of the neuraminidases from recent influenza A vaccine viruses and 2019-2020 circulating strains.

    Gao, Jin / Li, Xing / Klenow, Laura / Malik, Tahir / Wan, Hongquan / Ye, Zhiping / Daniels, Robert

    NPJ vaccines

    2022  Volume 7, Issue 1, Page(s) 79

    Abstract: ... from the recommended seasonal strains, NA is not extensively evaluated like hemagglutinin (H) during the strain ...

    Abstract Although viral-based influenza vaccines contain neuraminidase (NA or N) antigens from the recommended seasonal strains, NA is not extensively evaluated like hemagglutinin (H) during the strain selection process. Here, we compared the antigenicity of NAs from recently recommended H1N1 (2010-2021 seasons) and H3N2 (2015-2021 seasons) vaccine strains and viruses that circulated between September 2019 and December 2020. The antigenicity was evaluated by measuring NA ferret antisera titers that provide 50% inhibition of NA activity in an enzyme-linked lectin assay. Our results show that NAs from circulating H1N1 viruses and vaccine strains for the 2017-2021 seasons are all antigenically similar and distinct from the NA in the H1N1 strain recommended for the 2010-2017 seasons. Changes in N1 antigenicity were attributed to the accumulation of substitutions over time, especially the loss of an N-linked glycosylation site (Asn386) in current N1s. The NAs from circulating H3N2 viruses and the 2020-2021 vaccine strains showed similar antigenicity that varied across the N2s in the 2016-2020 vaccine strains and was distinct from the N2 in the 2015-2016 vaccine strain. These data suggest that the recent N1 antigenicity has remained similar since the loss of the head domain N-linked glycosylation site, whereas N2 antigenicity has changed more incrementally each season.
    Language English
    Publishing date 2022-07-14
    Publishing country England
    Document type Journal Article
    ISSN 2059-0105
    ISSN (online) 2059-0105
    DOI 10.1038/s41541-022-00500-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Correction to: Open coraco-clavicular ligament reconstruction (CCLR) in treatment of displaced distal clavicle fractures has low complication rate and excellent union rate: a systematic review.

    Malik, Shahbaz S / Malik, Sheraz / Tahir, Muaaz / Jordan, Robert W / Laprus, Hubert / D'Alessandro, Peter

    Archives of orthopaedic and trauma surgery

    2023  Volume 143, Issue 3, Page(s) 1479

    Language English
    Publishing date 2023-02-06
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 80407-1
    ISSN 1434-3916 ; 0003-9330 ; 0344-8444
    ISSN (online) 1434-3916
    ISSN 0003-9330 ; 0344-8444
    DOI 10.1007/s00402-023-04780-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Isolation by multistep chromatography improves the consistency of secreted recombinant influenza neuraminidase antigens.

    Kang, Hyeog / Malik, Tahir / Daniels, Robert

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2023  Volume 1232, Page(s) 123975

    Abstract: Recombinant protein-based approaches are ideally suited for producing vaccine antigens that are not overly abundant in viruses, such as influenza neuraminidase (NA). However, obtaining sufficient quantities of recombinant viral surface antigens remains ... ...

    Abstract Recombinant protein-based approaches are ideally suited for producing vaccine antigens that are not overly abundant in viruses, such as influenza neuraminidase (NA). However, obtaining sufficient quantities of recombinant viral surface antigens remains challenging, often resulting in the use of chimeric proteins with affinity tags that can invariably impact the antigen's properties. Here, we developed multistep chromatography approaches for purifying secreted recombinant NA (rNA) antigens that are derived from recent H1N1 and H3N2 viruses and produced using insect cells. Analytical analyses showed that these isolation procedures yielded homogenous tetrameric rNA preparations with consistent specific activities that were not possible from a common immobilized metal affinity chromatography purification procedure. The use of classical chromatography improved the rNA tetramer homogeneity by removing the requirement of the N-terminal poly-histidine affinity tag that was shown to promote higher order rNA oligomer formation. In addition, these procedures reduced the specific activity variation by eliminating the exposure to Ni
    MeSH term(s) Humans ; Influenza, Human ; Neuraminidase/genetics ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/metabolism ; Influenza A Virus, H3N2 Subtype/genetics ; Influenza A Virus, H3N2 Subtype/metabolism ; Influenza Vaccines ; Recombinant Proteins/genetics ; Chromatography ; RNA
    Chemical Substances Neuraminidase (EC 3.2.1.18) ; Influenza Vaccines ; Recombinant Proteins ; RNA (63231-63-0)
    Language English
    Publishing date 2023-12-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2023.123975
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Robust biometric system using session invariant multimodal EEG and keystroke dynamics by the ensemble of self-ONNs.

    Rahman, Arafat / Chowdhury, Muhammad E H / Khandakar, Amith / Tahir, Anas M / Ibtehaz, Nabil / Hossain, Md Shafayet / Kiranyaz, Serkan / Malik, Junaid / Monawwar, Haya / Kadir, Muhammad Abdul

    Computers in biology and medicine

    2022  Volume 142, Page(s) 105238

    Abstract: Harnessing the inherent anti-spoofing quality from electroencephalogram (EEG) signals has become a potential field of research in recent years. Although several studies have been conducted, still there are some vital challenges present in the deployment ... ...

    Abstract Harnessing the inherent anti-spoofing quality from electroencephalogram (EEG) signals has become a potential field of research in recent years. Although several studies have been conducted, still there are some vital challenges present in the deployment of EEG-based biometrics, which is stable and capable of handling the real-world scenario. One of the key challenges is the large signal variability of EEG when recorded on different days or sessions which impedes the performance of biometric systems significantly. To address this issue, a session invariant multimodal Self-organized Operational Neural Network (Self-ONN) based ensemble model combining EEG and keystroke dynamics is proposed in this paper. Our model is tested successfully on a large number of sessions (10 recording days) with many challenging noisy and variable environments for the identification and authentication tasks. In most of the previous studies, training and testing were performed either over a single recording session (same day) only or without ensuring appropriate splitting of the data on multiple recording days. Unlike those studies, in our work, we have rigorously split the data so that train and test sets do not share the data of the same recording day. The proposed multimodal Self-ONN based ensemble model has achieved identification accuracy of 98% in rigorous validation cases and outperformed the equivalent ensemble of deep CNN models. A novel Self-ONN Siamese network has also been proposed to measure the similarity of templates during the authentication task instead of the commonly used simple distance measure techniques. The multimodal Siamese network reduces the Equal Error Rate (EER) to 1.56% in rigorous authentication. The obtained results indicate that the proposed multimodal Self-ONN model can automatically extract session invariant unique non-linear features to identify and authenticate users with high accuracy.
    MeSH term(s) Biometric Identification/methods ; Biometry ; Data Collection ; Electroencephalography/methods ; Neural Networks, Computer
    Language English
    Publishing date 2022-01-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2022.105238
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Hepato-protective role of itraconazole mediated cytochrome p450 pathway inhibition in liver fibrosis.

    Hadi, Faheem / Awan, Sana Javaid / Tayyeb, Asima / Maqbool, Tahir / Shehzadi, Somia / Malik, Sabeen / Kausar, Humera / Malik, Arif

    Pakistan journal of pharmaceutical sciences

    2021  Volume 33, Issue 6(Supplementary), Page(s) 2751–2758

    Abstract: ... model was used and post treated evaluation was done by blood biochemistry, hematoxylin and eosin (H&E ...

    Abstract Liver is a vital organ and is routinely exposed to toxins. Carbon tetrachloride is one such noxious agent which cause toxicity in liver when CYP450 enzyme bio-activates it. Many hepatoprotective agents are available in market with severe side effects. Appropriate agent is required to combat such liver problems. Azole compounds have much therapeutic values in many diseases. Based upon this fact, present study is aimed to evaluate the repurposing of Itraconazole in the prevention of hepatic fibrosis via inhibition of cytochrome P450 pathway. For in-vitro evaluation of cyto-protective effects in HepG2 cells (untreated and treated groups), cell viability assays, antioxidant evaluation, enzyme linked immunosorbent assay (ELISA) and immunocytochemistry was used. For in-vivo evaluation, CCl4 induced liver fibrotic rat model was used and post treated evaluation was done by blood biochemistry, hematoxylin and eosin (H&E) staining and gene expression profiling. Results of the current study indicated hepatoprotective role of itraconazole via inhibition of CYP450 pathway inhibition. Therefore, Itraconazole use could be a potential therapeutic approach to prevent liver fibrosis.
    MeSH term(s) Animals ; Carbon Tetrachloride/metabolism ; Carbon Tetrachloride/toxicity ; Cell Survival/drug effects ; Cytochrome P-450 Enzyme Inhibitors/pharmacology ; Female ; Hep G2 Cells ; Humans ; Itraconazole/pharmacology ; Itraconazole/therapeutic use ; Liver/drug effects ; Liver Cirrhosis/drug therapy ; Protective Agents/pharmacology ; Rats ; Transcriptome
    Chemical Substances Cytochrome P-450 Enzyme Inhibitors ; Protective Agents ; Itraconazole (304NUG5GF4) ; Carbon Tetrachloride (CL2T97X0V0)
    Language English
    Publishing date 2021-04-21
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Longitudinal Lower Airway Microbial Signatures of Acute Cellular Rejection in Lung Transplantation.

    Natalini, Jake G / Wong, Kendrew K / Nelson, Nathaniel C / Wu, Benjamin G / Rudym, Darya / Lesko, Melissa B / Qayum, Seema / Lewis, Tyler C / Wong, Adrian / Chang, Stephanie H / Chan, Justin C Y / Geraci, Travis C / Li, Yonghua / Wang, Chan / Li, Huilin / Pamar, Prerna / Schnier, Joseph / Mahoney, Ian J / Malik, Tahir /
    Darawshy, Fares / Sulaiman, Imran / Kugler, Matthias C / Singh, Rajbir / Collazo, Destiny E / Chang, Miao / Patel, Shrey / Kyeremateng, Yaa / McCormick, Colin / Barnett, Clea R / Tsay, Jun-Chieh J / Brosnahan, Shari B / Singh, Shivani / Pass, Harvey I / Angel, Luis F / Segal, Leopoldo N

    American journal of respiratory and critical care medicine

    2024  

    Abstract: Rationale: ...

    Abstract Rationale:
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202309-1551OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Open coraco-clavicular ligament reconstruction (CCLR) in treatment of displaced distal clavicle fractures has low complication rate and excellent union rate: a systematic review.

    Malik, Shahbaz S / Malik, Sheraz / Tahir, Muaaz / Jordan, Robert W / Laprus, Hubert / D'Alessandro, Peter

    Archives of orthopaedic and trauma surgery

    2022  Volume 143, Issue 3, Page(s) 1459–1477

    Abstract: Background: It is well established that non-operative treatment of displaced distal clavicle fractures (DDCF) leads to a high non-union rate. A number of open surgical treatments in the past have shown good to excellent outcomes including shoulder ... ...

    Abstract Background: It is well established that non-operative treatment of displaced distal clavicle fractures (DDCF) leads to a high non-union rate. A number of open surgical treatments in the past have shown good to excellent outcomes including shoulder function and union rate. Despite this there is no consensus on the outcome of open coraco-clavicular ligament reconstruction (CCLR). The aim of this systematic review was to assess the union rate, complications and shoulder function of open CCLR techniques in the treatment of DDCF.
    Patients and methods: A review of the online databases MEDLINE and Embase was conducted on 1 January 2021 according to PRISMA guidelines. The review was registered prospectively in the PROSPERO database. Clinical studies reporting union rate, complications and shoulder function were included. The studies were appraised using the Methodological Index for Non-Randomized Studies (MINORS) tool.
    Results: The search strategy identified 18 studies eligible for inclusion with a total of 330 patients. These included 12 retrospective case series and 5 nonrandomized retrospective comparative studies and one RCT. All but one study reported on shoulder function, while all the studies reported on union rate and complications. The overall shoulder function was good to excellent using Constant-Murley score. The overall union rate was 97.6% and complication rate was 7.6%.
    Conclusion: Open CCLR for displaced distal clavicle fractures that have a disruption of CC ligament, is a reliable treatment with excellent union rate and good to excellent shoulder functional scores.
    Level of evidence: IV; Systematic review.
    MeSH term(s) Humans ; Clavicle/surgery ; Retrospective Studies ; Fractures, Bone/surgery ; Fracture Fixation, Internal/methods ; Ligaments ; Treatment Outcome ; Bone Plates
    Language English
    Publishing date 2022-02-18
    Publishing country Germany
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 80407-1
    ISSN 1434-3916 ; 0003-9330 ; 0344-8444
    ISSN (online) 1434-3916
    ISSN 0003-9330 ; 0344-8444
    DOI 10.1007/s00402-022-04384-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: DSCC_Net: Multi-Classification Deep Learning Models for Diagnosing of Skin Cancer Using Dermoscopic Images.

    Tahir, Maryam / Naeem, Ahmad / Malik, Hassaan / Tanveer, Jawad / Naqvi, Rizwan Ali / Lee, Seung-Won

    Cancers

    2023  Volume 15, Issue 7

    Abstract: Skin cancer is one of the most lethal kinds of human illness. In the present state of the health care system, skin cancer identification is a time-consuming procedure and if it is not diagnosed initially then it can be threatening to human life. To ... ...

    Abstract Skin cancer is one of the most lethal kinds of human illness. In the present state of the health care system, skin cancer identification is a time-consuming procedure and if it is not diagnosed initially then it can be threatening to human life. To attain a high prospect of complete recovery, early detection of skin cancer is crucial. In the last several years, the application of deep learning (DL) algorithms for the detection of skin cancer has grown in popularity. Based on a DL model, this work intended to build a multi-classification technique for diagnosing skin cancers such as melanoma (MEL), basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanocytic nevi (MN). In this paper, we have proposed a novel model, a deep learning-based skin cancer classification network (DSCC_Net) that is based on a convolutional neural network (CNN), and evaluated it on three publicly available benchmark datasets (i.e., ISIC 2020, HAM10000, and DermIS). For the skin cancer diagnosis, the classification performance of the proposed DSCC_Net model is compared with six baseline deep networks, including ResNet-152, Vgg-16, Vgg-19, Inception-V3, EfficientNet-B0, and MobileNet. In addition, we used SMOTE Tomek to handle the minority classes issue that exists in this dataset. The proposed DSCC_Net obtained a 99.43% AUC, along with a 94.17%, accuracy, a recall of 93.76%, a precision of 94.28%, and an F1-score of 93.93% in categorizing the four distinct types of skin cancer diseases. The rates of accuracy for ResNet-152, Vgg-19, MobileNet, Vgg-16, EfficientNet-B0, and Inception-V3 are 89.32%, 91.68%, 92.51%, 91.12%, 89.46% and 91.82%, respectively. The results showed that our proposed DSCC_Net model performs better as compared to baseline models, thus offering significant support to dermatologists and health experts to diagnose skin cancer.
    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15072179
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article: Tracing down the Updates on Dengue Virus-Molecular Biology, Antivirals, and Vaccine Strategies.

    Malik, Shiza / Ahsan, Omar / Mumtaz, Hassan / Tahir Khan, Muhammad / Sah, Ranjit / Waheed, Yasir

    Vaccines

    2023  Volume 11, Issue 8

    Abstract: Background: Nearly half of the world is at risk of developing dengue infection. Dengue virus is the causative agent behind this public healthcare concern. Millions of dengue cases are reported every year, leading to thousands of deaths. The scientific ... ...

    Abstract Background: Nearly half of the world is at risk of developing dengue infection. Dengue virus is the causative agent behind this public healthcare concern. Millions of dengue cases are reported every year, leading to thousands of deaths. The scientific community is working to develop effective therapeutic strategies in the form of vaccines and antiviral drugs against dengue.
    Methods: In this review, a methodological approach has been used to gather data from the past five years to include the latest developments against the dengue virus.
    Results: Different therapeutics and antiviral targets against the dengue virus are at different stages of development, but none have been approved by the FDA. Moreover, various vaccination strategies have also been discussed, including attenuated virus vaccines, recombinant subunit vaccines, viral vector vaccines, DNA vaccines, nanotechnology, and plant-based vaccines, which are used to develop effective vaccines for the dengue virus. Many dengue vaccines pass the initial phases of evaluation, but only two vaccines have been approved for public use. DENGVAXIA is the only FDA-approved vaccine against all four stereotypes of the dengue virus, but it is licensed for use only in individuals 6-16 years of age with laboratory-confirmed previous dengue infection and living in endemic countries. Takeda is the second vaccine approved for use in the European Union, the United Kingdom, Brazil, Argentina, Indonesia, and Thailand. It produced sustained antibody responses against all four serotypes of dengue virus, regardless of previous exposure and dosing schedule. Other dengue vaccine candidates at different stages of development are TV-003/005, TDENV PIV, V180, and some DNA vaccines.
    Conclusion: There is a need to put more effort into developing effective vaccines and therapeutics for dengue, as already approved vaccines and therapeutics have limitations. DENGVAXIA is approved for use in children and teenagers who are 6-16 years of age and have confirmed dengue infection, while Takeda is approved for use in certain countries, and it has withdrawn its application for FDA approval.
    Language English
    Publishing date 2023-08-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11081328
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top