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Article ; Online: Adjuvant therapeutic plasma exchange in septic shock.

David, Sascha / Bode, Christian / Putensen, Christian / Welte, Tobias / Stahl, Klaus

2021 Volume 47, Issue 3, Page(s) 352–354

MeSH term(s)	Humans ; Plasma Exchange ; Plasmapheresis ; Sepsis/therapy ; Shock, Septic/therapy
Language	English
Publishing date	2021-01-20
Publishing country	United States
Document type	Letter
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-020-06339-1
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Article ; Online: Current Trends in Mortality Attributable to Racial or Ethnic Disparities in Post-Surgical Population in The United States: A Population-Based Study.

Mpody, Christian / Best, Ana F / Lee, Clara N / Stahl, David L / Raman, Vidya T / Urman, Richard D / Tobias, Joseph D / Nafiu, Olubukola O

Annals of surgery open : perspectives of surgical history, education, and clinical approaches

2023 Volume 4, Issue 4, Page(s) e342

Abstract: Background: No study has contextualized the excess mortality attributable to racial and ethnic disparities in surgical outcomes. Further, not much effort has been made to quantify the effort needed to eliminate these disparities.: Objective: We ... ...

Abstract	Background: No study has contextualized the excess mortality attributable to racial and ethnic disparities in surgical outcomes. Further, not much effort has been made to quantify the effort needed to eliminate these disparities. Objective: We examined the current trends in mortality attributable to racial or ethnic disparities in the US postsurgical population. We then identified the target for mortality reduction that would be necessary to eliminate these disparities by 2030. Methods: We performed a population-based study of 1,512,974 high-risk surgical procedures among adults (18-64 years) performed across US hospitals between 2000 and 2020. Results: Between 2000 and 2020, the risk-adjusted mortality rates declined for all groups. Nonetheless, Black patients were more likely to die following surgery (adjusted relative risk 1.42; 95% CI, 1.39-1.46) driven by higher Black mortality in the northeast (1.60; 95% CI, 1.52-1.68), as well as the West (1.53; 95% CI, 1.43-1.62). Similarly, mortality risk remained consistently higher for Hispanics compared with White patients (1.21; 95% CI, 1.19-1.24), driven by higher mortality in the West (1.26; 95% CI, 1.21-1.31). Overall, 8364 fewer deaths are required for Black patients to experience mortality on the same scale as White patients. Similar figures for Hispanic patients are 4388. To eliminate the disparity between Black and White patients by 2030, we need a 2.7% annualized reduction in the projected mortality among Black patients. For Hispanics, the annualized reduction needed is 0.8%. Conclusions: Our data provides a framework for incorporating population and health systems measures for eliminating disparity in surgical mortality within the next decade.
Language	English
Publishing date	2023-09-28
Publishing country	United States
Document type	Journal Article
ISSN	2691-3593
ISSN (online)	2691-3593
DOI	10.1097/AS9.0000000000000342
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Article ; Online: Interdisziplinäre Netzwerke bei Erkrankungen der peripheren Nerven – am Beispiel des Tübinger Nerve Teams.

Stahl, Jan-Hendrik / Winter, Natalie / Kolbenschlag, Jonas / Lindig, Tobias / Schuhmann, Martin U / Wittlinger, Julia / Grimm, Alexander

Der Nervenarzt

2023 Volume 94, Issue 12, Page(s) 1081–1086

Abstract: Background: Nerve damage can be autoimmune inflammatory, metabolic or traumatic, among others, and can be difficult to differentiate.: Objective: What are the advantages of interdisciplinary networks and how do they work?: Material and method: ... ...

Title translation	Interdisciplinary networks in diseases of peripheral nerves-Exemplified by the Tübingen nerve team.
Abstract	Background: Nerve damage can be autoimmune inflammatory, metabolic or traumatic, among others, and can be difficult to differentiate. Objective: What are the advantages of interdisciplinary networks and how do they work? Material and method: Field report with case presentation from the University Hospital Tübingen in cooperation with the BG Accident Clinic Tübingen. Conclusion: Interdisciplinary networks improve the care of our patients and also serve as regular multidisciplinary continuing education.
MeSH term(s)	Humans ; Patient Care Team ; Peripheral Nerves ; Ambulatory Care Facilities
Language	German
Publishing date	2023-10-23
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	123291-5
ISSN	1433-0407 ; 0028-2804
ISSN (online)	1433-0407
ISSN	0028-2804
DOI	10.1007/s00115-023-01560-x
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Article ; Online: No evaluative conditioning effects with briefly presented stimuli.

Heycke, Tobias / Stahl, Christoph

Psychological research

2018 Volume 84, Issue 4, Page(s) 1020–1027

Abstract: Evaluative conditioning (EC) changes the preference towards a formerly neutral stimulus (conditioned stimulus; CS), by pairing it with a valent stimulus (unconditioned stimulus; US), in the direction of the valence of the US. When the CS is presented ... ...

Abstract	Evaluative conditioning (EC) changes the preference towards a formerly neutral stimulus (conditioned stimulus; CS), by pairing it with a valent stimulus (unconditioned stimulus; US), in the direction of the valence of the US. When the CS is presented suboptimally (i.e., too briefly to be consciously perceived), contingency awareness between CS and US can be ruled out. Hence, EC effects with suboptimally presented CSs would support theories claiming that contingency awareness is not necessary for EC effects to occur. Recent studies reported the absence of EC with briefly presented CSs when both CS and US were presented in the visual modality, even though the CSs were identified at above-chance levels. Challenging this finding, Heycke et al. (R Soc Open Sci 4(9):160935, 2017) found some evidence for an EC effect with briefly presented visual stimuli in a cross-modal paradigm with auditory USs, but that study did not assess CS visibility. The present study realized a close replication of this study, while deviated from it using different stimuli, introducing a brief practice phase, and adding a CS visibility check. Overall EC for briefly presented stimuli was absent, and results from the visibility check show that an EC effect with briefly presented CSs was only found, when the CSs were identified at above-chance levels.
MeSH term(s)	Adolescent ; Adult ; Awareness/physiology ; Conditioning, Classical/physiology ; Female ; Humans ; Male ; Photic Stimulation ; Young Adult
Language	English
Publishing date	2018-10-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1463034-5
ISSN	1430-2772 ; 0340-0727
ISSN (online)	1430-2772
ISSN	0340-0727
DOI	10.1007/s00426-018-1109-1
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Article ; Online: A Chemical Chaperone Restores Connexin 26 Mutant Activity.

Wang, Dahua / Wang, Hongling / Fan, Lu / Ludwig, Tobias / Wegner, Andre / Stahl, Frank / Harre, Jennifer / Warnecke, Athanasia / Zeilinger, Carsten

ACS pharmacology & translational science

2023 Volume 6, Issue 7, Page(s) 997–1005

Abstract: Mutations in connexin 26 (Cx26) cause hearing disorders of a varying degree. Herein, to identify compounds capable of restoring the function of mutated Cx26, a novel miniaturized microarray-based screening system was developed to perform an optical assay ...

Abstract	Mutations in connexin 26 (Cx26) cause hearing disorders of a varying degree. Herein, to identify compounds capable of restoring the function of mutated Cx26, a novel miniaturized microarray-based screening system was developed to perform an optical assay of Cx26 functionality. These molecules were identified through a viability assay using HeLa cells expressing wild-type (WT) Cx26, which exhibited sensitivity toward the HSP90 inhibitor radicicol in the submicromolar concentration range. Open Cx26 hemichannels are assumed to mediate the passage of molecules up to 1000 Da in size. Thus, by releasing radicicol, WT Cx26 active hemichannels in HeLa cells contribute to a higher survival rate and lower cell viability when Cx26 is mutated. HeLa cells expressing Cx26 mutations exhibited reduced viability in the presence of radicicol, such as the mutants F161S or R184P. Next, molecules exhibiting chemical chaperoning activity, suspected of restoring channel function, were assessed regarding whether they induced superior sensitivity toward radicicol and increased HeLa cell viability. Through a viability assay and microarray-based flux assay that uses Lucifer yellow in HeLa cells, compounds
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ISSN	2575-9108
ISSN (online)	2575-9108
DOI	10.1021/acsptsci.3c00056
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Article: A new tool for bile duct tissue sampling: ex vivo clinical evaluation of intraductal cryobiopsy for cholangioscopy.

Wirsing, Lukas / Linzenbold, Walter / Jaeger, Simon U / Stahl, Phillip / Ott, German / Leibold, Tobias / Enderle, Markus / Albert, Jörg / Peveling-Oberhag, Jan

Endoscopy international open

2022 Volume 10, Issue 6, Page(s) E809–E814

Abstract: Background and study ... ...

Abstract	Background and study aims
Language	English
Publishing date	2022-06-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722
ISSN (online)	2196-9736
ISSN	2364-3722
DOI	10.1055/a-1797-8966
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Article: Feasibility Study of Soft Tooling Inserts for Injection Molding with Integrated Automated Slides.

Vieten, Tobias / Stahl, Dennis / Schilling, Peter / Civelek, Faruk / Zimmermann, André

Micromachines

2021 Volume 12, Issue 7

Abstract: The production of injection-molding prototypes, e.g., molded interconnect devices (MID) prototypes, can be costly and time-consuming due to the process-specific inability to replace durable steel tooling with quicker fabricated aluminum tooling. Instead, ...

Abstract	The production of injection-molding prototypes, e.g., molded interconnect devices (MID) prototypes, can be costly and time-consuming due to the process-specific inability to replace durable steel tooling with quicker fabricated aluminum tooling. Instead, additively manufactured soft tooling is a solution for the production of small quantities and prototypes, but producing complex parts with, e.g., undercuts, is avoided due to the necessity of additional soft tooling components. The integration of automated soft slides into soft tooling has not yet been investigated and poses a challenge for the design and endurance of the tooling. The presented study covers the design and injection-molding trial of soft tooling with integrated automated slides for the production of a complex MID prototype. The design further addresses issues like the alignment of the mold components and the sealing of the complex parting plane. The soft tooling was additively manufactured via digital light processing from a silica-filled photopolymer, and 10 proper parts were injection-molded from a laser-direct structurable glass fiber-filled PET+PBT material before the first damage on the tooling occurred. Although improvements are suggested to enhance the soft tooling durability, the designed features worked as intended and are generally transferable to other part geometries.
Language	English
Publishing date	2021-06-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi12070730
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Article: Association of Severe Obesity and Chronic Obstructive Pulmonary Disease With Pneumonia Following Non-Cardiac Surgery.

Owusu-Bediako, Kwaku / Pfaff, Kayla / Tram, Nguyen K / Stahl, David L / Tobias, Joseph D / Nafiu, Olubukola O / Mpody, Christian

Journal of clinical medicine research

2022 Volume 14, Issue 6, Page(s) 237–243

Abstract: Background: Pneumonia is the third most common surgical complication after urinary tract infection and wound infections. In addition to increased mortality, patients who develop postoperative pneumonia have a higher risk of prolonged hospital stay, ... ...

Abstract	Background: Pneumonia is the third most common surgical complication after urinary tract infection and wound infections. In addition to increased mortality, patients who develop postoperative pneumonia have a higher risk of prolonged hospital stay, intensive care unit (ICU) admissions, and higher healthcare costs. Obesity and chronic obstructive pulmonary disease (COPD) are both independent risk factors for the development and severity of postoperative pneumonia, although the combined effect of these comorbidities is unknown. Therefore, we evaluated whether the combination of severe obesity and COPD is associated with an increased risk of postoperative pneumonia. Methods: We performed a multicenter retrospective cohort study of 365,273 patients aged 18 - 64 years who were either severely obese (body mass index (BMI) ≥ 40 kg/m Results: The co-occurrence of severe obesity and COPD appeared to have a protective effect on the risk of postoperative pneumonia. In the presence of COPD, patients with severe obesity were 14% less likely to develop pneumonia compared to their normal-weight counterparts (2.9% vs. 4.4%; adjusted relative risk (RR): 0.76; 95% confidence interval (CI): 0.60, 0.95). In addition, in the presence of COPD, severe obesity conferred a lower risk for requiring an extended length of stay (37.6% vs. 47.9%; adjusted RR: 0.83; 95% CI: 0.78, 0.89). Conclusions: Counterintuitively, the co-occurrence of severe obesity with COPD appeared to buffer the negative impact of COPD on postoperative pneumonia, unplanned tracheal reintubation, and prolonged hospital stay after noncardiac surgery. These findings are consistent with the obesity paradox and warrant further investigations.
Language	English
Publishing date	2022-06-27
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2548987-2
ISSN	1918-3011 ; 1918-3003
ISSN (online)	1918-3011
ISSN	1918-3003
DOI	10.14740/jocmr4741
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Article: Optimal treatment of the underlying aetiology is the most effective antimicrobial stewardship for chronic respiratory disease: a lesson learned from cystic fibrosis.

Rademacher, Jessica / Martin, Luise / Theloe, Anja / Stahl, Mirjam / Mall, Marcus A / Joean, Oana / Fuge, Jan / Hansen, Gesine / Welte, Tobias / Schütz, Katharina / Ringshausen, Felix C / Dittrich, Anna M

ERJ open research

2023 Volume 9, Issue 4

Abstract: AMS in chronic lung disease can be challenging. Causal treatment of treatable traits may be the most successful AMS strategy for patients with any chronic pulmonary disease and should be brought into focus. ...

Abstract	AMS in chronic lung disease can be challenging. Causal treatment of treatable traits may be the most successful AMS strategy for patients with any chronic pulmonary disease and should be brought into focus.
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00356-2023
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Article ; Online: Quantification of Facial Fat Compartment Variations: A Three-Dimensional Morphometric Analysis of the Cheek.

Estler, Arne / Grözinger, Gerd / Estler, Eva / Hepp, Tobias / Feng, You-Shan / Daigeler, Adrien / Seabra Robalo Gomes Jorge, Ana Cristina / Santos Stahl, Adelana / Nikolaou, Konstantin / Stahl, Stéphane

Plastic and reconstructive surgery

2023 Volume 152, Issue 4, Page(s) 617e–627e

Abstract: Background: Cheek contour is a main determinant of facial attractiveness. The aim of this study was to evaluate the relationship between age, sex, and body mass index (BMI) and cheek fat volume in a large cohort to better understand and treat facial ... ...

Abstract	Background: Cheek contour is a main determinant of facial attractiveness. The aim of this study was to evaluate the relationship between age, sex, and body mass index (BMI) and cheek fat volume in a large cohort to better understand and treat facial aging. Methods: The authors performed a retrospective review of the archives of the Department of Diagnostic and Interventional Radiology, University Hospital of Tübingen. Epidemiologic data and medical history were assessed. Cheek superficial and deep fat compartment volumes were measured on magnetic resonance images. Statistical analyses were performed using SPSS and SAS statistical software. Results: A total of 87 patients with a mean age of 46 years (range, 18 to 81 years) were included. The superficial and deep fat compartment volumes of the cheek increased with BMI ( P < 0.001 and P = 0.005), but there was no significant relationship between age and volume. The ratio of superficial versus deep fat did not change with age. No significant difference of the superficial or deep fat compartments was found between men and women in a regression analysis ( P = 0.931 and P = 0.057). Conclusions: Cheek fat volume measurements on magnetic resonance imaging scans using reconstruction software suggest that the fat volume of the cheek increases with BMI but does not change significantly with age. Further studies are needed to elucidate the role of age-related changes of bone structures or sagging of the fat compartments.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Cheek/diagnostic imaging ; Cheek/anatomy & histology ; Face/diagnostic imaging ; Face/anatomy & histology ; Aging ; Retrospective Studies ; Body Mass Index ; Adipose Tissue/diagnostic imaging ; Adipose Tissue/transplantation
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/PRS.0000000000010357
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