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  1. Book ; Online ; E-Book: Peptide and Protein Drug Delivery Using Polysaccharides

    Jain, Aakanchha / Malik, Sonia

    2024  

    Author's details Aakanchha Jain and Sonia Malik, editors
    MeSH term(s) Polysaccharides ; Drug Delivery Systems ; Peptides/therapeutic use ; Proteins/therapeutic use
    Keywords Peptide drugs/Dosage forms ; Protein drugs/Dosage forms ; Drugs/Dosage forms
    Subject code 615.3
    Language English
    Size 1 online resource (331 pages)
    Edition First edition.
    Publisher Academic Press - Elsevier
    Publishing place London, England
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-443-18926-9 ; 0-443-18925-0 ; 978-0-443-18926-5 ; 978-0-443-18925-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Gamma irradiation induced effects on in vitro shoot cultures and influence of monochromatic light regimes on irradiated shoot cultures of Dendrobium sonia orchid

    Billore, Vandita / Mirajkar, Shriram J / Suprasanna, Penna / Jain, Monica

    Biotechnology reports. 2019 June, v. 22

    2019  

    Abstract: ... of orchid, Dendrobium sonia, were investigated. The gamma irradiated shoot cultures grown under white, blue ...

    Abstract The effects of gamma radiation and monochromatic lights on growth of in vitro shoot cultures of orchid, Dendrobium sonia, were investigated. The gamma irradiated shoot cultures grown under white, blue, yellow and red monochromatic lights exhibited differential growth pattern. Shoot cultures gamma irradiated at 15–45 Gy showed reduced shoot length, fresh weight and leaf area. The monochromatic light significantly influenced survival rate and growth of irradiated shoots. The yellow and red light treatments positively influenced survival of gamma irradiated shoots with significant increase in fresh weight, shoot length and chlorophyll content. Yellow light was found to be most effective as leaf area was increased across the radiation dose range (15–100 Gy) compared to red light. The results demonstrated that the method of post-irradiation exposure could be useful to improve growth of gamma irradiated in vitro shoots, and help to recover orchid mutants with novel modifications.
    Keywords Dendrobium ; biotechnology ; chlorophyll ; gamma radiation ; irradiation ; leaf area ; mutants ; photoperiod ; red light ; shoots ; survival rate
    Language English
    Dates of publication 2019-06
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2801018-8
    ISSN 2215-017X
    ISSN 2215-017X
    DOI 10.1016/j.btre.2019.e00343
    Database NAL-Catalogue (AGRICOLA)

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  3. Book: Managing difficult problems in hand surgery

    Jain, Sonu A.

    challenges, complications, and revisions

    (Hand clinics ; volume 39, number 3 (August 2023))

    2023  

    Author's details editor Sonu A. Jain
    Series title Hand clinics ; volume 39, number 3 (August 2023)
    Collection
    Language English
    Size xiii Seiten, Seite 251-473, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT030349517
    ISBN 978-0-323-94005-4 ; 0-323-94005-6
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 989 -39,3- not available for loan Lesesaal EG

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  4. Article ; Online: Advancements in Genetic and Biochemical Insights: Unraveling the Etiopathogenesis of Neurodegeneration in Parkinson's Disease.

    Ratan, Yashumati / Rajput, Aishwarya / Pareek, Ashutosh / Pareek, Aaushi / Jain, Vivek / Sonia, Sonia / Farooqui, Zeba / Kaur, Ranjeet / Singh, Gurjit

    Biomolecules

    2024  Volume 14, Issue 1

    Abstract: Parkinson's disease (PD) is the second most prevalent neurodegenerative movement disorder worldwide, which is primarily characterized by motor impairments. Even though multiple hypotheses have been proposed over the decades that explain the pathogenesis ... ...

    Abstract Parkinson's disease (PD) is the second most prevalent neurodegenerative movement disorder worldwide, which is primarily characterized by motor impairments. Even though multiple hypotheses have been proposed over the decades that explain the pathogenesis of PD, presently, there are no cures or promising preventive therapies for PD. This could be attributed to the intricate pathophysiology of PD and the poorly understood molecular mechanism. To address these challenges comprehensively, a thorough disease model is imperative for a nuanced understanding of PD's underlying pathogenic mechanisms. This review offers a detailed analysis of the current state of knowledge regarding the molecular mechanisms underlying the pathogenesis of PD, with a particular emphasis on the roles played by gene-based factors in the disease's development and progression. This study includes an extensive discussion of the proteins and mutations of primary genes that are linked to PD, including α-synuclein,
    MeSH term(s) Humans ; Parkinson Disease/genetics ; Movement ; Mutation ; Risk Factors
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14010073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Addressing sequential and concurrent treatment regimens in a small n sequential, multiple assignment, randomized trial (snSMART) in the MISTIC study.

    Cheng, Yuwei / Tremoulet, Adriana / Burns, Jane / Jain, Sonia

    Journal of biopharmaceutical statistics

    2023  , Page(s) 1–19

    Abstract: Multisystem Inflammatory Syndrome in children (MIS-C) is a rare and novel pediatric complication linked to COVID-19 exposure, which was first identified in April 2020. A small n, Sequential, Multiple Assignment, Randomized Trial (snSMART) was applied to ... ...

    Abstract Multisystem Inflammatory Syndrome in children (MIS-C) is a rare and novel pediatric complication linked to COVID-19 exposure, which was first identified in April 2020. A small n, Sequential, Multiple Assignment, Randomized Trial (snSMART) was applied to the Multisystem Inflammatory Syndrome Therapies in Children Comparative Effectiveness Study (MISTIC) to efficiently evaluate multiple competing treatments. In the MISTIC snSMART study, participants are randomized to one of three interventions (steroids, infliximab or anakinra), and potentially re-randomized to the remaining two treatments depending on their response to the first randomized treatment. However, given the novelty and urgency of the MIS-C disease, in addition to patient welfare concerns, treatments were not always administered sequentially, but allowed to be administered concurrently if deemed medically necessary. We propose a pragmatic modification to the original snSMART design to address the analysis of concurrent versus sequential treatments in the MISTIC study. A modified Bayesian joint stage model is developed that can distinguish a concurrent treatment effect from a sequential treatment effect. A simulation study is conducted to demonstrate the improved accuracy and efficiency of the primary aim to estimate the first stage treatments' response rates and the secondary aim to estimate the combined first and second stage treatments' responses in the proposed model compared to the standard snSMART Bayesian joint stage model. We observed that the modified model has improved efficiency in terms of bias and rMSE under large sample size settings.
    Language English
    Publishing date 2023-12-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1131763-2
    ISSN 1520-5711 ; 1054-3406
    ISSN (online) 1520-5711
    ISSN 1054-3406
    DOI 10.1080/10543406.2023.2292206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3511: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Two unusual cases of hematuria reported on urine cytology.

    Jain, Swasti / Gupta, Prajwala / Raghav, Sonia / Bhardwaj, Minakshi

    CytoJournal

    2021  Volume 18, Page(s) 9

    Language English
    Publishing date 2021-04-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2158838-7
    ISSN 1742-6413 ; 0974-5963
    ISSN (online) 1742-6413
    ISSN 0974-5963
    DOI 10.25259/Cytojournal_9_2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Viral RNA Shedding and Transmission Potential of Asymptomatic and Pauci-symptomatic COVID-19 Patients.

    Gupta, Ajay / Jain, Sonia / Gupta, Vipul

    Open forum infectious diseases

    2021  Volume 8, Issue 8, Page(s) ofab112

    Language English
    Publishing date 2021-08-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofab112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Bayesian-bandit adaptive design for N-of-1 clinical trials.

    Shrestha, Sama / Jain, Sonia

    Statistics in medicine

    2021  Volume 40, Issue 7, Page(s) 1825–1844

    Abstract: N-of-1 trials, which are randomized, double-blinded, controlled, multiperiod, crossover trials on a single subject, have been applied to determine the heterogeneity of the individual's treatment effect in precision medicine settings. An aggregated N-of-1 ...

    Abstract N-of-1 trials, which are randomized, double-blinded, controlled, multiperiod, crossover trials on a single subject, have been applied to determine the heterogeneity of the individual's treatment effect in precision medicine settings. An aggregated N-of-1 design, which can estimate the population effect from these individual trials, is a pragmatic alternative when a randomized controlled trial (RCT) is infeasible. We propose a Bayesian adaptive design for both the individual and aggregated N-of-1 trials using a multiarmed bandit framework that is estimated via efficient Markov chain Monte Carlo. A Bayesian hierarchical structure is used to jointly model the individual and population treatment effects. Our proposed adaptive trial design is based on Thompson sampling, which randomly allocates individuals to treatments based on the Bayesian posterior probability of each treatment being optimal. While we use a subject-specific treatment effect and Bayesian posterior probability estimates to determine an individual's treatment allocation, our hierarchical model facilitates these individual estimates to borrow strength from the population estimates via shrinkage to the population mean. We present the design's operating characteristics and performance via a simulation study motivated by a recently completed N-of-1 clinical trial. We demonstrate that from a patient-centered perspective, subjects are likely to benefit from our adaptive design, in particular, for those individuals that deviate from the overall population effect.
    MeSH term(s) Bayes Theorem ; Cross-Over Studies ; Humans ; Markov Chains ; Monte Carlo Method ; Research Design
    Language English
    Publishing date 2021-01-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.8873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: A Lurking Threat of Community-Acquired

    Jindal, Navodhya / Jain, Sonia / Bhowmick, Arghya / Bhargava, Vyom

    Medicines (Basel, Switzerland)

    2022  Volume 9, Issue 4

    Abstract: Background: Acinetobacter spp. are a potential life-threatening cause of severe meningitis noted as a nosocomial infection after neurosurgical procedures in patients admitted to neurosurgical ICUs. Community-acquired Acinetobacter meningitis is extremely ...

    Abstract Background: Acinetobacter spp. are a potential life-threatening cause of severe meningitis noted as a nosocomial infection after neurosurgical procedures in patients admitted to neurosurgical ICUs. Community-acquired Acinetobacter meningitis is extremely rare, and only a few cases have been reported in the literature. Case presentation: In this study, we report a patient from Punjab, India, who was infected after a roadside accident in which he developed CSF otorrhea and subsequent meningitis with Acinetobacter lwoffii. The patient was managed with the cephalosporin group of antibiotics as per the sensitivity report. For the first time, we report a rare case report of community-acquired Acinetobacter meningitis from Punjab, India. Conclusions: This case report highlights the potential pathogenicity of Acinetobacter lwoffii and increases concerns that this organism might rapidly evolve into a dreadful antibiotic-resistant community pathogen.
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2777965-8
    ISSN 2305-6320
    ISSN 2305-6320
    DOI 10.3390/medicines9040027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A Lurking Threat of Community-Acquired Acinetobacter Meningitis—A Rare Case Report from Punjab, India

    Navodhya Jindal / Sonia Jain / Arghya Bhowmick / Vyom Bhargava

    Medicines, Vol 9, Iss 4, p

    2022  Volume 27

    Abstract: Background: Acinetobacter spp. are a potential life-threatening cause of severe meningitis noted as a nosocomial infection after neurosurgical procedures in patients admitted to neurosurgical ICUs. Community-acquired Acinetobacter meningitis is extremely ...

    Abstract Background: Acinetobacter spp. are a potential life-threatening cause of severe meningitis noted as a nosocomial infection after neurosurgical procedures in patients admitted to neurosurgical ICUs. Community-acquired Acinetobacter meningitis is extremely rare, and only a few cases have been reported in the literature. Case presentation: In this study, we report a patient from Punjab, India, who was infected after a roadside accident in which he developed CSF otorrhea and subsequent meningitis with Acinetobacter lwoffii . The patient was managed with the cephalosporin group of antibiotics as per the sensitivity report. For the first time, we report a rare case report of community-acquired Acinetobacter meningitis from Punjab, India. Conclusions: This case report highlights the potential pathogenicity of Acinetobacter lwoffii and increases concerns that this organism might rapidly evolve into a dreadful antibiotic-resistant community pathogen.
    Keywords community-acquired ; Acinetobacter ; meningitis ; nosocomial infection ; antibiotics ; Medicine ; R
    Subject code 290
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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