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  1. Article ; Online: Cytokines and Epidermal Lipid Abnormalities in Atopic Dermatitis: A Systematic Review.

    Upadhyay, Parth R / Seminario-Vidal, Lucia / Abe, Brian / Ghobadi, Cyrus / Sims, Jonathan T

    Cells

    2023  Volume 12, Issue 24

    Abstract: ... from its inception to 5 September 2023. Consistent with the dominant T ...

    Abstract Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and presents a major public health problem worldwide. It is characterized by a recurrent and/or chronic course of inflammatory skin lesions with intense pruritus. Its pathophysiologic features include barrier dysfunction, aberrant immune cell infiltration, and alterations in the microbiome that are associated with genetic and environmental factors. There is a complex crosstalk between these components, which is primarily mediated by cytokines. Epidermal barrier dysfunction is the hallmark of AD and is caused by the disruption of proteins and lipids responsible for establishing the skin barrier. To better define the role of cytokines in stratum corneum lipid abnormalities related to AD, we conducted a systematic review of biomedical literature in PubMed from its inception to 5 September 2023. Consistent with the dominant T
    MeSH term(s) Humans ; Dermatitis, Atopic/pathology ; Cytokines/metabolism ; Epidermis/metabolism ; Skin/pathology ; Lipids
    Chemical Substances Cytokines ; Lipids
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12242793
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  2. Article: Stereoselective two-carbon ring expansion of allylic amines

    Mikan, Charles P / Matthews, Aidan / Harris, Daniel / McIvor, Charlotte E / Waddell, Paul G / Sims, Mark T / Knowles, Jonathan P

    Chemical science

    2023  Volume 14, Issue 25, Page(s) 6992–6996

    Abstract: General methodologies enabling the two-carbon homologation of pyrrolidine and piperidine systems have yet to be developed. Herein we report that palladium-catalysed allylic amine rearrangements enable efficient two-carbon ring expansion of 2-alkenyl ... ...

    Abstract General methodologies enabling the two-carbon homologation of pyrrolidine and piperidine systems have yet to be developed. Herein we report that palladium-catalysed allylic amine rearrangements enable efficient two-carbon ring expansion of 2-alkenyl pyrrolidine and piperidines to their azepane and azocane counterparts. Conditions are mild, tolerant of a range of functional groups and the process can occur with high enantioretention. The products formed undergo a range of orthogonal transformations, making them ideal scaffolds for the creation of compound libraries.
    Language English
    Publishing date 2023-06-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc02303f
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  3. Article ; Online: The blood proteomic signature of prurigo nodularis reveals distinct inflammatory and neuropathic endotypes: A cluster analysis.

    Parthasarathy, Varsha / Cravero, Karen / Xu, Lillian / Deng, Junwen / Sun, Zhe / Engle, Sarah M / Sims, Jonathan T / Okragly, Angela J / Kwatra, Shawn G

    Journal of the American Academy of Dermatology

    2023  Volume 88, Issue 5, Page(s) 1101–1109

    Abstract: Background: Prurigo nodularis (PN) is an extremely pruritic, chronic inflammatory skin disease. Little is known about systemic inflammation in PN.: Objective: To characterize plasma inflammatory biomarkers in patients with PN and investigate the ... ...

    Abstract Background: Prurigo nodularis (PN) is an extremely pruritic, chronic inflammatory skin disease. Little is known about systemic inflammation in PN.
    Objective: To characterize plasma inflammatory biomarkers in patients with PN and investigate the presence of disease endotypes.
    Methods: In this cross-sectional study, Olink proteomic analysis was performed on plasma samples from patients with PN (n = 29) and healthy controls (n = 18).
    Results: Patients with PN had increased levels of 8 circulating biomarkers compared to controls, including tumor necrosis factor, C-X-C Motif Chemokine Ligand 9, interleukin-12B, and tumor necrosis factor receptor superfamily member 9 (P < .05). Two PN clusters were identified in cluster 1 (n = 13) and cluster 2 (n = 16). Cluster 2 had higher levels of 25 inflammatory markers than cluster 1. Cluster 1 had a greater percentage of patients with a history of myelopathy and spinal disc disease compared with cluster 2 (69% vs 25%, P = .03). Patients in cluster 2 were more likely to have a history of atopy (38% in cluster 2 vs 8% in cluster 1, P = .09).
    Limitations: Small sample size precludes robust subgroup analyses.
    Conclusion: This study provides evidence of neuroimmune-biased endotypes in PN and can aid clinicians in managing patients with PN that are nonresponsive to traditional therapies.
    MeSH term(s) Humans ; Prurigo/therapy ; Cross-Sectional Studies ; Proteomics ; Pruritus ; Neurodermatitis ; Cluster Analysis
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2023.01.042
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  4. Article ; Online: Serum Interleukin-13 and Caspase 8 are Elevated in Prurigo Nodularis.

    Ju, Teresa / Labib, Angelina / Nattkemper, Leigh / Engle, Sarah / Auxier, Autum / Hahn, Nathan / Sissons, Sean / Sims, Jonathan T / Sun, Zhe / Okragly, Angela J / Yosipovitch, Gil

    Acta dermato-venereologica

    2023  Volume 103, Page(s) adv00861

    MeSH term(s) Humans ; Prurigo ; Interleukin-13 ; Caspase 8 ; Neurodermatitis
    Chemical Substances Interleukin-13 ; Caspase 8 (EC 3.4.22.-)
    Language English
    Publishing date 2023-02-07
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/actadv.v103.4804
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  5. Article ; Online: Transcriptomic Analysis of Healthy and Atopic Dermatitis Samples Reveals the Role of IL-37 in Human Skin.

    Zhou, Jiajun / Gemperline, David C / Turner, Matthew J / Oldach, Jonathan / Molignano, Jennifer / Sims, Jonathan T / Stayrook, Keith R

    ImmunoHorizons

    2021  Volume 5, Issue 10, Page(s) 830–843

    Abstract: ... improve patient outcomes. Dysregulated T ...

    Abstract Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects up to one in five children and millions of adults in developed countries. Clinically, AD skin lesions manifest as subacute and/or chronic lichenified eczematous plaques, which are often intensely pruritic and prone to secondary bacterial and viral infections. Despite the emergence of novel therapeutic agents, treatment options and outcomes for AD remain suboptimal. An improved understanding of AD pathogenesis may help improve patient outcomes. Dysregulated T
    Language English
    Publishing date 2021-10-26
    Publishing country United States
    Document type Journal Article
    ISSN 2573-7732
    ISSN (online) 2573-7732
    DOI 10.4049/immunohorizons.2100055
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  6. Article ; Online: A Piercing Diagnosis - Occult Foreign Body as the Cause of Acute Inguinal Pain.

    Bays-Muchmore, Coral / Sims, Deion T / Gross, Joel A / Ilgen, Jonathan S

    Clinical practice and cases in emergency medicine

    2021  Volume 5, Issue 1, Page(s) 129–130

    Abstract: Case presentation: A 35-year-old woman presented to the emergency department with severe right inguinal pain. Her medical history was non-contributory and there was no known trauma or injury to the region. Amid concern for an incarcerated inguinal ... ...

    Abstract Case presentation: A 35-year-old woman presented to the emergency department with severe right inguinal pain. Her medical history was non-contributory and there was no known trauma or injury to the region. Amid concern for an incarcerated inguinal hernia, a computed tomography was obtained revealing a linear foreign body (FB) lateral to the femoral vessels. The FB was removed without complication at bedside and found to be a beading needle likely occultly lodged three days prior.
    Discussion: Occult inguinal FBs are rare but can lead to deep venous thrombosis or pulmonary embolism if in or near vessels. By nature of being occult, an absence of ingestion, insertion, or penetrative history should not preclude consideration of a FB etiology. Computed tomography imaging is crucial in determining the urgency of, and approach to, inguinal foreign body removal.
    Language English
    Publishing date 2021-02-09
    Publishing country United States
    Document type Journal Article
    ISSN 2474-252X
    ISSN (online) 2474-252X
    DOI 10.5811/cpcem.2020.12.50196
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  7. Article ; Online: To the Point: optimizing the learning environment in labor and delivery.

    Schaffir, Jonathan / Morgan, Helen Kang / Bhargava, Rashmi / Baecher-Lind, Laura / Chen, Katherine T / Fleming, Angela / Morosky, Christopher / Royce, Celeste S / Sims, Shireen Madani / Sonn, Tammy / Stephenson-Famy, Alyssa / Sutton, Jill M

    American journal of obstetrics & gynecology MFM

    2023  Volume 5, Issue 9, Page(s) 101090

    Abstract: The labor and delivery floor is a unique learning environment that poses challenges to teaching medical students, with a potentially detrimental effect on their evaluations of the obstetrics and gynecology clerkship. This article, from the "To the Point" ...

    Abstract The labor and delivery floor is a unique learning environment that poses challenges to teaching medical students, with a potentially detrimental effect on their evaluations of the obstetrics and gynecology clerkship. This article, from the "To the Point" series prepared by the Association of Professors of Gynecology and Obstetrics Undergraduate Medical Education Committee, offers specific suggestions for improving undergraduate medical education in obstetrics with attention to student preparation, faculty development, nonphysician staff involvement, and patient education. Optimizing the learning environment in labor and delivery would improve student experiences and perceptions of our specialty.
    MeSH term(s) Humans ; Clinical Clerkship ; Gynecology ; Obstetrics/education ; Students, Medical ; Education, Medical, Undergraduate
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-9333
    ISSN (online) 2589-9333
    DOI 10.1016/j.ajogmf.2023.101090
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  8. Article ; Online: Strategies to Create a More Gender Identity Inclusive Learning Environment in Preclinical and Clinical Medical Education.

    Baecher-Lind, Laura / Sutton, Jill M / Bhargava, Rashmi / Chen, Katherine T / Fleming, Angela / Morgan, Helen Kang / Morosky, Christopher M / Schaffir, Jonathan / Sonn, Tammy / Royce, Celeste S / Stephenson-Famy, Alyssa / Madani Sims, Shireen

    Academic medicine : journal of the Association of American Medical Colleges

    2023  Volume 98, Issue 12, Page(s) 1351–1355

    Abstract: Abstract: Recognition of the spectrum of gender identities has been a recent phenomenon in the medical profession. Over the past 20 years, medical literature related to gender identity diversity has increased several-fold, yet it more commonly addresses ...

    Abstract Abstract: Recognition of the spectrum of gender identities has been a recent phenomenon in the medical profession. Over the past 20 years, medical literature related to gender identity diversity has increased several-fold, yet it more commonly addresses clinical care rather than aspects related to medical education. Medical educators continue to struggle with appropriate language and inclusive approaches when discussing gender-based aspects of medical education. Reproductive health education, including obstetrics and gynecology clerkships, is particularly vulnerable to missteps and anachronisms regarding gender identity.This article aims to provide preclinical and clinical medical educators with strategies to identify and predict situations where missteps related to gender identity inclusivity may occur in their curriculum or learning environment, and to develop approaches to improve gender identity inclusivity within medical education. The authors explore 3 areas that commonly pose challenges for medical educators: inclusive language and terminology, anatomy education, and reproductive genetics and genetic counseling. They hope the tools and strategies provided here will be useful to reproductive health medical educators across specialties to enable the realization of a more inclusive learning environment in reproductive health.
    MeSH term(s) Humans ; Male ; Female ; Gender Identity ; Gynecology ; Education, Medical ; Learning ; Obstetrics
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000005334
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  9. Article ; Online: Current practices and perspectives on clerkship grading in obstetrics and gynecology.

    Chen, Katherine T / Baecher-Lind, Laura / Morosky, Christopher M / Bhargava, Rashmi / Fleming, Angela / Royce, Celeste S / Schaffir, Jonathan A / Sims, Shireen Madani / Sonn, Tammy / Stephenson-Famy, Alyssa / Sutton, Jill M / Morgan, Helen Kang

    American journal of obstetrics and gynecology

    2023  Volume 230, Issue 1, Page(s) 97.e1–97.e6

    Abstract: Background: Clerkship grades in obstetrics and gynecology play an increasingly important role in the competitive application process to residency programs. An analysis of clerkship grading practices has not been queried in the past 2 decades in our ... ...

    Abstract Background: Clerkship grades in obstetrics and gynecology play an increasingly important role in the competitive application process to residency programs. An analysis of clerkship grading practices has not been queried in the past 2 decades in our specialty.
    Objective: This study aimed to investigate obstetrics and gynecology clerkship directors' practices and perspectives in grading.
    Study design: A 12-item electronic survey was developed and distributed to clerkship directors with active memberships in the Association of Professors of Gynecology and Obstetrics.
    Results: A total of 174 of 236 clerkship directors responded to the survey (a response rate of 73.7%). Respondents reported various grading systems with the fewest (20/173 [11.6%]) using a 2-tiered or pass or fail system and the most (72/173 [41.6%]) using a 4-tiered system. Nearly one-third of clerkship directors (57/163 [35.0%]) used a National Board of Medical Examiners subject examination score threshold to achieve the highest grade. Approximately 45 of 151 clerkship directors (30.0%) had grading committees. Exactly half of the clerkship directors (87/174 [50.0%]) reported requiring unconscious bias training for faculty who assess students. In addition, some responded that students from groups underrepresented in medicine (50/173 [28.9%]) and introverted students (105/173 [60.7%]) received lower evaluations. Finally, 65 of 173 clerkship directors (37.6%) agreed that grades should be pass or fail.
    Conclusion: Considerable heterogeneity exists in obstetrics and gynecology clerkship directors' practices and perspectives in grading. Strategies to mitigate inequities and improve the reliability of grading include the elimination of a subject examination score threshold to achieve the highest grade and the implementation of both unconscious bias training and grading committees.
    MeSH term(s) Humans ; Gynecology/education ; Reproducibility of Results ; Educational Measurement ; Clinical Clerkship ; Obstetrics/education ; Students, Medical
    Language English
    Publishing date 2023-09-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80016-8
    ISSN 1097-6868 ; 0002-9378
    ISSN (online) 1097-6868
    ISSN 0002-9378
    DOI 10.1016/j.ajog.2023.09.020
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  10. Article ; Online: Interleukin-33 antibody failed to demonstrate benefit in a phase II, double-blind, randomized, placebo-controlled study in adult patients with moderate-to-severe atopic dermatitis.

    Laquer, Vivian / Parra, Viviana / Lacour, Jean-Philippe / Takahashi, Hidetoshi / Knorr, Jack / Okragly, Angela J / James, Douglas E / Sims, Jonathan T / Chang, Ching-Yun / Chao, Jeannie / Klekotka, Paul

    The British journal of dermatology

    2022  Volume 187, Issue 4, Page(s) 599–602

    MeSH term(s) Adult ; Antibodies ; Dermatitis, Atopic/drug therapy ; Double-Blind Method ; Humans ; Immunologic Tests ; Interleukin-33
    Chemical Substances Antibodies ; Interleukin-33
    Language English
    Publishing date 2022-07-29
    Publishing country England
    Document type Clinical Trial, Phase II ; Letter ; Randomized Controlled Trial
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.21631
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