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  1. Article ; Online: Structural and molecular imaging in dementia: the heterogeneity of Alzheimer's disease.

    Barkhof, Frederik

    European radiology

    2023  Volume 33, Issue 11, Page(s) 8055–8056

    MeSH term(s) Humans ; Alzheimer Disease/diagnostic imaging ; Dementia/diagnostic imaging ; Cognitive Dysfunction ; Molecular Imaging
    Language English
    Publishing date 2023-05-31
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-09751-5
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  2. Article ; Online: The need for speed: recovering undersampled MRI scans for glioma imaging.

    Barkhof, Frederik / Parker, Geoff Jm

    The Lancet. Oncology

    2024  Volume 25, Issue 3, Page(s) 274–275

    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Glioma/diagnostic imaging
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(24)00036-6
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    Zs.MO 460: Show issues

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  3. Article ; Online: Multiple sclerosis can be diagnosed solely with dissemination in space: Yes.

    Toosy, Ahmed T / Barkhof, Frederik

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2024  , Page(s) 13524585241245313

    Language English
    Publishing date 2024-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585241245313
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  4. Article ; Online: Consistency between Treatment Effects on Clinical and Brain Atrophy Outcomes in Alzheimer's Disease Trials.

    Ten Kate, M / Barkhof, F / Schwarz, A J

    The journal of prevention of Alzheimer's disease

    2024  Volume 11, Issue 1, Page(s) 38–47

    Abstract: Background: Longitudinal changes in volumetric MRI outcome measures have been shown to correlate well with longitudinal changes in clinical instruments and have been widely used as biomarker outcomes in clinical trials for Alzheimer's disease (AD). ... ...

    Abstract Background: Longitudinal changes in volumetric MRI outcome measures have been shown to correlate well with longitudinal changes in clinical instruments and have been widely used as biomarker outcomes in clinical trials for Alzheimer's disease (AD). While instances of discordant findings have been noted in some trials, especially the recent amyloid-removing therapies, the overall relationship between treatment effects on brain atrophy and clinical outcomes, and how it might depend on treatment target or mechanism, clinical instrument or imaging variable is not yet clear.
    Objective: To systematically assess the consistency and therapeutic class-dependence of treatment effects on clinical outcomes and on brain atrophy in published reports of clinical trials conducted in mild cognitive impairment (MCI) and/or AD.
    Design: Quantitative review of the published literature. The consistency of treatment effects on clinical and brain atrophy outcomes was assessed in terms of statistical agreement with hypothesized equal magnitude effects (e.g., 30% slowing of both) and nominal directional concordance, as a function of therapeutic class.
    Setting: Interventional randomized clinical trials.
    Participants: MCI or AD trial participants.
    Intervention: Treatments included were those that involved ingestion or injection of a putatively active substance into the body, encompassing both pharmacological and controlled dietary interventions.
    Measurements: Each trial included in the analysis reported at least one of the required clinical outcomes (ADAS-Cog, CDR-SB or MMSE) and at least one of the required imaging outcomes (whole brain, ventricular or hippocampal volume).
    Results: Data from 35 trials, comprising 185 pairwise comparisons, were included. Overall, the 95% confidence bounds overlapped with the line of identity for 150/185 (81%) of the imaging-clinical variable pairs. The greatest proportion of outliers was found in trials of anti-amyloid antibodies that have been shown to dramatically reduce the level of PET-detectable amyloid plaques, for which only 13/33 (39%) of observations overlapped the identity line. A Deming regression calculated using all data points yielded a slope of 0.54, whereas if data points from the amyloid remover class were excluded, the Deming regression line had a slope of 0.92. Directional discordance of treatment effects was also most pronounced for the amyloid-removing class, and for comparisons involving ventricular volume.
    Conclusion: Our results provide a frame of reference for the interpretation of clinical and brain atrophy results from future clinical trials and highlight the importance of mechanism of action in the interpretation of imaging results.
    MeSH term(s) Humans ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Cognitive Dysfunction/pathology ; Brain ; Hippocampus/pathology ; Atrophy/pathology
    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2782183-3
    ISSN 2426-0266 ; 2274-5807
    ISSN (online) 2426-0266
    ISSN 2274-5807
    DOI 10.14283/jpad.2023.92
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  5. Article ; Online: Computerised emergency work-up for mass-like brain MRI lesions: can explainable AI support radiologists?

    Ferles, Alexandros / Barkhof, Frederik

    European radiology

    2023  Volume 33, Issue 8, Page(s) 5856–5858

    MeSH term(s) Humans ; Multiparametric Magnetic Resonance Imaging ; Artificial Intelligence ; Deep Learning ; Magnetic Resonance Imaging ; Neoplasms ; Brain/diagnostic imaging
    Language English
    Publishing date 2023-06-20
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-09863-y
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  6. Article ; Online: Brain Shrinkage in Anti-β-Amyloid Alzheimer Trials: Neurodegeneration or Pseudoatrophy?

    Barkhof, Frederik / Knopman, David S

    Neurology

    2023  Volume 100, Issue 20, Page(s) 941–942

    MeSH term(s) Humans ; Amyloid beta-Peptides/metabolism ; Alzheimer Disease/drug therapy ; Brain/diagnostic imaging ; Brain/metabolism ; Head
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000207268
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  7. Article ; Online: The optic nerve should be included as one of the typical CNS regions for establishing dissemination in space when diagnosing MS - Commentary.

    Barkhof, Frederik

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2017  Volume 24, Issue 2, Page(s) 125–126

    MeSH term(s) Humans ; Multiple Sclerosis ; Optic Nerve
    Language English
    Publishing date 2017-10-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458517738060
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  8. Article ; Online: Seeing more with less: virtual gadolinium-enhanced glioma imaging.

    Ferles, Alexandros / Barkhof, Frederik

    The Lancet. Digital health

    2021  Volume 3, Issue 12, Page(s) e754–e755

    MeSH term(s) Contrast Media ; Diagnostic Imaging ; Gadolinium ; Glioma/diagnostic imaging ; Humans
    Chemical Substances Contrast Media ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2021-10-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2589-7500
    ISSN (online) 2589-7500
    DOI 10.1016/S2589-7500(21)00219-3
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  9. Article ; Online: Early Detection of Incipient Alzheimer Pathology: Time Is of the Essence.

    Barkhof, Frederik / Pressman, Peter S

    Neurology

    2021  Volume 96, Issue 14, Page(s) 647–648

    MeSH term(s) Aged ; Alzheimer Disease/diagnosis ; Amyloid beta-Peptides ; Early Diagnosis ; Humans ; Positron-Emission Tomography ; tau Proteins
    Chemical Substances Amyloid beta-Peptides ; tau Proteins
    Language English
    Publishing date 2021-03-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000011739
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  10. Article ; Online: Staying Connected: The Relevance of Motor-specific Transcallosal Fibers.

    Barkhof, Frederik / Pontillo, Giuseppe

    Radiology

    2021  Volume 302, Issue 3, Page(s) 650–651

    MeSH term(s) Corpus Callosum ; Humans ; Motor Cortex
    Language English
    Publishing date 2021-11-30
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.212510
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