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  1. Article ; Online: Thermosensitive TRP Channels Are Functionally Expressed and Influence the Lipogenesis in Human Meibomian Gland Cells.

    Keller, Melina / Mergler, Stefan / Li, Aruna / Zahn, Ingrid / Paulsen, Friedrich / Garreis, Fabian

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: While the involvement of thermosensitive transient receptor potential channels (TRPs) in dry eye disease (DED) has been known for years, their expression in the meibomian gland (MG) has never been investigated. This study aims to show their expression ... ...

    Abstract While the involvement of thermosensitive transient receptor potential channels (TRPs) in dry eye disease (DED) has been known for years, their expression in the meibomian gland (MG) has never been investigated. This study aims to show their expression and involvement in the lipogenesis of the MG, providing a possible new drug target in the treatment of DED. Our RT-PCR, Western blot and immunofluorescence analysis showed the expression of
    MeSH term(s) Humans ; Meibomian Glands ; Lipogenesis/genetics ; Meibomian Gland Dysfunction ; Blotting, Western ; Capsaicin/pharmacology
    Chemical Substances Capsaicin (S07O44R1ZM)
    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25074043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bedeutung von transienten Rezeptorpotenzialkanälen für die okuläre Oberfläche: Einblick und Ausblick – von der Laborforschung zur klinischen Praxis.

    Mergler, Stefan / Pleyer, Uwe

    Klinische Monatsblatter fur Augenheilkunde

    2020  Volume 237, Issue 5, Page(s) 637–643

    Abstract: Optimal vision requires an ocular surface with vital epithelial coverage and a stable tear film. A multitude of endogenous and external factors may alter this delicate balance. Studies over the last decade have established that ... ...

    Title translation Importance of Transient Receptor Potential Channels of the Ocular Surface: Insights and Outlook - from Laboratory Research to Clinical Practice.
    Abstract Optimal vision requires an ocular surface with vital epithelial coverage and a stable tear film. A multitude of endogenous and external factors may alter this delicate balance. Studies over the last decade have established that Ca
    MeSH term(s) Calcium ; Conjunctiva ; Cornea ; Tears ; Transient Receptor Potential Channels
    Chemical Substances Transient Receptor Potential Channels ; Calcium (SY7Q814VUP)
    Language German
    Publishing date 2020-04-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-1120-8754
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  3. Article ; Online: Effects of butyrate

    Liebe, Franziska / Liebe, Hendrik / Sponder, Gerhard / Mergler, Stefan / Stumpff, Friederike

    Pflugers Archiv : European journal of physiology

    2022  Volume 474, Issue 3, Page(s) 315–342

    Abstract: The ruminal epithelium absorbs large quantities of ... ...

    Abstract The ruminal epithelium absorbs large quantities of NH
    MeSH term(s) Animals ; Biological Transport/physiology ; Butyrates/metabolism ; Cattle ; Epithelium/metabolism ; HEK293 Cells ; Humans ; Hydrogen-Ion Concentration ; TRPV Cation Channels/metabolism
    Chemical Substances Butyrates ; TRPV Cation Channels ; TRPV3 protein, human ; TRPV4 protein, human
    Language English
    Publishing date 2022-01-31
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-021-02647-7
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  4. Article ; Online: Joint CB1 and NGF Receptor Activation Suppresses TRPM8 Activation in Etoposide-Resistant Retinoblastoma Cells.

    Ludwiczak, Szymon / Reinhard, Jacqueline / Reinach, Peter S / Li, Aruna / Oronowicz, Jakub / Yousf, Aisha / Kakkassery, Vinodh / Mergler, Stefan

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: In childhood, retinoblastoma (RB) is the most common primary tumor in the eye. Long term therapeutic management with etoposide of this life-threatening condition may have diminishing effectiveness since RB cells can develop cytostatic resistance to this ... ...

    Abstract In childhood, retinoblastoma (RB) is the most common primary tumor in the eye. Long term therapeutic management with etoposide of this life-threatening condition may have diminishing effectiveness since RB cells can develop cytostatic resistance to this drug. To determine whether changes in receptor-mediated control of Ca
    MeSH term(s) Humans ; Cell Line ; Etoposide/pharmacology ; Etoposide/therapeutic use ; Membrane Proteins/metabolism ; Receptor, Nerve Growth Factor/metabolism ; Retinal Neoplasms/drug therapy ; Retinoblastoma/drug therapy ; Retinoblastoma/metabolism ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism ; Receptor, Cannabinoid, CB1/metabolism
    Chemical Substances Etoposide (6PLQ3CP4P3) ; Membrane Proteins ; Receptor, Nerve Growth Factor ; TRPM Cation Channels ; TRPM8 channel-associated factor 1 protein, human ; TRPM8 protein, human ; Receptor, Cannabinoid, CB1
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Angiotensin-(1-7) mediated calcium signalling by MAS.

    Sureshkumar, Priyavathi / Souza Dos Santos, Robson Augusto / Alenina, Natalia / Mergler, Stefan / Bader, Michael

    Peptides

    2023  Volume 165, Page(s) 171010

    Abstract: The G protein-coupled receptor, MAS, is the receptor of the endogenous ligand, Angiotensin (Ang)-(1-7). It is a promising drug target since the Ang-(1-7)/MAS axis is protective in the cardiovascular system. Therefore, a characterization of MAS signalling ...

    Abstract The G protein-coupled receptor, MAS, is the receptor of the endogenous ligand, Angiotensin (Ang)-(1-7). It is a promising drug target since the Ang-(1-7)/MAS axis is protective in the cardiovascular system. Therefore, a characterization of MAS signalling is important for developing novel therapeutics for cardiovascular diseases. In this paper, we show that Ang-(1-7) increases intracellular calcium in transiently MAS-transfected HEK293 cells. The calcium influx induced by the activation of MAS is dependent on plasma membrane Ca
    MeSH term(s) Humans ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Mas ; Calcium ; HEK293 Cells
    Chemical Substances Proto-Oncogene Proteins ; Proto-Oncogene Mas ; angiotensin I (1-7) (IJ3FUK8MOF) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2023.171010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Erweiterung der zellbasierten Calcium-Imaging-Methode im eukaryotischen zellfreien Proteinsynthese-System für die transient-receptor-potential (TRP) - Ionenkanäle

    Sureshkumar, Priyavathi [Verfasser] / Bier, Frank Fabian [Akademischer Betreuer] / Kubick, Stefan Akademischer Betreuer] / [Bader, Michael [Akademischer Betreuer] / Mergler, Stefan [Akademischer Betreuer] / Bier, Frank Fabian [Gutachter] / Mergler, Stefan [Gutachter] / Baumann, Otto [Gutachter] / Hinderlich, Stephan [Gutachter]

    2023  

    Author's details Priyavathi Sureshkumar ; Gutachter: Frank Fabian Bier, Stefan Mergler, Otto Baumann, Stephan Hinderlich ; Frank Fabian Bier, Stefan Kubick, Michael Bader, Stefan Mergler
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language German
    Publisher Universität Potsdam
    Publishing place Potsdam
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article ; Online: L-Carnitine Suppresses Transient Receptor Potential Vanilloid Type 1 Activation in Human Corneal Epithelial Cells.

    Lucius, Alexander / Chhatwal, Sirjan / Valtink, Monika / Reinach, Peter S / Li, Aruna / Pleyer, Uwe / Mergler, Stefan

    International journal of molecular sciences

    2023  Volume 24, Issue 14

    Abstract: Tear film hyperosmolarity induces dry eye syndrome (DES) through transient receptor potential vanilloid type 1 (TRPV1) activation. L-carnitine is a viable therapeutic agent since it protects against this hypertonicity-induced response. Here, we ... ...

    Abstract Tear film hyperosmolarity induces dry eye syndrome (DES) through transient receptor potential vanilloid type 1 (TRPV1) activation. L-carnitine is a viable therapeutic agent since it protects against this hypertonicity-induced response. Here, we investigated whether L-carnitine inhibits TRPV1 activation by blocking heat- or capsaicin-induced increases in Ca
    MeSH term(s) Humans ; Carnitine/pharmacology ; Carnitine/metabolism ; Capsaicin/pharmacology ; Capsaicin/metabolism ; Calcium/metabolism ; Antineoplastic Agents/metabolism ; Epithelial Cells/metabolism ; TRPV Cation Channels/metabolism
    Chemical Substances Carnitine (S7UI8SM58A) ; capsazepine (LFW48MY844) ; Capsaicin (S07O44R1ZM) ; Calcium (SY7Q814VUP) ; Antineoplastic Agents ; TRPV Cation Channels
    Language English
    Publishing date 2023-07-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411815
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  8. Article: Bedeutung von transienten Rezeptorpotenzialkanälen für die okuläre Oberfläche: Einblick und Ausblick – von der Laborforschung zur klinischen Praxis

    Mergler, Stefan / Pleyer, Uwe

    Klinische Monatsblätter für Augenheilkunde

    2020  

    Abstract: Für eine optimale visuelle Funktion ist eine Augenoberfläche mit einem vitalen Epithelverband und stabilen Tränenfilm erforderlich. Eine Vielzahl von endogenen und externen Faktoren kann die empfindliche Homöostase der Augenoberfläche beeinflussen und zu ...

    Abstract Für eine optimale visuelle Funktion ist eine Augenoberfläche mit einem vitalen Epithelverband und stabilen Tränenfilm erforderlich. Eine Vielzahl von endogenen und externen Faktoren kann die empfindliche Homöostase der Augenoberfläche beeinflussen und zu einem „trockenen Auge“ führen. Studien im letzten Jahrzehnt haben gezeigt, dass Ca 2+ ein wichtiger Faktor bei der Kontrolle der Epithelfunktion der Augenoberfläche ist. Dabei konnten insbesondere transiente Rezeptorpotenzialkanäle (TRPs) als wichtige Komponenten in Hornhaut- und Bindehautzellen identifiziert werden. Die TRPs sind nicht selektive Kationenkanäle, die als molekulare Sensoren wärme-, nozi- bzw. osmosensibel sind. Unsere Ca 2+ -Imaging- und Patch-Clamp-Studien zeigen, dass die Aktivität von 2 TRP-Isoformen, TRPV1 und TRPM8, durch Änderungen der Osmolarität, der Außentemperatur und einiger endogener Substrate moduliert werden kann. Diese TRPs werden sowohl an nicht neuronalen als auch an neuronalen Hornhautzellen exprimiert. Darüber hinaus beeinflussen diese Wechselwirkungen die Expression von Zytokinen, die inflammatorische Prozesse fördern oder hemmen und damit einen wichtigen Beitrag zur Physiologie des Trockenen Auges leisten. Zusammengenommen führen diese Ergebnisse nicht nur zu einem besseren Verständnis der Pathophysiologie von Schmerz- und Entzündungsreaktionen der Augenoberfläche. Diese Studien können auch neue Wege aufzeigen, um die Pathophysiologie der Krankheit zu verstehen und die Entwicklung neuer therapeutischer Angriffspunkte beim Syndrom des Trockenen Auges fördern.
    Keywords Hornhaut ; Trockenes Auge ; proinflammatorische Zytokine ; TRP-Kanäle ; cornea ; dry eye ; pro-inflammatory cytokines ; TRP channels
    Language German
    Publishing date 2020-04-14
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0023-2165 ; 0344-6360 ; 0344-6387
    ISSN (online) 1439-3999
    ISSN 0023-2165 ; 0344-6360 ; 0344-6387
    DOI 10.1055/a-1120-8754
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  9. Article ; Online: Angiotensin-(1−7) mediated calcium signalling by MAS

    Sureshkumar, Priyavathi / Souza dos Santos, Robson Augusto / Alenina, Natalia / Mergler, Stefan / Bader, Michael

    Peptides. 2023 July, v. 165 p.171010-

    2023  

    Abstract: The G protein-coupled receptor, MAS, is the receptor of the endogenous ligand, Angiotensin (Ang)-(1−7). It is a promising drug target since the Ang-(1−7)/MAS axis is protective in the cardiovascular system. Therefore, a characterization of MAS signalling ...

    Abstract The G protein-coupled receptor, MAS, is the receptor of the endogenous ligand, Angiotensin (Ang)-(1−7). It is a promising drug target since the Ang-(1−7)/MAS axis is protective in the cardiovascular system. Therefore, a characterization of MAS signalling is important for developing novel therapeutics for cardiovascular diseases. In this paper, we show that Ang-(1−7) increases intracellular calcium in transiently MAS-transfected HEK293 cells. The calcium influx induced by the activation of MAS is dependent on plasma membrane Ca²⁺ channels, phospholipase C, and protein kinase C. Specifically, we could demonstrate that MAS employs non-selective, transient receptor potential channels (TRPs) for calcium entry.
    Keywords G-protein coupled receptors ; calcium ; cardiovascular system ; drugs ; ligands ; peptides ; phospholipase C ; plasma membrane ; protein kinase C ; therapeutics ; Ang-1–7 ; AT1 Receptor ; AT2 Receptor ; GPCR ; RAAS ; TRP ; PLC-ß ; PKC ; HBSS ; Angiotensin ; MAS ; Trp channel
    Language English
    Dates of publication 2023-07
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 769028-9
    ISSN 1873-5169 ; 0196-9781
    ISSN (online) 1873-5169
    ISSN 0196-9781
    DOI 10.1016/j.peptides.2023.171010
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Neurotrophe Keratopathie : Grundlagen, Diagnostik und Therapie.

    Mergler, Stefan / Dietrich-Ntoukas, Tina / Pleyer, Uwe

    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft

    2019  Volume 116, Issue 8, Page(s) 797–810

    Abstract: Corneal nerves are responsible for the reception of pain, temperature, and touch and are an important component of homeostasis of the ocular surface. When the corneal innervation is reduced, degenerative changes can be manifested as neurotrophic ... ...

    Title translation Neurotrophic keratopathy : Principles, diagnostics and treatment.
    Abstract Corneal nerves are responsible for the reception of pain, temperature, and touch and are an important component of homeostasis of the ocular surface. When the corneal innervation is reduced, degenerative changes can be manifested as neurotrophic keratopathy (NK). In a stage-dependent course, corneal epithelial alterations and ulcers may occur, even leading to perforation. The cause of NK is predominantly damage to the trigeminal nerve, which can be caused by infections (especially herpesviruses), metabolic diseases (such as diabetes mellitus) and by surgical procedures. The diagnosis of NK requires a detailed medical and ocular history, assessment of corneal sensitivity, and a complete ocular examination. The treatment of NK is oriented to the clinical severity and aims to restore the integrity of the ocular surface in order to prevent further disease progression.
    MeSH term(s) Cornea ; Corneal Dystrophies, Hereditary ; Disease Progression ; Humans ; Keratitis ; Trigeminal Nerve Diseases
    Language German
    Publishing date 2019-08-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1105167-x
    ISSN 1433-0423 ; 0941-293X
    ISSN (online) 1433-0423
    ISSN 0941-293X
    DOI 10.1007/s00347-019-0946-7
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