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  1. Article ; Online: Ecotoxicology of Polymetallic Nodule Seabed Mining: The Effects of Cobalt and Nickel on Phytoplankton Growth and Pigment Concentration.

    Ou, Rimei / Huang, Hao / He, Xuebao / Lin, Shuangshuang / Ou, Danyun / Li, Weiwen / Qiu, Jinli / Wang, Lei

    Toxics

    2023  Volume 11, Issue 12

    Abstract: In order to improve the understanding of the environmental impacts of polymetallic nodule mining, ecotoxicological studies were conducted on the growth of model phytoplankton ... ...

    Abstract In order to improve the understanding of the environmental impacts of polymetallic nodule mining, ecotoxicological studies were conducted on the growth of model phytoplankton species
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics11121005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Variants located in intron 6 of

    Qu, Yujin / Bai, Jinli / Jiao, Hui / Qi, Hong / Huang, Wenchen / OuYang, Shijia / Peng, Xiaoyin / Jin, Yuwei / Wang, Hong / Song, Fang

    Heliyon

    2024  Volume 10, Issue 6, Page(s) e28015

    Abstract: Accurate genetic diagnosis is necessary for guiding the treatment of spinal muscular atrophy (SMA). An updated consensus for the diagnosis and management of SMA was published in 2018. However, clinicians should remain alert to some pitfalls of genetic ... ...

    Abstract Accurate genetic diagnosis is necessary for guiding the treatment of spinal muscular atrophy (SMA). An updated consensus for the diagnosis and management of SMA was published in 2018. However, clinicians should remain alert to some pitfalls of genetic testing that can occur when following a routine diagnosis. In this study, we report the diagnosis of three unrelated individuals who were initially misdiagnosed as carrying a homozygous deletion of
    Language English
    Publishing date 2024-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Simulation Experiment of Environmental Impact of Deep-Sea Mining: Response of Phytoplankton Community to Polymetallic Nodules and Sediment Enrichment in Surface Water.

    Ou, Rimei / Cai, Lei / Qiu, Jinli / Huang, Hao / Ou, Danyun / Li, Weiwen / Lin, Fanyu / He, Xuebao / Wang, Lei / Wu, Risheng

    Toxics

    2022  Volume 10, Issue 10

    Abstract: In this paper, simulation experiments were conducted to study the response of phytoplankton biomass and community composition to the influence of polymetallic nodules and sediment at four stations in the western Pacific in 2021. ... ...

    Abstract In this paper, simulation experiments were conducted to study the response of phytoplankton biomass and community composition to the influence of polymetallic nodules and sediment at four stations in the western Pacific in 2021. Chlorophyll
    Language English
    Publishing date 2022-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics10100610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Inapparent decrease in phytoplankton biomass accompanied by significant size composition succession in the shellfish aquaculture farm in the western Taiwan strait

    Yu Mo / Aifeng Li / Zhaohe Luo / Cun Jia / Rimei Ou / Jinli Qiu / Xinyu Chang / Hao Huang / Lei Wang

    Frontiers in Marine Science, Vol

    2023  Volume 10

    Abstract: We conducted an annual monthly sampling in the aquaculture areas of Lianjiang and Zhangpu, Fujian province, in the west coast of the Taiwan Strait, to gain insight into the effects of shellfish aquaculture on total phytoplankton biomass and its ... ...

    Abstract We conducted an annual monthly sampling in the aquaculture areas of Lianjiang and Zhangpu, Fujian province, in the west coast of the Taiwan Strait, to gain insight into the effects of shellfish aquaculture on total phytoplankton biomass and its distribution in phytoplankton size fractions. We observed that the total chlorophyll-a (TChl-a) concentration was higher in Zhangpu (annual mean 2.690 ± 2.375 μg/L) than in Lianjiang (annual mean 1.700 ± 1.500 μg/L) and that Lianjiang had a high N/P ratio during the study, which may have been the main reason for the differences in phytoplankton biomass between the two shellfish aquaculture areas. The response of phytoplankton to shellfish aquaculture was different in the northern versus southern areas. During the aquaculture period of Lianjiang, the TChl-a concentration of surface water was approximately 14% lower than that of bottom water, and such a decreasing trend of Chl-a concentration was consistently present in micro-, nano-, and pico-size fractions. Phytoplankton depletion was not observed during investigation in Zhangpu, which showed highly variable in environmental factors. The contribution of pico-sized Chl-a to TChl-a is evaluated by shellfish aquaculture to some extent in Lianjiang. The shift from the dominance of nano-phytoplankton to the dominance of micro- phytoplankton and pico-phytoplankton was caused mainly by seasonal variation in environmental conditions. In complex marine environments, the distribution of phytoplankton biomass in phytoplankton size fractions showed no significant response to shellfish aquaculture.
    Keywords phytoplankton ; size structure ; aquaculture ; hydrodynamic ; Taiwan strait ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
    Subject code 333
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Isolation, Structural, Functional, and Bioactive Properties of Cereal Arabinoxylan─A Critical Review.

    He, Hong-Ju / Qiao, Jinli / Liu, Yan / Guo, Qingbin / Ou, Xingqi / Wang, Xiaochan

    Journal of agricultural and food chemistry

    2021  Volume 69, Issue 51, Page(s) 15437–15457

    Abstract: Arabinoxylans (AXs) are widely distributed in various cereal grains, such as wheat, corn, rye, barley, rice, and oat. The AX molecule contains a linear (1,4)-β-D- ... ...

    Abstract Arabinoxylans (AXs) are widely distributed in various cereal grains, such as wheat, corn, rye, barley, rice, and oat. The AX molecule contains a linear (1,4)-β-D-xyl
    MeSH term(s) Edible Grain ; Hordeum ; Triticum ; Xylans
    Chemical Substances Xylans
    Language English
    Publishing date 2021-11-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.1c04506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Isolation, Structural, Functional, and Bioactive Properties of Cereal Arabinoxylan─A Critical Review

    He, Hong-Ju / Qiao, Jinli / Liu, Yan / Guo, Qingbin / Ou, Xingqi / Wang, Xiaochan

    Journal of agricultural and food chemistry. 2021 Nov. 29, v. 69, no. 51

    2021  

    Abstract: Arabinoxylans (AXs) are widely distributed in various cereal grains, such as wheat, corn, rye, barley, rice, and oat. The AX molecule contains a linear (1,4)-β-D-xylp backbone substituted by α-L-araf units and occasionally t-xylp and t-glcpA through α-(1, ...

    Abstract Arabinoxylans (AXs) are widely distributed in various cereal grains, such as wheat, corn, rye, barley, rice, and oat. The AX molecule contains a linear (1,4)-β-D-xylp backbone substituted by α-L-araf units and occasionally t-xylp and t-glcpA through α-(1,2) and/or α-(1,3) glycosidic linkages. Arabinoxylan shows diversified functional and bioactive properties, influenced by their molecular mass, branching degree, ferulic acid (FA) content, and the substitution position and chain length of the side chains. This Review summarizes the extraction methods for various cereal sources, compares their structural features and functional/bioactive properties, and highlights the established structure–function/bioactivity relationships, intending to explore the potential functions of AXs and their industrial applications.
    Keywords arabinoxylan ; barley ; corn ; ferulic acid ; food chemistry ; molecular weight ; oats ; rice ; rye ; wheat
    Language English
    Dates of publication 2021-1129
    Size p. 15437-15457.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.1c04506
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Novel Alu-mediated deletions of the SMN1 gene were identified by ultra-long read sequencing technology in patients with spinal muscular atrophy.

    Bai, Jinli / Qu, Yujin / OuYang, Shijia / Jiao, Hui / Wang, Yang / Li, Jingjing / Huang, Wenchen / Zhao, Yunlong / Peng, Xiaoyin / Wang, Depeng / Jin, Yuwei / Wang, Hong / Song, Fang

    Neuromuscular disorders : NMD

    2023  Volume 33, Issue 5, Page(s) 382–390

    Abstract: Spinal muscular atrophy (SMA) is a neuromuscular disease caused by biallelic variants of the survival motor neuron 1 (SMN1) gene. In this study, our aim was to make a molecular diagnosis in two patients with SMA carrying only one SMN1 copy number. Using ... ...

    Abstract Spinal muscular atrophy (SMA) is a neuromuscular disease caused by biallelic variants of the survival motor neuron 1 (SMN1) gene. In this study, our aim was to make a molecular diagnosis in two patients with SMA carrying only one SMN1 copy number. Using ultra-long read sequencing (Ultra-LRS), 1415 bp deletion and 3348 bp deletion of the SMN1 gene were identified in patient 1 and the father of patient 2, respectively. Ultra-LRS revealed two novel deletions, starting from the SMN1 promoter to intron 1. It also accurately provided the location of the deletion breakpoints in the SMN1 gene: chr5 g.70,924,798-70,926,212 for a 1415 bp deletion; chr5 g.70,922,695-70,926,042 for a 3348 bp deletion. By analyzing the breakpoint junctions, we identified that these genomic sequences were composed of Alu sequences, including AluJb, AluYm1, AluSq, and AluYm1, indicating that Alu-mediated rearrangements are a mechanism of SMN1 deletion events. In addition, full-length SMN1 transcripts and SMN protein in patient 1 were significantly decreased (p < 0.01), suggesting that a 1415 bp deletion that included the transcription and translation initiation sites of the SMN1 gene had severe consequences for SMN expression. Ultra-LRS can easily distinguish highly homozygous genes compared to other detection technologies, which is useful for detecting SMN1 intragenic mutations, to quickly discover structural rearrangements and to precisely present the breakpoint positions.
    MeSH term(s) Humans ; Muscular Atrophy, Spinal/diagnosis ; Muscular Atrophy, Spinal/genetics ; Mutation ; Homozygote ; Promoter Regions, Genetic ; Motor Neurons ; Survival of Motor Neuron 1 Protein/genetics
    Chemical Substances Survival of Motor Neuron 1 Protein ; SMN1 protein, human
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077681-3
    ISSN 1873-2364 ; 0960-8966
    ISSN (online) 1873-2364
    ISSN 0960-8966
    DOI 10.1016/j.nmd.2023.03.001
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  8. Article ; Online: Single-nucleotide polymorphisms influence the promoter activities of systemic lupus erythematosus-associated genes.

    Qiu, Jinjun / Qin, Xiaoming / Wen, Jinli / Wu, Li / Kong, Lei / Ou, Yangxi / Yang, Shucai

    Biotechnology letters

    2020  Volume 42, Issue 10, Page(s) 1887–1896

    Abstract: Systemic lupus erythematosus (SLE) is a protypical autoimmune disease and genetic factors play important roles in its pathogenesis. Since present SLE susceptibility loci are mainly studied through meta-analysis of genome-wide association study, we ... ...

    Abstract Systemic lupus erythematosus (SLE) is a protypical autoimmune disease and genetic factors play important roles in its pathogenesis. Since present SLE susceptibility loci are mainly studied through meta-analysis of genome-wide association study, we performed promoter activity analysis to examine the biological functions of SLE-associated single-nucleotide polymorphisms (SNPs). We found at SNP positions rs1341239, rs1800795, rs1800796, rs1800872, rs1800871, rs187238, rs360719, rs8178822, rs3761549, different alleles influenced respective promoter activities in different manners, and the effects also appeared under glucocorticoid treatment. In addition, some SNPs showed strong correlations with levels of respective serum factors, but in most cases the associations were only demonstrated in SLE individuals. Our study has further disclose the functional roles of SLE-associate SNPs in SLE pathogenesis.
    MeSH term(s) Adult ; Female ; Forkhead Transcription Factors/genetics ; Genome-Wide Association Study ; Humans ; Interleukins/genetics ; Lupus Erythematosus, Systemic/genetics ; Polymorphism, Single Nucleotide/genetics ; Promoter Regions, Genetic/genetics ; Young Adult
    Chemical Substances FOXP3 protein, human ; Forkhead Transcription Factors ; Interleukins
    Language English
    Publishing date 2020-05-25
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 423853-9
    ISSN 1573-6776 ; 0141-5492
    ISSN (online) 1573-6776
    ISSN 0141-5492
    DOI 10.1007/s10529-020-02916-y
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  9. Article: Single-nucleotide polymorphisms influence the promoter activities of systemic lupus erythematosus-associated genes

    Qiu, Jinjun / Qin, Xiaoming / Wen, Jinli / Wu, Li / Kong, Lei / Ou, Yangxi / Yang, Shucai

    Biotechnology letters. 2020 Oct., v. 42, no. 10

    2020  

    Abstract: Systemic lupus erythematosus (SLE) is a protypical autoimmune disease and genetic factors play important roles in its pathogenesis. Since present SLE susceptibility loci are mainly studied through meta-analysis of genome-wide association study, we ... ...

    Abstract Systemic lupus erythematosus (SLE) is a protypical autoimmune disease and genetic factors play important roles in its pathogenesis. Since present SLE susceptibility loci are mainly studied through meta-analysis of genome-wide association study, we performed promoter activity analysis to examine the biological functions of SLE-associated single-nucleotide polymorphisms (SNPs). We found at SNP positions rs1341239, rs1800795, rs1800796, rs1800872, rs1800871, rs187238, rs360719, rs8178822, rs3761549, different alleles influenced respective promoter activities in different manners, and the effects also appeared under glucocorticoid treatment. In addition, some SNPs showed strong correlations with levels of respective serum factors, but in most cases the associations were only demonstrated in SLE individuals. Our study has further disclose the functional roles of SLE-associate SNPs in SLE pathogenesis.
    Keywords biotechnology ; blood serum ; genome-wide association study ; glucocorticoids ; lupus erythematosus ; meta-analysis ; pathogenesis
    Language English
    Dates of publication 2020-10
    Size p. 1887-1896.
    Publishing place Springer Netherlands
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 423853-9
    ISSN 1573-6776 ; 0141-5492
    ISSN (online) 1573-6776
    ISSN 0141-5492
    DOI 10.1007/s10529-020-02916-y
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Ganoderma lucidum

    Xie, Jinli / Liu, Yanghanxiu / Chen, Bohui / Zhang, Guangwen / Ou, Shiyi / Luo, Jianming / Peng, Xichun

    Food & nutrition research

    2019  Volume 63

    Abstract: Background: The effects of β-glucan on colitis mice are contradictory in previous reports. As a result, it is still unclear whether there is an anti-colitis effect in : Objective: This study aimed to investigate whether GLP consumption improved rat ... ...

    Abstract Background: The effects of β-glucan on colitis mice are contradictory in previous reports. As a result, it is still unclear whether there is an anti-colitis effect in
    Objective: This study aimed to investigate whether GLP consumption improved rat dextran sodium sulfate (DSS)-induced colitis by regulating gut microbiota and altering colonic epithelial expression.
    Design: The disease activity index (DAI) scores and the cecal short chain fatty acid (SCFA) levels of DSS-induced colitis rats fed with a GLP diet (Group GLP,
    Results: GLP consumption significantly lowered animal DAI scores by producing more SCFAs by increasing SCFA-producing bacteria such as
    Conclusions: GLP consumption alleviated DSS-induced colitis and may have potential for ulcerative colitis relief.
    Language English
    Publishing date 2019-02-12
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 2418338-6
    ISSN 1654-661X ; 1654-661X ; 1654-6628
    ISSN (online) 1654-661X
    ISSN 1654-661X ; 1654-6628
    DOI 10.29219/fnr.v63.1559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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