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Article ; Online: The Day the Computers Went Down.

Hsia, Katie L

2020 Volume 273, Issue 4, Page(s) e138

MeSH term(s)	Computers/statistics & numerical data ; Humans ; Surgery, Computer-Assisted/statistics & numerical data ; Surgical Procedures, Operative/methods
Language	English
Publishing date	2020-10-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000004445
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Article ; Online: Characterizing the Reaction of Doctors to COVID-19 on Twitter.

Hsia, Katie / Kong, Edward

Journal of quantitative description: digital media

2022 Volume 2

Abstract: With the recent surges of new COVID-19 variants, clear public health messaging on social media has become more vital than ever. One important source of public health information are messages and reactions expressed by medical professionals. However, the ... ...

Abstract	With the recent surges of new COVID-19 variants, clear public health messaging on social media has become more vital than ever. One important source of public health information are messages and reactions expressed by medical professionals. However, the content of messages promogulated by these experts are not fully understood. In this study, we demonstrate how unique Twitter data can be used to explore doctors' reactions to the early months of the COVID-19 pandemic. We examine 265,412 English-language tweets about COVID-19 from doctors and a comparable subset of tweets from non-doctors using two-sample t-tests with a Bonferroni-corrected significance threshold. We elucidate how discussion differed over time and in comparison to non-doctors. Tweets spiked surrounding major events and in locations with rising case numbers. Discussion from doctors initially focused on the origin of the virus in Wuhan, later switching to calls to "stay home." Doctors tweeted more often about public health and healthcare workers, whereas non-doctors were more likely to tweet about political topics, including China and the Trump administration. The differences in how doctors and non-doctors engage about COVID-19 can provide insight into the similarities and differences in communication between medical experts and the public. For example, in future surges, experts could tailor their health messaging around topics of interest to the general public to increase engagement. Alternatively, topics that differ across groups may warrant educational messages to better align expert and public perspectives. By identifying both areas of shared purpose and differences in prioritized topics, future public health communications may benefit from analyses that compare the social media messages promulgated by various groups.
Language	English
Publishing date	2022-05-05
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-8813
ISSN (online)	2673-8813
DOI	10.51685/jqd.2022.012
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Article ; Online: Colorectal Neoplasia in Asian Americans Undergoing First Time Asymptomatic Average-risk Screening Colonoscopies.

Chen, Brendan / Hsia, Katie / Loscalzo, Kirsten / Fai, Caitlin / Gupta, Samir / Jangi, Sushrut

Journal of clinical gastroenterology

2024

Abstract: Goals: We identified the prevalence and subtype of colorectal neoplasia removed during index screening colonoscopies in a large Asian American population.: Background: Asian Americans are the fastest growing demographic group in the United States yet ...

Abstract	Goals: We identified the prevalence and subtype of colorectal neoplasia removed during index screening colonoscopies in a large Asian American population. Background: Asian Americans are the fastest growing demographic group in the United States yet there is a paucity of data on the characteristics of colorectal neoplasia found in this cohort. Study: Cross-sectional study of 2208 index colonoscopies performed on average-risk Asian and White patients at a large, tertiary academic center. Patients were identified via diagnostic or procedure codes between 2015 and 2020, with retrospective classification of polyp histopathology. Univariate and multivariate analysis were performed to identify risk factors associated with colorectal neoplasia. Results: A total of 2208 patients were identified, of which 1085 were Asian. When adjusted for age and sex, Asians were as likely as Whites to have any type of colorectal neoplasia [44.2% vs. 43.5%, odds ratio (OR)=0.93, (CI: 0.78-1.11)]. On multivariate analysis, Asians were less likely to have sessile serrated polyps (5.5% vs. 9.9%, OR=0.53, 95% CI: 0.38-0.73) and more likely to have tubular adenomas in the left colon (22.6% vs. 18.0%, OR=1.33, 95% CI: 1.08-1.64) compared with Whites. Conclusions: Quality measures, such as sessile serrated polyp detection rates, may need to take into account demographic factors such as race. The prevalence of colorectal neoplasia among Asian Americans is substantial and warrants efforts to promote optimal uptake of colorectal cancer screening tests.
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/MCG.0000000000001969
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Article: Inhibition of metastatic brain cancer in Sonic Hedgehog medulloblastoma using caged nitric oxide albumin nanoparticles.

Soltys, Bohdan J / Grausam, Katie B / Messerli, Shanta M / Hsia, Carleton J C / Zhao, Haotian

Frontiers in oncology

2023 Volume 13, Page(s) 1129533

Abstract: Medulloblastoma is a tumor of the cerebellum that metastasizes to the leptomeninges of the central nervous system (CNS), including to forebrain and to spinal cord. The inhibitory effect of polynitroxylated albumin (PNA), a caged nitroxide nanoparticle, ... ...

Abstract	Medulloblastoma is a tumor of the cerebellum that metastasizes to the leptomeninges of the central nervous system (CNS), including to forebrain and to spinal cord. The inhibitory effect of polynitroxylated albumin (PNA), a caged nitroxide nanoparticle, on leptomeningeal dissemination and metastatic tumor growth was studied in a Sonic Hedgehog transgenic mouse model. PNA treated mice showed an increased lifespan with a mean survival of 95 days (n = 6,
Language	English
Publishing date	2023-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1129533
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Article ; Online: Splenomegaly, Non-Traumatic Splenic Rupture, and Pancytopenia in Patient with Human Granulocytic Anaplasmosis.

Hsia, Katie / Johnson, Jennie / Rice, Donald

Rhode Island medical journal (2013)

2021 Volume 104, Issue 2, Page(s) 60–62

Abstract: Background: Splenic rupture is a well-described complication of babesiosis but is rarely associated with anaplasmosis.: Case presentation: We report a case of a 37-year-old man with no significant past medical history who presented with malaise, ... ...

Abstract	Background: Splenic rupture is a well-described complication of babesiosis but is rarely associated with anaplasmosis. Case presentation: We report a case of a 37-year-old man with no significant past medical history who presented with malaise, myalgias, arthralgias and severe left upper quadrant pain. He was found to have splenic rupture secondary to infection by Anaplasma phagocytophilum. He reported a single tick bite the week prior to onset of his symptoms. On presentation, he was found to have left upper quadrant abdominal tenderness, pancytopenia, and splenomegaly with evidence of splenic rupture and hemoperitoneum on contrasted computed tomography. Blood smear did not demonstrate intraerythrocytic parasites or morulae. His hemoperitoneum was treated conservatively and he was empirically treated for babesiosis. Diagnosis was confirmed by a positive serum PCR for Anaplasma phagocytophilum. Conclusions: This case study adds to the small number of prior case reports and provides evidence for anaplasmosis-associated splenic rupture.
MeSH term(s)	Adult ; Anaplasma phagocytophilum ; Anaplasmosis/complications ; Anaplasmosis/diagnosis ; Humans ; Male ; Pancytopenia ; Splenic Rupture/diagnostic imaging ; Splenic Rupture/etiology ; Splenomegaly/etiology
Language	English
Publishing date	2021-03-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	419430-5
ISSN	2327-2228 ; 0363-7913
ISSN (online)	2327-2228
ISSN	0363-7913
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Article ; Online: Dynamics of the Gut Mycobiome in Patients With Ulcerative Colitis.

Jangi, Sushrut / Hsia, Katie / Zhao, Naisi / Kumamoto, Carol A / Friedman, Sonia / Singh, Siddharth / Michaud, Dominique S

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2023 Volume 22, Issue 4, Page(s) 821–830.e7

Abstract: Background & aims: Intestinal fungi have been implicated in the pathogenesis of ulcerative colitis (UC). However, it remains unclear if fungal composition is altered during active versus quiescent disease.: Methods: We analyzed clinical and ... ...

Abstract	Background & aims: Intestinal fungi have been implicated in the pathogenesis of ulcerative colitis (UC). However, it remains unclear if fungal composition is altered during active versus quiescent disease. Methods: We analyzed clinical and metagenomic data from the Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD), available via the IBD Plexus Program of the Crohn's & Colitis Foundation. We evaluated the fungal composition of fecal samples from 421 patients with UC during clinical activity and remission. Within a longitudinal subcohort (n = 52), we assessed for dynamic taxonomic changes across alterations in clinical activity over time. We examined if fungal amplicon sequence variants and fungal-bacterial relationships were altered during activity versus remission. Finally, we classified activity in UC using a supervised machine learning random forest model trained on fungal abundance data. Results: During clinical activity, the relative abundance of genus Candida was increased 3.5-fold (P-adj < 1 × 10 Conclusions: Clinical activity in UC is associated with an increased relative abundance of Candida, cross-sectionally and dynamically over time. The role of fecal Candida as a target for therapeutics in UC should be evaluated.
MeSH term(s)	Adult ; Humans ; Colitis, Ulcerative/pathology ; Mycobiome ; Prospective Studies ; Crohn Disease/complications ; Inflammatory Bowel Diseases/complications ; Feces/microbiology
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2023.09.023
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Article ; Online: Microbial butyrate capacity is reduced in inflamed mucosa in patients with ulcerative colitis.

Jangi, Sushrut / Moyer, John / Sandlow, Sarah / Fu, May / Chen, Hannah / Shum, Ann / Hsia, Katie / Cersosimo, Laura / Yeliseyev, Vladimir / Zhao, Naisi / Bry, Lynn / Michaud, Dominique S

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3479

Abstract: Reduced butyrate-production capacity has been reported in fecal microbial communities in patients with active ulcerative colitis. However, the butyrate-production capacity of the mucosal microbiome from active vs quiescent mucosa in ulcerative colitis ... ...

Abstract	Reduced butyrate-production capacity has been reported in fecal microbial communities in patients with active ulcerative colitis. However, the butyrate-production capacity of the mucosal microbiome from active vs quiescent mucosa in ulcerative colitis has been unexplored. We sought to determine the diversity and relative abundance of mucosal bacterial and fungal communities from endoscopically active vs quiescent mucosa in patients with UC, and aimed to predict contributions of mucosal microbial communities to butyrate synthesis. Systematic, segmental right- and left-sided biopsies were obtained from endoscopically active (n = 13) or quiescent (n = 17) colonic mucosa, among 15 patients with pan-colonic ulcerative colitis. Dietary fiber intake of patients was performed using the validated five-item FiberScreen questionnaire. Amplicon sequencing of mucosal bacteria and fungi was performed. The diversity and relative abundance of mucosal bacterial and fungal taxa were quantified, and predicted contributions to butyrate synthesis were ascertained. Bacterial alpha and beta diversity were similar between active vs quiescent mucosa. Butyrogenic taxa were significantly increased in quiescence, including Butyricimonas, Subdoligranulum, and Alistipes. Predicted butyrate kinase activity was significantly and concomitantly increased in quiescent mucosa. Fiber intake was positively correlated with butyrogenic microbes. Compared to mucosal bacterial prevalence, mucosal fungi were detected in low prevalence. Butyrogenic microbes are relatively increased in quiescent mucosa in ulcerative colitis, and may be related to increased fiber intake during quiescence. Manipulation of the mucosal microbiome towards butyrate-producing bacteria may be associated with endoscopic quiescence.
MeSH term(s)	Humans ; Colitis, Ulcerative/pathology ; Butyrates ; Colon/pathology ; Biopsy ; Intestinal Mucosa/pathology ; Bacteria/genetics
Chemical Substances	Butyrates
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54257-9
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Article ; Online: Alterations in the Fungal Microbiome in Ulcerative Colitis.

Hsia, Katie / Zhao, Naisi / Chung, Mei / Algarrahi, Khalid / Montaser Kouhsari, Laleh / Fu, May / Chen, Hannah / Singh, Siddharth / Michaud, Dominique S / Jangi, Sushrut

Inflammatory bowel diseases

2023 Volume 29, Issue 10, Page(s) 1613–1621

Abstract: Background: Although gut fungi have been implicated in the immunopathogenesis of inflammatory bowel disease, the fungal microbiome has not been deeply explored across endohistologic activity and treatment exposure in ulcerative colitis.: Methods: We ... ...

Abstract	Background: Although gut fungi have been implicated in the immunopathogenesis of inflammatory bowel disease, the fungal microbiome has not been deeply explored across endohistologic activity and treatment exposure in ulcerative colitis. Methods: We analyzed data from the SPARC IBD (Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease) registry. We evaluated the fungal composition of fecal samples from 98 patients with ulcerative colitis across endoscopic activity (n = 43), endohistologic activity (n = 41), and biologic exposure (n = 82). Across all subgroups, we assessed fungal diversity and differential abundance of taxonomic groups. Results: We identified 500 unique fungal amplicon sequence variants across the cohort of 82 patients, dominated by phylum Ascomycota. Compared with endoscopic remission, patients with endoscopic activity had increased Saccharomyces (log2 fold change = 4.54; adjusted P < 5 × 10-5) and increased Candida (log2 fold change = 2.56; adjusted P < .03). After adjusting for age, sex, and biologic exposure among patients with endoscopic activity, Saccharomyces (log2 fold change = 7.76; adjusted P < 1 × 10-15) and Candida (log2 fold change = 7.28; adjusted P< 1 × 10-8) remained enriched during endoscopic activity compared with quiescence. Conclusions: Endoscopic inflammation in ulcerative colitis is associated with an expansion of Saccharomyces and Candida compared with remission. The role of these fungal taxa as potential biomarkers and targets for personalized approaches to therapeutics in ulcerative colitis should be evaluated.
MeSH term(s)	Adult ; Humans ; Colitis, Ulcerative/therapy ; Mycobiome ; Prospective Studies ; Gastrointestinal Microbiome ; Inflammatory Bowel Diseases/microbiology ; Candida ; Biological Products
Chemical Substances	Biological Products
Language	English
Publishing date	2023-05-21
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1340971-2
ISSN	1536-4844 ; 1078-0998
ISSN (online)	1536-4844
ISSN	1078-0998
DOI	10.1093/ibd/izad082
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Article: Elevated Total Serum Immunoglobulin A Levels in Patients with Suspicion for Celiac Disease.

Sia, Twan / Bacchus, Leeon / Cunningham, Evan / Hsia, Katie / Miller, Megan / Epstein, Taylor / Myftija, Yasmine / Mousad, Albert / Dinesh, Yerramalla Sai / Maddisetty, Harika / Chandra, Vinay / Guo, Ziqi / Gupta, Anya / Johnson, Stephanie / Logan, Julia / Mawyer, Emily / Scheve, Ally / Yu, Haitong / Leung, John

Journal of clinical medicine

2023 Volume 12, Issue 15

Abstract: Patients with classic symptoms of celiac disease are often initially tested for serum tissue transglutaminase-immunoglobulin A (tTG-IgA) and total serum immunoglobulin A (IgA) levels concurrently, as IgA deficiency can lead to falsely low tTG-IgA. There ... ...

Abstract	Patients with classic symptoms of celiac disease are often initially tested for serum tissue transglutaminase-immunoglobulin A (tTG-IgA) and total serum immunoglobulin A (IgA) levels concurrently, as IgA deficiency can lead to falsely low tTG-IgA. There are no guidelines for incidental findings of elevated total serum IgA when testing for celiac disease. In our study, we described the proportion of patients with suspicion of celiac disease who had elevated total serum IgA and the factors that may be associated with these findings. We studied the management of these patients with incidental findings of elevated total serum IgA to identify its clinical significance. To investigate, we performed a retrospective chart review of patients who underwent celiac disease serologic testing at a single clinic from January 2017 to June 2022. We reported further laboratory workup and follow-up for patients with incidental findings of elevated total serum IgA by board-certified immunologists. In our chart review, 848 patients were identified, 85 (10.0%) of whom were found to be negative for celiac disease but had elevated total serum IgA levels (median IgA 351 mg/dL, interquartile range 324-382). Out of 85 patients, 73 were further evaluated by immunologists, with 55 patients undergoing additional laboratory workup. None were diagnosed with specific immunologic conditions. Male sex was identified as associated with elevated total serum IgA findings, and constipation was found in a statistically significant greater frequency of patients with normal total serum IgA rather than elevated total serum IgA. To provide external validation of our findings, we created a second patient cohort within the Stanford Research Repository database. Out of 33,875 patients identified, a similarly high proportion of patients were negative for celiac disease but had elevated total serum IgA levels (9.3%, 3140 patients). In this separate patient cohort, male sex was also identified as being associated with elevated total serum IgA. Our study also provides preliminary evidence that patients with incidental findings of elevated total serum IgA may not need further management or workup, as these abnormalities may not be clinically relevant without other clinical suspicions.
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12155101
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Article ; Online: Elevated Total Serum Immunoglobulin A Levels in Patients with Suspicion for Celiac Disease

Twan Sia / Leeon Bacchus / Evan Cunningham / Katie Hsia / Megan Miller / Taylor Epstein / Yasmine Myftija / Albert Mousad / Yerramalla Sai Dinesh / Harika Maddisetty / Vinay Chandra / Ziqi Guo / Anya Gupta / Stephanie Johnson / Julia Logan / Emily Mawyer / Ally Scheve / Haitong Yu / John Leung

Journal of Clinical Medicine, Vol 12, Iss 5101, p

2023 Volume 5101

Abstract	Patients with classic symptoms of celiac disease are often initially tested for serum tissue transglutaminase-immunoglobulin A (tTG-IgA) and total serum immunoglobulin A (IgA) levels concurrently, as IgA deficiency can lead to falsely low tTG-IgA. There are no guidelines for incidental findings of elevated total serum IgA when testing for celiac disease. In our study, we described the proportion of patients with suspicion of celiac disease who had elevated total serum IgA and the factors that may be associated with these findings. We studied the management of these patients with incidental findings of elevated total serum IgA to identify its clinical significance. To investigate, we performed a retrospective chart review of patients who underwent celiac disease serologic testing at a single clinic from January 2017 to June 2022. We reported further laboratory workup and follow-up for patients with incidental findings of elevated total serum IgA by board-certified immunologists. In our chart review, 848 patients were identified, 85 (10.0%) of whom were found to be negative for celiac disease but had elevated total serum IgA levels (median IgA 351 mg/dL, interquartile range 324–382). Out of 85 patients, 73 were further evaluated by immunologists, with 55 patients undergoing additional laboratory workup. None were diagnosed with specific immunologic conditions. Male sex was identified as associated with elevated total serum IgA findings, and constipation was found in a statistically significant greater frequency of patients with normal total serum IgA rather than elevated total serum IgA. To provide external validation of our findings, we created a second patient cohort within the Stanford Research Repository database. Out of 33,875 patients identified, a similarly high proportion of patients were negative for celiac disease but had elevated total serum IgA levels (9.3%, 3140 patients). In this separate patient cohort, male sex was also identified as being associated with elevated total serum IgA. Our study also ...
Keywords	IgA ; tissue transglutaminase-immunoglobulin A ; tTG-IgA ; serology ; celiac ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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