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Article: Charge-transfer chemistry of two corticosteroids used adjunctively to treat COVID-19. Part I: Complexation of hydrocortisone and dexamethasone donors with DDQ acceptor in five organic solvents.

Adam, Abdel Majid A / Saad, Hosam A / Refat, Moamen S / Hegab, Mohamed S

2022 Volume 357, Page(s) 119092

Abstract: COVID-19 is the disease caused by a novel coronavirus (CoV) named the severe acute respiratory syndrome coronavirus 2 (termed SARS coronavirus 2 or SARS-CoV-2). Since the first case reported in December 2019, infections caused by this novel virus have ... ...

Abstract	COVID-19 is the disease caused by a novel coronavirus (CoV) named the severe acute respiratory syndrome coronavirus 2 (termed SARS coronavirus 2 or SARS-CoV-2). Since the first case reported in December 2019, infections caused by this novel virus have led to a continuous global pandemic that has placed an unprecedented burden on health, economic, and social systems worldwide. In response, multiple therapeutic options have been developed to stop this pandemic. One of these options is based on traditional corticosteroids, however, chemical modifications to enhance their efficacy remain largely unexplored. Obtaining additional insight into the chemical and physical properties of pharmacologically effective drugs used to combat COVID-19 will help physicians and researchers alike to improve current treatments and vaccines (i.e., Pfizer-BioNTech, AstraZeneca, Moderna, Janssen). Herein, we examined the charge-transfer properties of two corticosteroids used as adjunctive therapies in the treatment of COVID-19, hydrocortisone and dexamethasone, as donors with 2,3-dichloro-5,6-dicyano-
Language	English
Publishing date	2022-04-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491496-7
ISSN	1873-3166 ; 0167-7322
ISSN (online)	1873-3166
ISSN	0167-7322
DOI	10.1016/j.molliq.2022.119092
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Data on charge-transfer interaction between 1-methyl-3-trifluoromethyl-2-pyrazoline-5-one with PA, CLA, TFQ, DDQ and TCNQ π-acceptors.

Adam, Abdel Majid A / Altalhi, Tariq A / Saad, Hosam A / Refat, Moamen S / Hegab, Mohamed S

Data in brief

2021 Volume 36, Page(s) 107137

Abstract: This article is related to a research paper entitled "Exploring the charge-transfer chemistry of fluorine-containing pyrazolin-5-ones: The complexation of 1-methyl-3-trifluoromethyl-2-pyrazoline-5-one with five π-acceptors" [J. Mol. Liq. 331 (2021) ... ...

Abstract	This article is related to a research paper entitled "Exploring the charge-transfer chemistry of fluorine-containing pyrazolin-5-ones: The complexation of 1-methyl-3-trifluoromethyl-2-pyrazoline-5-one with five π-acceptors" [J. Mol. Liq. 331 (2021) 115814] [1]. Herein we present photographic data that showed the color change after mixing methanolic solutions of 1-methyl-3-trifluoromethyl-2-pyrazoline-5-one (donor) with each of the investigated π-acceptor [picric acid (PA), chloranilic acid (CLA), fluoranil (TFQ), DDQ, and TCNQ]. Stoichiometry data for the interaction of the donor with all acceptors determined in solution state by the spectrophotometric titration method and the Job's continuous variation method were presented. The data presented are useful for understand that the charge-transfer (CT) complexation between a donor and an acceptor, generally, is characterized by a strong color change, and to understand the stoichiometry between these molecules.
Language	English
Publishing date	2021-05-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2021.107137
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Charge-transfer complexation of TCNE with azithromycin, the antibiotic used worldwide to treat the coronavirus disease (COVID-19). Part IV: A comparison between solid and liquid interactions.

Adam, Abdel Majid A / Refat, Moamen S / Altalhi, Tariq A / Alsuhaibani, Khaled Saleh

Journal of molecular liquids

2021 Volume 340, Page(s) 117224

Abstract: Finding a cure or vaccine for the coronavirus disease (COVID-19) is the most pressing issue facing the world in 2020 and 2021. One of the more promising current treatment protocols is based on the antibiotic azithromycin (AZM) alone or in combination ... ...

Abstract	Finding a cure or vaccine for the coronavirus disease (COVID-19) is the most pressing issue facing the world in 2020 and 2021. One of the more promising current treatment protocols is based on the antibiotic azithromycin (AZM) alone or in combination with other drugs (e.g., chloroquine, hydroxychloroquine). We believe gaining new insight into the charge-transfer (CT) chemistry of this antibiotic will help researchers and physicians alike to improve these treatment protocols. Therefore, in this work, we examine the CT interaction between AZM (donor) and tetracyanoethylene (TCNE, acceptor) in either solid or liquid forms. We found that, for both phases of starting materials, AZM reacted strongly with TCNE to produce a colored, stable complex with 1:2 AZM to TCNE stoichiometry via a n → π* transition (AZM → TCNE). Even though both methodologies yielded the same product, we recommend the solid-solid interaction since it is more straightforward, environmentally friendly, and cost- and time-effective.
Language	English
Publishing date	2021-08-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491496-7
ISSN	1873-3166 ; 0167-7322
ISSN (online)	1873-3166
ISSN	0167-7322
DOI	10.1016/j.molliq.2021.117224
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Charge-transfer chemistry of azithromycin, the antibiotic used worldwide to treat the coronavirus disease (COVID-19). Part III: A green protocol for facile synthesis of complexes with TCNQ, DDQ, and TFQ acceptors.

Adam, Abdel Majid A / Saad, Hosam A / Alsuhaibani, Amnah M / Refat, Moamen S / Hegab, Mohamed S

Journal of molecular liquids

2021 Volume 335, Page(s) 116250

Abstract: Investigating the chemical properties of molecules used to combat the COVID-19 pandemic is of vital and pressing importance. In continuation of works aimed to explore the charge-transfer chemistry of azithromycin, the antibiotic used worldwide to treat ... ...

Abstract	Investigating the chemical properties of molecules used to combat the COVID-19 pandemic is of vital and pressing importance. In continuation of works aimed to explore the charge-transfer chemistry of azithromycin, the antibiotic used worldwide to treat COVID-19, the disease resulting from infection with the novel SARS-CoV-2 virus, in this work, a highly efficient, simple, clean, and eco-friendly protocol was used for the facile synthesis of charge-transfer complexes (CTCs) containing azithromycin and three π-acceptors: 7,7,8,8-tetracyanoquinodimethane (TCNQ), 2,3-dichloro-5,6-dicyano-
Language	English
Publishing date	2021-04-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491496-7
ISSN	1873-3166 ; 0167-7322
ISSN (online)	1873-3166
ISSN	0167-7322
DOI	10.1016/j.molliq.2021.116250
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Charge-transfer chemistry of two corticosteroids used adjunctively to treat COVID-19. Part II: The CT reaction of hydrocortisone and dexamethasone donors with TCNQ and fluoranil acceptors in five organic solvents.

Refat, Moamen S / Albogami, Bander / Adam, Abdel Majid A / Saad, Hosam A / Alsuhaibani, Amnah Mohammed / Miyan, Lal / Hegab, Mohamed S

Journal of molecular liquids

2022 Volume 363, Page(s) 119878

Abstract: Hydrocortisone (termed as D1) and dexamethasone (termed as D2) are corticosteroids currently used to treat COVID-19. COVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Exploring additional chemical properties of ...

Abstract	Hydrocortisone (termed as D1) and dexamethasone (termed as D2) are corticosteroids currently used to treat COVID-19. COVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Exploring additional chemical properties of drugs used in the treatment protocols for COVID-19 could help scientists alike improve these treatment protocols and potentially even the vaccines (i.e., Janssen, Moderna, AstraZeneca, Pfizer-BioNTech). In this work, the charge-transfer (CT) properties of these two corticosteroids (D1 and D2) with two universal acceptors: 7,8,8-tetracyanoquinodimethane (termed as TCNQ) and fluoranil (termed as TFQ) in five different solvents were investigated. The examined solvents were MeOH, EtOH, MeCN, CH
Language	English
Publishing date	2022-07-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491496-7
ISSN	1873-3166 ; 0167-7322
ISSN (online)	1873-3166
ISSN	0167-7322
DOI	10.1016/j.molliq.2022.119878
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nano-structured complexes of reserpine and quinidine drugs with chloranilic acid based on intermolecular H-bond: spectral and surface morphology studies.

Adam, Abdel Majid A

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2014 Volume 127, Page(s) 107–114

Abstract: The study of the drug-acceptor interaction may be useful in understanding the drug-receptor interactions and the mechanism of drug action. Here, complexes of reserpine (Res) and quinidine (Qui) drugs with chloranilic acid (CLA) have been synthesized. ... ...

Abstract	The study of the drug-acceptor interaction may be useful in understanding the drug-receptor interactions and the mechanism of drug action. Here, complexes of reserpine (Res) and quinidine (Qui) drugs with chloranilic acid (CLA) have been synthesized. Then, these complexes were characterized chemically and structurally using CHN elemental analysis, infrared (IR) and electronic absorption spectroscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM). The stoichiometry of the H-bonded complex was found to have a 1:1 ratio, so these complexes can be formulated as [(Drug)(CLA)]. IR measurements confirmed the presence of intermolecular H-bond. Application of Debye-Scherrer equation indicates that the formed complexes are in the range of nano-size. The Res complex exhibits a remarkable crystalline morphology. It was also found that the particle size of Res complex is 1.533 time higher than that of Qui complex. Interestingly, free Res molecular weight is higher than that of free Qui by the same ratio (precisely; 1.525).
MeSH term(s)	Adrenergic Uptake Inhibitors/chemistry ; Adrenergic alpha-Antagonists/chemistry ; Benzoquinones/chemistry ; Hydrogen Bonding ; Nanoparticles/chemistry ; Quinidine/chemistry ; Reserpine/chemistry ; Spectrum Analysis
Chemical Substances	Adrenergic Uptake Inhibitors ; Adrenergic alpha-Antagonists ; Benzoquinones ; Reserpine (8B1QWR724A) ; Quinidine (ITX08688JL) ; chloranilic acid (YJ8L3BB7Y4)
Language	English
Publishing date	2014-06-05
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2014.02.077
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Article: Charge-transfer chemistry of azithromycin, the antibiotic used worldwide to treat the coronavirus disease (COVID-19). Part I: Complexation with iodine in different solvents.

Adam, Abdel Majid A / Saad, Hosam A / Alsuhaibani, Amnah M / Refat, Moamen S / Hegab, Mohamed S

Journal of molecular liquids

2020 Volume 325, Page(s) 115187

Abstract: Around the world, the antibiotic azithromycin (AZM) is currently being used to treat the coronavirus disease (COVID-19) in conjunction with hydroxychloroquine or chloroquine. Investigating the chemical and physical properties of compounds used alone or ... ...

Abstract	Around the world, the antibiotic azithromycin (AZM) is currently being used to treat the coronavirus disease (COVID-19) in conjunction with hydroxychloroquine or chloroquine. Investigating the chemical and physical properties of compounds used alone or in combination to combat the COVID-19 pandemic is of vital and pressing importance. The purpose of this study was to characterize the charge transfer (CT) complexation of AZM with iodine in four different solvents: CH
Language	English
Publishing date	2020-12-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491496-7
ISSN	1873-3166 ; 0167-7322
ISSN (online)	1873-3166
ISSN	0167-7322
DOI	10.1016/j.molliq.2020.115187
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Data on charge-transfer interaction between 1-methyl-3-trifluoromethyl-2-pyrazoline-5-one with PA, CLA, TFQ, DDQ and TCNQ π-acceptors

Adam, Abdel Majid A. / Altalhi, Tariq A. / Saad, Hosam A. / Refat, Moamen S. / Hegab, Mohamed S.

Data in Brief. 2021 June, v. 36

2021

Abstract: This article is related to a research paper entitled “Exploring the charge-transfer chemistry of fluorine-containing pyrazolin-5-ones: The complexation of 1-methyl-3-trifluoromethyl-2-pyrazoline-5-one with five π-acceptors” [J. Mol. Liq. 331 (2021) ... ...

Abstract	This article is related to a research paper entitled “Exploring the charge-transfer chemistry of fluorine-containing pyrazolin-5-ones: The complexation of 1-methyl-3-trifluoromethyl-2-pyrazoline-5-one with five π-acceptors” [J. Mol. Liq. 331 (2021) 115814] [1]. Herein we present photographic data that showed the color change after mixing methanolic solutions of 1-methyl-3-trifluoromethyl-2-pyrazoline-5-one (donor) with each of the investigated π-acceptor [picric acid (PA), chloranilic acid (CLA), fluoranil (TFQ), DDQ, and TCNQ]. Stoichiometry data for the interaction of the donor with all acceptors determined in solution state by the spectrophotometric titration method and the Job's continuous variation method were presented. The data presented are useful for understand that the charge-transfer (CT) complexation between a donor and an acceptor, generally, is characterized by a strong color change, and to understand the stoichiometry between these molecules.
Keywords	color ; stoichiometry ; titration
Language	English
Dates of publication	2021-06
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2021.107137
Database	NAL-Catalogue (AGRICOLA)

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Article: Charge-transfer chemistry of azithromycin, the antibiotic used worldwide to treat the coronavirus disease (COVID-19). Part II: Complexation with several π-acceptors (PA, CLA, CHL).

Adam, Abdel Majid A / Saad, Hosam A / Alsuhaibani, Amnah M / Refat, Moamen S / Hegab, Mohamed S

Journal of molecular liquids

2020 Volume 325, Page(s) 115121

Abstract: Finding a vaccine or cure for the coronavirus disease (COVID-19) responsible for the worldwide pandemic and its economic, medical, and psychological burdens is one of the most pressing issues presently facing the global community. One of the current ... ...

Abstract	Finding a vaccine or cure for the coronavirus disease (COVID-19) responsible for the worldwide pandemic and its economic, medical, and psychological burdens is one of the most pressing issues presently facing the global community. One of the current treatment protocols involves the antibiotic azithromycin (AZM) alone or in combination with other compounds. Obtaining additional insight into the charge-transfer (CT) chemistry of this antibiotic could help researchers and clinicians to improve such treatment protocols. Toward this aim, we investigated the CT interactions between AZM and three π-acceptors: picric acid (PA), chloranilic acid (CLA), and chloranil (CHL) in MeOH solvent. AZM formed colored products at a 1:1 stoichiometry with the acceptors through intermolecular hydrogen bonding. An n → π* interaction was also proposed for the AZM-CHL CT product. The synthesized CT products had markedly different morphologies from the free reactants, exhibiting a semi-crystalline structure composed of spherical particles with diameters ranging from 50 to 90 nm.
Language	English
Publishing date	2020-12-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491496-7
ISSN	1873-3166 ; 0167-7322
ISSN (online)	1873-3166
ISSN	0167-7322
DOI	10.1016/j.molliq.2020.115121
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Charge-transfer interaction of aspartame and neotame with several π-acceptors: Stoichiometric data.

Adam, Abdel Majid A / Altalhi, Tariq A / Saad, Hosam A / Alsuhaibani, Amnah M / Refat, Moamen S / Hegab, Mohamed S

Data in brief

2021 Volume 36, Page(s) 107092

Abstract: This data article is related to a research paper entitled ``Correlations between spectroscopic data for charge-transfer complexes of two artificial sweeteners, aspartame and neotame, generated with several π-acceptors'' [J. Mol. Liq. 333 (2021) 115904] [ ... ...

Abstract	This data article is related to a research paper entitled ``Correlations between spectroscopic data for charge-transfer complexes of two artificial sweeteners, aspartame and neotame, generated with several π-acceptors'' [J. Mol. Liq. 333 (2021) 115904] [1]. Herein we present stoichiometric data of charge-transfer (CT) complexes generated from the interaction between aspartame and neotame with three π-acceptors in methanol solvent at room temperature. The investigated π-acceptors were picric acid (PA), chloranilic acid (CA), and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), where the methods used to determine the stoichiometry of the CT interaction were the spectrophotometric titration method and the Job's continuous variation method.
Language	English
Publishing date	2021-04-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2021.107092
Database	MEDical Literature Analysis and Retrieval System OnLINE

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