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Article ; Online: Synchronous rare tumors in a pediatric patient with a de novo cancer predisposition syndrome.

Ohlsen, Timothy J D / Scanlon, Samantha / Perez, Francisco A / Ermoian, Ralph P / Paulson, Vera A / Hauptman, Jason S / Crotty, Erin E / Ting, Michelle A

Pediatric blood & cancer

2022 Volume 69, Issue 11, Page(s) e29746

MeSH term(s)	Child ; Disease Susceptibility ; Genetic Predisposition to Disease ; Humans ; Neoplasms, Multiple Primary/genetics ; Neoplasms, Multiple Primary/pathology
Language	English
Publishing date	2022-04-28
Publishing country	United States
Document type	Letter
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.29746
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Article ; Online: Author Correction: Observed controls on resilience of groundwater to climate variability in sub-Saharan Africa.

Cuthbert, Mark O / Taylor, Richard G / Favreau, Guillaume / Todd, Martin C / Shamsudduha, Mohammad / Villholth, Karen G / MacDonald, Alan M / Scanlon, Bridget R / Kotchoni, D O Valerie / Vouillamoz, Jean-Michel / Lawson, Fabrice M A / Adjomayi, Philippe Armand / Kashaigili, Japhet / Seddon, David / Sorensen, James P R / Ebrahim, Girma Yimer / Owor, Michael / Nyenje, Philip M / Nazoumou, Yahaya /

Goni, Ibrahim / Ousmane, Boukari Issoufou / Sibanda, Tenant / Ascott, Matthew J / Macdonald, David M J / Agyekum, William / Koussoubé, Youssouf / Wanke, Heike / Kim, Hyungjun / Wada, Yoshihide / Lo, Min-Hui / Oki, Taikan / Kukuric, Neno

Nature

2020 Volume 588, Issue 7838, Page(s) E25

Language	English
Publishing date	2020-12-02
Publishing country	England
Document type	Published Erratum
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-020-2985-2
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Article ; Online: Electrosynthesis of Biocompatible Free-Standing PEDOT Thin Films at a Polarized Liquid|Liquid Interface.

Lehane, Rob A / Gamero-Quijano, Alonso / Malijauskaite, Sigita / Holzinger, Angelika / Conroy, Michele / Laffir, Fathima / Kumar, Amit / Bangert, Ursel / McGourty, Kieran / Scanlon, Micheál D

Journal of the American Chemical Society

2022 Volume 144, Issue 11, Page(s) 4853–4862

Abstract: Conducting polymers (CPs) find applications in energy conversion and storage, sensors, and biomedical technologies once processed into thin films. Hydrophobic CPs, like poly(3,4-ethylenedioxythiophene) (PEDOT), typically require surfactant additives, ... ...

Abstract	Conducting polymers (CPs) find applications in energy conversion and storage, sensors, and biomedical technologies once processed into thin films. Hydrophobic CPs, like poly(3,4-ethylenedioxythiophene) (PEDOT), typically require surfactant additives, such as poly(styrenesulfonate) (PSS), to aid their aqueous processability as thin films. However, excess PSS diminishes CP electrochemical performance, biocompatibility, and device stability. Here, we report the electrosynthesis of PEDOT thin films at a polarized liquid\|liquid interface, a method nonreliant on conductive solid substrates that produces free-standing, additive-free, biocompatible, easily transferrable, and scalable 2D PEDOT thin films of any shape or size in a single step at ambient conditions. Electrochemical control of thin film nucleation and growth at the polarized liquid\|liquid interface allows control over the morphology, transitioning from 2D (flat on both sides with a thickness of <50 nm) to "Janus" 3D (with flat and rough sides, each showing distinct physical properties, and a thickness of >850 nm) films. The PEDOT thin films were
MeSH term(s)	Bridged Bicyclo Compounds, Heterocyclic/chemistry ; Electric Conductivity ; Electrodes ; Polymers/chemistry
Chemical Substances	Bridged Bicyclo Compounds, Heterocyclic ; Polymers ; poly(3,4-ethylene dioxythiophene)
Language	English
Publishing date	2022-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.1c12373
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Article ; Online: Observed controls on resilience of groundwater to climate variability in sub-Saharan Africa.

Nature

2019 Volume 572, Issue 7768, Page(s) 230–234

Abstract: Groundwater in sub-Saharan Africa supports livelihoods and poverty ... ...

Abstract	Groundwater in sub-Saharan Africa supports livelihoods and poverty alleviation
MeSH term(s)	Africa South of the Sahara ; Desert Climate ; Droughts/statistics & numerical data ; Groundwater/analysis ; Rain
Language	English
Publishing date	2019-08-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-019-1441-7
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Article: Electrosynthesis of Biocompatible Free-Standing PEDOT Thin Films at a Polarized Liquid|Liquid Interface

Lehane, Rob A. / Gamero-Quijano, Alonso / Malijauskaite, Sigita / Holzinger, Angelika / Conroy, Michele / Laffir, Fathima / Kumar, Amit / Bangert, Ursel / McGourty, Kieran / Scanlon, Micheál D.

Journal of the American Chemical Society. 2022 Mar. 09, v. 144, no. 11

2022

Abstract	Conducting polymers (CPs) find applications in energy conversion and storage, sensors, and biomedical technologies once processed into thin films. Hydrophobic CPs, like poly(3,4-ethylenedioxythiophene) (PEDOT), typically require surfactant additives, such as poly(styrenesulfonate) (PSS), to aid their aqueous processability as thin films. However, excess PSS diminishes CP electrochemical performance, biocompatibility, and device stability. Here, we report the electrosynthesis of PEDOT thin films at a polarized liquid\|liquid interface, a method nonreliant on conductive solid substrates that produces free-standing, additive-free, biocompatible, easily transferrable, and scalable 2D PEDOT thin films of any shape or size in a single step at ambient conditions. Electrochemical control of thin film nucleation and growth at the polarized liquid\|liquid interface allows control over the morphology, transitioning from 2D (flat on both sides with a thickness of <50 nm) to “Janus” 3D (with flat and rough sides, each showing distinct physical properties, and a thickness of >850 nm) films. The PEDOT thin films were p-doped (approaching the theoretical limit), showed high π–π conjugation, were processed directly as thin films without insulating PSS and were thus highly conductive without post-processing. This work demonstrates that interfacial electrosynthesis directly produces PEDOT thin films with distinctive molecular architectures inaccessible in bulk solution or at solid electrode–electrolyte interfaces and emergent properties that facilitate technological advances. In this regard, we demonstrate the PEDOT thin film’s superior biocompatibility as scaffolds for cellular growth, opening immediate applications in organic electrochemical transistor (OECT) devices for monitoring cell behavior over extended time periods, bioscaffolds, and medical devices, without needing physiologically unstable and poorly biocompatible PSS.
Keywords	biocompatibility ; cell growth ; electrochemistry ; electrosynthesis ; energy conversion ; films (materials) ; hydrophobicity ; surfactants ; transistors
Language	English
Dates of publication	2022-0309
Size	p. 4853-4862.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.1c12373
Database	NAL-Catalogue (AGRICOLA)

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Article: Perceptions of physical activity engagement among adults with rheumatoid arthritis and rheumatologists.

Iversen, Maura D / Scanlon, Lauren / Frits, Michelle / Shadick, Nancy A / Sharby, Nancy

International journal of clinical rheumatology

2015 Volume 10, Issue 2, Page(s) 67–77

Abstract: Aim: Physical activity (PA) among adults with rheumatoid arthritis (RA) is suboptimal. This study assessed PA motivations and perceptions in adults with RA and rheumatologists.: Methods: Patients and rheumatologists participated in structured ... ...

Abstract	Aim: Physical activity (PA) among adults with rheumatoid arthritis (RA) is suboptimal. This study assessed PA motivations and perceptions in adults with RA and rheumatologists. Methods: Patients and rheumatologists participated in structured interviews led by a behavioral scientist. Sessions were audiotaped, transcribed and coded. Results: Twenty-three patients (mean age = 63 [standard deviation = 10], 96% female) and seven rheumatologists (57% male, 29% fellows) participated. Nine themes emerged: communication with the rheumatologist, environment/access, symptom management, social support, mental health, breaking inactivity cycles, integrating PA into routines, staying in control and challenge/intimidation. Highly active patients viewed PA differently than low active patients. The need to compete with RA-free individuals may impede PA. Conclusion: Understanding how patients conceptualize PA will enable clinicians to formulate PA strategies to motivate patients.
Language	English
Publishing date	2015-06-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2596494-X
ISSN	1758-4280 ; 1758-4272
ISSN (online)	1758-4280
ISSN	1758-4272
DOI	10.2217/ijr.15.3
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Article ; Online: Observed controls on resilience of groundwater to climate variability in sub-Saharan Africa

Cuthbert, Mark O. / Taylor, R.G. / Favreau, G. / Todd, Martin C. / Shamsudduha, Mohammad / Villholth, Karen G. / MacDonald, Alan M. / Scanlon, Bridget R. / Kotchoni, D.O. Valerie / Vouillamoz, Jean-Michel / Lawson, Fabrice M.A. / Adjomayi, Philippe Armand / Kashaigili, Japhet J. / Seddon, D. / Sorensen, J.P.R. / Ebrahim, Girma Yimer / Owor, M. / Nyenje, P.M. / Nazoumou, Y /

Goni, I. / Ousmane, B.I. / Sibanda, T. / Ascott, Matthew J. / Macdonald, David M.J. / Agyekum, W. / Koussoube, Y. / Wanke, H. / Kim, H. / Wada, Y. / Lo, M.-H. / Oki, T. / Kukuric, N.

Nature

2019

Abstract: Groundwater in sub-Saharan Africa supports livelihoods and poverty alleviation1,2 , maintains vital ecosystems, and strongly influences terrestrial water and energy budgets3 . Yet the hydrological processes that govern groundwater recharge and ... ...

Abstract	Groundwater in sub-Saharan Africa supports livelihoods and poverty alleviation1,2 , maintains vital ecosystems, and strongly influences terrestrial water and energy budgets3 . Yet the hydrological processes that govern groundwater recharge and sustainability—and their sensitivity to climatic variability—are poorly constrained4,5 . Given the absence of firm observational constraints, it remains to be seen whether model-based projections of decreased water resources in dry parts of the region4 are justified. Here we show, through analysis of multidecadal groundwater hydrographs across sub-Saharan Africa, that levels of aridity dictate the predominant recharge processes, whereas local hydrogeology influences the type and sensitivity of precipitation–recharge relationships. Recharge in some humid locations varies by as little as five per cent (by coefficient of variation) across a wide range of annual precipitation values. Other regions, by contrast, show roughly linear precipitation–recharge relationships, with precipitation thresholds (of roughly ten millimetres or less per day) governing the initiation of recharge. These thresholds tend to rise as aridity increases, and recharge in drylands is more episodic and increasingly dominated by focused recharge through losses from ephemeral overland flows. Extreme annual recharge is commonly associated with intense rainfall and flooding events, themselves often driven by large-scale climate controls. Intense precipitation, even during years of lower overall precipitation, produces some of the largest years of recharge in some dry subtropical locations. Our results therefore challenge the ‘high certainty’ consensus regarding decreasing water resources4 in such regions of sub-Saharan Africa. The potential resilience of groundwater to climate variability in many areas that is revealed by these precipitation–recharge relationships is essential for informing reliable predictions of climate-change impacts and adaptation strategies.
Keywords	groundwater recharge ; climate change ; resilience ; groundwater table ; observation ; precipitation ; hydrology ; hydrography ; models ; arid zones ; rain
Language	English
Publishing date	2019-11-14T03:37:28Z
Publisher	Springer
Publishing country	fr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Observed controls on resilience of groundwater to climate variability in sub-Saharan Africa

Cuthbert, Mark O. / Taylor, Richard G. / Favreau, Guillaume / Todd, Martin C. / Shamsudduha, Mohammad / Villholth, Karen G. / MacDonald, Alan M. / Scanlon, Bridget R. / Kotchoni, D.O. Valerie / Vouillamoz, Jean-Michel / Lawson, Fabrice M.A. / Adjomayi, Philippe Armand / Kashaigili, Japhet J. / Seddon, David / Sorensen, James P. R. / Ebrahim, Girma Yimer / Owor, Michael / Nyenje, Philip M. / Nazoumou, Yahaya /

Goni, Ibrahim / Ousmane, Boukari Issoufou / Sibanda, Tenant / Ascott, Matthew J. / Macdonald, David M.J. / Agyekum, William / Koussoubé, Youssouf / Wanke, Heike / Kim, Hyungjun / Wada, Yoshihide / Lo, Min-Hui / Oki, Taikan / Kukuric, Neno

Nature

2019

Abstract: Groundwater in sub-Saharan Africa supports livelihoods and poverty alleviation1,2, maintains vital ecosystems, and strongly influences terrestrial water and energy budgets3. Yet the hydrological processes that govern groundwater recharge and ... ...

Abstract	Groundwater in sub-Saharan Africa supports livelihoods and poverty alleviation1,2, maintains vital ecosystems, and strongly influences terrestrial water and energy budgets3. Yet the hydrological processes that govern groundwater recharge and sustainability—and their sensitivity to climatic variability—are poorly constrained4,5. Given the absence of firm observational constraints, it remains to be seen whether model-based projections of decreased water resources in dry parts of the region4 are justified. Here we show, through analysis of multidecadal groundwater hydrographs across sub-Saharan Africa, that levels of aridity dictate the predominant recharge processes, whereas local hydrogeology influences the type and sensitivity of precipitation–recharge relationships. Recharge in some humid locations varies by as little as five per cent (by coefficient of variation) across a wide range of annual precipitation values. Other regions, by contrast, show roughly linear precipitation–recharge relationships, with precipitation thresholds (of roughly ten millimetres or less per day) governing the initiation of recharge. These thresholds tend to rise as aridity increases, and recharge in drylands is more episodic and increasingly dominated by focused recharge through losses from ephemeral overland flows. Extreme annual recharge is commonly associated with intense rainfall and flooding events, themselves often driven by large-scale climate controls. Intense precipitation, even during years of lower overall precipitation, produces some of the largest years of recharge in some dry subtropical locations. Our results therefore challenge the ‘high certainty’ consensus regarding decreasing water resources4 in such regions of sub-Saharan Africa. The potential resilience of groundwater to climate variability in many areas that is revealed by these precipitation–recharge relationships is essential for informing reliable predictions of climate-change impacts and adaptation strategies.
Language	English
Publishing date	2019-08-16T13:22:19Z
Publisher	Springer
Publishing country	fr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: From Inception to ConcePTION: Genesis of a Network to Support Better Monitoring and Communication of Medication Safety During Pregnancy and Breastfeeding.

Thurin, Nicolas H / Pajouheshnia, Romin / Roberto, Giuseppe / Dodd, Caitlin / Hyeraci, Giulia / Bartolini, Claudia / Paoletti, Olga / Nordeng, Hedvig / Wallach-Kildemoes, Helle / Ehrenstein, Vera / Dudukina, Elena / MacDonald, Thomas / De Paoli, Giorgia / Loane, Maria / Damase-Michel, Christine / Beau, Anna-Belle / Droz-Perroteau, Cécile / Lassalle, Régis / Bergman, Jorieke /

Clinical pharmacology and therapeutics

2021 Volume 111, Issue 1, Page(s) 321–331

Abstract: In 2019, the Innovative Medicines Initiative (IMI) funded the ConcePTION project-Building an ecosystem for better monitoring and communicating safety of medicines use in pregnancy and breastfeeding: validated and regulatory endorsed workflows for fast, ... ...

Abstract	In 2019, the Innovative Medicines Initiative (IMI) funded the ConcePTION project-Building an ecosystem for better monitoring and communicating safety of medicines use in pregnancy and breastfeeding: validated and regulatory endorsed workflows for fast, optimised evidence generation-with the vision that there is a societal obligation to rapidly reduce uncertainty about the safety of medication use in pregnancy and breastfeeding. The present paper introduces the set of concepts used to describe the European data sources involved in the ConcePTION project and illustrates the ConcePTION Common Data Model (CDM), which serves as the keystone of the federated ConcePTION network. Based on data availability and content analysis of 21 European data sources, the ConcePTION CDM has been structured with six tables designed to capture data from routine healthcare, three tables for data from public health surveillance activities, three curated tables for derived data on population (e.g., observation time and mother-child linkage), plus four metadata tables. By its first anniversary, the ConcePTION CDM has enabled 13 data sources to run common scripts to contribute to major European projects, demonstrating its capacity to facilitate effective and transparent deployment of distributed analytics, and its potential to address questions about utilization, effectiveness, and safety of medicines in special populations, including during pregnancy and breastfeeding, and, more broadly, in the general population.
MeSH term(s)	Breast Feeding ; Communication ; Databases as Topic/organization & administration ; Drug Information Services/standards ; Drug-Related Side Effects and Adverse Reactions ; Europe ; Female ; Health Information Exchange ; Humans ; Information Storage and Retrieval ; Pregnancy
Language	English
Publishing date	2021-11-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.2476
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Article ; Online: Variants of SLC6A4 in depression risk following severe TBI.

Failla, Michelle D / Burkhardt, Josh N / Miller, Megan A / Scanlon, Joelle M / Conley, Yvette P / Ferrell, Robert E / Wagner, Amy K

Brain injury

2013 Volume 27, Issue 6, Page(s) 696–706

Abstract: Background: Post-traumatic depression (PTD) may be a result of several factors like secondary injury chemical cascades as well as psycho-social factors following traumatic brain injury (TBI). While the role of serotonin in the pathology and treatment of ...

Abstract	Background: Post-traumatic depression (PTD) may be a result of several factors like secondary injury chemical cascades as well as psycho-social factors following traumatic brain injury (TBI). While the role of serotonin in the pathology and treatment of idiopathic major depression may be somewhat controversial, it is unclear what role serotonin may play in PTD following a TBI. Objective: To assess serotonergic function and genetic risk for PTD development over 1 year following TBI. Research design: Examination of variation in the serotonin transporter gene [SLC6A4 (5-HTTLPR, rs25331, and a variable number of tandem repeats variant in Intron 2)] in 109 subjects with moderate-severe injury. Depression was assessed using the Patient Health Questionnaire (PHQ-9) at 6 and/or 12 months post-injury. Main outcomes and results: At 6 months post-injury, subjects with a history of pre-morbid mood disorders and 5-HTTLPR L-homozygotes were at greater risk for PTD. Contrary to major depression, subjects without pre-morbid mood disorders (n = 80) and S-carriers were 2.803-times less likely to be depressed compared to L-homozygotes. At 12 months post-injury, LG-carriers were also less likely to experience PTD. Temporal analysis also showed 5-HTTLPR associations in PTD development across recovery. Conclusions: This study suggests a unique injury- and temporally-specific interaction between TBI and genetic risk for depression.
MeSH term(s)	Adolescent ; Adult ; Aged ; Brain Injuries/complications ; Brain Injuries/genetics ; Brain Injuries/physiopathology ; Depression/etiology ; Depression/genetics ; Depression/physiopathology ; Female ; Genotype ; Glasgow Coma Scale ; Humans ; Male ; Middle Aged ; Risk Factors ; Serotonin Plasma Membrane Transport Proteins/genetics ; Severity of Illness Index ; Surveys and Questionnaires ; United States/epidemiology
Chemical Substances	SLC6A4 protein, human ; Serotonin Plasma Membrane Transport Proteins
Language	English
Publishing date	2013-04-05
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639115-1
ISSN	1362-301X ; 0269-9052
ISSN (online)	1362-301X
ISSN	0269-9052
DOI	10.3109/02699052.2013.775481
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