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Article ; Online: Sex difference in the association between excessive daytime sleepiness and health-related quality of life in community-dwelling older adults: The Yilan study, Taiwan.

Chen, Chao-Han / Hsu, Nai-Wei / Chen, Hsi-Chung

2024 Volume 183, Page(s) 107945

Abstract: Objectives: The association between excessive daytime sleepiness and health-related quality of life among older adults and at-risk individuals remains unclear. This study examined relationships between excessive daytime sleepiness and unfavorable health- ...

Abstract	Objectives: The association between excessive daytime sleepiness and health-related quality of life among older adults and at-risk individuals remains unclear. This study examined relationships between excessive daytime sleepiness and unfavorable health-related quality of life and explored the moderating effect of sex. Study design: This was a community-based study of adults aged 65 years or more. Excessive daytime sleepiness was defined as a score exceeding 10 on the Epworth Sleepiness Scale. Multiple logistic regression analyses were used to examine the relationships between excessive daytime sleepiness and health-related quality of life. The moderating effect of sex was examined by testing interaction terms. Main outcome measures: Health-related quality of life was measured using the Short Form 12 Health Survey, which includes a physical component summary and a mental component summary. Unfavorable health-related quality of life was defined as the lowest tertile of the scores for both components. Results: In total, 3788 individuals participated. After controlling for covariates, older adults with excessive daytime sleepiness did not have an unfavorable physical component summary but were more likely to have an unfavorable mental component summary (odds ratio 1.96; 95 % confidence interval 1.47-2.61). When stratified by sex, excessive daytime sleepiness was associated with a poor physical component summary in men (odds ratio 1.77, 95 % confidence interval 1.00-3.13) but not in women. Conclusions: Excessive daytime sleepiness was associated with a poor mental component summary in both sexes; however, the association with a poor physical component summary was specific to men.
MeSH term(s)	Humans ; Male ; Female ; Aged ; Independent Living ; Quality of Life ; Sex Characteristics ; Taiwan/epidemiology ; Surveys and Questionnaires ; Disorders of Excessive Somnolence/epidemiology
Language	English
Publishing date	2024-02-16
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2024.107945
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Zs.A 1432: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Taxonomy and Phylogeography of the Freshwater Crab

Shih, Hsi-Te / Hsu, Jhih-Wei / Chang, Kai / Chen, Min-Wan

Zoological studies

2023 Volume 62, Page(s) e37

Abstract: The freshwater ... ...

Abstract	The freshwater crabs
Language	English
Publishing date	2023-07-21
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2105348-0
ISSN	1810-522X ; 1810-522X
ISSN (online)	1810-522X
ISSN	1810-522X
DOI	10.6620/ZS.2023.62-37
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Article ; Online: The need for precise and accurate imaging navigation in cervical spine surgery for rheumatoid arthritis.

Huang, Chih-Wei / Lin, Mao-Shih / Tzeng, Chung-Yuh / Chen, Tse-Yu / Tsou, Hsi-Kai

International journal of rheumatic diseases

2024 Volume 27, Issue 2, Page(s) e15084

MeSH term(s)	Humans ; Diagnostic Imaging ; Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/surgery ; Arthritis, Rheumatoid/diagnostic imaging ; Arthritis, Rheumatoid/surgery
Language	English
Publishing date	2024-02-20
Publishing country	England
Document type	Editorial
ZDB-ID	2426924-4
ISSN	1756-185X ; 1756-1841
ISSN (online)	1756-185X
ISSN	1756-1841
DOI	10.1111/1756-185X.15084
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Article ; Online: The differential pattern of associations between nighttime sleep disturbances with dimensions of daytime sleepiness in community-dwelling older adults, the Yilan study, Taiwan.

Chen, Ching / Hsu, Nai-Wei / Chen, Hsi-Chung

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

2023 Volume 24, Issue 2, Page(s) 212–222

Abstract: Background: The association between nighttime sleep disturbance and daytime sleepiness remains unclear. This study aimed to examine the relationships between various domains of nighttime sleep disturbance, daytime sleepiness, and their specific ... ...

Abstract	Background: The association between nighttime sleep disturbance and daytime sleepiness remains unclear. This study aimed to examine the relationships between various domains of nighttime sleep disturbance, daytime sleepiness, and their specific dimensions. Methods: This was a community-based cross-sectional study. The participants were adults aged 65 years and older from Yilan City, Taiwan. Daytime sleepiness (DS) was defined using the Epworth Sleepiness Scale (ESS) with scores ≥ 11. The ESS dimensions were further examined using exploratory factor analysis. The highest 15% factor scores for each factor were defined as factor-specific DS. Various domains of nighttime sleep disturbance were assessed using the Pittsburgh Sleep Quality Index. Logistic regression analysis was used to examine the independent relationships among various nighttime sleep disturbances, ESS, and its dimensions. Results: Of the 2585 participants, a total of 59.0% were women. Two factors were identified by exploratory factor analysis and were designated as 'passive factor' and 'active factor'. Multiple logistic regression analyses elucidated that short sleep duration was a common risk indicator for ESS-defined (odds ratio (OR): 2.01; 95% confidence interval (CI): 1.43-2.83), passive factor-defined (OR: 2.23, 95% CI: 1.65-3.00), and active factor-defined DS (OR: 1.47, 95% CI: 1.07-2.00). Hypnotic use was associated with a lower risk of both ESS-defined (OR: 0.66, 95% CI: 0.47-0.92) and passive factor-defined DS (OR:0.69, 95% CI: 0.52-0.92). Bathroom use (OR: 1.41, 95% CI: 1.04-1.91), coughing or snoring (OR: 2.14, 95% CI: 1.01-4.56), and sleep efficiency (OR: 0.42; 95% CI: 0.31-0.57) were uniquely associated with active factor-defined DS. Conclusion: Two factors were identified in the ESS, revealing factor-specific correlates of DS. Specifically, ESS- and passive factor-defined DS shared similar correlates. In contrast, some correlates seem unique to active-factor-defined DS.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Taiwan/epidemiology ; Cross-Sectional Studies ; Independent Living ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/epidemiology ; Sleep ; Disorders of Excessive Somnolence/diagnosis ; Disorders of Excessive Somnolence/epidemiology
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2213105-X
ISSN	1479-8301 ; 1346-3500
ISSN (online)	1479-8301
ISSN	1346-3500
DOI	10.1111/psyg.13063
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Zs.A 6210: Show issues

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Article ; Online: Different dimensions of daytime sleepiness predicted mortality in older adults: Sex and muscle power-specific risk in Yilan Study, Taiwan.

Chen, Hsi-Chung / Hsu, Nai-Wei / Lin, Ching-Heng

Sleep medicine

2023 Volume 113, Page(s) 84–91

Abstract: Objectives: This study aimed to investigate the relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined.: Methods: This 9-year follow-up study was conducted with ...

Abstract	Objectives: This study aimed to investigate the relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Methods: This 9-year follow-up study was conducted with community-dwelling individuals aged ≥65 years. Daytime sleepiness was evaluated using the Epworth Sleepiness Scale (ESS). Exploratory factor analysis (EFA) was used to examine the ESS factors. Handgrip strength was measured to assess physical function, and the highest quartile was defined as good muscle power. Cox regression analysis was used to estimate the 9-year all-cause mortality risk. The interaction terms were examined to evaluate their moderating effect. Results: In total, 2588 individuals participated in the study. The EFA explored two factors: the passive factor (PF) and the active factor (AF). After controlling for various covariates, the cutoff-defined daytime sleepiness (ESS≥11), total raw scores, and factor scores of the ESS all failed to predict mortality risk. The 3-way interaction terms showed statistical significance in terms of [sex × PF × muscle power (p = 0.03)] but not for [sex × AF × muscle power (p = 0.11)]. Specifically, PF predicted mortality risk in women with good muscle power (hazard ratio (HR): 1.48; 95 % confidence interval (CI): 1.04-2.10), which is female-specific. In contrast, AF predicted mortality risk only in men with good muscle power (HR: 1.35; 95 % CI: 1.02-1.78). Conclusions: The ESS-measured daytime sleepiness in older adults is multidimensional. The mortality risk for each dimension was determined based on sex and physical function.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Follow-Up Studies ; Taiwan/epidemiology ; Hand Strength ; Disorders of Excessive Somnolence ; Muscles
Language	English
Publishing date	2023-11-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012041-2
ISSN	1878-5506 ; 1389-9457
ISSN (online)	1878-5506
ISSN	1389-9457
DOI	10.1016/j.sleep.2023.11.026
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Zs.A 5315: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Therapeutic Options Targeting the Ataxia-Telangiectasia Mutated (ATM)-mediated DNA Damage Response, Macropinocytosis, and Adaptive Immunity in Ovarian Cancer.

Tseng, Cai-Chieh / Ku, Min-Hsi / Wu, Yun-Chieh / Huang, Wei-Lun / Wu, Wei-Ming / Pai, Ching Hua / Chen, Chi-Wei

Anticancer research

2024 Volume 44, Issue 4, Page(s) 1353–1364

Abstract: Ataxia-telangiectasia mutated (ATM) is a pivotal protein with versatile kinase activity that responds to DNA damage. While its well-established role as a DNA repair protein is widely recognized, the understanding of its noncanonical functions in ovarian ... ...

Abstract	Ataxia-telangiectasia mutated (ATM) is a pivotal protein with versatile kinase activity that responds to DNA damage. While its well-established role as a DNA repair protein is widely recognized, the understanding of its noncanonical functions in ovarian cancer remains limited. Numerous studies have investigated the potential of targeting ATM for ovarian cancer treatment. In addition to its involvement in homologous recombination repair (HRR), an increasing body of research suggests that ATM plays a role in cellular metabolism and adaptive immunity. This review focuses on the current evidence and provides a perspective on how targeting ATM in ovarian cancer can address HRR-deficient genotypes, influence macropinocytosis, and enhance immune checkpoint blockade (ICB) therapy. It underscores the diverse avenues through which targeting ATM is a potential tailored treatment for ovarian cancer.
MeSH term(s)	Female ; Humans ; Adaptive Immunity ; Ataxia Telangiectasia Mutated Proteins/genetics ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Cycle Proteins/metabolism ; DNA Damage ; DNA Repair ; DNA-Binding Proteins/genetics ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Protein Serine-Threonine Kinases/metabolism ; Tumor Suppressor Proteins/metabolism
Chemical Substances	Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1) ; ATM protein, human (EC 2.7.11.1) ; Cell Cycle Proteins ; DNA-Binding Proteins ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Tumor Suppressor Proteins
Language	English
Publishing date	2024-03-25
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16931
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Zs.A 1642: Show issues

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Article ; Online: Dissolved and particulate nitrogen species partitioning and distribution in the Danshuei River estuary, northern Taiwan.

Fang, Tien Hsi / Chen, Wei Hsiang

Marine pollution bulletin

2021 Volume 164, Page(s) 111981

Abstract: Danshuei River Estuary (DRE) total and inorganic nitrogen in the dissolved (TDN, DIN) and particulate (TPN, PIN) phases were analyzed to study their distribution and partitioning. The carbon contents in particles were also analyzed. The upper estuary ... ...

Abstract	Danshuei River Estuary (DRE) total and inorganic nitrogen in the dissolved (TDN, DIN) and particulate (TPN, PIN) phases were analyzed to study their distribution and partitioning. The carbon contents in particles were also analyzed. The upper estuary contained higher ammonium concentration (304-557 μM), leading to TDN completely dominating (>95%) the total N (TDN + TPN) pool within the DRE. Ammonium played a crucial role in controlling the speciation variation of DIN and partitioning between dissolved and particulate phases. Nitrification seemed to occur in the salinity >30 region where elevated percentages of nitrite and nitrate were observed. PON dominated the particulate N and contributed an average of 62% of the TPN pool. A constant organic C/N ratio (6.55) was observed in particles, indicating that POM was mainly from phytoplankton detritus. The N distribution coefficient values, log(K
MeSH term(s)	Carbon/analysis ; Environmental Monitoring ; Estuaries ; Nitrogen/analysis ; Rivers ; Taiwan
Chemical Substances	Carbon (7440-44-0) ; Nitrogen (N762921K75)
Language	English
Publishing date	2021-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2021.111981
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Article ; Online: The effect of anions in the synthesis and structure of pyrazolylamidino copper(II) complexes.

Hsieh, Chang-Chih / Liao, Po-Kuang / Chen, Chia-Wei / Chiang, Ming-Hsi / Horng, Yih-Chern

Dalton transactions (Cambridge, England : 2003)

2023 Volume 52, Issue 14, Page(s) 4429–4441

Abstract: Six new pyrazolylamidino Cu(II) complexes are synthesized directly from the reactions of Cu(X) ...

Abstract	Six new pyrazolylamidino Cu(II) complexes are synthesized directly from the reactions of Cu(X)
Language	English
Publishing date	2023-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d3dt00103b
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Article ; Online: Total Skin Treatment with Helical Arc Radiotherapy.

Nien, Hsin-Hua / Hsieh, Chen-Hsi / Shueng, Pei-Wei / Tien, Hui-Ju

International journal of molecular sciences

2023 Volume 24, Issue 5

Abstract: For widespread cutaneous lymphoma, such as mycosis fungoides or leukemia cutis, in patients with acute myeloid leukemia (AML) and for chronic myeloproliferative diseases, total skin irradiation is an efficient treatment modality for disease control. ... ...

Abstract	For widespread cutaneous lymphoma, such as mycosis fungoides or leukemia cutis, in patients with acute myeloid leukemia (AML) and for chronic myeloproliferative diseases, total skin irradiation is an efficient treatment modality for disease control. Total skin irradiation aims to homogeneously irradiate the skin of the entire body. However, the natural geometric shape and skin folding of the human body pose challenges to treatment. This article introduces treatment techniques and the evolution of total skin irradiation. Articles on total skin irradiation by helical tomotherapy and the advantages of total skin irradiation by helical tomotherapy are reviewed. Differences among each treatment technique and treatment advantages are compared. Adverse treatment effects and clinical care during irradiation and possible dose regimens are mentioned for future prospects of total skin irradiation.
MeSH term(s)	Humans ; Mycosis Fungoides ; Skin Neoplasms/radiotherapy ; Radiotherapy, Intensity-Modulated/methods ; Leukemia/therapy ; Lymphoma, T-Cell, Cutaneous ; Radiotherapy Dosage ; Whole-Body Irradiation/methods
Language	English
Publishing date	2023-02-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24054492
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Article: New Synthesized Activating Transcription Factor 3 Inducer SW20.1 Suppresses Resistin-Induced Metabolic Syndrome.

Tran, Tu T / Huang, Wei-Jan / Lin, Heng / Chen, Hsi-Hsien

Biomedicines

2023 Volume 11, Issue 6

Abstract: Obesity is an emerging concern globally with increasing prevalence. Obesity is associated with many diseases, such as cardiovascular disease, dyslipidemia, and cancer. Thus, effective new antiobesity drugs should be urgently developed. We synthesized ... ...

Abstract	Obesity is an emerging concern globally with increasing prevalence. Obesity is associated with many diseases, such as cardiovascular disease, dyslipidemia, and cancer. Thus, effective new antiobesity drugs should be urgently developed. We synthesized SW20.1, a compound that induces activating transcription factor 3 (ATF3) expression. The results of Oil Red O staining and quantitative real-time polymerase chain reaction revealed that SW20.1 was more effective in reducing lipid accumulation in 3T3-L1 preadipocytes than the previously synthesized ST32db, and that it inhibited the expression of the genes involved in adipogenesis and lipogenesis. A chromatin immunoprecipitation assay indicated that SW20.1 inhibited adipogenesis and lipogenesis by binding to the upstream promoter region of resistin at two sites (-2861/-2854 and -241/-234). In mice, the intraperitoneal administration of SW20.1 reduced body weight, white adipocyte weight in different regions, serum cholesterol levels, adipogenesis-related gene expression, hepatic steatosis, and serum resistin levels. Overall, SW20.1 exerts antiobesity effects by inhibiting resistin through the ATF3 pathway. Our study results indicate that SW20.1 is a promising therapeutic drug for diet-induced obesity.
Language	English
Publishing date	2023-05-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11061509
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